YU71503A - 4-(2-butilamino)-2,7-dimetil-8-(2-metil-6-metoksipirid-3-il) pirazolo/1,5-a/-1,3,5-triazin,njegovi enantiomeri i farmaceutski prihvatljive soli kao ligandi receptora za faktor koji oslobađa kortikotropin - Google Patents
4-(2-butilamino)-2,7-dimetil-8-(2-metil-6-metoksipirid-3-il) pirazolo/1,5-a/-1,3,5-triazin,njegovi enantiomeri i farmaceutski prihvatljive soli kao ligandi receptora za faktor koji oslobađa kortikotropinInfo
- Publication number
- YU71503A YU71503A YU71503A YUP71503A YU71503A YU 71503 A YU71503 A YU 71503A YU 71503 A YU71503 A YU 71503A YU P71503 A YUP71503 A YU P71503A YU 71503 A YU71503 A YU 71503A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- methoxypyrid
- pyrazolo
- butylamino
- enantiomers
- triazine
- Prior art date
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Addiction (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
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- Emergency Medicine (AREA)
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- Psychology (AREA)
Abstract
Antagonisti faktora koji oslobađa kortikotropin (CRF) prikazani su formulom (I) kao i njihova upotreba u lečenju depresije i drugih psihijatrijskih, neuroloških poremećaja isto kao i lečenje imunoloških, kardiovaskularnih ili srčanih bolesti i hipersenzitivnosti debelog creva udruženoj sa psihopatološkim poremećajem i stresom.[Corticotropin releasing factor (CRF) antagonists of Formula (I), and its use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heartrelated diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27540301P | 2001-03-13 | 2001-03-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU71503A true YU71503A (sh) | 2006-05-25 |
| RS50863B RS50863B (sr) | 2010-08-31 |
Family
ID=23052141
Country Status (36)
| Country | Link |
|---|---|
| US (4) | US20030125330A1 (sh) |
| EP (1) | EP1368094B1 (sh) |
| JP (1) | JP4549630B2 (sh) |
| KR (1) | KR100875595B1 (sh) |
| CN (1) | CN100427093C (sh) |
| AR (1) | AR032986A1 (sh) |
| AT (1) | ATE355102T1 (sh) |
| AU (1) | AU2002245605B2 (sh) |
| BG (1) | BG66331B1 (sh) |
| BR (1) | BR0208357A (sh) |
| CA (1) | CA2440553C (sh) |
| CY (1) | CY1106607T1 (sh) |
| CZ (1) | CZ20032481A3 (sh) |
| DE (1) | DE60218434T2 (sh) |
| DK (1) | DK1368094T3 (sh) |
| EE (1) | EE05433B1 (sh) |
| ES (1) | ES2282401T3 (sh) |
| GE (1) | GEP20053608B (sh) |
| HK (1) | HK1057182A1 (sh) |
| HR (1) | HRP20030822B1 (sh) |
| HU (1) | HU229317B1 (sh) |
| IL (2) | IL157615A0 (sh) |
| IS (1) | IS2839B (sh) |
| MX (1) | MXPA03008185A (sh) |
| MY (1) | MY146935A (sh) |
| NO (1) | NO328580B1 (sh) |
| NZ (1) | NZ528207A (sh) |
| PL (1) | PL208278B1 (sh) |
| PT (1) | PT1368094E (sh) |
| RS (1) | RS50863B (sh) |
| RU (1) | RU2292347C2 (sh) |
| SK (1) | SK287603B6 (sh) |
| TW (1) | TWI257388B (sh) |
| UA (1) | UA74634C2 (sh) |
| WO (1) | WO2002072202A1 (sh) |
| ZA (1) | ZA200306995B (sh) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7094782B1 (en) * | 1996-07-24 | 2006-08-22 | Bristol-Myers Squibb Company | Azolo triazines and pyrimidines |
| WO2002072202A1 (en) * | 2001-03-13 | 2002-09-19 | Bristol-Myers Squibb Pharma Company | 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands |
| FR2842809A1 (fr) * | 2002-07-26 | 2004-01-30 | Greenpharma Sas | NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
| AR041470A1 (es) | 2002-10-17 | 2005-05-18 | Upjohn Co | Compuestos de pirrolo (1,2 - b) piridazina y sus usos |
| US7329658B2 (en) | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
| US7176210B2 (en) * | 2003-02-10 | 2007-02-13 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| US7041671B2 (en) * | 2003-04-02 | 2006-05-09 | Pfizer Inc | Pyrrolo[1,2-b]pyridazine compounds and their uses |
| US7034023B2 (en) * | 2003-04-04 | 2006-04-25 | Pfizer Inc | Pyrrolo[1,2-B]pyridazine compounds and their uses |
| US7056920B2 (en) | 2003-04-04 | 2006-06-06 | Pfizer Inc | Pyrrolo[1,2-B]pyridazine compounds and their uses |
| JP2006523675A (ja) * | 2003-04-15 | 2006-10-19 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | ピロロ［１，２−ｂ］ピリダジン化合物及びそれらの使用 |
