PA8484001A1 - Suministro de agente activo aerosolizado modulado con resistencia de flujo. - Google Patents
Suministro de agente activo aerosolizado modulado con resistencia de flujo.Info
- Publication number
- PA8484001A1 PA8484001A1 PA19998484001A PA8484001A PA8484001A1 PA 8484001 A1 PA8484001 A1 PA 8484001A1 PA 19998484001 A PA19998484001 A PA 19998484001A PA 8484001 A PA8484001 A PA 8484001A PA 8484001 A1 PA8484001 A1 PA 8484001A1
- Authority
- PA
- Panama
- Prior art keywords
- active agent
- supply
- flow resistance
- aerosolized active
- modulated
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 abstract 4
- 238000009472 formulation Methods 0.000 abstract 3
- 230000003434 inspiratory effect Effects 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Fruits And Vegetables (AREA)
- Illuminated Signs And Luminous Advertising (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Soft Magnetic Materials (AREA)
- Paints Or Removers (AREA)
Abstract
LA PRESENTE INVENCIÓN ESTÁ DIRIGIDA A MÉTODOS Y DISPOSITIVOS PARA EL SUMINISTRO DE UNA FORMULACIÓN DE AGENTE ACTIVO AL PULMÒN DE UN PACIENTE HUMANO. LA FORMULACIÒN DE AGENTE ACTIVO PUEDE SER EN FORMA DE POLVO SECO, PUEDE SER NEBULIZADA, O PUEDE SER EN MEZCLA CON UN PROPULSOR. LA FORMULACIÒN DE AGENTE ACTIVO SE SUMINISTRA A UN PACIENTE A UN BAJO ÌNDICE DE FLUJO INSPIRATORIO DURANTE UN PERÍODO DE TIEMPO INICIAL, PARA INCREMENTAR LA BIODISPONIBILIDAD DEL AGENTE ACTIVO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10370298P | 1998-10-09 | 1998-10-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8484001A1 true PA8484001A1 (es) | 2000-09-29 |
Family
ID=22296604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA19998484001A PA8484001A1 (es) | 1998-10-09 | 1999-10-07 | Suministro de agente activo aerosolizado modulado con resistencia de flujo. |
Country Status (50)
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US20060171899A1 (en) * | 1998-12-10 | 2006-08-03 | Akwete Adjei | Water-stabilized aerosol formulation system and method of making |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US6606992B1 (en) * | 1999-06-30 | 2003-08-19 | Nektar Therapeutics | Systems and methods for aerosolizing pharmaceutical formulations |
WO2001085136A2 (en) | 2000-05-10 | 2001-11-15 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
GB2380946A (en) * | 2001-08-31 | 2003-04-23 | Medic Aid Ltd | Nebuliser arrangement |
MXPA04005865A (es) | 2001-12-19 | 2004-09-13 | Nektar Therapeutics | Suministro de aminoglucosidos a los pulmones. |
EP1894591B1 (en) | 2002-03-20 | 2013-06-26 | MannKind Corporation | Cartridge for an inhalation apparatus |
JP4286498B2 (ja) * | 2002-05-14 | 2009-07-01 | アクティヴァエロ ゲーエムベーハー | エアロゾルを管理するための装置 |
ATE399185T1 (de) | 2002-12-31 | 2008-07-15 | Nektar Therapeutics Al Corp | Maleinsäureamid polymerderivate und ihre biokonjugate |
AU2004297228A1 (en) | 2003-12-03 | 2005-06-23 | Nektar Therapeutics Al, Corporation | Method of preparing maleimide functionalized polymers |
US9022027B2 (en) | 2004-02-20 | 2015-05-05 | Pneumoflex Systems, Llc | Nebulizer with intra-oral vibrating mesh |
DK1786784T3 (da) | 2004-08-20 | 2011-02-14 | Mannkind Corp | Katalyse af diketopiperazinsyntese |
CN104436170B (zh) | 2004-08-23 | 2018-02-23 | 曼金德公司 | 用于药物输送的二酮哌嗪盐 |
US7832394B2 (en) * | 2004-12-22 | 2010-11-16 | Schechter Alan M | Apparatus for dispensing pressurized contents |
HUE028623T2 (en) | 2005-09-14 | 2016-12-28 | Mannkind Corp | Active substance formulation method based on increasing the affinity of the active ingredient for binding to the surface of crystalline microparticles |
