ZA200102766B - Flow resistance modulated aerosolized active agent delivery. - Google Patents

Flow resistance modulated aerosolized active agent delivery. Download PDF

Info

Publication number
ZA200102766B
ZA200102766B ZA200102766A ZA200102766A ZA200102766B ZA 200102766 B ZA200102766 B ZA 200102766B ZA 200102766 A ZA200102766 A ZA 200102766A ZA 200102766 A ZA200102766 A ZA 200102766A ZA 200102766 B ZA200102766 B ZA 200102766B
Authority
ZA
South Africa
Prior art keywords
active agent
flow rate
agent formulation
resistance
aerosolized
Prior art date
Application number
ZA200102766A
Other languages
English (en)
Inventor
Andrew Clark
Carlos Schuler
Steve Paboojian
Original Assignee
Inhale Therapeutic Syst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhale Therapeutic Syst filed Critical Inhale Therapeutic Syst
Publication of ZA200102766B publication Critical patent/ZA200102766B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0021Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Illuminated Signs And Luminous Advertising (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Soft Magnetic Materials (AREA)
  • Paints Or Removers (AREA)
  • Preparation Of Fruits And Vegetables (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
ZA200102766A 1998-10-09 2001-04-04 Flow resistance modulated aerosolized active agent delivery. ZA200102766B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10370298P 1998-10-09 1998-10-09

Publications (1)

Publication Number Publication Date
ZA200102766B true ZA200102766B (en) 2001-10-05

Family

ID=22296604

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200102766A ZA200102766B (en) 1998-10-09 2001-04-04 Flow resistance modulated aerosolized active agent delivery.

Country Status (50)

