ZA200105596B - The use of 4-H-1-benzopyran-4-one derivatives as inhibitors of smooth muscle cell proliferation. - Google Patents

The use of 4-H-1-benzopyran-4-one derivatives as inhibitors of smooth muscle cell proliferation. Download PDF

Info

Publication number
ZA200105596B
ZA200105596B ZA200105596A ZA200105596A ZA200105596B ZA 200105596 B ZA200105596 B ZA 200105596B ZA 200105596 A ZA200105596 A ZA 200105596A ZA 200105596 A ZA200105596 A ZA 200105596A ZA 200105596 B ZA200105596 B ZA 200105596B
Authority
ZA
South Africa
Prior art keywords
alkyl
alkylamino
phenyl
cycloalkyl
hydrogen
Prior art date
Application number
ZA200105596A
Other languages
English (en)
Inventor
Winston Campbell Patterson
Jennifer A Dumont
Original Assignee
Aventis Pharma Inc
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc, Univ Texas filed Critical Aventis Pharma Inc
Publication of ZA200105596B publication Critical patent/ZA200105596B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA200105596A 1999-02-01 2001-07-06 The use of 4-H-1-benzopyran-4-one derivatives as inhibitors of smooth muscle cell proliferation. ZA200105596B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24338099A 1999-02-01 1999-02-01

Publications (1)

Publication Number Publication Date
ZA200105596B true ZA200105596B (en) 2002-10-07

Family

ID=22918541

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200105596A ZA200105596B (en) 1999-02-01 2001-07-06 The use of 4-H-1-benzopyran-4-one derivatives as inhibitors of smooth muscle cell proliferation.

Country Status (38)

