ZA200303729B - Compounds specific to adenosine A1, A2A, and A3 receptor and uses thereof. - Google Patents
Compounds specific to adenosine A1, A2A, and A3 receptor and uses thereof. Download PDFInfo
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- ZA200303729B ZA200303729B ZA200303729A ZA200303729A ZA200303729B ZA 200303729 B ZA200303729 B ZA 200303729B ZA 200303729 A ZA200303729 A ZA 200303729A ZA 200303729 A ZA200303729 A ZA 200303729A ZA 200303729 B ZA200303729 B ZA 200303729B
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Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
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- Biochemistry (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/728,616 US7160890B2 (en) | 1999-12-02 | 2000-12-01 | Compounds specific to adenosine A3 receptor and uses thereof |
| US09/728,316 US6680322B2 (en) | 1999-12-02 | 2000-12-01 | Compounds specific to adenosine A1 receptors and uses thereof |
| US09/728,607 US6664252B2 (en) | 1999-12-02 | 2000-12-01 | 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200303729B true ZA200303729B (en) | 2004-05-14 |
Family
ID=27419112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200303729A ZA200303729B (en) | 2000-12-01 | 2003-05-14 | Compounds specific to adenosine A1, A2A, and A3 receptor and uses thereof. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1347980A4 (de) |
| JP (1) | JP4579497B2 (de) |
| CN (1) | CN1263757C (de) |
| AP (1) | AP1893A (de) |
| AU (1) | AU2002248151B2 (de) |
| BR (1) | BR0115847A (de) |
| CA (1) | CA2430577A1 (de) |
| CZ (1) | CZ20031831A3 (de) |
| EA (1) | EA007254B1 (de) |
| HU (1) | HUP0400692A3 (de) |
| IL (1) | IL155962A0 (de) |
| ME (1) | MEP35308A (de) |
| MX (1) | MXPA03004717A (de) |
| NO (1) | NO327207B1 (de) |
| NZ (1) | NZ525885A (de) |
| OA (1) | OA13295A (de) |
| PL (1) | PL363245A1 (de) |
| WO (1) | WO2002057267A1 (de) |
| YU (1) | YU42703A (de) |
| ZA (1) | ZA200303729B (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5090531A (en) * | 1990-01-10 | 1992-02-25 | Lord Corporation | Electrophoretic fluid differential |
| CZ302486B6 (cs) | 1998-06-02 | 2011-06-15 | Osi Pharmaceuticals, Inc. | N-6-Substituovaný 7-deazapurin, zpusob jeho prípravy a farmaceutická kompozice s jeho obsahem |
| US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| DE10148883A1 (de) * | 2001-10-04 | 2003-04-10 | Merck Patent Gmbh | Pyrimidinderivate |
| EP1450811B1 (de) * | 2001-11-30 | 2009-10-21 | OSI Pharmaceuticals, Inc. | Verbindungen, die für Adenosin A1 und A3 Rezeptoren spezifisch sind, und deren Anwendungen |
| CA2469316A1 (en) * | 2001-12-07 | 2003-06-19 | Vertex Pharmaceuticals, Inc. | Pyrimidine-based compounds useful as gsk-3 inhibitors |
| EA011809B1 (ru) | 2001-12-20 | 2009-06-30 | Оси Фармасьютикалз, Инк. | Пиримидиновые соединения, их применение в качестве a-селективных антагонистов и способ их получения |
| CN1816551A (zh) | 2001-12-20 | 2006-08-09 | Osi药物公司 | 吡咯并嘧啶A2b选择性拮抗剂化合物,它们的合成及用途 |
| CA2502429A1 (en) * | 2002-10-31 | 2004-05-21 | Amgen Inc. | Antiinflammation agents |
| HUP0203976A3 (en) * | 2002-11-15 | 2004-08-30 | Sanofi Aventis | Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| UY29177A1 (es) | 2004-10-25 | 2006-05-31 | Astex Therapeutics Ltd | Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos |
| EP3421471B1 (de) | 2006-04-25 | 2021-05-26 | Astex Therapeutics Limited | Purin- und deazapurinderivate als pharmazeutische verbindungen |
| US20070260203A1 (en) * | 2006-05-04 | 2007-11-08 | Allergan, Inc. | Vasoactive agent intraocular implant |
| TW200808819A (en) * | 2006-06-19 | 2008-02-16 | Solvay Pharm Gmbh | Use of adenosine A1 antagonists in radiocontrast media induced nephrophaty |
| WO2009047563A1 (en) | 2007-10-11 | 2009-04-16 | Astrazeneca Ab | Pyrrolo [2, 3 -d] pyrimidin derivatives as protein kinase b inhibitors |
