SK285307B6 - Substituovaný derivát triazolopyridazínu, spôsob jeho výroby, farmaceutický prostriedok s jeho obsahom a jeho použitie - Google Patents
Substituovaný derivát triazolopyridazínu, spôsob jeho výroby, farmaceutický prostriedok s jeho obsahom a jeho použitie Download PDFInfo
- Publication number
- SK285307B6 SK285307B6 SK1955-2000A SK19552000A SK285307B6 SK 285307 B6 SK285307 B6 SK 285307B6 SK 19552000 A SK19552000 A SK 19552000A SK 285307 B6 SK285307 B6 SK 285307B6
- Authority
- SK
- Slovakia
- Prior art keywords
- compound
- formula
- pyridazine
- ethyl
- triazolo
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 27
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 3
- CBHTTYDJRXOHHL-UHFFFAOYSA-N 2h-triazolo[4,5-c]pyridazine Chemical class N1=NC=CC2=C1N=NN2 CBHTTYDJRXOHHL-UHFFFAOYSA-N 0.000 title abstract description 4
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- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims description 16
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 15
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9813576.7A GB9813576D0 (en) | 1998-06-24 | 1998-06-24 | Therapeutic agents |
| PCT/GB1999/001897 WO1999067245A1 (en) | 1998-06-24 | 1999-06-15 | A substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK19552000A3 SK19552000A3 (sk) | 2001-08-06 |
| SK285307B6 true SK285307B6 (sk) | 2006-10-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1955-2000A SK285307B6 (sk) | 1998-06-24 | 1999-06-15 | Substituovaný derivát triazolopyridazínu, spôsob jeho výroby, farmaceutický prostriedok s jeho obsahom a jeho použitie |
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| EP (1) | EP1090004B1 (cs) |
| JP (1) | JP4749545B2 (cs) |
| KR (1) | KR100604108B1 (cs) |
| CN (1) | CN1138779C (cs) |
| AR (1) | AR018925A1 (cs) |
| AT (1) | ATE239730T1 (cs) |
| AU (1) | AU757315B2 (cs) |
| BG (1) | BG64989B1 (cs) |
| BR (1) | BR9911563A (cs) |
| CA (1) | CA2335328C (cs) |
| CO (1) | CO5031239A1 (cs) |
| CZ (1) | CZ291409B6 (cs) |
| DE (1) | DE69907675T2 (cs) |
| EA (1) | EA003332B1 (cs) |
| EE (1) | EE200000767A (cs) |
| ES (1) | ES2196824T3 (cs) |
| GB (1) | GB9813576D0 (cs) |
| GE (1) | GEP20033143B (cs) |
| HR (1) | HRP20000879A2 (cs) |
| HU (1) | HUP0102894A3 (cs) |
| ID (1) | ID27771A (cs) |
| IL (2) | IL139775A0 (cs) |
| IS (1) | IS2258B (cs) |
| MY (1) | MY124341A (cs) |
| NO (1) | NO317992B1 (cs) |
| NZ (1) | NZ508290A (cs) |
| PE (1) | PE20000710A1 (cs) |
| PL (1) | PL204650B1 (cs) |
| RS (1) | RS49746B (cs) |
| SK (1) | SK285307B6 (cs) |
| TR (1) | TR200003789T2 (cs) |
| TW (1) | TWI222449B (cs) |
| WO (1) | WO1999067245A1 (cs) |
| ZA (1) | ZA200007485B (cs) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2345443A (en) * | 1999-01-08 | 2000-07-12 | Merck Sharp & Dohme | Use of triazolo-pyridazines for treating premenstrual syndrome |
| US20050042194A1 (en) | 2000-05-11 | 2005-02-24 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| GB0111191D0 (en) * | 2001-05-08 | 2001-06-27 | Merck Sharp & Dohme | Therapeutic agents |
| JP4817661B2 (ja) | 2002-12-18 | 2011-11-16 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼインヒビターとしてのトリアゾロピリダジン |
| WO2006061428A2 (en) * | 2004-12-10 | 2006-06-15 | Universität Zürich | Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain |
| US8501738B2 (en) | 2009-06-23 | 2013-08-06 | Concert Pharmaceuticals, Inc. | Substituted triazolo-pyridazine derivatives |
| US20110082147A1 (en) * | 2009-07-24 | 2011-04-07 | Concert Pharmaceuticals, Inc. | Substituted imidazotriazines |
| WO2011047315A1 (en) | 2009-10-15 | 2011-04-21 | Concert Pharmaceuticals, Inc. | Subsitituted benzimidazoles |
| PH12012501361A1 (en) | 2009-12-31 | 2012-10-22 | Centro Nac De Investigaciones Oncologicas Cnio | Tricyclic compounds for use as kinase inhibitors |
| WO2012098387A1 (en) * | 2011-01-18 | 2012-07-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors |
| WO2013045519A1 (en) | 2011-09-27 | 2013-04-04 | Genfit | Derivatives of 6-substituted triazolopyridazines as rev-erb agonists |
| UA125463C2 (uk) | 2016-01-27 | 2022-03-16 | Універсітет Цюріх | ЗАСТОСУВАННЯ МОДУЛЯТОРІВ GABA<sub>A</sub>-РЕЦЕПТОРА ДЛЯ ЛІКУВАННЯ СВЕРБЕЖУ |
| WO2019204446A1 (en) * | 2018-04-18 | 2019-10-24 | Neurocycle Therapeutics, Inc. | Gabaa positive allosteric modulator compounds, methods of making, and uses thereof |
| MX2021003010A (es) | 2018-09-13 | 2021-05-27 | Saniona As | Un ligando del receptor acido gamma-aminobutirico a (gabaa). |
| HU231223B1 (hu) | 2018-09-28 | 2022-01-28 | Richter Gedeon Nyrt. | GABAA A5 receptor modulátor hatású biciklusos vegyületek |
| WO2021191837A1 (en) | 2020-03-26 | 2021-09-30 | Richter Gedeon Nyrt. | 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa α5 receptor modulators |
| WO2025141131A1 (en) | 2023-12-27 | 2025-07-03 | Saniona A/S | A gabaa receptor ligand and the use thereof in medicine, in particular in the treatment of epilepsy |
Family Cites Families (1)
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| YU2899A (sh) * | 1996-07-25 | 2000-03-21 | Merck Sharp & Dohme Limited | Supstituisani triazolo-piridazin derivati kao ligandi za gaba receptore |
-
1998
- 1998-06-24 GB GBGB9813576.7A patent/GB9813576D0/en not_active Ceased
-
1999
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2000
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2001
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20120615 |