IN2015DN00888A (es) | 2006-02-22 | 2015-07-10 | Mannkind Corp | |
JP5504156B2 (ja) | 2007-06-15 | 2014-05-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 吸入器 |
EP2082762A1 (en) * | 2008-01-24 | 2009-07-29 | Boehringer Ingelheim International Gmbh | Inhaler |
GB0802028D0 (en) † | 2008-02-05 | 2008-03-12 | Dunne Stephen T | Powder inhaler flow regulator |
DK2254629T3 (en) * | 2008-03-27 | 2016-01-25 | Mannkind Corp | The dry powder inhalation |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
ES2570400T3 (es) | 2008-06-13 | 2016-05-18 | Mannkind Corp | Un inhalador de polvo seco y un sistema para el suministro de fármacos |
JP5479465B2 (ja) | 2008-06-20 | 2014-04-23 | マンカインド コーポレイション | 吸入努力をリアルタイムにプロファイルする対話式機器および方法 |
TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
EP2405963B1 (en) | 2009-03-11 | 2013-11-06 | MannKind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
KR101875969B1 (ko) | 2009-06-12 | 2018-07-06 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
JP5784622B2 (ja) | 2009-11-03 | 2015-09-24 | マンカインド コーポレ−ション | 吸入活動をシミュレートするための装置及び方法 |
MX359281B (es) | 2010-06-21 | 2018-09-21 | Mannkind Corp | Sistema y metodos para suministrar un farmaco en polvo seco. |
ES2842407T3 (es) | 2010-12-22 | 2021-07-14 | Syqe Medical Ltd | Sistema de administración de fármacos |
US20140202457A1 (en) | 2011-01-20 | 2014-07-24 | Pneumoflex Systems, Llc | Metered dose nebulizer |
US9452270B2 (en) | 2011-01-20 | 2016-09-27 | Pneumoflex Systems, Llc | Nebulizer having replaceable nozzle assembly and suction line |
US8671934B2 (en) | 2011-01-20 | 2014-03-18 | Pneumoflex Systems, Llc | Nebulizer that is activated by negative inspiratory pressure |
JOP20120023B1 (ar) | 2011-02-04 | 2022-03-14 | Novartis Ag | صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية |
MX353285B (es) | 2011-04-01 | 2018-01-05 | Mannkind Corp | Paquete de blister para cartuchos farmaceuticos. |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
CN103945859A (zh) | 2011-10-24 | 2014-07-23 | 曼金德公司 | 用于治疗疼痛的方法和组合物 |
WO2014012069A2 (en) | 2012-07-12 | 2014-01-16 | Mannkind Corporation | Dry powder drug delivery systems and methods |
EP2911690A1 (en) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalable influenza vaccine compositions and methods |
US10034988B2 (en) | 2012-11-28 | 2018-07-31 | Fontem Holdings I B.V. | Methods and devices for compound delivery |
JP6429788B6 (ja) * | 2012-11-28 | 2019-01-30 | フォンテム ホールディングス 1 ビー. ブイ. | 化合物送達のためのデバイス |
US9452139B2 (en) | 2013-03-14 | 2016-09-27 | Novartis Ag | Respirable agglomerates of porous carrier particles and micronized drug |
AU2014229361B2 (en) | 2013-03-14 | 2016-08-04 | Novartis Ag | Deamorphization of spray-dried formulations via spray-blending |
AU2014228415B2 (en) | 2013-03-15 | 2018-08-09 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
KR102321339B1 (ko) | 2013-07-18 | 2021-11-02 | 맨카인드 코포레이션 | 열-안정성 건조 분말 약제학적 조성물 및 방법 |
US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
US10194693B2 (en) | 2013-09-20 | 2019-02-05 | Fontem Holdings 1 B.V. | Aerosol generating device |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
ES2904293T3 (es) | 2014-06-30 | 2022-04-04 | Syqe Medical Ltd | Dispositivo para vaporización e inhalación de sustancias aisladas |
AU2015283590B2 (en) | 2014-06-30 | 2020-04-16 | Syqe Medical Ltd. | Methods, devices and systems for pulmonary delivery of active agents |
AU2015283593B2 (en) | 2014-06-30 | 2019-08-22 | Syqe Medical Ltd. | Drug dose cartridge for an inhaler device |
