ZA200208898B - Adenosine A2A receptor antagonists. - Google Patents
Adenosine A2A receptor antagonists. Download PDFInfo
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- ZA200208898B ZA200208898B ZA200208898A ZA200208898A ZA200208898B ZA 200208898 B ZA200208898 B ZA 200208898B ZA 200208898 A ZA200208898 A ZA 200208898A ZA 200208898 A ZA200208898 A ZA 200208898A ZA 200208898 B ZA200208898 B ZA 200208898B
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- ZA
- South Africa
- Prior art keywords
- alkyl
- alkoxy
- compound
- formula
- mmol
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20714300P | 2000-05-26 | 2000-05-26 |
Publications (1)
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|---|---|
| ZA200208898B true ZA200208898B (en) | 2004-03-01 |
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| ZA200208898A ZA200208898B (en) | 2000-05-26 | 2002-11-01 | Adenosine A2A receptor antagonists. |
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| US (4) | US6630475B2 (ja) |
| EP (1) | EP1283839B1 (ja) |
| JP (3) | JP4574112B2 (ja) |
| KR (1) | KR100520907B1 (ja) |
| CN (2) | CN1247588C (ja) |
| AR (1) | AR028621A1 (ja) |
| AT (1) | ATE293627T1 (ja) |
| AU (2) | AU6808901A (ja) |
| BR (1) | BRPI0111015B8 (ja) |
| CA (1) | CA2410237C (ja) |
| CZ (1) | CZ303790B6 (ja) |
| DE (1) | DE60110219T2 (ja) |
| DK (1) | DK1283839T3 (ja) |
| EC (1) | ECSP024364A (ja) |
| ES (1) | ES2237576T3 (ja) |
| HK (1) | HK1049007B (ja) |
| HU (1) | HU230420B1 (ja) |
| IL (3) | IL152726A0 (ja) |
| MX (1) | MXPA02011625A (ja) |
| MY (1) | MY132006A (ja) |
| NO (1) | NO325008B1 (ja) |
| NZ (1) | NZ522326A (ja) |
| PE (1) | PE20020062A1 (ja) |
| PL (1) | PL218764B1 (ja) |
| PT (1) | PT1283839E (ja) |
| RU (1) | RU2315053C2 (ja) |
| SI (1) | SI1283839T1 (ja) |
| SK (1) | SK287748B6 (ja) |
| TW (1) | TWI288137B (ja) |
| WO (1) | WO2001092264A1 (ja) |
| ZA (1) | ZA200208898B (ja) |
Families Citing this family (87)
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| BRPI0111015B8 (pt) * | 2000-05-26 | 2021-05-25 | Merck Sharp & Dohme | composto antagonista de receptor a2a de adenosina, composição farmacêutica compreendendo o mesmo, seu uso e processos para a preparação de compostos intermediários |
| US20030139395A1 (en) * | 2001-09-13 | 2003-07-24 | Schering Corporation | Combination of an adenosine A2a receptor antagonist and an antidepressant or anxiolytic |
| MXPA04003474A (es) | 2001-10-15 | 2004-07-30 | Schering Corp | Imidazo (4,3-e)-1,2,4-triazolo(1,5-c) pirimidinas como antagonistas del receptor de adenosina a2a. |
| FR2832405B1 (fr) * | 2001-11-19 | 2004-12-10 | Sanofi Synthelabo | Tetrahydropyridyl-alkyl-heterocycles azotes, procede pour leur preparation et compositions pharmaceutiques les contenant |
| AR038366A1 (es) | 2001-11-30 | 2005-01-12 | Schering Corp | Compuestos de 1,2,4-triazolo [1,5-c] pirimidinas sustituidas, antagonistas del receptor de adenosina a2a, composiciones farmaceuticas, el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de enfermedades del sistema nervioso central y un kit que comprende combinacion |
| MXPA04005158A (es) | 2001-11-30 | 2004-08-11 | Schering Corp | Antagonistas receptores de adenosina a2a biciclica de (1.2.4]- triazol. |
| WO2003048165A1 (en) * | 2001-11-30 | 2003-06-12 | Schering Corporation | ADENOSINE A2a RECEPTOR ANTAGONISTS |
| CA2813048A1 (en) | 2002-01-28 | 2003-08-07 | Kyowa Hakko Kirin Co., Ltd. | Composition for use in treating patients suffering from movement disorder |
| IL160133A0 (en) * | 2002-05-30 | 2004-06-20 | King Pharmaceuticals Res & Dev | Pharmaceutically active compounds having a tricyclic pyrazolotriazolopyrimidine ring structure and methods of use |
| ES2354875T3 (es) | 2002-12-19 | 2011-03-18 | Schering Corporation | Uso de antagonistas del receptor a2a de la adenosina para el tratamiento o prevención del síndrome extrapiramidal. |
| US20060106040A1 (en) * | 2002-12-19 | 2006-05-18 | Michael Grzelak | Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
| US20070010522A1 (en) | 2003-04-09 | 2007-01-11 | Chi Vu | Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists |
| NZ542823A (en) * | 2003-04-23 | 2009-03-31 | Schering Corp | 2-Alkynyl- and 2-alkenyl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists |
| CN1787821A (zh) * | 2003-06-10 | 2006-06-14 | 协和发酵工业株式会社 | 一种治疗焦虑症的方法 |
| EP1636187A1 (en) * | 2003-06-12 | 2006-03-22 | Novo Nordisk A/S | Substituted piperazine carbamates for use as inhibitors of hormone sensitive lipase |
| JP4800216B2 (ja) * | 2003-10-24 | 2011-10-26 | エグゼリクシス， インコーポレイテッド | ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法 |
| PT1678182E (pt) * | 2003-10-28 | 2007-04-30 | Schering Corp | Processo para preparar 5-amino-pirazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pirimidinas |
| DE602004009962T2 (de) | 2003-12-01 | 2008-08-28 | Schering Corp. | Verfahren zur herstellung von substituierten 5-aminopyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidinen |
| ATE516011T1 (de) * | 2003-12-19 | 2011-07-15 | Schering Corp | Pharmazeutische zusammensetzungen eines a2a rezeptorantagonisten |
| DE602005020127D1 (de) * | 2004-04-21 | 2010-05-06 | Schering Corp | Pyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidine als antagonisten des adenosin-a2a-rezeptors |
| ATE556712T1 (de) * | 2005-06-07 | 2012-05-15 | Kyowa Hakko Kirin Co Ltd | A2a antagonisten zur behandlung von motorischen störungen |
| AR057817A1 (es) * | 2005-09-19 | 2007-12-19 | Schering Corp | Antagonistas del receptor a2a de 2-heteroaril-pirazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pirimidin adenosina. composiciones farmaceuticas |
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