YU57500A - Hidroksamidi (4-arilsulfonilamino)-tetrahidropiran-4- karboksilne kiseline - Google Patents

Hidroksamidi (4-arilsulfonilamino)-tetrahidropiran-4- karboksilne kiseline

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Publication number
YU57500A
YU57500A YU57500A YU57500A YU57500A YU 57500 A YU57500 A YU 57500A YU 57500 A YU57500 A YU 57500A YU 57500 A YU57500 A YU 57500A YU 57500 A YU57500 A YU 57500A
Authority
YU
Yugoslavia
Prior art keywords
disease
aortic aneurysm
cancer
tumor
treatment
Prior art date
Application number
YU57500A
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English (en)
Inventor
Lawrence Alan Reiter
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of YU57500A publication Critical patent/YU57500A/sh

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
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    • A61P37/02—Immunomodulators
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical

Abstract

Jedinjenje formule (I), gde je Q kao sto je definisano, koje se koristi za tretman stanja koja se biraju iz grupe koju cine artritis (ukljucujuci osteoartritis i reumatoidni artritis), inflamatorna bolest utrobe, Crohn-ova bolest, emfizem, hronicna opstruktivna bolest pluca, toksicnost usled transplantacije organa, kaheksija, alergijske reakcije, alergijska hipersenzitivnost na dodir, rak, ulceracija tkiva, restenoza, periodontalne bolesti, epidermoliza, buloza, osteoporoza, odbacivanje implanta vestackog zgloba, ateroskleroza (ukljucujuci raskidanje ateroskleroticnog plaka), aneurizma aorte (ukljucujuci aneurizmu abdominalne aorte i aneurizmu mozdane aorte), kongestivna srcana mana, infarkt miokarda, mozdani udar, cerebralna ishemija, traume glave, povrede kicmene mozdine, neuro-degenerativni poremecaji (akutni i hronicni), auto-imuni poremecaji, Huntington-ova bolest, Parkinson-ova bolest, migrena, depresija, periferna neuropatija, bol, cerebralna amiloidna angiopatija, poboljsanje spoznaje, aminotrofna lateralna skleroza, multipla skleroza, okularna angiogeneza, povrede roznjace, makularna degeneracija, abnormalno zarastanje rana, opekotine, dijabetes, pocetak tumora, rast tumora, metastaza tumora, ubodi roznjace, skleritis, AIDS, sepsa i septicki sok. Pored toga, jedinjenja ovog pronalaska se mogu koristiti u kombinovanoj terapiji sa standardnim nesteroidnim anti-inflamatornim lekovima (NSAID) i analgeticima, i u kombinaciji sa citotoksicnim lekovima, kao sto su adriamycin, daunomycin, cis-platina, etoposide, taxol, taxotere i drugim alkaloidima, kao sto su vincristine, za lecenje raka.
YU57500A 1998-04-10 1999-03-24 Hidroksamidi (4-arilsulfonilamino)-tetrahidropiran-4- karboksilne kiseline YU57500A (sh)

Applications Claiming Priority (1)

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US8136498P 1998-04-10 1998-04-10

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YU57500A true YU57500A (sh) 2003-10-31

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YU57500A YU57500A (sh) 1998-04-10 1999-03-24 Hidroksamidi (4-arilsulfonilamino)-tetrahidropiran-4- karboksilne kiseline

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US (1) US6087392A (sh)
EP (1) EP1070058B1 (sh)
JP (1) JP3660873B2 (sh)
KR (1) KR100430183B1 (sh)
CN (1) CN1296481A (sh)
AP (1) AP968A (sh)
AR (1) AR019263A1 (sh)
AT (1) ATE239005T1 (sh)
AU (1) AU758701B2 (sh)
BG (1) BG104917A (sh)
BR (1) BR9909562A (sh)
CA (1) CA2327758C (sh)
CO (1) CO5050369A1 (sh)
CZ (1) CZ20003737A3 (sh)
DE (1) DE69907435T2 (sh)
DK (1) DK1070058T3 (sh)
DZ (1) DZ2753A1 (sh)
EA (1) EA004227B1 (sh)
ES (1) ES2192397T3 (sh)
GT (1) GT199900043A (sh)
HR (1) HRP20000648A2 (sh)
HU (1) HUP0101613A3 (sh)
ID (1) ID26222A (sh)
IL (1) IL138637A0 (sh)
IS (1) IS5619A (sh)
MA (1) MA24832A1 (sh)
MY (1) MY132929A (sh)
NO (1) NO20005076L (sh)
NZ (1) NZ506806A (sh)
OA (1) OA11498A (sh)
PA (1) PA8469501A1 (sh)
PE (1) PE20000414A1 (sh)
PL (1) PL343518A1 (sh)
PT (1) PT1070058E (sh)
SA (1) SA99200091A (sh)
SK (1) SK284154B6 (sh)
TN (1) TNSN99053A1 (sh)
TR (1) TR200002951T2 (sh)
UA (1) UA55526C2 (sh)
WO (1) WO1999052889A1 (sh)
YU (1) YU57500A (sh)
ZA (1) ZA992629B (sh)

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