| AR070127A1 (es) | 2008-01-11 | 2010-03-17 | Novartis Ag | Pirrolo - pirimidinas y pirrolo -piridinas |
| EP2247596A2 (de) | 2008-01-11 | 2010-11-10 | Natco Pharma Limited | Neuartige pyrazol-[3,4-d-]pyrimidin-derivate als wirkstoffe gegen krebs |
| SI2694056T1 (sl) | 2011-04-01 | 2019-12-31 | Astrazeneca Ab | Terapevtsko zdravljenje |
| DK2785349T4 (da) | 2011-11-30 | 2023-01-09 | Astrazeneca Ab | Kombinationsbehandling af cancer |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| CN104350056A (zh) * | 2012-06-07 | 2015-02-11 | 霍夫曼-拉罗奇有限公司 | 端锚聚合酶的吡咯并嘧啶酮和吡咯并吡啶酮抑制剂 |
| CA2915561C (en) | 2013-06-21 | 2020-09-22 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
| EA035601B1 (ru) | 2013-06-21 | 2020-07-14 | Зенит Эпидженетикс Лтд. | Бициклические ингибиторы бромодомена |
| CN105593224B (zh) | 2013-07-31 | 2021-05-25 | 恒元生物医药科技(苏州)有限公司 | 作为溴结构域抑制剂的新型喹唑啉酮类化合物 |
| EP3227281A4 (de) | 2014-12-01 | 2018-05-30 | Zenith Epigenetics Ltd. | Substituierte pyridinone als bromodomain-inhibitoren |
| CA2966303A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| CA2966449A1 (en) | 2014-12-11 | 2016-06-16 | Zenith Epigenetics Ltd. | Substituted heterocycles as bromodomain inhibitors |
| EP3233846A4 (de) | 2014-12-17 | 2018-07-18 | Zenith Epigenetics Ltd. | Inhibitoren von bromdomänen |
| CN108349977B (zh) * | 2015-01-20 | 2021-05-25 | 无锡福祈制药有限公司 | Jak抑制剂 |
| KR102006684B1 (ko) | 2015-04-29 | 2019-08-02 | 우시 포춘 파마슈티컬 컴퍼니 리미티드 | Jak 억제제 |
| CA2983481C (en) | 2015-05-29 | 2020-04-14 | Wuxi Fortune Pharmaceutical Co., Ltd | Janus kinase inhibitor |
| CN105771672B (zh) * | 2016-04-18 | 2018-03-02 | 天津工业大学 | 一种抗污染抗菌芳香聚酰胺反渗透复合膜及制备方法 |
| CN108570054B (zh) * | 2017-03-07 | 2021-07-16 | 广州再极医药科技有限公司 | 氨基嘧啶并五元杂环化合物、其中间体、制备方法、药物组合物及应用 |
| CN108017584B (zh) * | 2017-06-20 | 2021-03-23 | 南开大学 | A3腺苷受体的小分子拮抗剂 |
| KR20210033444A (ko) * | 2018-06-04 | 2021-03-26 | 엑스사이언티아 엘티디 | 아데노신 수용체 길항제로서 피라졸로피리미딘 화합물 |
| CN110128316B (zh) * | 2019-05-22 | 2021-08-31 | 北京大学深圳研究生院 | 5位取代的β-脯氨酸及其衍生物的制备方法 |
| CN110272373B (zh) * | 2019-07-02 | 2022-07-29 | 天津国际生物医药联合研究院 | 一种具有选择性的腺苷a1受体拮抗剂及其应用 |
| CN114085178A (zh) * | 2021-12-29 | 2022-02-25 | 苏州楚凯药业有限公司 | 一种4-甲基-1-丙基-2-氨基-1h-吡咯-3-腈的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2895961B2 (ja) * | 1992-12-17 | 1999-05-31 | フアイザー・インコーポレイテツド | Ｃｒｆアンタゴニストとしてのピロロピリミジン |
| US5780450A (en) * | 1995-11-21 | 1998-07-14 | Alcon Laboratories, Inc. | Use of adenosine uptake inhibitors for treating retinal or optic nerve head damage |
| CZ302486B6 (cs) * | 1998-06-02 | 2011-06-15 | Osi Pharmaceuticals, Inc. | N-6-Substituovaný 7-deazapurin, zpusob jeho prípravy a farmaceutická kompozice s jeho obsahem |
| KR100840727B1 (ko) * | 1999-12-02 | 2008-06-23 | 오에스아이 파마슈티컬스, 인코포레이티드 | 아데노신 ａ1, ａ2ａ 및 ａ3 수용체 특이 화합물 및 그의 사용방법 |
| EP1450811B1 (de) * | 2001-11-30 | 2009-10-21 | OSI Pharmaceuticals, Inc. | Verbindungen, die für Adenosin A1 und A3 Rezeptoren spezifisch sind, und deren Anwendungen |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP4579497B2 (ja) | 2010-11-10 |
| EP1347980A4 (de) | 2005-02-09 |
| MEP35308A (en) | 2011-02-10 |
| NO327207B1 (no) | 2009-05-11 |
| YU42703A (sh) | 2006-03-03 |
| OA13295A (en) | 2007-04-13 |
| CN1489590A (zh) | 2004-04-14 |
| CZ20031831A3 (cs) | 2004-05-12 |
| NO20032482D0 (no) | 2003-06-02 |
| MXPA03004717A (es) | 2004-06-30 |
| AU2002248151B2 (en) | 2008-02-21 |
| CA2430577A1 (en) | 2002-07-25 |
| BR0115847A (pt) | 2004-02-25 |
| NZ525885A (en) | 2005-01-28 |
| NO20032482L (no) | 2003-07-28 |
| HUP0400692A3 (en) | 2007-09-28 |
| CN1263757C (zh) | 2006-07-12 |
| IL155962A0 (en) | 2003-12-23 |
| EA007254B1 (ru) | 2006-08-25 |
| EA200300628A1 (ru) | 2003-12-25 |
| AP2003002807A0 (en) | 2003-06-30 |
| EP1347980A1 (de) | 2003-10-01 |
| WO2002057267A1 (en) | 2002-07-25 |
| AP1893A (en) | 2008-09-23 |
| PL363245A1 (en) | 2004-11-15 |
| JP2004517896A (ja) | 2004-06-17 |
| HUP0400692A2 (hu) | 2004-07-28 |
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