DK3160558T3 (da) * | 2014-06-30 | 2020-04-27 | Syqe Medical Ltd | Strømningsregulerende indåndingsanordning |
CA3199049A1 (en) * | 2014-06-30 | 2016-01-07 | Syqe Medical Ltd. | Flow regulating inhaler device |
WO2016001924A2 (en) | 2014-06-30 | 2016-01-07 | Syqe Medical Ltd. | Methods, devices and systems for pulmonary delivery of active agents |
US11298477B2 (en) | 2014-06-30 | 2022-04-12 | Syqe Medical Ltd. | Methods, devices and systems for pulmonary delivery of active agents |
US10987048B2 (en) | 2014-08-13 | 2021-04-27 | Elwha Llc | Systems, methods, and devices to incentivize inhaler use |
US10245393B2 (en) * | 2014-08-13 | 2019-04-02 | Elwha Llc | Methods, systems, and devices related to a supplemental inhaler |
US10765817B2 (en) | 2014-08-13 | 2020-09-08 | Elwha, Llc | Methods, systems, and devices related to delivery of alcohol with an inhaler |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
US11806331B2 (en) | 2016-01-06 | 2023-11-07 | Syqe Medical Ltd. | Low dose therapeutic treatment |
CA3024721A1 (en) | 2016-05-19 | 2017-11-23 | Mannkind Corporation | Apparatus, system and method for detecting and monitoring inhalations |
WO2018071435A1 (en) * | 2016-10-11 | 2018-04-19 | Microdose Therapeutx, Inc. | Inhaler and methods of use thereof |
WO2018217800A1 (en) | 2017-05-22 | 2018-11-29 | Insmed Incorporated | Glycopeptide derivative compounds and uses thereof |
Family Cites Families (132)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US78212A (en) | 1868-05-26 | Improvement in machines for molding wood-screws | ||
US2587215A (en) * | 1949-04-27 | 1952-02-26 | Frank P Priestly | Inhalator |
US3221733A (en) * | 1961-10-02 | 1965-12-07 | Bennett Respiration Products I | Pressure breathing therapy unit |
US3788310A (en) * | 1970-03-25 | 1974-01-29 | Westinghouse Electric Corp | Flow control apparatus |
GB1392945A (en) * | 1972-08-23 | 1975-05-07 | Fisons Ltd | Inhalation device |
SE408265B (sv) | 1975-12-12 | 1979-06-05 | Draco Ab | Anordning for koldioxiddriven endosaerosol, avsedd for inhalering |
US4086918A (en) * | 1976-02-11 | 1978-05-02 | Chesebrough-Pond's Inc. | Inhalation device |
US4170228A (en) * | 1976-11-05 | 1979-10-09 | C. R. Bard, Inc. | Variable flow incentive spirometer |
US4106503A (en) * | 1977-03-11 | 1978-08-15 | Richard R. Rosenthal | Metering system for stimulating bronchial spasm |
US4231375A (en) * | 1977-10-20 | 1980-11-04 | Boehringer John R | Pulmonary exerciser |
GB1598053A (en) | 1978-01-31 | 1981-09-16 | Fisons Ltd | Pocket inhaler |
US4227522A (en) * | 1978-09-05 | 1980-10-14 | Syntex Puerto Rico, Inc. | Inhalation device |
US4274404A (en) * | 1979-04-13 | 1981-06-23 | American Safety Flight Systems, Inc. | Oxygen supply system controlled by user exhalation |
IT1116047B (it) * | 1979-04-27 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma |
US4284083A (en) * | 1979-05-29 | 1981-08-18 | Lester Victor E | Inhalation incentive device |
US4259951A (en) * | 1979-07-30 | 1981-04-07 | Chesebrough-Pond's Inc. | Dual valve for respiratory device |
DE3023648A1 (de) * | 1980-06-24 | 1982-01-21 | Jaeger, Erich, 8700 Würzburg | Einrichtung zur untersuchung der atemwege auf reizstoff-ueberempfindlichkeit |
US4391283A (en) * | 1981-03-24 | 1983-07-05 | Whitman Medical Corporation | Incentive spirometer |
US4484577A (en) | 1981-07-23 | 1984-11-27 | Key Pharmaceuticals, Inc. | Drug delivery method and inhalation device therefor |
US4442856A (en) * | 1981-08-18 | 1984-04-17 | Puritan-Bennett | Oxygen regulator and alarm system for an anesthesia machine |
US4533137A (en) * | 1982-01-19 | 1985-08-06 | Healthscan Inc. | Pulmonary training method |
