MX2020010878A - Compuestos moduladores alostericos positivos gabaa, metodos de preparacion y usos de los mismos. - Google Patents
Compuestos moduladores alostericos positivos gabaa, metodos de preparacion y usos de los mismos.Info
- Publication number
- MX2020010878A MX2020010878A MX2020010878A MX2020010878A MX2020010878A MX 2020010878 A MX2020010878 A MX 2020010878A MX 2020010878 A MX2020010878 A MX 2020010878A MX 2020010878 A MX2020010878 A MX 2020010878A MX 2020010878 A MX2020010878 A MX 2020010878A
- Authority
- MX
- Mexico
- Prior art keywords
- making
- methods
- positive allosteric
- allosteric modulator
- modulator compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
En el presente documento se describen polimorfos que comprenden 2',6-difluoro-5'-[3-(1-hidroxi-1-metiletil)-imidazo[1,2-b][1,2,4] triazin-7-il]bifenil-2-carbonitrilo (TPA023B) o sales del mismo. En un aspecto del presente documento se describe una sal polimórfica cristalina o cocristal de TPA023B con ácido fosfórico. En el presente documento también se describen métodos de preparación y uso de los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862659226P | 2018-04-18 | 2018-04-18 | |
PCT/US2019/027880 WO2019204446A1 (en) | 2018-04-18 | 2019-04-17 | Gabaa positive allosteric modulator compounds, methods of making, and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020010878A true MX2020010878A (es) | 2021-01-29 |
Family
ID=68239798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020010878A MX2020010878A (es) | 2018-04-18 | 2019-04-17 | Compuestos moduladores alostericos positivos gabaa, metodos de preparacion y usos de los mismos. |
Country Status (14)
Country | Link |
---|---|
US (2) | US11542263B2 (es) |
EP (1) | EP3781566A4 (es) |
JP (1) | JP7449272B2 (es) |
KR (1) | KR20210011921A (es) |
CN (1) | CN112384513A (es) |
AU (1) | AU2019255282A1 (es) |
BR (1) | BR112020021104A2 (es) |
CA (1) | CA3096890A1 (es) |
CL (1) | CL2020002663A1 (es) |
IL (1) | IL278067A (es) |
MX (1) | MX2020010878A (es) |
SG (1) | SG11202010220QA (es) |
TW (1) | TW202012402A (es) |
WO (1) | WO2019204446A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7449272B2 (ja) * | 2018-04-18 | 2024-03-13 | ニューロサイクル・セラピューティクス・インコーポレイテッド | Gabaa陽性アロステリックモジュレーター化合物、その作製の方法および使用 |
WO2020191047A1 (en) * | 2019-03-18 | 2020-09-24 | Neurocycle Therapeutics, Inc. | Use of gabaa receptor modulators for treatment of pain |
CA3154222A1 (en) * | 2019-10-22 | 2021-04-29 | Matthew TOCZKO | Gabaa positive allosteric modulator compounds, methods of making, and uses thereof |
JP2022554159A (ja) * | 2019-10-23 | 2022-12-28 | ニューロサイクル・セラピューティクス・インコーポレイテッド | Gabaa受容体モジュレーターによるてんかん状態の治療 |
US20210401849A1 (en) * | 2020-06-30 | 2021-12-30 | University Of Mississippi Medical Center | Methods for treating benzodiazepine misuse/use disorder |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9813576D0 (en) | 1998-06-24 | 1998-08-19 | Merck Sharp & Dohme | Therapeutic agents |
US6936608B2 (en) * | 2000-11-10 | 2005-08-30 | Merck Sharp & Dohme Ltd. | Imidazo-triazine derivatives as ligands for GABA receptors |
GB0117277D0 (en) * | 2001-07-16 | 2001-09-05 | Merck Sharp & Dohme | Therapeutic agents |
TWI248936B (en) * | 2001-03-21 | 2006-02-11 | Merck Sharp & Dohme | Imidazo-pyrimidine derivatives as ligands for GABA receptors |
SI2300455T1 (sl) * | 2008-05-21 | 2017-12-29 | Incyte Holdings Corporation | Soli 2-fluoro-n-metil-4-(7-(kinolin-6-il-metil)-imidazo(1,2-b)1,2,4) triazin-2-il)benzamid in postopki v zvezi z njihovo pripravo |
WO2011011712A1 (en) * | 2009-07-24 | 2011-01-27 | Concert Pharmaceuticals, Inc. | Substituted imidazotriazines |
MX2018009252A (es) * | 2016-01-27 | 2019-01-21 | Univ Zuerich | Uso de moduladores de receptores de gabaa para el tratamiento de picor. |
JP7449272B2 (ja) * | 2018-04-18 | 2024-03-13 | ニューロサイクル・セラピューティクス・インコーポレイテッド | Gabaa陽性アロステリックモジュレーター化合物、その作製の方法および使用 |
-
2019
- 2019-04-17 JP JP2021506619A patent/JP7449272B2/ja active Active
- 2019-04-17 MX MX2020010878A patent/MX2020010878A/es unknown
- 2019-04-17 CN CN201980041321.7A patent/CN112384513A/zh active Pending
- 2019-04-17 WO PCT/US2019/027880 patent/WO2019204446A1/en active Application Filing