Country Link
US (1) US8408200B2 (sr)
EP (1) EP1119384B1 (sr)
JP (2) JP4378057B2 (sr)
KR (1) KR100652532B1 (sr)
CN (2) CN1447704A (sr)
AP (1) AP1646A (sr)
AR (1) AR020760A1 (sr)
AT (1) ATE297771T1 (sr)
AU (1) AU754724B2 (sr)
BG (1) BG105377A (sr)
BR (1) BR9914384A (sr)
CA (1) CA2346791C (sr)
CO (1) CO5060481A1 (sr)
CZ (1) CZ20011181A3 (sr)
DE (1) DE69925849T2 (sr)
DK (1) DK1119384T3 (sr)
DZ (1) DZ2906A1 (sr)
EA (1) EA003405B1 (sr)
EE (1) EE04608B1 (sr)
EG (1) EG22111A (sr)
ES (1) ES2243094T3 (sr)
GE (1) GEP20043259B (sr)
GT (1) GT199900174A (sr)
HK (1) HK1040645B (sr)
HR (1) HRP20010253B1 (sr)
HU (1) HU225057B1 (sr)
ID (1) ID28354A (sr)
IL (1) IL142215A (sr)
IS (1) IS2289B (sr)
LT (2) LT4902B (sr)
LV (1) LV12685B (sr)
MA (1) MA25865A1 (sr)
MY (1) MY129112A (sr)
NO (1) NO20011742L (sr)
NZ (1) NZ510853A (sr)
OA (1) OA11791A (sr)
PA (1) PA8484001A1 (sr)
PE (1) PE20001281A1 (sr)
PL (1) PL193881B1 (sr)
PT (1) PT1119384E (sr)
RO (1) RO120532B1 (sr)
RS (1) RS49848B (sr)
SA (1) SA99200835B1 (sr)
SK (1) SK287044B6 (sr)
TN (1) TNSN99188A1 (sr)
TR (1) TR200101033T2 (sr)
UA (1) UA73924C2 (sr)
UY (1) UY25731A1 (sr)
WO (1) WO2000021594A2 (sr)
ZA (1) ZA200102766B (sr)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US20060171899A1 (en) * 1998-12-10 2006-08-03 Akwete Adjei Water-stabilized aerosol formulation system and method of making
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US6606992B1 (en) * 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
PT1280520E (pt) 2000-05-10 2014-12-16 Novartis Ag Pós à base de fosfolípidos para administração de fármacos
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
GB2380946A (en) * 2001-08-31 2003-04-23 Medic Aid Ltd Nebuliser arrangement
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
SI1494732T1 (sl) 2002-03-20 2008-08-31 Mannking Corp Inhalacijski aparat
JP4286498B2 (ja) * 2002-05-14 2009-07-01 アクティヴァエロ ゲーエムベーハー エアロゾルを管理するための装置
MXPA05007163A (es) 2002-12-31 2005-09-21 Nektar Therapeutics Al Corp Derivados polimericos de acido maleamico y sus bioconjugados.
AU2004297228A1 (en) 2003-12-03 2005-06-23 Nektar Therapeutics Al, Corporation Method of preparing maleimide functionalized polymers
US9022027B2 (en) 2004-02-20 2015-05-05 Pneumoflex Systems, Llc Nebulizer with intra-oral vibrating mesh
EP1786784B1 (en) 2004-08-20 2010-10-27 MannKind Corporation Catalysis of diketopiperazine synthesis
KR101306384B1 (ko) 2004-08-23 2013-09-09 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는디케토디옥산염
US7832394B2 (en) * 2004-12-22 2010-11-16 Schechter Alan M Apparatus for dispensing pressurized contents
AU2006290227B2 (en) 2005-09-14 2012-08-02 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
RU2403059C2 (ru) 2006-02-22 2010-11-10 Маннкайнд Корпорейшн Способ улучшения фармацевтических свойств микрочастиц, содержащих дикетопиперазин и активный агент
WO2008151796A2 (en) * 2007-06-15 2008-12-18 Boehringer Ingelheim International Gmbh Inhaler
EP2082762A1 (en) 2008-01-24 2009-07-29 Boehringer Ingelheim International Gmbh Inhaler
GB0802028D0 (en) 2008-02-05 2008-03-12 Dunne Stephen T Powder inhaler flow regulator
SG192447A1 (en) * 2008-03-27 2013-08-30 Mannkind Corp A dry powder inhalation system
KR101629154B1 (ko) 2008-06-13 2016-06-21 맨카인드 코포레이션 건조 분말 흡입기 및 약물 투여 시스템
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
DK2300083T3 (da) 2008-06-20 2013-07-22 Mannkind Corp Interaktivt apparat og fremgangsmåde til realtids-profilering af inhalationsforsøg
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