US4444202A (en) * | 1982-03-31 | 1984-04-24 | Howard Rubin | Breathing exerciser |
US4778054A (en) * | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
FI79651C (fi) | 1982-10-08 | 1990-02-12 | Glaxo Group Ltd | Doseringsanordning foer medicin. |
US4495944A (en) * | 1983-02-07 | 1985-01-29 | Trutek Research, Inc. | Inhalation therapy apparatus |
GB8328808D0 (en) * | 1983-10-28 | 1983-11-30 | Riker Laboratories Inc | Inhalation responsive dispensers |
NZ209900A (en) * | 1984-10-16 | 1989-08-29 | Univ Auckland | Automatic inhaler |
US4592348A (en) * | 1984-12-17 | 1986-06-03 | Waters Iv William C | Aerosol inhaler |
GR861995B (en) * | 1985-07-30 | 1986-11-04 | Glaxo Group Ltd | Devices for administering medicaments to patients |
SE453566B (sv) * | 1986-03-07 | 1988-02-15 | Draco Ab | Anordning vid pulverinhalatorer |
US4926852B1 (en) * | 1986-06-23 | 1995-05-23 | Univ Johns Hopkins | Medication delivery system phase one |
EP0363060B1 (en) * | 1988-10-04 | 1994-04-27 | The Johns Hopkins University | Aerosol inhaler |
US4984158A (en) * | 1988-10-14 | 1991-01-08 | Hillsman Dean | Metered dose inhaler biofeedback training and evaluation system |
US5033655A (en) * | 1989-02-15 | 1991-07-23 | Liquid Molding Systems Inc. | Dispensing package for fluid products and the like |
US4991745A (en) * | 1989-04-25 | 1991-02-12 | Liquid Molding Systems, Inc. | Dispensing valve with trampoline-like construction |
ES2087911T3 (es) * | 1989-04-28 | 1996-08-01 | Riker Laboratories Inc | Dispositivo de inhalacion de polvo seco. |
US4955371A (en) * | 1989-05-08 | 1990-09-11 | Transtech Scientific, Inc. | Disposable inhalation activated, aerosol device for pulmonary medicine |
US5201308A (en) * | 1990-02-14 | 1993-04-13 | Newhouse Michael T | Powder inhaler |
US5042467A (en) * | 1990-03-28 | 1991-08-27 | Trudell Medical | Medication inhaler with fitting having a sonic signalling device |
DE4027391A1 (de) * | 1990-08-30 | 1992-03-12 | Boehringer Ingelheim Kg | Treibgasfreies inhalationsgeraet |
DE4029183A1 (de) * | 1990-09-14 | 1992-03-19 | Dieter Kuhn | Durchflussregler |
GB9021433D0 (en) * | 1990-10-02 | 1990-11-14 | Atomic Energy Authority Uk | Power inhaler |
FR2667509B1 (fr) * | 1990-10-04 | 1995-08-25 | Valois | Inhalateur a poudre, dispositif de conditionnement de microdoses de poudre sous forme de bandes adaptees a etre utilisees dans un inhalateur a poudre, et procede de fabrication de ces bandes. |
US5042472A (en) * | 1990-10-15 | 1991-08-27 | Merck & Co., Inc. | Powder inhaler device |
GB9024760D0 (en) * | 1990-11-14 | 1991-01-02 | Riker Laboratories Inc | Inhalation device and medicament carrier |
GB9026191D0 (en) | 1990-12-01 | 1991-01-16 | Harris Pharma Ltd | Breath actuated dispensing device |
US5040527A (en) * | 1990-12-18 | 1991-08-20 | Healthscan Products Inc. | Metered dose inhalation unit with slide means |
AU651882B2 (en) * | 1991-05-14 | 1994-08-04 | Visiomed Group Limited | Aerosol inhalation device |
US6055980A (en) * | 1991-05-20 | 2000-05-02 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US5492112A (en) * | 1991-05-20 | 1996-02-20 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US5327883A (en) * | 1991-05-20 | 1994-07-12 | Dura Pharmaceuticals, Inc. | Apparatus for aerosolizing powdered medicine and process and using |
JP3230056B2 (ja) * | 1991-07-02 | 2001-11-19 | インヘイル・インコーポレーテッド | 薬剤のエーロゾル化服用量を形成する装置 |
US5337740A (en) * | 1991-08-01 | 1994-08-16 | New England Pharmaceuticals, Inc. | Inhalation devices |
US5161524A (en) | 1991-08-02 | 1992-11-10 | Glaxo Inc. | Dosage inhalator with air flow velocity regulating means |
