YU48819B - Postupak za pripremanje derivata 8-hlorohinolona - Google Patents

Postupak za pripremanje derivata 8-hlorohinolona

Info

Publication number
YU48819B
YU48819B YU165791A YU165791A YU48819B YU 48819 B YU48819 B YU 48819B YU 165791 A YU165791 A YU 165791A YU 165791 A YU165791 A YU 165791A YU 48819 B YU48819 B YU 48819B
Authority
YU
Yugoslavia
Prior art keywords
group
carbon atoms
atom
alkyl
atoms
Prior art date
Application number
YU165791A
Other languages
English (en)
Other versions
YU165791A (sh
Inventor
Yusuke Yukimoto
Tohru Kaneuchi
Yoichi Kimura
Katsuhiro Kawakami
Isao Hayakawa
Original Assignee
Daiichi Pharmaceutical Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co. Ltd. filed Critical Daiichi Pharmaceutical Co. Ltd.
Priority to HR930084A priority Critical patent/HRP930084B1/xx
Publication of YU165791A publication Critical patent/YU165791A/sh
Publication of YU48819B publication Critical patent/YU48819B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Postupak za pripremanje derivata 8-hlorohinolona, prikazanog formulom (III): u kojoj X predstavlja atom halogena, R3 predstavlja 4- do 8-clanu, zasicenu heterociklicnu grupu, koja kao clanove prstena sadrzi jedan do dva atoma azota, pri cemu heterociklicna grupa moze jos da sadrzi, kao clan prstena, atom kiseonika ili sumpora, a moze da ima jedan ili vise supstituenata koji su izabrani iz grupe koja se sastoji od amino-grupe, mono- ili dialkilamino-grupe, sa 1 do 6 atoma ugljenika u svom alkil-delu, alkil-grupe, sa 1 do 6 atoma ugljenika, alkilen-grupe, sa 2 do 6 atoma ugljenika, koji mogu da budu vezani za atom ugljenika koji se nalazi u heterociklicnoj grupi, kako bi obrazovali spiro-prsten, atoma halogena i alkoksi-grupe sa 1 do 6 atoma ugljenika, prema kome hinolon-jedinjenje, formule (I) u kojoj X predstavlja atom halogena, R1 predstavlja atom vodonika, alkil-grupu, sa 1 do 6 atoma ugljenika ili fenilalkil-grupu koja eventualno u svom fenil-delu sadrzi nitro-grupu, atom hlora ili alkoksil-grupu, a R2 predstavlja 4- do 8-clanu, zasicenu heterociklicnu grupu, koja kao clanove prstena sadrzi jedan ili dva atoma azota, pri cemu ova heterociklicna grupa moze jos da sadrzi, kao clan prstena, atom kiseonika ili sumpora, a moze da ima jedan ili vise supstituenata koji su izabrani iz grupe koja se sastoji od amino-grupe, mono- ili dialkilamino-grupe, sa 1 do 6 atoma ugljenika u svom alkil-delu, dalje, kao zastitne grupe, alkilkarbonilamino-grupe, sa 2 do 7 atoma ugljenika, alkiloksikarbonil-amino-grupe, sa 2 do 7 atoma ugljenika, halogenalkilkarbonil-grupe, sa 2 do 7 atoma ugljenika, alkiloksikarbonil-amino-grupe, sa 2 do 7 atoma ugljenika, fenilalkiloksikarbonilamino-grupe, koja u svome fenil-delu moze da sadrzi nitro-grupu ili atom hlora, alkil-grupe, sa 1 do 6 atoma ugljenika, alkilen-grupe, sa 2 do 6 atoma ugljenika, koji vezani za atom ugljenika koji se nalazi u heterociklicnoj grupi, obrazuju spiro-prsten, atoma halogena i alkoksi-grupe sa 1 do 6 atoma ugljenika, reaguje sa sredstvom za hlorovanje, a u slucaju kada je potrebno vrsi se hidroliza estarske grupe, a u datom slucaju uklanjajne zastitne grupe. - Prijava sadrzi jos 14 zavisnih zahteva.
YU165791A 1990-10-18 1991-10-14 Postupak za pripremanje derivata 8-hlorohinolona YU48819B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HR930084A HRP930084B1 (en) 1990-10-18 1993-02-01 Production of 8-chloroquinoline derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27977890 1990-10-18
JP22815391 1991-05-30

Publications (2)

Publication Number Publication Date
YU165791A YU165791A (sh) 1994-05-10
YU48819B true YU48819B (sh) 2001-12-26

Family

ID=26528079

Family Applications (1)

Application Number Title Priority Date Filing Date
YU165791A YU48819B (sh) 1990-10-18 1991-10-14 Postupak za pripremanje derivata 8-hlorohinolona

