WO2005120515A3 - Novel sulfonamides as inhibitors of histone deacetylase for the treatment of disease - Google Patents

Novel sulfonamides as inhibitors of histone deacetylase for the treatment of disease Download PDF

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Publication number
WO2005120515A3
WO2005120515A3 PCT/US2005/020770 US2005020770W WO2005120515A3 WO 2005120515 A3 WO2005120515 A3 WO 2005120515A3 US 2005020770 W US2005020770 W US 2005020770W WO 2005120515 A3 WO2005120515 A3 WO 2005120515A3
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WIPO (PCT)
Prior art keywords
disorders
disclosed
histone deacetylase
inhibitors
disease
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Application number
PCT/US2005/020770
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French (fr)
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WO2005120515A2 (en
Inventor
James Malecha
Stewart Noble
Christian Hassig
Paul Wash
Brandon Wiley
Charles Lawrence
Timothy Hoffman
Original Assignee
Kalypsys Inc
James Malecha
Stewart Noble
Christian Hassig
Paul Wash
Brandon Wiley
Charles Lawrence
Timothy Hoffman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from US10/865,743 external-priority patent/US7271195B2/en
Priority claimed from PCT/US2004/018502 external-priority patent/WO2004110418A2/en
Application filed by Kalypsys Inc, James Malecha, Stewart Noble, Christian Hassig, Paul Wash, Brandon Wiley, Charles Lawrence, Timothy Hoffman filed Critical Kalypsys Inc
Priority to JP2007527796A priority Critical patent/JP2008515777A/en
Priority to EP05788746A priority patent/EP1773398A2/en
Priority to AU2005251816A priority patent/AU2005251816A1/en
Priority to CA002567835A priority patent/CA2567835A1/en
Publication of WO2005120515A2 publication Critical patent/WO2005120515A2/en
Publication of WO2005120515A3 publication Critical patent/WO2005120515A3/en

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
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    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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  • Chemical & Material Sciences (AREA)
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  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Disclosed herein are carbonyl compounds of having the structural formula (I) or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
PCT/US2005/020770 2004-06-10 2005-06-09 Novel sulfonamides as inhibitors of histone deacetylase for the treatment of disease WO2005120515A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2007527796A JP2008515777A (en) 2004-06-10 2005-06-09 Novel sulfonamides as histone deacetylase inhibitors for disease treatment
EP05788746A EP1773398A2 (en) 2004-06-10 2005-06-09 Novel sulfonamides as inhibitors of histone deacetylase for the treatment of disease
AU2005251816A AU2005251816A1 (en) 2004-06-10 2005-06-09 Novel sulfonamides as inhibitors of histone deacetylase for the treatment of disease
CA002567835A CA2567835A1 (en) 2004-06-10 2005-06-09 Novel sulfonamides as inhibitors of histone deacetylase for the treatment of disease

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10/865,743 2004-06-10
US10/865,743 US7271195B2 (en) 2003-06-10 2004-06-10 Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease
USPCT/US2004/018502 2004-06-10
PCT/US2004/018502 WO2004110418A2 (en) 2003-06-10 2004-06-10 Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease
US63501904P 2004-12-09 2004-12-09
US60/635,019 2004-12-09

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WO2005120515A2 WO2005120515A2 (en) 2005-12-22
WO2005120515A3 true WO2005120515A3 (en) 2006-03-30

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PCT/US2005/020770 WO2005120515A2 (en) 2004-06-10 2005-06-09 Novel sulfonamides as inhibitors of histone deacetylase for the treatment of disease

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JP (1) JP2008515777A (en)
AU (1) AU2005251816A1 (en)
CA (1) CA2567835A1 (en)
WO (1) WO2005120515A2 (en)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
JP2006028104A (en) * 2004-07-16 2006-02-02 Kyowa Hakko Kogyo Co Ltd Histone deacetylase inhibitor
AR050552A1 (en) * 2004-09-02 2006-11-01 Osi Pharm Inc MERCAPTOAMIDS AS INHIBITORS OF HISTONA DEACETILASE
WO2007016354A1 (en) * 2005-07-29 2007-02-08 Kalypsys, Inc. Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease
US7981874B2 (en) 2006-07-20 2011-07-19 Merck Sharp & Dohme Corp. Phosphorus derivatives as histone deacetylase inhibitors
US7786139B2 (en) 2006-11-21 2010-08-31 Omeros Corporation PDE10 inhibitors and related compositions and methods
WO2013169858A1 (en) 2012-05-08 2013-11-14 The Broad Institute, Inc. Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy

Citations (1)

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US4129656A (en) * 1976-01-20 1978-12-12 Hoechst Aktiengesellschaft Thiazolidine derivatives, salidiuretic compositions and methods of effecting salidiuresis employing them

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DE2436263C2 (en) * 1974-07-27 1983-02-17 Hoechst Ag, 6000 Frankfurt Thiazolidine derivatives and processes for their preparation
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