US6119688A (en) * | 1991-08-26 | 2000-09-19 | 3M Innovative Properties Company | Powder dispenser |
US5167506A (en) * | 1991-10-24 | 1992-12-01 | Minnesota Mining And Manufacturing Company | Inhalation device training system |
US5213236A (en) * | 1991-12-06 | 1993-05-25 | Liquid Molding Systems, Inc. | Dispensing valve for packaging |
US5409144A (en) * | 1991-12-06 | 1995-04-25 | Liquid Molding Systems Inc. | Dispensing valve for packaging |
DE4211475A1 (de) * | 1991-12-14 | 1993-06-17 | Asta Medica Ag | Pulverinhalator |
US5320094A (en) * | 1992-01-10 | 1994-06-14 | The Johns Hopkins University | Method of administering insulin |
EP0558879B1 (en) * | 1992-03-04 | 1997-05-14 | Astra Aktiebolag | Disposable inhaler |
US5639441A (en) * | 1992-03-06 | 1997-06-17 | Board Of Regents Of University Of Colorado | Methods for fine particle formation |
US5785049A (en) * | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
US5284133A (en) * | 1992-07-23 | 1994-02-08 | Armstrong Pharmaceuticals, Inc. | Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means |
US5333106A (en) * | 1992-10-09 | 1994-07-26 | Circadian, Inc. | Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers |
HU217917B (hu) * | 1992-10-19 | 2000-05-28 | Dura Pharmaceuticals Inc. | Inhalálókészülék száraz porok inhalálásához |
DE4239402A1 (de) * | 1992-11-24 | 1994-05-26 | Bayer Ag | Pulverinhalator |
DE69426415T2 (de) * | 1993-01-29 | 2001-07-26 | Aradigm Corp., Hayward | Intrapulmonares hormonabgabesystem |
US5743250A (en) * | 1993-01-29 | 1998-04-28 | Aradigm Corporation | Insulin delivery enhanced by coached breathing |
US5888477A (en) * | 1993-01-29 | 1999-03-30 | Aradigm Corporation | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin |
US5364838A (en) * | 1993-01-29 | 1994-11-15 | Miris Medical Corporation | Method of administration of insulin |
US5672581A (en) * | 1993-01-29 | 1997-09-30 | Aradigm Corporation | Method of administration of insulin |
US5558085A (en) * | 1993-01-29 | 1996-09-24 | Aradigm Corporation | Intrapulmonary delivery of peptide drugs |
US5873358A (en) * | 1993-01-29 | 1999-02-23 | Aradigm Corporation | Method of maintaining a diabetic patient's blood glucose level in a desired range |
FR2701399B1 (fr) | 1993-02-16 | 1995-03-31 | Valois | Dispositif portatif de pulvérisation à actionnement déclenché par l'inhalation. |
DE69413528T2 (de) | 1993-04-06 | 1999-05-06 | Minnesota Mining And Mfg. Co., Saint Paul, Minn. | Vorrichtung zum deagglomerieren für trockenpulverinhalatoren |
LT3388B (en) | 1993-08-17 | 1995-08-25 | Geceviciaus Imone Loro R | An advertising stand |
DE69413989T2 (de) * | 1993-08-18 | 1999-04-08 | Fisons Plc, Ipswich, Suffolk | Inhalator mit atemstromregelung |
US5655520A (en) * | 1993-08-23 | 1997-08-12 | Howe; Harvey James | Flexible valve for administering constant flow rates of medicine from a nebulizer |
GB9326574D0 (en) | 1993-12-31 | 1994-03-02 | King S College London | Dry power inhalers |
US5479920A (en) * | 1994-03-01 | 1996-01-02 | Vortran Medical Technology, Inc. | Breath actuated medicinal aerosol delivery apparatus |
DK0748213T3 (da) | 1994-03-07 | 2004-08-02 | Nektar Therapeutics | Fremgangsmåder og sammensætninger til pulmonal indgivelse af insulin |
US6102036A (en) * | 1994-04-12 | 2000-08-15 | Smoke-Stop | Breath activated inhaler |
US5483954A (en) | 1994-06-10 | 1996-01-16 | Mecikalski; Mark B. | Inhaler and medicated package |
US5653223A (en) * | 1994-09-08 | 1997-08-05 | Pruitt; Michael D. | Accurately controlled portable nebulizer |