MX2011009512A (es) 2009-03-11 2011-11-29 Mannkind Corp Aparato, sistema y metodo para medir la resistencia de un inhalador.
SG176738A1 (en) 2009-06-12 2012-01-30 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
BR112012033060A2 (pt) 2010-06-21 2018-02-27 Mannkind Corp métodos de sistema de liberação de fármaco em pó seco
EP2654864B1 (en) 2010-12-22 2020-10-28 Syqe Medical Ltd. System for drug delivery
US8671934B2 (en) 2011-01-20 2014-03-18 Pneumoflex Systems, Llc Nebulizer that is activated by negative inspiratory pressure
US9452270B2 (en) 2011-01-20 2016-09-27 Pneumoflex Systems, Llc Nebulizer having replaceable nozzle assembly and suction line
US20140202457A1 (en) 2011-01-20 2014-07-24 Pneumoflex Systems, Llc Metered dose nebulizer
JOP20120023B1 (ar) 2011-02-04 2022-03-14 Novartis Ag صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
US9233159B2 (en) 2011-10-24 2016-01-12 Mannkind Corporation Methods and compositions for treating pain
SG10201605800UA (en) * 2012-07-12 2016-09-29 Mannkind Corp Dry powder drug delivery system and methods
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
KR102169734B1 (ko) * 2012-11-28 2020-10-26 이-니코틴 테크놀로지, 인크. 화합물 전달을 위한 방법 및 장치
US10034988B2 (en) 2012-11-28 2018-07-31 Fontem Holdings I B.V. Methods and devices for compound delivery
US9452139B2 (en) 2013-03-14 2016-09-27 Novartis Ag Respirable agglomerates of porous carrier particles and micronized drug
BR112015020443A8 (pt) 2013-03-14 2019-11-12 Novartis Ag formulação em pó para inalação, seus usos e seu processo de preparação, e composição farmacêutica
JP6523247B2 (ja) 2013-03-15 2019-05-29 マンカインド コーポレイション 微結晶性ジケトピペラジン粒子の製造方法および乾燥粉末組成物の製造方法
CN114848614A (zh) 2013-07-18 2022-08-05 曼金德公司 热稳定性干粉药物组合物和方法
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
US10194693B2 (en) 2013-09-20 2019-02-05 Fontem Holdings 1 B.V. Aerosol generating device
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
ES2904669T3 (es) * 2014-06-30 2022-04-05 Syqe Medical Ltd Cartucho de dosis de fármaco para un dispositivo inhalador
ES2898173T3 (es) 2014-06-30 2022-03-04 Syqe Medical Ltd Dispositivos y sistemas para la administración pulmonar de principios activos
EP3939639A1 (en) 2014-06-30 2022-01-19 Syqe Medical Ltd. Drug dose cartridge for an inhaler device
AU2015283590B2 (en) 2014-06-30 2020-04-16 Syqe Medical Ltd. Methods, devices and systems for pulmonary delivery of active agents
IL285111B (en) * 2014-06-30 2022-07-01 Syqe Medical Ltd Flow regulating inhaler
WO2016001921A2 (en) 2014-06-30 2016-01-07 Syqe Medical Ltd. Method and device for vaporization and inhalation of isolated substances
US11298477B2 (en) 2014-06-30 2022-04-12 Syqe Medical Ltd. Methods, devices and systems for pulmonary delivery of active agents
US10245393B2 (en) * 2014-08-13 2019-04-02 Elwha Llc Methods, systems, and devices related to a supplemental inhaler
US10765817B2 (en) 2014-08-13 2020-09-08 Elwha, Llc Methods, systems, and devices related to delivery of alcohol with an inhaler
US10987048B2 (en) 2014-08-13 2021-04-27 Elwha Llc Systems, methods, and devices to incentivize inhaler use
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
CA3009599A1 (en) 2016-01-06 2017-07-13 Syqe Medical Ltd. Low dose therapeutic treatment
CA3024721A1 (en) 2016-05-19 2017-11-23 Mannkind Corporation Apparatus, system and method for detecting and monitoring inhalations
WO2018071425A1 (en) * 2016-10-11 2018-04-19 Microdose Therapeutx, Inc. Inhaler and methods of use thereof
CN110891590B (zh) 2017-05-22 2023-07-18 英斯麦德公司 糖肽衍生物化合物及其用途

