ZA200007485B - A substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom. - Google Patents

A substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom. Download PDF

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Publication number
ZA200007485B
ZA200007485B ZA200007485A ZA200007485A ZA200007485B ZA 200007485 B ZA200007485 B ZA 200007485B ZA 200007485 A ZA200007485 A ZA 200007485A ZA 200007485 A ZA200007485 A ZA 200007485A ZA 200007485 B ZA200007485 B ZA 200007485B
Authority
ZA
South Africa
Prior art keywords
compound
formula
triazolo
triazol
ethyl
Prior art date
Application number
ZA200007485A
Other languages
English (en)
Inventor
Carling William Robert
Castro Pineiro Jose Luis
Cowden Cameron John
Davies Antony John
Andrew Madin
Mccabe James Francis
Pearce Gareth Edward Stephen
Street Leslie Joseph
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of ZA200007485B publication Critical patent/ZA200007485B/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200007485A 1998-06-24 2000-12-14 A substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom. ZA200007485B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9813576.7A GB9813576D0 (en) 1998-06-24 1998-06-24 Therapeutic agents

Publications (1)

Publication Number Publication Date
ZA200007485B true ZA200007485B (en) 2002-01-07

Family

ID=10834265

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200007485A ZA200007485B (en) 1998-06-24 2000-12-14 A substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom.

Country Status (35)

Country Link
US (1) US6630471B1 (cs)
EP (1) EP1090004B1 (cs)
JP (1) JP4749545B2 (cs)
KR (1) KR100604108B1 (cs)
CN (1) CN1138779C (cs)
AR (1) AR018925A1 (cs)
AT (1) ATE239730T1 (cs)
AU (1) AU757315B2 (cs)
BG (1) BG64989B1 (cs)
BR (1) BR9911563A (cs)
CA (1) CA2335328C (cs)
CO (1) CO5031239A1 (cs)
CZ (1) CZ291409B6 (cs)
DE (1) DE69907675T2 (cs)
EA (1) EA003332B1 (cs)
EE (1) EE200000767A (cs)
ES (1) ES2196824T3 (cs)
GB (1) GB9813576D0 (cs)
GE (1) GEP20033143B (cs)
HR (1) HRP20000879A2 (cs)
HU (1) HUP0102894A3 (cs)
ID (1) ID27771A (cs)
IL (2) IL139775A0 (cs)
IS (1) IS2258B (cs)
MY (1) MY124341A (cs)
NO (1) NO317992B1 (cs)
NZ (1) NZ508290A (cs)
PE (1) PE20000710A1 (cs)
PL (1) PL204650B1 (cs)
RS (1) RS49746B (cs)
SK (1) SK285307B6 (cs)
TR (1) TR200003789T2 (cs)
TW (1) TWI222449B (cs)
WO (1) WO1999067245A1 (cs)
ZA (1) ZA200007485B (cs)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2345443A (en) * 1999-01-08 2000-07-12 Merck Sharp & Dohme Use of triazolo-pyridazines for treating premenstrual syndrome
US20050042194A1 (en) 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
GB0111191D0 (en) * 2001-05-08 2001-06-27 Merck Sharp & Dohme Therapeutic agents
CA2510534C (en) * 2002-12-18 2011-09-20 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
WO2006061428A2 (en) * 2004-12-10 2006-06-15 Universität Zürich Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
EP2454259A1 (en) * 2009-06-23 2012-05-23 Concert Pharmaceuticals Inc. Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators
EP2456311A4 (en) * 2009-07-24 2013-01-23 Concert Pharmaceuticals Inc SUBSTITUTED IMIDASOTRIAZINES
US8278460B2 (en) 2009-10-15 2012-10-02 Concert Pharmaceuticals, Inc. Substituted benzimidazoles
PH12012501361A1 (en) 2009-12-31 2012-10-22 Centro Nac De Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
WO2012098387A1 (en) * 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
WO2013045519A1 (en) 2011-09-27 2013-04-04 Genfit Derivatives of 6-substituted triazolopyridazines as rev-erb agonists
SG11201806393QA (en) 2016-01-27 2018-08-30 Univ Zuerich Use of gabaa receptor modulators for treatment of itch
MX2020010878A (es) 2018-04-18 2021-01-29 Neurocycle Therapeutics Inc Compuestos moduladores alostericos positivos gabaa, metodos de preparacion y usos de los mismos.
MX2021003010A (es) 2018-09-13 2021-05-27 Saniona As Un ligando del receptor acido gamma-aminobutirico a (gabaa).
HU231223B1 (hu) 2018-09-28 2022-01-28 Richter Gedeon Nyrt. GABAA A5 receptor modulátor hatású biciklusos vegyületek
EP4126858A1 (en) 2020-03-26 2023-02-08 Richter Gedeon Nyrt. Dihydro-2-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators
WO2025141131A1 (en) 2023-12-27 2025-07-03 Saniona A/S A gabaa receptor ligand and the use thereof in medicine, in particular in the treatment of epilepsy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2194205T3 (es) * 1996-07-25 2003-11-16 Merck Sharp & Dohme Derivados de triazolo-piridazina sustituidos como ligandos para los receptores gaba.

Also Published As

Publication number Publication date
WO1999067245A1 (en) 1999-12-29
NZ508290A (en) 2003-09-26
EA003332B1 (ru) 2003-04-24
HUP0102894A3 (en) 2003-03-28
BR9911563A (pt) 2001-03-20
NO20006576L (no) 2001-02-14
SK285307B6 (sk) 2006-10-05
GEP20033143B (en) 2003-12-25
EP1090004A1 (en) 2001-04-11
ATE239730T1 (de) 2003-05-15
TWI222449B (en) 2004-10-21
RS49746B (sr) 2008-04-04
NO317992B1 (no) 2005-01-17
CZ20004872A3 (cs) 2001-07-11
BG64989B1 (bg) 2006-11-30
CA2335328C (en) 2007-11-27
MY124341A (en) 2006-06-30
HRP20000879A2 (en) 2001-06-30
CZ291409B6 (cs) 2003-03-12
SK19552000A3 (sk) 2001-08-06
PL204650B1 (pl) 2010-01-29
BG105152A (en) 2001-10-31
CN1138779C (zh) 2004-02-18
ID27771A (id) 2001-04-26
DE69907675D1 (de) 2003-06-12
ES2196824T3 (es) 2003-12-16
JP4749545B2 (ja) 2011-08-17
EE200000767A (et) 2002-06-17
CN1307579A (zh) 2001-08-08
KR20010053136A (ko) 2001-06-25
EA200100071A1 (ru) 2001-06-25
IS5730A (is) 2000-11-24
IS2258B (is) 2007-06-15
IL139775A (en) 2007-02-11
JP2002518501A (ja) 2002-06-25
GB9813576D0 (en) 1998-08-19
YU77800A (sh) 2003-10-31
KR100604108B1 (ko) 2006-07-26
AU4630199A (en) 2000-01-10
HUP0102894A2 (hu) 2001-11-28
DE69907675T2 (de) 2004-03-04
PE20000710A1 (es) 2000-08-14
PL345332A1 (en) 2001-12-17
CA2335328A1 (en) 1999-12-29
EP1090004B1 (en) 2003-05-07
AU757315B2 (en) 2003-02-13
US6630471B1 (en) 2003-10-07
AR018925A1 (es) 2001-12-12
NO20006576D0 (no) 2000-12-21
CO5031239A1 (es) 2001-04-27
TR200003789T2 (tr) 2001-04-20
IL139775A0 (en) 2002-02-10

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