ES2302332T3 (es) * | 1994-09-21 | 2008-07-01 | Nektar Therapeutics | Aparato y metodos para dispersar medicamentos en polvo seco. |
US5993421A (en) | 1994-12-02 | 1999-11-30 | Science Incorporated | Medicament dispenser |
SE9404439D0 (sv) | 1994-12-21 | 1994-12-21 | Astra Ab | Inhalation device |
US5522380A (en) * | 1995-01-18 | 1996-06-04 | Dwork; Paul | Metered dose medication adaptor with improved incentive spirometer |
PT805696E (pt) | 1995-01-23 | 2000-08-31 | Direct Haler A S | Inalador |
US5568910A (en) | 1995-03-02 | 1996-10-29 | Delmarva Laboratories, Inc. | Anesthesia machine |
US5513630A (en) * | 1995-03-08 | 1996-05-07 | Century; Theodore J. | Powder dispenser |
US5586550A (en) | 1995-08-31 | 1996-12-24 | Fluid Propulsion Technologies, Inc. | Apparatus and methods for the delivery of therapeutic liquids to the respiratory system |
US5921237A (en) * | 1995-04-24 | 1999-07-13 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US5622166A (en) * | 1995-04-24 | 1997-04-22 | Dura Pharmaceuticals, Inc. | Dry powder inhaler delivery system |
US5666945A (en) * | 1995-06-07 | 1997-09-16 | Salter Labs | Pneumatically-operated gas demand apparatus |
US5654007A (en) * | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
US5826571A (en) | 1995-06-08 | 1998-10-27 | Innovative Devices, Llc | Device for use with metered dose inhalers (MDIS) |
GB9513218D0 (en) | 1995-06-29 | 1995-09-06 | Fisons Plc | Inhalation device and method |
DE19523516C1 (de) * | 1995-06-30 | 1996-10-31 | Asta Medica Ag | Inhalator zum Verabreichen von Medikamenten aus Blisterpackungen |
US5823183A (en) | 1995-08-02 | 1998-10-20 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US5988163A (en) | 1995-08-02 | 1999-11-23 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament |
US5692496A (en) * | 1995-08-02 | 1997-12-02 | Innovative Devices, Llc | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US5603315A (en) * | 1995-08-14 | 1997-02-18 | Reliable Engineering | Multiple mode oxygen delivery system |
US5865173A (en) * | 1995-11-06 | 1999-02-02 | Sunrise Medical Hhg Inc. | Bilevel CPAP system with waveform control for both IPAP and EPAP |
DE59605366D1 (de) * | 1995-12-07 | 2000-07-06 | Jago Pharma Ag Muttenz | Inhalator zur mehrfachen dosisweisen abgabe eines pharmakologischen trockenpulvers |
JP2000503565A (ja) * | 1996-01-03 | 2000-03-28 | グラクソ、グループ、リミテッド | 吸入装置 |
US5699789A (en) | 1996-03-11 | 1997-12-23 | Hendricks; Mark R. | Dry powder inhaler |
DE19613185A1 (de) * | 1996-04-02 | 1997-10-09 | Pfeiffer Erich Gmbh & Co Kg | Dosiereinrichtung für strömungsfähige Medien wie Pulver/Luft-Dispersionen |
US5875776A (en) * | 1996-04-09 | 1999-03-02 | Vivorx Pharmaceuticals, Inc. | Dry powder inhaler |
US5826633A (en) | 1996-04-26 | 1998-10-27 | Inhale Therapeutic Systems | Powder filling systems, apparatus and methods |
GB2312848B (en) * | 1996-04-26 | 1999-11-17 | Bespak Plc | Controlled flow inhalers |
ES2205210T3 (es) | 1996-04-29 | 2004-05-01 | Quadrant Technologies Ltd. | Procedimientos de inhalacion de polvos secos. |
AUPN973596A0 (en) * | 1996-05-08 | 1996-05-30 | Resmed Limited | Control of delivery pressure in cpap treatment or assisted respiration |
US5813401A (en) * | 1996-10-15 | 1998-09-29 | Radcliff; Janet H. | Nebulizer automatic control valve |
GB2318737B (en) * | 1996-10-30 | 2000-06-14 | Bespak Plc | Improved inhalers |
SE9700422D0 (sv) * | 1997-02-07 | 1997-02-07 | Astra Ab | Single dose inhaler II |
GB2323039B (en) * | 1997-03-03 | 2001-03-14 | Bespak Plc | Improved inhalation apparatus |
GB9705657D0 (en) * | 1997-03-19 | 1997-05-07 | Bacon Raymond J | Dispenser |