Country Status (16)

Country Link
KR (1) KR100253047B1 (sh)
CN (1) CN1038509C (sh)
AR (1) AR247884A1 (sh)
AT (1) AT402501B (sh)
EE (1) EE03027B1 (sh)
ES (1) ES2039300B1 (sh)
FI (1) FI100531B (sh)
GR (1) GR1000997B (sh)
HU (1) HU221195B1 (sh)
MX (1) MX9101668A (sh)
MY (1) MY109714A (sh)
NO (1) NO179517C (sh)
PL (1) PL168831B1 (sh)
PT (1) PT99268B (sh)
RU (1) RU2049778C1 (sh)
YU (1) YU48819B (sh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696132A (en) * 1991-05-28 1997-12-09 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
CN1184221C (zh) * 2001-08-08 2005-01-12 中国医学科学院医药生物技术研究所 有7－(7－氨甲基－5－氮杂螺[2,4]庚烷)取代基的新喹啉羧酸衍生物及其制备方法
CN103483315B (zh) * 2013-09-18 2015-07-01 浙江司太立制药股份有限公司 7-(3-氨甲基-4-烷氧亚胺基-1-吡咯烷基)-1-[(1r,2s)-2-氟环丙基]喹诺酮羧酸类化合物及其制备方法
CN103709100A (zh) * 2013-12-31 2014-04-09 南京工业大学 一种8-氯代喹诺酮衍生物的制备方法
CN104892600B (zh) * 2015-06-04 2017-02-01 浙江司太立制药股份有限公司 7‑（3‑氨甲基‑4‑取代苄氧亚胺基‑1‑吡咯烷基）萘啶酮羧酸类化合物
CN107513053A (zh) * 2015-08-10 2017-12-26 江苏吴中医药集团有限公司 一种西他沙星水合物的制备方法
CN105669646B (zh) * 2016-02-26 2018-03-09 济川药业集团有限公司 一种西他沙星的合成方法
CN113527200B (zh) * 2021-05-27 2022-12-02 北京斯利安药业有限公司 一种氯喹那多的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2840437A1 (de) * 1978-09-16 1980-04-03 Hoechst Ag 8-chlor-5,6,7,8-tetrahydro-2-chinolon und 8-brom-5,6,7,8-tetrahydro-2-chinolon, deren hydrochlorid bzw. hydrobromid und verfahren zu deren herstellung
EP0191185B1 (en) * 1984-12-14 1990-03-07 Daiichi Seiyaku Co., Ltd. Quinoline-carboxylic acid derivatives
JPH0635457B2 (ja) * 1985-06-28 1994-05-11 杏林製薬株式会社 ピリドンカルボン酸誘導体およびその製造方法
DE3635218A1 (de) * 1986-10-16 1988-04-21 Bayer Ag 7-amino-1-cyclopropyl-8-chlor-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS6490183A (en) * 1987-09-30 1989-04-06 Kyorin Seiyaku Kk Production of quinolonecarboxylic acid derivative
JPH0196786A (ja) * 1987-10-09 1989-04-14 Toshiba Corp 改札装置のデータ集計処理方式
IL90062A (en) * 1988-04-27 1994-10-07 Daiichi Seiyaku Co History of pyridonecarboxylic acid, their preparation and pharmaceutical preparations containing them
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives

Also Published As

Publication number Publication date
PT99268A (pt) 1992-08-31
NO179517B (no) 1996-07-15
NO914053L (no) 1992-04-21
FI100531B (fi) 1997-12-31
RU2049778C1 (ru) 1995-12-10
FI914875A (fi) 1992-04-19
CN1062906A (zh) 1992-07-22
PL168831B1 (pl) 1996-04-30
PT99268B (pt) 1999-04-30
ES2039300A1 (es) 1993-09-16
NO179517C (no) 1996-10-23
MX9101668A (es) 1992-06-05
HU913280D0 (en) 1992-01-28
CN1038509C (zh) 1998-05-27
MY109714A (en) 1997-04-30
GR910100427A (en) 1992-09-25
EE03027B1 (et) 1997-08-15
ES2039300B1 (es) 1994-05-16
KR920008007A (ko) 1992-05-27
KR100253047B1 (ko) 2000-05-01
AT402501B (de) 1997-06-25
HUT59388A (en) 1992-05-28
FI914875A0 (fi) 1991-10-16
AR247884A1 (es) 1995-04-28
NO914053D0 (no) 1991-10-16
ATA206691A (de) 1996-10-15
YU165791A (sh) 1994-05-10
PL292087A1 (en) 1992-11-16
HU221195B1 (en) 2002-08-28
GR1000997B (el) 1993-03-31

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