DE69807085D1 - Heterocyclyl-substituierte annellierte pyridine und pyrimidine als antagonisten des corticotropin freisetzenden hormons (crh), verwendbar für die behandlung von cns und stress - Google Patents
Heterocyclyl-substituierte annellierte pyridine und pyrimidine als antagonisten des corticotropin freisetzenden hormons (crh), verwendbar für die behandlung von cns und stressInfo
- Publication number
- DE69807085D1 DE69807085D1 DE69807085T DE69807085T DE69807085D1 DE 69807085 D1 DE69807085 D1 DE 69807085D1 DE 69807085 T DE69807085 T DE 69807085T DE 69807085 T DE69807085 T DE 69807085T DE 69807085 D1 DE69807085 D1 DE 69807085D1
- Authority
- DE
- Germany
- Prior art keywords
- antagonists
- stress
- treatment
- annelleled
- crh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5743297P | 1997-09-02 | 1997-09-02 | |
PCT/US1998/018080 WO1999011643A1 (en) | 1997-09-02 | 1998-09-01 | Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (crh) antagonists, useful for treating cns and stress-related disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69807085D1 true DE69807085D1 (de) | 2002-09-12 |
Family
ID=22010535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69807085T Expired - Lifetime DE69807085D1 (de) | 1997-09-02 | 1998-09-01 | Heterocyclyl-substituierte annellierte pyridine und pyrimidine als antagonisten des corticotropin freisetzenden hormons (crh), verwendbar für die behandlung von cns und stress |
Country Status (11)
Country | Link |
---|---|
US (2) | US6245769B1 (de) |
EP (1) | EP1012151B1 (de) |
JP (1) | JP2001514260A (de) |
CN (1) | CN1278819A (de) |
AT (1) | ATE221886T1 (de) |
AU (1) | AU9041198A (de) |
BR (1) | BR9814458A (de) |
CA (1) | CA2303280A1 (de) |
DE (1) | DE69807085D1 (de) |
IL (1) | IL134748A0 (de) |
WO (1) | WO1999011643A1 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6992188B1 (en) | 1995-12-08 | 2006-01-31 | Pfizer, Inc. | Substituted heterocyclic derivatives |
WO2001024807A2 (en) | 1999-10-01 | 2001-04-12 | Johnson & Johnson Consumer Companies, Inc. | Method for calming human beings using personal care compositions |
US6589952B2 (en) | 2000-07-14 | 2003-07-08 | Bristol-Myers Squibb Pharma Company | Imidazo[1,2-a]pyrazines for the treatment of neurological disorders |
US20020151527A1 (en) * | 2000-12-20 | 2002-10-17 | Benjamin Wiegand | Method for reducing acne or improving skin tone |
US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
JP4549630B2 (ja) | 2001-03-13 | 2010-09-22 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | コルチコトロピン放出因子受容体リガンドとしての、4−(2−ブチルアミノ)−2,7−ジメチル−8−(2−メチル−6−メトキシピリド−3−イル)ピラゾロ−[1,5−a]−1,3,5−トリアジン、その鏡像異性体および薬学的に許容できる塩類 |
US7205306B2 (en) | 2001-05-14 | 2007-04-17 | Bristol-Myers Squibb Pharma Company | Substituted pyrazinones, pyridines and pyrimidines as corticotropin releasing factor ligands |
WO2002100863A1 (en) | 2001-06-12 | 2002-12-19 | Glaxo Group Limited | Corticotropin releasing factor antagonists |
JP2005500041A (ja) | 2001-06-29 | 2005-01-06 | アブ サイエンス | 強力で選択的かつ非毒性のc−kit阻害剤 |
DE60216281T2 (de) | 2001-06-29 | 2007-07-05 | Ab Science | Die verwendung von tyrosinkinasehemmer zur behandlung von allergischen erkrankungen |
WO2003002105A2 (en) * | 2001-06-29 | 2003-01-09 | Ab Science | Use of tyrosine kinase inhibitors for treating bone loss |
ES2274075T3 (es) | 2001-06-29 | 2007-05-16 | Ab Science | Utilizacion de inhibidores de c-kit para tratar enfermedades inflamatorias intestinales (eii). |
DE60212627T2 (de) | 2001-06-29 | 2007-06-14 | Ab Science | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung von entzündlichen Krankheiten |