US6006747A (en) | 1997-03-20 | 1999-12-28 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US6131571A (en) | 1997-04-30 | 2000-10-17 | University Of Florida | Ventilation apparatus and anesthesia delivery system |
AU8592898A (en) * | 1997-07-25 | 1999-02-16 | Minnesota Innovative Technologies & Instruments Corporation (Miti) | Control device for supplying supplemental respiratory oxygen |
DE19734022C2 (de) * | 1997-08-06 | 2000-06-21 | Pari Gmbh | Inhalationstherapiegerät mit einem Ventil zur Begrenzung des Inspirationsflusses |
CA2212430A1 (en) * | 1997-08-07 | 1999-02-07 | George Volgyesi | Inhalation device |
US5855202A (en) * | 1997-10-08 | 1999-01-05 | Andrade; Joseph R. | Aerosol holding chamber for a metered-dose inhaler |
US6067984A (en) * | 1997-10-14 | 2000-05-30 | Piper; Samuel David | Pulmonary modulator apparatus |
US6032667A (en) * | 1997-10-30 | 2000-03-07 | Instrumentarium Corporation | Variable orifice pulse valve |
US6116238A (en) * | 1997-12-02 | 2000-09-12 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US6076523A (en) * | 1998-01-15 | 2000-06-20 | Nellcor Puritan Bennett | Oxygen blending in a piston ventilator |
PL343276A1 (en) * | 1998-03-16 | 2001-08-13 | Inhale Therapeutic Syst | Aerosolized active agent delivery |
US6142146A (en) | 1998-06-12 | 2000-11-07 | Microdose Technologies, Inc. | Inhalation device |
-
1999
- 1999-07-10 UA UA2001042326A patent/UA73924C2/uk unknown
- 1999-09-29 UY UY25731A patent/UY25731A1/es not_active Application Discontinuation
- 1999-09-30 PE PE1999000992A patent/PE20001281A1/es not_active Application Discontinuation
- 1999-10-05 EG EG125099A patent/EG22111A/xx active
- 1999-10-06 DZ DZ990206A patent/DZ2906A1/xx active
- 1999-10-07 AU AU12028/00A patent/AU754724B2/en not_active Ceased
- 1999-10-07 AP APAP/P/2001/002116A patent/AP1646A/en active
- 1999-10-07 NZ NZ510853A patent/NZ510853A/en not_active IP Right Cessation
- 1999-10-07 ID IDW20010790A patent/ID28354A/id unknown
- 1999-10-07 MY MYPI99004331A patent/MY129112A/en unknown
- 1999-10-07 PT PT99970333T patent/PT1119384E/pt unknown
- 1999-10-07 ES ES99970333T patent/ES2243094T3/es not_active Expired - Lifetime
- 1999-10-07 EA EA200100338A patent/EA003405B1/ru not_active IP Right Cessation
- 1999-10-07 TR TR2001/01033T patent/TR200101033T2/xx unknown
- 1999-10-07 PA PA19998484001A patent/PA8484001A1/es unknown
- 1999-10-07 RO ROA200100395A patent/RO120532B1/ro unknown
- 1999-10-07 AT AT99970333T patent/ATE297771T1/de active
- 1999-10-07 CA CA002346791A patent/CA2346791C/en not_active Expired - Fee Related
- 1999-10-07 CZ CZ20011181A patent/CZ20011181A3/cs unknown
- 1999-10-07 EP EP99970333A patent/EP1119384B1/en not_active Expired - Lifetime
- 1999-10-07 WO PCT/US1999/023698 patent/WO2000021594A2/en active IP Right Grant
- 1999-10-07 BR BR9914384-4A patent/BR9914384A/pt not_active IP Right Cessation
- 1999-10-07 GE GEAP19995888A patent/GEP20043259B/en unknown
- 1999-10-07 KR KR1020017004241A patent/KR100652532B1/ko not_active IP Right Cessation
- 1999-10-07 CN CN2010101368205A patent/CN101804230B/zh not_active Expired - Fee Related
- 1999-10-07 PL PL99347906A patent/PL193881B1/pl not_active IP Right Cessation
- 1999-10-07 SK SK477-2001A patent/SK287044B6/sk not_active IP Right Cessation
- 1999-10-07 RS YUP-261/01A patent/RS49848B/sr unknown
- 1999-10-07 OA OA1200100086A patent/OA11791A/en unknown
- 1999-10-07 JP JP2000575566A patent/JP4378057B2/ja not_active Expired - Fee Related
- 1999-10-07 CN CN99811894A patent/CN1447704A/zh active Pending
- 1999-10-07 DE DE69925849T patent/DE69925849T2/de not_active Expired - Lifetime