Family Cites Families (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US78212A (en) 1868-05-26 Improvement in machines for molding wood-screws
US2587215A (en) 1949-04-27 1952-02-26 Frank P Priestly Inhalator
US3221733A (en) * 1961-10-02 1965-12-07 Bennett Respiration Products I Pressure breathing therapy unit
US3788310A (en) 1970-03-25 1974-01-29 Westinghouse Electric Corp Flow control apparatus
GB1392945A (en) 1972-08-23 1975-05-07 Fisons Ltd Inhalation device
SE408265B (sv) 1975-12-12 1979-06-05 Draco Ab Anordning for koldioxiddriven endosaerosol, avsedd for inhalering
US4086918A (en) * 1976-02-11 1978-05-02 Chesebrough-Pond's Inc. Inhalation device
US4170228A (en) * 1976-11-05 1979-10-09 C. R. Bard, Inc. Variable flow incentive spirometer
US4106503A (en) 1977-03-11 1978-08-15 Richard R. Rosenthal Metering system for stimulating bronchial spasm
US4231375A (en) * 1977-10-20 1980-11-04 Boehringer John R Pulmonary exerciser
GB1598053A (en) 1978-01-31 1981-09-16 Fisons Ltd Pocket inhaler
US4227522A (en) * 1978-09-05 1980-10-14 Syntex Puerto Rico, Inc. Inhalation device
US4274404A (en) 1979-04-13 1981-06-23 American Safety Flight Systems, Inc. Oxygen supply system controlled by user exhalation
IT1116047B (it) 1979-04-27 1986-02-10 Sigma Tau Ind Farmaceuti Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma
US4284083A (en) * 1979-05-29 1981-08-18 Lester Victor E Inhalation incentive device
US4259951A (en) * 1979-07-30 1981-04-07 Chesebrough-Pond's Inc. Dual valve for respiratory device
DE3023648A1 (de) * 1980-06-24 1982-01-21 Jaeger, Erich, 8700 Würzburg Einrichtung zur untersuchung der atemwege auf reizstoff-ueberempfindlichkeit
US4391283A (en) * 1981-03-24 1983-07-05 Whitman Medical Corporation Incentive spirometer
US4484577A (en) 1981-07-23 1984-11-27 Key Pharmaceuticals, Inc. Drug delivery method and inhalation device therefor
US4442856A (en) 1981-08-18 1984-04-17 Puritan-Bennett Oxygen regulator and alarm system for an anesthesia machine
US4533137A (en) * 1982-01-19 1985-08-06 Healthscan Inc. Pulmonary training method
US4444202A (en) * 1982-03-31 1984-04-24 Howard Rubin Breathing exerciser
US4778054A (en) 1982-10-08 1988-10-18 Glaxo Group Limited Pack for administering medicaments to patients
NL192564C (nl) 1982-10-08 1997-10-03 Glaxo Group Ltd Inrichting voor het toedienen van medicamenten aan patiënten.
US4495944A (en) * 1983-02-07 1985-01-29 Trutek Research, Inc. Inhalation therapy apparatus
GB8328808D0 (en) * 1983-10-28 1983-11-30 Riker Laboratories Inc Inhalation responsive dispensers
NZ209900A (en) 1984-10-16 1989-08-29 Univ Auckland Automatic inhaler
US4592348A (en) 1984-12-17 1986-06-03 Waters Iv William C Aerosol inhaler
SE8603252L (sv) 1985-07-30 1987-01-31 Glaxo Group Ltd Anordning for att tillfora lekemedel till patienter
SE453566B (sv) 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
US4926852B1 (en) 1986-06-23 1995-05-23 Univ Johns Hopkins Medication delivery system phase one
EP0363060B1 (en) * 1988-10-04 1994-04-27 The Johns Hopkins University Aerosol inhaler
US4984158A (en) * 1988-10-14 1991-01-08 Hillsman Dean Metered dose inhaler biofeedback training and evaluation system
US5033655A (en) 1989-02-15 1991-07-23 Liquid Molding Systems Inc. Dispensing package for fluid products and the like
US4991745A (en) 1989-04-25 1991-02-12 Liquid Molding Systems, Inc. Dispensing valve with trampoline-like construction
DE69034007T2 (de) 1989-04-28 2003-05-08 Riker Laboratories Inc Inhalationsvorrichtung für Trockenpulver
US4955371A (en) 1989-05-08 1990-09-11 Transtech Scientific, Inc. Disposable inhalation activated, aerosol device for pulmonary medicine
US5201308A (en) * 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
US5042467A (en) 1990-03-28 1991-08-27 Trudell Medical Medication inhaler with fitting having a sonic signalling device
DE4027391A1 (de) 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
DE4029183A1 (de) 1990-09-14 1992-03-19 Dieter Kuhn Durchflussregler
GB9021433D0 (en) 1990-10-02 1990-11-14 Atomic Energy Authority Uk Power inhaler
FR2667509B1 (fr) 1990-10-04 1995-08-25 Valois Inhalateur a poudre, dispositif de conditionnement de microdoses de poudre sous forme de bandes adaptees a etre utilisees dans un inhalateur a poudre, et procede de fabrication de ces bandes.