Country Link
US (1) US6399633B1 (enExample)
EP (1) EP1150746B1 (enExample)
JP (1) JP4755759B2 (enExample)
KR (1) KR100793047B1 (enExample)
CN (1) CN1219556C (enExample)
AP (1) AP1469A (enExample)
AR (1) AR042569A1 (enExample)
AT (1) ATE275428T1 (enExample)
AU (1) AU777368B2 (enExample)
BG (1) BG65151B1 (enExample)
BR (1) BR0007911A (enExample)
CA (1) CA2360668C (enExample)
CR (1) CR6448A (enExample)
CZ (1) CZ300395B6 (enExample)
DE (1) DE60013555T2 (enExample)
DK (1) DK1150746T3 (enExample)
EA (1) EA004786B1 (enExample)
EE (1) EE04851B1 (enExample)
ES (1) ES2226792T3 (enExample)
HK (1) HK1042445B (enExample)
HR (1) HRP20010521A2 (enExample)
HU (1) HU229263B1 (enExample)
ID (1) ID30180A (enExample)
IL (1) IL144668A (enExample)
ME (1) MEP10508A (enExample)
NO (1) NO330512B1 (enExample)
NZ (1) NZ512822A (enExample)
OA (1) OA11755A (enExample)
PL (1) PL197693B1 (enExample)
PT (1) PT1150746E (enExample)
RS (1) RS50242B (enExample)
SI (1) SI1150746T1 (enExample)
SK (1) SK286747B6 (enExample)
TR (1) TR200102223T2 (enExample)
TW (1) TWI273907B (enExample)
UA (1) UA73110C2 (enExample)
WO (1) WO2000044362A2 (enExample)
ZA (1) ZA200105596B (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0102480D0 (en) * 2001-01-31 2001-03-14 Cyclacel Ltd Marker
AU2003234733B2 (en) * 2002-04-17 2009-01-29 Cytokinetics, Inc. Compounds, compositions, and methods
US7132100B2 (en) 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
US7425618B2 (en) 2002-06-14 2008-09-16 Medimmune, Inc. Stabilized anti-respiratory syncytial virus (RSV) antibody formulations
US20040082613A1 (en) * 2002-06-28 2004-04-29 Schneider Michael D. Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy
US20040106647A1 (en) * 2002-06-28 2004-06-03 Schneider Michael D. Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy
CA2497628A1 (en) * 2002-09-05 2004-03-18 Medimmune, Inc. Methods of preventing or treating cell malignancies by administering cd2 antagonists
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
JP4764818B2 (ja) 2003-04-11 2011-09-07 メディミューン,エルエルシー 組換えil−9抗体およびその使用
US20060228350A1 (en) * 2003-08-18 2006-10-12 Medimmune, Inc. Framework-shuffling of antibodies
CA2536238C (en) 2003-08-18 2015-04-07 Medimmune, Inc. Humanization of antibodies
JP2008518023A (ja) 2004-10-27 2008-05-29 メディミューン,インコーポレーテッド 同族抗原に対する親和性を改変することによる抗体特異性の調節
CA2602035C (en) 2005-03-18 2015-06-16 Medimmune, Inc. Framework-shuffling of antibodies
WO2007002543A2 (en) 2005-06-23 2007-01-04 Medimmune, Inc. Antibody formulations having optimized aggregation and fragmentation profiles
WO2007010342A1 (en) * 2005-07-15 2007-01-25 Sahajanand Biotech Private Limited Implantable medical devices comprising a flavonoid or derivative thereof for prevention of restenosis
JP2008255008A (ja) * 2005-07-19 2008-10-23 Tokyo Medical & Dental Univ 滑膜細胞増殖抑制剤
WO2007016525A2 (en) * 2005-07-29 2007-02-08 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
TWI405771B (zh) 2006-08-28 2013-08-21 Kyowa Hakko Kirin Co Ltd 具拮抗性之人類light專一性人類單株抗體
WO2008092231A1 (en) 2007-02-01 2008-08-07 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular diseases
JP5456658B2 (ja) 2007-03-30 2014-04-02 メディミューン,エルエルシー 抗体製剤
PL2346837T3 (pl) 2008-06-26 2015-07-31 Resverlogix Corp Sposoby wytwarzania pochodnych chinazolinonu
US8952021B2 (en) 2009-01-08 2015-02-10 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
EP2408454B1 (en) 2009-03-18 2024-07-24 Resverlogix Corp. Novel anti-inflammatory agents
CN102458405B (zh) 2009-04-22 2017-06-23 雷斯韦洛吉克斯公司 新抗炎剂
WO2012007327A1 (en) 2010-07-12 2012-01-19 Dkfz Deutsches Krebsforschungszentrum Wogonin for the prevention and therapy of cardiac hypertrophy
WO2012103165A2 (en) 2011-01-26 2012-08-02 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies and uses thereof
RS58911B1 (sr) 2011-11-01 2019-08-30 Resverlogix Corp Oralne formulacije sa trenutnim otpuštanjem za supstituisane hinazolinone
AU2013295848B2 (en) 2012-07-25 2018-05-24 Celldex Therapeutics, Inc. Anti-KIT antibodies and uses thereof
EP2906598A1 (en) 2012-10-09 2015-08-19 Igenica Biotherapeutics, Inc. Anti-c16orf54 antibodies and methods of use thereof
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
MX2015007921A (es) 2012-12-21 2016-03-03 Zenith Epigenetics Corp Compuestos heterociclicos novedosos como inhibidores de bromodominio.
CA2914369C (en) 2013-06-06 2023-02-14 Igenica Biotherapeutics, Inc. Anti-c10orf54 antibodies and uses thereof
RS62189B1 (sr) 2013-08-26 2021-08-31 Biontech Research And Development Inc Nukleinske kiseline koje kodiraju humana antitela na sijalil-luis a
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
EP3868405A1 (en) 2014-06-04 2021-08-25 BioNTech Research and Development, Inc. Human monoclonal antibodies to ganglioside gd2
KR102693806B1 (ko) 2014-12-11 2024-08-09 피에르 파브르 메디카먼트 항-c10orf54 항체들 및 그들의 용도들
LT3265123T (lt) 2015-03-03 2023-01-25 Kymab Limited Antikūnai, naudojimas ir būdai
JP6903585B2 (ja) 2015-03-13 2021-07-14 レスバーロジックス コーポレイション 補体関連疾患の治療のための組成物および治療方法
BR112017022666A8 (pt) 2015-04-20 2022-10-18 Tolero Pharmaceuticals Inc Preparando resposta à alvocidib por perfilamento mitocondrial
TR201911032T4 (tr) 2015-05-18 2019-08-21 Tolero Pharmaceuticals Inc Artırılmış biyoyararlanıma sahip alvocıdıb ön ilaçları.
JP7083497B2 (ja) 2015-08-03 2022-06-13 スミトモ ファーマ オンコロジー, インコーポレイテッド がんの処置のための併用療法
WO2017096017A1 (en) 2015-12-02 2017-06-08 Stsciences, Inc. Antibodies specific to glycosylated btla (b- and t- lymphocyte attenuator)
AU2016365318B2 (en) 2015-12-02 2024-04-18 Board Of Regents, The University Of Texas System Antibodies and molecules that immunospecifically bind to BTN1A1 and the therapeutic uses thereof
EP3503923B1 (en) 2016-08-23 2023-10-04 Eisai R&D Management Co., Ltd. Combination therapies for the treatment of hepatocellular carcinoma
EP3534947A1 (en) 2016-11-03 2019-09-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
US11279694B2 (en) 2016-11-18 2022-03-22 Sumitomo Dainippon Pharma Oncology, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
KR102517650B1 (ko) 2017-03-16 2023-04-05 에자이 알앤드디 매니지먼트 가부시키가이샤 유방암의 치료를 위한 조합물 요법
CN111148762A (zh) 2017-05-31 2020-05-12 斯特库伯株式会社 免疫特异性结合至btn1a1的抗体和分子及其治疗性用途
CN111051346A (zh) 2017-05-31 2020-04-21 斯特库伯株式会社 使用免疫特异性结合btn1a1的抗体和分子治疗癌症的方法
KR20200026209A (ko) 2017-06-06 2020-03-10 주식회사 에스티큐브앤컴퍼니 Btn1a1 또는 btn1a1-리간드에 결합하는 항체 및 분자를 사용하여 암을 치료하는 방법
US11497756B2 (en) 2017-09-12 2022-11-15 Sumitomo Pharma Oncology, Inc. Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib
US11707522B2 (en) 2017-10-13 2023-07-25 Boehringer Ingelheim International Gmbh Human antibodies to Tn antigen
MX2021000786A (es) 2018-07-20 2021-06-15 Pf Medicament Receptor para supresor de ig del dominio v de activación de células t (vista).
KR20210099066A (ko) 2018-12-04 2021-08-11 스미토모 다이니폰 파마 온콜로지, 인크. 암의 치료를 위한 작용제로서 사용하기 위한 cdk9 억제제 및 그의 다형체
US11793802B2 (en) 2019-03-20 2023-10-24 Sumitomo Pharma Oncology, Inc. Treatment of acute myeloid leukemia (AML) with venetoclax failure
CN113559244B (zh) * 2021-08-02 2023-12-26 华中科技大学同济医学院附属协和医院 Ctrp13脂肪因子的新用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN164232B (enExample) * 1986-04-11 1989-02-04 Hoechst India
US5284856A (en) * 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
US5733920A (en) 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
US5849733A (en) 1996-05-10 1998-12-15 Bristol-Myers Squibb Co. 2-thio or 2-oxo flavopiridol analogs
US5908934A (en) 1996-09-26 1999-06-01 Bristol-Myers Squibb Company Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs
ATE391719T1 (de) 1997-02-05 2008-04-15 Warner Lambert Co Pyrido (2,3-d) pyrimidine und 4-amino-primidine als inhibitoren der zellulären proliferation

Also Published As

Publication number Publication date
BG65151B1 (bg) 2007-04-30
MEP10508A (en) 2010-06-10
OA11755A (en) 2005-07-19
JP4755759B2 (ja) 2011-08-24
AU3209800A (en) 2000-08-18
AP1469A (en) 2005-09-26
SI1150746T1 (en) 2005-02-28
HU229263B1 (en) 2013-10-28
CR6448A (es) 2004-03-17
NO20013335L (no) 2001-09-25
HK1042445A1 (en) 2002-08-16
DE60013555D1 (de) 2004-10-14
WO2000044362A3 (en) 2001-04-05
PT1150746E (pt) 2004-12-31
CA2360668C (en) 2009-03-17
JP2002535356A (ja) 2002-10-22
HK1042445B (zh) 2006-01-13
TR200102223T2 (tr) 2004-12-21
TWI273907B (en) 2007-02-21
KR100793047B1 (ko) 2008-01-10
IL144668A (en) 2005-06-19
AR042569A1 (es) 2005-06-29
DK1150746T3 (da) 2005-01-10
HUP0200804A3 (en) 2004-03-29
CZ300395B6 (cs) 2009-05-06
ES2226792T3 (es) 2005-04-01
PL197693B1 (pl) 2008-04-30
YU54401A (sh) 2004-05-12
WO2000044362A2 (en) 2000-08-03
NO20013335D0 (no) 2001-07-05
SK286747B6 (sk) 2009-04-06
BG105751A (en) 2002-02-28
DE60013555T2 (de) 2005-09-29
EP1150746A2 (en) 2001-11-07
NO330512B1 (no) 2011-05-09
IL144668A0 (en) 2002-05-23
UA73110C2 (en) 2005-06-15
HUP0200804A2 (hu) 2002-12-28
ATE275428T1 (de) 2004-09-15
CN1338958A (zh) 2002-03-06
CA2360668A1 (en) 2000-08-03
US6399633B1 (en) 2002-06-04
ID30180A (id) 2001-11-08
AU777368B2 (en) 2004-10-14
SK10862001A3 (sk) 2002-07-02
EE04851B1 (et) 2007-06-15
AP2001002218A0 (en) 2001-09-30
EA200100742A1 (ru) 2001-12-24
CN1219556C (zh) 2005-09-21
RS50242B (sr) 2009-07-15
BR0007911A (pt) 2001-10-16
HRP20010521A2 (en) 2002-08-31
CZ20012804A3 (cs) 2002-08-14
KR20010093309A (ko) 2001-10-27
NZ512822A (en) 2005-01-28
EE200100385A (et) 2002-12-16
EP1150746B1 (en) 2004-09-08
PL350735A1 (en) 2003-01-27
EA004786B1 (ru) 2004-08-26

Similar Documents

Publication Publication Date Title
EP1150746B1 (en) The use of 4-h-1-benzopryan-4-one derivatives as inhibitors of smooth muscle cell proliferation
Hu et al. Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death
US10214491B2 (en) Activators and therapeutic applications thereof
US7056908B2 (en) Pharmaceutical compositions and methods for preventing skin tumor formation and causing regression of existing tumors
MXPA01007278A (en) The use of 4-h-1-benzopyran-4-one derivatives as inhibitors of smooth muscle cell proliferation
US6495588B2 (en) Scytonemin and methods of using thereof
EP1727528A2 (en) Inhibition of mixed lineage kinases and uses therefor