| US7208596B2 (en) * | 2003-11-25 | 2007-04-24 | Bristol-Myers Squibb Pharma Company | Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof |
| US7153961B2 (en) | 2003-11-25 | 2006-12-26 | Bristol-Myers Squibb Pharma Co. | Salt and crystalline form thereof of a corticotropin releasing factor receptor antagonist |
| MY146388A (en) * | 2006-09-20 | 2012-08-15 | Lilly Co Eli | Thiazole pyrazolopyrimidines as crfi receptor antagonists |
| WO2013160317A2 (en) * | 2012-04-23 | 2013-10-31 | Holsboermaschmeyer Neurochemie Gmbh | Crhr1 antagonists for use in the treatment of patients having crh overactivity |
| GB201210686D0 (en) | 2012-06-15 | 2012-08-01 | Holsboermaschmeyer Neurochemie Gmbh | V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level |
| WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| GB201310782D0 (en) | 2013-06-17 | 2013-07-31 | Max Planck Innovation Gmbh | Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms |
| KR102079844B1 (ko) * | 2016-09-20 | 2020-02-20 | 가톨릭대학교 산학협력단 | 담석 용해제를 포함하는 담낭 질환 치료용 약학 조성물 |
| EP4175572A4 (en) | 2020-08-12 | 2024-03-27 | Spruce Biosciences Inc | METHODS AND COMPOSITIONS FOR TREATING POLYCYSTIC OVARIAN SYNDROME |
| US11708372B2 (en) | 2021-11-19 | 2023-07-25 | Spruce Biosciences, Inc. | Crystalline composition of tildacerfont and methods of use and preparation thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW444018B (en) * | 1992-12-17 | 2001-07-01 | Pfizer | Pyrazolopyrimidines |
| JP3398152B2 (ja) | 1993-10-12 | 2003-04-21 | ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー | １ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体 |
| TW530047B (en) | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
| NZ331647A (en) | 1996-03-26 | 2000-03-27 | Du Pont Pharm Co | Aryloxy- and arylthio-fused pyridines and pyrimidines and derivatives |
| US6107300A (en) | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
| WO1997044308A1 (en) | 1996-05-24 | 1997-11-27 | The Dow Chemical Company | Process for preparing aliphatic ester compounds and alkanols |
| EE04316B1 (et) * | 1996-07-24 | 2004-06-15 | Dupont Pharmaceuticals Company | Asolotriasiinid ja -pürimidiinid, neid sisaldavadfarmatseutilised kompositsioonid ning nende kasutamine ravimite valmistamiseks |
| US6191131B1 (en) * | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
| DE69738197T2 (de) | 1996-07-24 | 2008-07-17 | Bristol-Myers Squibb Pharma Co. | Azolotriazine und pyrimidine |
| DE69736711T2 (de) * | 1996-08-28 | 2007-09-20 | Pfizer Inc. | Substituierte 6,5-heterobicyclische-derivate |
| AU8181098A (en) | 1997-07-03 | 1999-01-25 | Du Pont Pharmaceuticals Company | Aryl-and arylamino-substituted heterocycles as corticotropin releasing hormone antagonists |
| CN1268137A (zh) * | 1997-07-03 | 2000-09-27 | 杜邦药品公司 | 治疗神经失调的咪唑并嘧啶和咪唑并吡啶 |
| UA62972C2 (en) | 1997-07-03 | 2004-01-15 | Application of imidazopyrimidins and imidazopyridins for the treatment of neural disorders | |
| DE69807085D1 (de) | 1997-09-02 | 2002-09-12 | Bristol Myers Squibb Pharma Co | Heterocyclyl-substituierte annellierte pyridine und pyrimidine als antagonisten des corticotropin freisetzenden hormons (crh), verwendbar für die behandlung von cns und stress |
| WO1999038868A1 (en) * | 1998-01-28 | 1999-08-05 | Du Pont Pharmaceuticals Company | Azolo triazines and pyrimidines |
| US6194410B1 (en) | 1998-03-11 | 2001-02-27 | Hoffman-La Roche Inc. | Pyrazolopyrimidine and pyrazolines and process for preparation thereof |
| CA2326884A1 (en) | 1998-04-03 | 1999-10-14 | Dupont Pharmaceuticals Company | Thiazolo¬4,5-d|pyrimidines and pyridines as corticotropin releasing factor (crf) antagonists |
| US6124463A (en) | 1998-07-02 | 2000-09-26 | Dupont Pharmaceuticals | Benzimidazoles as corticotropin release factor antagonists |
| WO2002072202A1 (en) * | 2001-03-13 | 2002-09-19 | Bristol-Myers Squibb Pharma Company | 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands |
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2002
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