US5042472A (en) 1990-10-15 1991-08-27 Merck & Co., Inc. Powder inhaler device
GB9024760D0 (en) 1990-11-14 1991-01-02 Riker Laboratories Inc Inhalation device and medicament carrier
GB9026191D0 (en) 1990-12-01 1991-01-16 Harris Pharma Ltd Breath actuated dispensing device
US5040527A (en) 1990-12-18 1991-08-20 Healthscan Products Inc. Metered dose inhalation unit with slide means
AU651882B2 (en) 1991-05-14 1994-08-04 Visiomed Group Limited Aerosol inhalation device
US5492112A (en) * 1991-05-20 1996-02-20 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6055980A (en) 1991-05-20 2000-05-02 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5327883A (en) * 1991-05-20 1994-07-12 Dura Pharmaceuticals, Inc. Apparatus for aerosolizing powdered medicine and process and using
CA2444415A1 (en) * 1991-07-02 1993-01-21 Nektar Therapeutics Method and device for delivering aerosolized medicaments
US5337740A (en) 1991-08-01 1994-08-16 New England Pharmaceuticals, Inc. Inhalation devices
US5161524A (en) 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US6029661A (en) 1991-08-26 2000-02-29 3M Innovative Properties Company Powder dispenser
US5167506A (en) * 1991-10-24 1992-12-01 Minnesota Mining And Manufacturing Company Inhalation device training system
US5213236A (en) 1991-12-06 1993-05-25 Liquid Molding Systems, Inc. Dispensing valve for packaging
US5409144A (en) 1991-12-06 1995-04-25 Liquid Molding Systems Inc. Dispensing valve for packaging
DE4211475A1 (de) 1991-12-14 1993-06-17 Asta Medica Ag Pulverinhalator
US5320094A (en) 1992-01-10 1994-06-14 The Johns Hopkins University Method of administering insulin
EP0558879B1 (en) 1992-03-04 1997-05-14 Astra Aktiebolag Disposable inhaler
US5639441A (en) 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US5284133A (en) 1992-07-23 1994-02-08 Armstrong Pharmaceuticals, Inc. Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means
US5333106A (en) * 1992-10-09 1994-07-26 Circadian, Inc. Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers
NZ257056A (en) 1992-10-19 1996-08-27 Dura Pharma Inc Dry powder inhaler: housing with mixing chamber and impeller
DE4239402A1 (de) 1992-11-24 1994-05-26 Bayer Ag Pulverinhalator
US5743250A (en) 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US5873358A (en) 1993-01-29 1999-02-23 Aradigm Corporation Method of maintaining a diabetic patient's blood glucose level in a desired range
US5888477A (en) 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5364838A (en) * 1993-01-29 1994-11-15 Miris Medical Corporation Method of administration of insulin
US5672581A (en) 1993-01-29 1997-09-30 Aradigm Corporation Method of administration of insulin
US5558085A (en) 1993-01-29 1996-09-24 Aradigm Corporation Intrapulmonary delivery of peptide drugs
ES2154673T3 (es) 1993-01-29 2001-04-16 Aradigm Corp Suministro intrapulmonar de hormonas.
FR2701399B1 (fr) 1993-02-16 1995-03-31 Valois Dispositif portatif de pulvérisation à actionnement déclenché par l'inhalation.
WO1994023772A2 (en) 1993-04-06 1994-10-27 Minnesota Mining And Manufacturing Company Deagglomerators for dry powder inhalers
LT3388B (en) 1993-08-17 1995-08-25 Geceviciaus Imone Loro R An advertising stand
ES2122319T3 (es) 1993-08-18 1998-12-16 Fisons Plc Inhalador con regulacion del caudal de aire.
US5655520A (en) * 1993-08-23 1997-08-12 Howe; Harvey James Flexible valve for administering constant flow rates of medicine from a nebulizer
GB9326574D0 (en) 1993-12-31 1994-03-02 King S College London Dry power inhalers
US5479920A (en) * 1994-03-01 1996-01-02 Vortran Medical Technology, Inc. Breath actuated medicinal aerosol delivery apparatus
EP0748213B1 (en) 1994-03-07 2004-04-14 Nektar Therapeutics Methods and compositions for pulmonary delivery of insulin
US6102036A (en) 1994-04-12 2000-08-15 Smoke-Stop Breath activated inhaler
US5483954A (en) 1994-06-10 1996-01-16 Mecikalski; Mark B. Inhaler and medicated package
US5653223A (en) 1994-09-08 1997-08-05 Pruitt; Michael D. Accurately controlled portable nebulizer
CA2555600C (en) 1994-09-21 2008-01-29 Nektar Therapeutics Apparatus and methods for dispersing dry powder medicaments
US5993421A (en) 1994-12-02 1999-11-30 Science Incorporated Medicament dispenser
SE9404439D0 (sv) 1994-12-21 1994-12-21 Astra Ab Inhalation device