AU2002354575A1 (en) | 2001-07-12 | 2003-01-29 | Bristol-Myers Squibb Pharma Company | Tetrahydropurinones as corticotropin releasing factor |
JP4398724B2 (ja) * | 2001-07-13 | 2010-01-13 | ビーティージー・インターナショナル・リミテッド | ピリミジン誘導体を含有する医薬 |
WO2003006015A1 (en) | 2001-07-13 | 2003-01-23 | Bristol-Myers Squibb Pharma Company | Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands |
WO2003043637A1 (en) | 2001-11-20 | 2003-05-30 | Bristol-Myers Squibb Pharma Company | 3,7-dihydro-purine-2,6-dione derivatives as crf receptor ligands |
GB2411478A (en) * | 2002-01-29 | 2005-08-31 | Johnson & Johnson Consumer | Method of measuring the stress or relaxation level of a mammal |
GB0203045D0 (en) * | 2002-02-08 | 2002-03-27 | Johnson & Johnson Consumer | Method of afefecting sleep and sleep-related behaviours |
US20040175438A1 (en) * | 2003-03-03 | 2004-09-09 | Benjamin Wiegand | Methods for alleviating symptoms associated with menopause using sensory regimen |
AU2004274403A1 (en) * | 2003-09-03 | 2005-03-31 | Aventis Pharmaceuticals Inc. | 5-aryl-Pyrazolo(4,3-d)pyrimidines, pyridines, and pyrazines and related compounds |
US7572805B2 (en) | 2004-07-14 | 2009-08-11 | Bristol-Myers Squibb Company | Pyrrolo(oxo)isoquinolines as 5HT ligands |
JP2008520749A (ja) * | 2004-11-23 | 2008-06-19 | レディ ユーエス セラピューティックス, インコーポレイテッド | 新規二環式ヘテロ環化合物、その調製のためのプロセス、およびその新規二環式ヘテロ環化合物を含む組成物 |
US7238702B2 (en) * | 2005-02-10 | 2007-07-03 | Bristol-Myers Squibb Company | Dihydroquinazolinones as 5HT modulators |
ES2393768T3 (es) | 2005-05-26 | 2012-12-27 | Neuron Systems, Inc | Derivado de quinolina para el tratamiento de enfermedades retinianas |
JP2009502959A (ja) * | 2005-07-28 | 2009-01-29 | ブリストル−マイヤーズ スクイブ カンパニー | セロトニン受容体アゴニストおよびアンタゴニストとしての置換テトラヒドロ−1h−ピリド[4,3,b]インドール |
US7795436B2 (en) * | 2005-08-24 | 2010-09-14 | Bristol-Myers Squibb Company | Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists |
US7851468B2 (en) * | 2006-05-15 | 2010-12-14 | Cephalon, Inc. | Substituted pyrazolo[3,4-d]pyrimidines |
TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
TW200902499A (en) | 2007-05-15 | 2009-01-16 | Astrazeneca Ab | New compounds |
ES2494365T3 (es) * | 2008-01-30 | 2014-09-15 | Genentech, Inc. | Compuestos de pirazolopirimidina que inhiben PI3K y métodos de uso |
TW201020244A (en) | 2008-11-14 | 2010-06-01 | Astrazeneca Ab | New compounds |
CN102224152B (zh) | 2008-11-20 | 2014-05-21 | 健泰科生物技术公司 | 吡唑并吡啶pi3k抑制剂化合物及使用方法 |
CA2778949C (en) | 2009-10-30 | 2018-02-27 | Janssen Pharmaceutica Nv | Imidazo[1,2-b]pyridazine derivatives and their use as pde10 inhibitors |
US8329705B2 (en) | 2009-12-30 | 2012-12-11 | Arqule, Inc. | Substituted triazolo-pyrazine compounds |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
CN103619846B (zh) | 2011-06-27 | 2016-08-17 | 詹森药业有限公司 | 1-芳基-4-甲基-[1,2,4]三唑[4,3-a]喹喔啉衍生物 |
JP6426603B2 (ja) | 2012-06-26 | 2018-11-21 | ヤンセン ファーマシューティカ エヌ.ベー. | 神経障害または代謝障害の治療に使用するための、1−アリール−4−メチル−[1,2,4]トリアゾロ[4,3−a]−キノキサリン化合物などのPDE2阻害剤とPDE10阻害剤との組合せ |
EP2869822B1 (de) | 2012-07-09 | 2016-09-14 | Janssen Pharmaceutica, N.V. | Hemmer des phosphodiesterase-10-enzyms |
UA116395C2 (uk) | 2013-09-06 | 2018-03-12 | Ф. Хоффманн-Ля Рош Аг | ПОХІДНІ ТРИАЗОЛ[4,5-b]ПІРИМІДИНУ |
JP6830895B2 (ja) * | 2015-02-18 | 2021-02-17 | バック・インスティテュート・フォー・リサーチ・オン・エイジング | ストレス誘発性p−tauを低下させるトリアゾロピリジン及びトリアゾロピリミジン |
US10550085B2 (en) | 2015-08-21 | 2020-02-04 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
JP7311162B2 (ja) | 2017-10-10 | 2023-07-19 | アルデイラ セラピューティクス, インコーポレイテッド | 炎症性障害の処置 |
TWI701251B (zh) * | 2018-02-06 | 2020-08-11 | 大陸商江蘇恒瑞醫藥股份有限公司 | 吡唑并[1,5-a][1,3,5]三-2-胺類衍生物、其製備方法及其在醫藥上的應用 |