- 1999-10-07 US US09/414,384 patent/US8408200B2/en not_active Expired - Fee Related
- 1999-10-07 DK DK99970333T patent/DK1119384T3/da active
- 1999-10-07 HU HU0103805A patent/HU225057B1/hu not_active IP Right Cessation
- 1999-10-07 EE EEP200100212A patent/EE04608B1/xx not_active IP Right Cessation
- 1999-10-08 CO CO99064137A patent/CO5060481A1/es unknown
- 1999-10-08 GT GT199900174A patent/GT199900174A/es unknown
- 1999-10-08 TN TNTNSN99188A patent/TNSN99188A1/fr unknown
- 1999-10-08 AR ARP990105113A patent/AR020760A1/es active IP Right Grant
- 1999-10-11 MA MA25813A patent/MA25865A1/fr unknown
- 1999-12-25 SA SA99200835A patent/SA99200835B1/ar unknown
-
2001
- 2001-03-21 IS IS5904A patent/IS2289B/is unknown
- 2001-03-22 IL IL142215A patent/IL142215A/en not_active IP Right Cessation
- 2001-03-23 BG BG105377A patent/BG105377A/bg unknown
- 2001-04-04 ZA ZA200102766A patent/ZA200102766B/en unknown
- 2001-04-06 HR HR20010253A patent/HRP20010253B1/xx not_active IP Right Cessation
- 2001-04-06 NO NO20011742A patent/NO20011742L/no not_active Application Discontinuation
- 2001-05-02 LT LT2001051A patent/LT4902B/lt not_active IP Right Cessation
- 2001-05-07 LV LV010070A patent/LV12685B/xx unknown
- 2001-05-25 LT LT2001057A patent/LT4907B/lt not_active IP Right Cessation
-
2002
- 2002-02-01 HK HK02100814.2A patent/HK1040645B/zh not_active IP Right Cessation
-
2009
- 2009-01-07 JP JP2009002017A patent/JP2009136688A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PA8484001A1 (es) | Suministro de agente activo aerosolizado modulado con resistencia de flujo. | |
AR018161A1 (es) | Dispositivo para administrar un agente activo a los pulmones de un paciente humano | |
DE60233967D1 (de) | Verbesserte essbare filmformulierungen mit maltodextrin | |
WO2002005789A3 (de) | Lösung, dispersion oder emulsion bildende folien-dermatika | |
DE60143889D1 (de) | Parasiticide formulierung und methode zur herstellung dieser formulierung | |
WO2003011259A8 (en) | Improved edible film formulations containing maltodextrin | |
GT199900164AA (es) | Pelicula consumible que se adhiere y se disuelve en la boca de un consumidor. | |
CO5130023A1 (es) | Administracion de agente activo en polvo seco agente activo y un inhibidor del crecimiento higroscopico | |
JP2017513907A (ja) | 過酸化物製剤ならびにその使用のための方法および塗布器 | |
AR119031A1 (es) | Formulaciones farmacéuticas antibacterianas de amplio espectro que comprenden lisozima y métodos de utilización de la misma | |
SV2004001226A (es) | Uso de una combinacion de compuestos en un inhalador de polvo seco, ref. pcs 25280 | |
BR0314804A (pt) | Forma de dosagem de liberação modificada | |
JPS56161323A (en) | Anti-inflammatory and pain-killing gel | |
IL152328A (en) | Preparations containing a combination of defibrotide and one or more hematopoietic factors and their use | |
HN1999000170A (es) | Suministro de agente activo aerosolizado modulado con resistencia de flujo. | |
WO2005090461A3 (en) | Thermoplastic films and methods for making | |
BR9916814A (pt) | Composição cosmética pulverizável e matriz utilizável nessa composição para uma administração dérmica | |
CN204133840U (zh) | 百穴灸盒 | |
WO2001045727A3 (en) | Stabilized veterinary compositions comprising more than one antiviral agent | |
ECSP993174A (es) | Suministro de agente activo aerosolizado modulado con resistencia de flujo. | |
CN205268643U (zh) | 一种止汗贴 | |
ECSP992889A (es) | Administracion de un agente activo en aerosol | |
JPS5735511A (en) | Dermatic medicine for external application | |
TWM509653U (zh) | 改良式噴霧面罩 | |
JP2004167197A (ja) | 薬気発散マスク |