US5522380A (en) 1995-01-18 1996-06-04 Dwork; Paul Metered dose medication adaptor with improved incentive spirometer
UA35643C2 (uk) 1995-01-23 2001-04-16 Директ-Халер А/С Інгалятор
US5568910A (en) 1995-03-02 1996-10-29 Delmarva Laboratories, Inc. Anesthesia machine
US5513630A (en) 1995-03-08 1996-05-07 Century; Theodore J. Powder dispenser
US5586550A (en) 1995-08-31 1996-12-24 Fluid Propulsion Technologies, Inc. Apparatus and methods for the delivery of therapeutic liquids to the respiratory system
US5622166A (en) 1995-04-24 1997-04-22 Dura Pharmaceuticals, Inc. Dry powder inhaler delivery system
US5921237A (en) 1995-04-24 1999-07-13 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5654007A (en) 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
US5666945A (en) * 1995-06-07 1997-09-16 Salter Labs Pneumatically-operated gas demand apparatus
US5826571A (en) 1995-06-08 1998-10-27 Innovative Devices, Llc Device for use with metered dose inhalers (MDIS)
GB9513218D0 (en) 1995-06-29 1995-09-06 Fisons Plc Inhalation device and method
DE19523516C1 (de) 1995-06-30 1996-10-31 Asta Medica Ag Inhalator zum Verabreichen von Medikamenten aus Blisterpackungen
US5988163A (en) 1995-08-02 1999-11-23 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament
US5692496A (en) * 1995-08-02 1997-12-02 Innovative Devices, Llc Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5823183A (en) 1995-08-02 1998-10-20 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5603315A (en) 1995-08-14 1997-02-18 Reliable Engineering Multiple mode oxygen delivery system
US5865173A (en) * 1995-11-06 1999-02-02 Sunrise Medical Hhg Inc. Bilevel CPAP system with waveform control for both IPAP and EPAP
ATE193455T1 (de) * 1995-12-07 2000-06-15 Jago Pharma Ag Inhalator zur mehrfachen dosisweisen abgabe eines pharmakologischen trockenpulvers
KR19990077014A (ko) 1996-01-03 1999-10-25 그레이엄 브레레톤 흡입 장치
US5699789A (en) 1996-03-11 1997-12-23 Hendricks; Mark R. Dry powder inhaler
DE19613185A1 (de) 1996-04-02 1997-10-09 Pfeiffer Erich Gmbh & Co Kg Dosiereinrichtung für strömungsfähige Medien wie Pulver/Luft-Dispersionen
US5875776A (en) 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
US5826633A (en) 1996-04-26 1998-10-27 Inhale Therapeutic Systems Powder filling systems, apparatus and methods
GB2312848B (en) 1996-04-26 1999-11-17 Bespak Plc Controlled flow inhalers
JP2000510109A (ja) 1996-04-29 2000-08-08 デュラ・ファーマシューティカルズ・インコーポレイテッド 乾燥粉末の吸入方法
AUPN973596A0 (en) 1996-05-08 1996-05-30 Resmed Limited Control of delivery pressure in cpap treatment or assisted respiration
US5813401A (en) 1996-10-15 1998-09-29 Radcliff; Janet H. Nebulizer automatic control valve
GB2318737B (en) * 1996-10-30 2000-06-14 Bespak Plc Improved inhalers
SE9700422D0 (sv) 1997-02-07 1997-02-07 Astra Ab Single dose inhaler II
GB2323039B (en) * 1997-03-03 2001-03-14 Bespak Plc Improved inhalation apparatus
GB9705657D0 (en) * 1997-03-19 1997-05-07 Bacon Raymond J Dispenser
US6006747A (en) 1997-03-20 1999-12-28 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6131571A (en) 1997-04-30 2000-10-17 University Of Florida Ventilation apparatus and anesthesia delivery system
EP0998318B1 (en) 1997-07-25 2005-04-27 Minnesota Innovative Technologies & Instruments Corporation (MITI) Control device for supplying supplemental respiratory oxygen
DE19734022C2 (de) 1997-08-06 2000-06-21 Pari Gmbh Inhalationstherapiegerät mit einem Ventil zur Begrenzung des Inspirationsflusses
CA2212430A1 (en) 1997-08-07 1999-02-07 George Volgyesi Inhalation device
US5855202A (en) 1997-10-08 1999-01-05 Andrade; Joseph R. Aerosol holding chamber for a metered-dose inhaler
US6067984A (en) 1997-10-14 2000-05-30 Piper; Samuel David Pulmonary modulator apparatus
US6032667A (en) 1997-10-30 2000-03-07 Instrumentarium Corporation Variable orifice pulse valve
US6116238A (en) 1997-12-02 2000-09-12 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6076523A (en) 1998-01-15 2000-06-20 Nellcor Puritan Bennett Oxygen blending in a piston ventilator
SK13632000A3 (sk) * 1998-03-16 2001-03-12 Inhale Therapeutic Systems, Inc. Spôsob podávania aktívnej látky do pľúc ľudského pacienta a zariadenie na jeho vykonávanie
US6142146A (en) 1998-06-12 2000-11-07 Microdose Technologies, Inc. Inhalation device