JP2021533154A (ja) | 2018-08-06 | 2021-12-02 | アルデイラ セラピューティクス, インコーポレイテッド | 多形化合物およびその使用 |
US11197821B2 (en) | 2018-09-25 | 2021-12-14 | Aldeyra Therapeutics, Inc. | Formulations for treatment of dry eye disease |
JP2022526917A (ja) | 2019-03-26 | 2022-05-27 | アルデイラ セラピューティクス, インコーポレイテッド | 眼科用製剤およびその使用 |
JP2022530967A (ja) | 2019-05-02 | 2022-07-05 | アルデイラ セラピューティクス, インコーポレイテッド | 多形化合物およびその使用 |
CN112500416B (zh) * | 2019-07-30 | 2021-12-17 | 厦门宝太生物科技股份有限公司 | 一种吡唑并三嗪类化合物中间体的制备方法 |
WO2021231792A1 (en) | 2020-05-13 | 2021-11-18 | Aldeyra Therapeutics, Inc. | Pharmaceutical formulations and uses thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2643903A1 (fr) * | 1989-03-03 | 1990-09-07 | Union Pharma Scient Appl | Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux |
ATE139232T1 (de) * | 1989-10-11 | 1996-06-15 | Teijin Ltd | Bizyklische pyrimidinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung |
IT227968Y1 (it) | 1992-11-17 | 1998-01-21 | Moris Baroni | Ago per endovene e prelievi di forma estensibile, autoinglobante per evitare punture e contagi a persone e ambienti dopo l'uso |
TW444018B (en) * | 1992-12-17 | 2001-07-01 | Pfizer | Pyrazolopyrimidines |
WO1995010506A1 (en) * | 1993-10-12 | 1995-04-20 | The Du Pont Merck Pharmaceutical Company | 1n-alkyl-n-arylpyrimidinamines and derivatives thereof |
US5968944A (en) * | 1994-06-06 | 1999-10-19 | Pfizer Inc. | Substituted pyrazoles as corticotropin-releasing factor (CRF) antagonists |
TW530047B (en) | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
MX9606504A (es) | 1994-06-16 | 1997-03-29 | Pfizer | Compuestos biciclicos. |
US5563143A (en) | 1994-09-21 | 1996-10-08 | Pfizer Inc. | Catechol diether compounds as inhibitors of TNF release |
EP0831829B1 (de) | 1995-06-07 | 2003-08-20 | Pfizer Inc. | Heterocyclische kondensierte pyrimidin-derivate |
DE69628804T2 (de) * | 1995-12-08 | 2003-12-18 | Pfizer Inc., New York | Substitutierte heterozyclische Derivate als CRF Antagonisten |
EP0888349B1 (de) | 1996-01-23 | 2002-05-22 | Novartis AG | Pyrrolopyrimidinen und verfahren zu deren herstellung |
TW440563B (en) * | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
-
1998
- 1998-09-01 AU AU90411/98A patent/AU9041198A/en not_active Abandoned
- 1998-09-01 BR BR9814458-8A patent/BR9814458A/pt not_active IP Right Cessation
- 1998-09-01 EP EP98942330A patent/EP1012151B1/de not_active Expired - Lifetime
- 1998-09-01 IL IL13474898A patent/IL134748A0/xx unknown
- 1998-09-01 AT AT98942330T patent/ATE221886T1/de not_active IP Right Cessation
- 1998-09-01 DE DE69807085T patent/DE69807085D1/de not_active Expired - Lifetime
- 1998-09-01 JP JP2000508682A patent/JP2001514260A/ja active Pending
- 1998-09-01 US US09/145,231 patent/US6245769B1/en not_active Expired - Lifetime
- 1998-09-01 CN CN98810908A patent/CN1278819A/zh active Pending
- 1998-09-01 WO PCT/US1998/018080 patent/WO1999011643A1/en active IP Right Grant
- 1998-09-01 CA CA002303280A patent/CA2303280A1/en not_active Abandoned
-
2001
- 2001-02-21 US US09/789,673 patent/US6525056B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1012151A1 (de) | 2000-06-28 |
JP2001514260A (ja) | 2001-09-11 |
EP1012151B1 (de) | 2002-08-07 |
US6245769B1 (en) | 2001-06-12 |
CN1278819A (zh) | 2001-01-03 |
AU9041198A (en) | 1999-03-22 |
BR9814458A (pt) | 2001-10-23 |
CA2303280A1 (en) | 1999-03-11 |
ATE221886T1 (de) | 2002-08-15 |
WO1999011643A1 (en) | 1999-03-11 |
US20010025042A1 (en) | 2001-09-27 |
US6525056B2 (en) | 2003-02-25 |
IL134748A0 (en) | 2001-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |