ZA200004383B - Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue. - Google Patents

Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue.

Info

Publication number
ZA200004383B
ZA200004383B ZA200004383A ZA200004383A ZA200004383B ZA 200004383 B ZA200004383 B ZA 200004383B ZA 200004383 A ZA200004383 A ZA 200004383A ZA 200004383 A ZA200004383 A ZA 200004383A ZA 200004383 B ZA200004383 B ZA 200004383B
Authority
ZA
South Africa
Prior art keywords
epitopes
directed against
detection
antibodies directed
envelope proteins
Prior art date
Application number
ZA200004383A
Other languages
English (en)
Inventor
Geert Maertens
Erik Depla
Marie-Ange Buyse
Original Assignee
Innogenetics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics Nv filed Critical Innogenetics Nv
Publication of ZA200004383B publication Critical patent/ZA200004383B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C07K16/109—Hepatitis C virus; Hepatitis G virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA200004383A 1998-03-27 2000-08-24 Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue. ZA200004383B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98870060A EP0947525A1 (en) 1998-03-27 1998-03-27 Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue

Publications (1)

Publication Number Publication Date
ZA200004383B true ZA200004383B (en) 2003-01-28

Family

ID=8237012

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200004383A ZA200004383B (en) 1998-03-27 2000-08-24 Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue.

Country Status (19)

Country Link
US (2) US6521403B1 (ja)
EP (2) EP0947525A1 (ja)
JP (1) JP3657515B2 (ja)
KR (1) KR20010042225A (ja)
CN (1) CN1294598A (ja)
AT (1) ATE336512T1 (ja)
AU (1) AU756495B2 (ja)
BR (1) BR9909026A (ja)
CA (1) CA2321179A1 (ja)
DE (1) DE69932812T2 (ja)
ES (1) ES2272065T3 (ja)
HU (1) HUP0103650A3 (ja)
IL (1) IL138586A0 (ja)
NZ (1) NZ506553A (ja)
PL (1) PL343638A1 (ja)
PT (1) PT1064309E (ja)
TR (1) TR200002695T2 (ja)
WO (1) WO1999050301A2 (ja)
ZA (1) ZA200004383B (ja)

Families Citing this family (23)

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JPH09503396A (ja) * 1994-07-29 1997-04-08 インノジェネティクス・エヌ・ブイ 診断用及び治療用の精製ｃ型肝炎ウイルスエンベロープ蛋白
US20030180284A1 (en) * 1998-11-05 2003-09-25 Board Of Trustees Of Leland Stanford Junior University Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes
JP2003513022A (ja) * 1999-10-27 2003-04-08 インノジェネティクス・エヌ・ブイ 天然に似たコンフォメーションを有する酸化還元の可逆的なｈｃｖタンパク質
EP1535628B1 (en) * 1999-11-24 2013-07-31 Novartis Vaccines and Diagnostics, Inc. Hbv/hcv virus-like particle
EP1178116A1 (en) * 2000-08-03 2002-02-06 Hybrigenics S.A. Sid nucleic acids and polypeptides selected from a pathogenic strain of hepatitis C virus and applications thereof
JP2004524829A (ja) * 2000-12-01 2004-08-19 アメリカ合衆国 Ｃ型肝炎ウイルスのｅ２糖タンパク質に特異的なモノクローナル抗体、ならびにｃ型肝炎の診断、治療、および予防におけるそれらの使用
ATE425187T1 (de) * 2001-01-12 2009-03-15 Molecules Of Man Ab Materialien und methoden zur behandlung von hepatitis c
EA200701870A1 (ru) * 2003-09-22 2008-02-28 Грин Пептайд Ко., Лтд. Пептид, происходящий из вируса гепатита с
EP1574517A1 (en) 2004-03-09 2005-09-14 Innogenetics N.V. HCV E1 comprising specific disulfide bridges
EP1602664A1 (en) * 2004-03-08 2005-12-07 Innogenetics N.V. HCV E1 comprising specific disulfide bridges
US7309589B2 (en) * 2004-08-20 2007-12-18 Vironix Llc Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing
WO2006033012A2 (en) * 2004-09-24 2006-03-30 Pfizer Limited Method of screening for modulators of hepatitis c virus infection
WO2007101103A2 (en) * 2006-02-23 2007-09-07 University Of California, San Diego Compositions and assays for inhibiting hcv infection
EP2004685A4 (en) * 2006-03-22 2009-04-29 Genimmune N V HEPATITIS C VIRUS NEUTRALIZING ANTIBODIES
CN101336110B (zh) * 2006-06-01 2011-06-01 程云 预防或治疗肝损伤的肽及其衍生物及其应用
CN101679512A (zh) 2007-02-21 2010-03-24 马萨诸塞州大学 抗丙型肝炎病毒（hcv）人抗体及其用途
WO2010038789A1 (ja) 2008-09-30 2010-04-08 東レ株式会社 Ｃ型肝炎ウイルスのエンベロープタンパク質２に結合する抗体及びそれを用いたｃ型肝炎ウイルスの遺伝子型の同定方法
US20100104555A1 (en) * 2008-10-24 2010-04-29 The Scripps Research Institute HCV neutralizing epitopes
WO2014065822A1 (en) * 2012-10-26 2014-05-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hepatitis c virus neutralizing epitopes, antibodies, and methods
CN107615065B (zh) * 2015-03-23 2020-07-24 以埃森生物科学股份有限公司的名义经营的埃森仪器股份有限公司 对生物材料评估腺病毒或腺相关病毒的病毒类型的非缔合的病毒尺寸颗粒
CN109232722B (zh) * 2018-09-26 2021-06-29 广州市第八人民医院 Hcv包膜蛋白高度保守区域的肽段317-325及其用途
CN109160942B (zh) * 2018-09-26 2021-06-29 广州市第八人民医院 Hcv包膜蛋白高度保守区域的肽段502-518及其用途
KR20230050761A (ko) 2021-10-08 2023-04-17 김민준 과제기한 자동알림

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308750A (en) 1989-12-22 1994-05-03 Abbott Laboratories Monoclonal antibodies to putative HCV E2/NS1 proteins and methods for using same
JPH06504431A (ja) 1990-11-08 1994-05-26 カイロン　コーポレイション Ｃ型肝炎ウイルスアシアロ糖タンパク質
JP3483555B2 (ja) * 1991-01-31 2004-01-06 アボット・ラボラトリーズ 推定ｈｃｖエンベロープ領域に対するモノクローナル抗体およびその使用方法
FR2677372B1 (fr) 1991-06-06 1994-11-10 Pasteur Institut Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques.
DE4209215A1 (de) * 1991-07-04 1993-01-07 Boehringer Mannheim Gmbh Hcv peptidantigene und verfahren zur bestimmung von hcv
IT1249684B (it) 1991-07-19 1995-03-09 Sorin Biomedica Spa Epitopi della proteina env del virus dell'epatite c.
WO1993015193A1 (en) 1992-01-31 1993-08-05 Abbott Laboratories Mammalian expression systems for hcv proteins
BR9305435A (pt) * 1992-03-06 1994-12-27 Innogenetics Nv Processo para determinação de peptídeos correspondendo a epítopos imunologicamente importantes e seu uso em um processo para determinação de anticorpos ou peptídeos biotinilados correspondendo a epítopos imunologicamente importantes, processo para preparação dos mesmos e composições contendo os mesmos
JPH05344899A (ja) 1992-06-11 1993-12-27 Kokuritsu Yobou Eisei Kenkyusho Ｃ型肝炎ウイルス外被タンパク質の産生法
US6261569B1 (en) * 1992-08-27 2001-07-17 Deakin Research Limited Retro-, inverso- and retro-inverso synthetic peptide analogues
US5514539A (en) 1993-06-29 1996-05-07 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
US5610009A (en) 1994-01-28 1997-03-11 Abbott Laboratories Mammalian expression systems for hepatitis C virus envelope genes
JPH09503396A (ja) 1994-07-29 1997-04-08 インノジェネティクス・エヌ・ブイ 診断用及び治療用の精製ｃ型肝炎ウイルスエンベロープ蛋白
US6110465A (en) * 1995-06-07 2000-08-29 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of isolates of hepatitis C virus and the use of reagents derived from these hypervariable sequences in diagnostic methods and vaccines

Also Published As

Publication number Publication date
WO1999050301A3 (en) 1999-11-25
KR20010042225A (ko) 2001-05-25
TR200002695T2 (tr) 2000-12-21
US20030129746A1 (en) 2003-07-10
JP3657515B2 (ja) 2005-06-08
AU3602299A (en) 1999-10-18
EP0947525A1 (en) 1999-10-06
ATE336512T1 (de) 2006-09-15
CN1294598A (zh) 2001-05-09
PL343638A1 (en) 2001-08-27
IL138586A0 (en) 2001-10-31
DE69932812T2 (de) 2007-04-12
NZ506553A (en) 2002-11-26
US6521403B1 (en) 2003-02-18
CA2321179A1 (en) 1999-10-07
EP1064309A2 (en) 2001-01-03
HUP0103650A2 (hu) 2002-01-28
US6841353B2 (en) 2005-01-11
EP1064309B1 (en) 2006-08-16
PT1064309E (pt) 2006-12-29
HUP0103650A3 (en) 2005-10-28
JP2002510038A (ja) 2002-04-02
AU756495B2 (en) 2003-01-16
DE69932812D1 (de) 2006-09-28
ES2272065T3 (es) 2007-04-16
WO1999050301A2 (en) 1999-10-07
BR9909026A (pt) 2000-12-05

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