Also Published As

Publication number Publication date
DK1119384T3 (da) 2005-09-19
PL347906A1 (en) 2002-04-22
EA200100338A1 (ru) 2001-10-22
LT4902B (lt) 2002-03-25
OA11791A (en) 2005-08-10
KR100652532B1 (ko) 2006-12-01
HRP20010253A2 (en) 2002-06-30
CA2346791C (en) 2007-12-11
PE20001281A1 (es) 2000-11-08
SK287044B6 (sk) 2009-10-07
IS5904A (is) 2001-03-21
SK4772001A3 (en) 2001-10-08
HUP0103805A2 (hu) 2002-02-28
RO120532B1 (ro) 2006-03-30
JP2002527151A (ja) 2002-08-27
IS2289B (is) 2007-10-15
NO20011742L (no) 2001-06-06
AP1646A (en) 2006-07-31
AU754724B2 (en) 2002-11-21
CA2346791A1 (en) 2000-04-20
PL193881B1 (pl) 2007-03-30
NZ510853A (en) 2003-08-29
CN1447704A (zh) 2003-10-08
CN101804230B (zh) 2012-10-17
TR200101033T2 (tr) 2001-11-21
PT1119384E (pt) 2005-09-30
PA8484001A1 (es) 2000-09-29
US8408200B2 (en) 2013-04-02
EG22111A (en) 2002-07-31
DZ2906A1 (fr) 2004-12-28
DE69925849T2 (de) 2006-05-18
LT2001051A (en) 2002-01-25
IL142215A (en) 2007-07-24
HUP0103805A3 (en) 2002-08-28
GEP20043259B (en) 2004-06-25
YU26101A (sh) 2003-02-28
CZ20011181A3 (cs) 2001-08-15
AP2001002116A0 (en) 2001-06-30
NO20011742D0 (no) 2001-04-06
HU225057B1 (en) 2006-05-29
WO2000021594A2 (en) 2000-04-20
AU1202800A (en) 2000-05-01
SA99200835B1 (ar) 2006-12-17
CO5060481A1 (es) 2001-07-30
LT4907B (lt) 2002-04-25
HK1040645A1 (en) 2002-06-21
AR020760A1 (es) 2002-05-29
WO2000021594A3 (en) 2000-08-31
LV12685B (lv) 2001-10-20
EA003405B1 (ru) 2003-04-24
MA25865A1 (fr) 2003-10-01
EE04608B1 (et) 2006-04-17
BR9914384A (pt) 2001-06-26
EP1119384A2 (en) 2001-08-01
DE69925849D1 (de) 2005-07-21
EP1119384B1 (en) 2005-06-15
HRP20010253B1 (en) 2006-12-31
GT199900174A (es) 2001-03-31
MY129112A (en) 2007-03-30
CN101804230A (zh) 2010-08-18
ID28354A (id) 2001-05-17
JP2009136688A (ja) 2009-06-25
ES2243094T3 (es) 2005-11-16
LV12685A (en) 2001-07-20
LT2001057A (en) 2002-02-25
UY25731A1 (es) 1999-11-17
HK1040645B (zh) 2005-12-30
RS49848B (sr) 2008-08-07
BG105377A (bg) 2001-12-31
ATE297771T1 (de) 2005-07-15
JP4378057B2 (ja) 2009-12-02
TNSN99188A1 (fr) 2005-11-10
EE200100212A (et) 2002-06-17
US20020168322A1 (en) 2002-11-14
UA73924C2 (en) 2005-10-17
KR20010075568A (ko) 2001-08-09

Similar Documents

Publication Publication Date Title
AU754724B2 (en) Flow resistance modulated aerosolized active agent delivery
AU750539B2 (en) Aerosolized active agent delivery
AU2006201914B2 (en) Aerosolized active agent delivery
MXPA01003614A (en) Flow resistance modulated aerosolized active agent delivery
CZ20003075A3 (cs) Způsob podávání aktivního činidla, způsob podávání inzulínu, zařízení pro zvýšení biologické dostupnosti aktivního činidla a zařízení pro podávání inzulínu
MXPA00008994A (en) Aerosolized active agent delivery