- 2019-04-17 SG SG11202010220QA patent/SG11202010220QA/en unknown
- 2019-04-17 KR KR1020207033073A patent/KR20210011921A/ko unknown
- 2019-04-17 BR BR112020021104-4A patent/BR112020021104A2/pt unknown
- 2019-04-17 AU AU2019255282A patent/AU2019255282A1/en active Pending
- 2019-04-17 TW TW108113441A patent/TW202012402A/zh unknown
- 2019-04-17 CA CA3096890A patent/CA3096890A1/en active Pending
- 2019-04-17 EP EP19788410.9A patent/EP3781566A4/en active Pending
-
2020
- 2020-10-15 IL IL278067A patent/IL278067A/en unknown
- 2020-10-15 CL CL2020002663A patent/CL2020002663A1/es unknown
- 2020-10-16 US US17/072,282 patent/US11542263B2/en active Active
-
2022
- 2022-12-28 US US18/089,661 patent/US20230139418A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
TW202012402A (zh) | 2020-04-01 |
BR112020021104A2 (pt) | 2021-02-23 |
JP7449272B2 (ja) | 2024-03-13 |
SG11202010220QA (en) | 2020-11-27 |
KR20210011921A (ko) | 2021-02-02 |
JP2021522330A (ja) | 2021-08-30 |
CA3096890A1 (en) | 2019-10-24 |
CL2020002663A1 (es) | 2021-06-11 |
IL278067A (en) | 2020-11-30 |
US20210040103A1 (en) | 2021-02-11 |
US20230139418A1 (en) | 2023-05-04 |
WO2019204446A1 (en) | 2019-10-24 |
EP3781566A1 (en) | 2021-02-24 |
AU2019255282A1 (en) | 2020-11-05 |
CN112384513A (zh) | 2021-02-19 |
US11542263B2 (en) | 2023-01-03 |
EP3781566A4 (en) | 2022-06-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2020010878A (es) | Compuestos moduladores alostericos positivos gabaa, metodos de preparacion y usos de los mismos. | |
SG11202111524YA (en) | Process for the preparation of precursor compounds for lithium battery cathodes | |
PH12019550128A1 (en) | Pyrrolo [1,2-b] pyridazine derivatives | |
PH12017501061B1 (en) | 3-substituted 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection | |
TN2019000133A1 (en) | PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF | |
MX2019012927A (es) | Sales del inhibidor fosfoinositida 3-cinasa (pi3k) y procesos para su preparacion. | |
MX358682B (es) | Derivados de pirazolo [1,5a]pirimidina y de tieno[3,2b] pirimidina como moduladores de la cinasa asociada al receptor de la interleucina 4 (irak4). | |
BR112014032338A2 (pt) | cristais de sal | |
BR112017001565A2 (pt) | ?composto, métodos para tratar uma infecção e para fabricar um medicamento, composição farmacêutica, e, uso de um composto? | |
WO2014128545A3 (en) | An improved process for the preparation of dolutegravir | |
MX2018004332A (es) | Sales farmaceuticas, formas fisicas y composiciones de inhibidores de pirrolopirimidina cinasa, y metodos para fabricar las mismas. | |
AU2017319080A1 (en) | Pyrazolo[1,5-a]pyrimidine compound | |
CL2021000276A1 (es) | Polimorfo cristalino del clorhidrato de 8-bromo-2-(1-metilpiperidin-4-ilamin)-4-(4-fenoxifenilamin)pirido[4,3-d]pirimidin-5(6h)-ona y método para prepararlo. | |
MX2022004642A (es) | Compuestos moduladores alostericos positivos de gabaa, metodos de preparacion y usos de los mismos. | |
WO2015123519A8 (en) | Preparation of 3,4-dihydro-1,4-benzoxazepin-5(2h)-one derivatives by cyclisation of 2-(am i no ethyloxy) benzoic acid derivatives | |
BR112014000085A2 (pt) | derivados de ácido carboxílico com um anel oxazolo[4,5-c]piridina | |
MX2019007891A (es) | Sales de oxalato de tianeptina y polimorfos. | |
MY164134A (en) | Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring | |
EA201291289A1 (ru) | Кристаллическое производное тиенопиримидина | |
MX2016005173A (es) | Un polimorfo estable de la sal de (2r)-4-oxo-4-[3-(trifluorometil) -5,6-dihidro[1,2,4]triazolo[4,3-a]pirazin-7(8h)-il]-1-(2,4,5-trif luorofenil)butan-2-amina con acido l-tartarico. | |
MX2017003415A (es) | Un derivado de tetrahidropirrolo [3,4-d] [1,3]tiazina como inhibidor de bace. | |
EA202190643A1 (ru) | УЛУЧШЕННЫЙ СПОСОБ ПРОИЗВОДСТВА 3-[(1S)-1-ИМИДАЗО[1,2-a]ПИРИДИН-6-ИЛЭТИЛ]-5-(1-МЕТИЛПИРАЗОЛ-4-ИЛ)ТРИАЗОЛО[4,5-b]ПИРАЗИНА И ЕГО ПОЛИМОРФНЫХ ФОРМ | |
MX2020008066A (es) | Formas de sal de compuesto organico. | |
CO2017002070A2 (es) | Un proceso para la preparación de derivados de 3-fenil/heteroaril-6-fenoxi-8-alquilamino-imidazo[1,2-b] piridazina | |
PH12020551701A1 (en) | Meglumine salts of thienopyrimidines |