ES2039300A1 - Procedimiento para preparar derivados de 8-cloroquinolona. - Google Patents
Procedimiento para preparar derivados de 8-cloroquinolona.Info
- Publication number
- ES2039300A1 ES2039300A1 ES919102304A ES9102304A ES2039300A1 ES 2039300 A1 ES2039300 A1 ES 2039300A1 ES 919102304 A ES919102304 A ES 919102304A ES 9102304 A ES9102304 A ES 9102304A ES 2039300 A1 ES2039300 A1 ES 2039300A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- translation
- preparing
- procedure
- machine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 8-CLOROQUINOLONA. COMPRENDE HACER REACCIONAR UNA QUINOLONA DE FORMULA (I) CON UN AGENTE CLORANTE SELECCIONADO ENTRE CLORURO DE SULFURILO, HIPOCLORITO DE SODIO, N-CLOROSUCCIONIMIDA, CLORO Y UN ESTER DEL ACIDO HIPOCLOROSO DE FORMULA RBS4 SCOCL, EN UN DISOLVENTE ORGANICO Y A UNA TEMPERATURA COMPRENDIDA ENTRE 0GC Y LA TEMPERATURA DE REFLUJO DEL DISOLVENTE DURANTE 5 MINUTOS A 10 HORAS, PARA PRODUCIR LOS COMPUESTOS DE FORMULA (II). ADEMAS, DICHO COMPUESTO DE FORMULA (II) PUEDE SOMETERSE A ELIMINACION DEL GRUPO PROTECTOR Y/O A UNA HIDROLISIS DEL GRUPO ESTER PARA DAR LOS COMPUESTOS DE FORMULA (II). EN DICHAS FORMULAS, X REPRESENTA UN ATOMO DE HALOGENO Y RBS1 SC, RBS2 SC, RBS3 SC Y RBS4 SC REPRESENTAN DIFERENTES RADICALES ORGANICOS. ESTOS PRODUCTOS TIENEN APLICACION COMO POTENCIALES AGENTES ANTIMICROBIANOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP27977890 | 1990-10-18 | ||
JP22815391 | 1991-05-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2039300A1 true ES2039300A1 (es) | 1993-09-16 |
ES2039300B1 ES2039300B1 (es) | 1994-05-16 |
Family
ID=26528079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09102304A Expired - Fee Related ES2039300B1 (es) | 1990-10-18 | 1991-10-17 | Procedimiento para preparar derivados de 8-cloroquinolona. |
Country Status (16)
Country | Link |
---|---|
KR (1) | KR100253047B1 (es) |
CN (1) | CN1038509C (es) |
AR (1) | AR247884A1 (es) |
AT (1) | AT402501B (es) |
EE (1) | EE03027B1 (es) |
ES (1) | ES2039300B1 (es) |
FI (1) | FI100531B (es) |
GR (1) | GR1000997B (es) |
HU (1) | HU221195B1 (es) |
MX (1) | MX9101668A (es) |
MY (1) | MY109714A (es) |
NO (1) | NO179517C (es) |
PL (1) | PL168831B1 (es) |
PT (1) | PT99268B (es) |
RU (1) | RU2049778C1 (es) |
YU (1) | YU48819B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100232937B1 (ko) * | 1991-05-28 | 1999-12-01 | 스즈키 다다시 | 피리돈카복실산 유도체 및 이를 함유하는 항균제 |
ZA946853B (en) * | 1993-09-10 | 1995-04-24 | Daiichi Seiyaku Co | Crystals of antimicrobial compound. |
CN1184221C (zh) * | 2001-08-08 | 2005-01-12 | 中国医学科学院医药生物技术研究所 | 有7-(7-氨甲基-5-氮杂螺[2,4]庚烷)取代基的新喹啉羧酸衍生物及其制备方法 |
CN103483315B (zh) * | 2013-09-18 | 2015-07-01 | 浙江司太立制药股份有限公司 | 7-(3-氨甲基-4-烷氧亚胺基-1-吡咯烷基)-1-[(1r,2s)-2-氟环丙基]喹诺酮羧酸类化合物及其制备方法 |
CN103709100A (zh) * | 2013-12-31 | 2014-04-09 | 南京工业大学 | 一种8-氯代喹诺酮衍生物的制备方法 |
CN104892600B (zh) * | 2015-06-04 | 2017-02-01 | 浙江司太立制药股份有限公司 | 7‑(3‑氨甲基‑4‑取代苄氧亚胺基‑1‑吡咯烷基)萘啶酮羧酸类化合物 |
CN107513053A (zh) * | 2015-08-10 | 2017-12-26 | 江苏吴中医药集团有限公司 | 一种西他沙星水合物的制备方法 |
CN105669646B (zh) * | 2016-02-26 | 2018-03-09 | 济川药业集团有限公司 | 一种西他沙星的合成方法 |
CN113527200B (zh) * | 2021-05-27 | 2022-12-02 | 北京斯利安药业有限公司 | 一种氯喹那多的制备方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2000185A6 (es) * | 1985-06-28 | 1988-01-01 | Kyorin Seiyaku Kk | Procedimiento para preparar derivados de acidos piridoncaboxilicos |
EP0264050A2 (de) * | 1986-10-16 | 1988-04-20 | Bayer Ag | 7-Amino-1-cyclopropyl-8-chlor-6-fluor-1, 4-dihydro-4-oxo-3-chinolincarbonsäuren, Verfahren zu ihrer Herstellung sowie diese enthaltende antibakterielle Mittel |
JPS6490183A (en) * | 1987-09-30 | 1989-04-06 | Kyorin Seiyaku Kk | Production of quinolonecarboxylic acid derivative |
JPH0196786A (ja) * | 1987-10-09 | 1989-04-14 | Toshiba Corp | 改札装置のデータ集計処理方式 |
EP0341493A2 (en) * | 1988-04-27 | 1989-11-15 | Daiichi Pharmaceutical Co., Ltd. | Optically active pyridonecarboxylic acid derivatives |
EP0357047A1 (en) * | 1988-08-31 | 1990-03-07 | Daiichi Pharmaceutical Co., Ltd. | Spiro compounds |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2840437A1 (de) * | 1978-09-16 | 1980-04-03 | Hoechst Ag | 8-chlor-5,6,7,8-tetrahydro-2-chinolon und 8-brom-5,6,7,8-tetrahydro-2-chinolon, deren hydrochlorid bzw. hydrobromid und verfahren zu deren herstellung |
DE3576335D1 (de) * | 1984-12-14 | 1990-04-12 | Daiichi Seiyaku Co | Chinolincarbonsaeure-derivate. |
-
1991
- 1991-10-12 MY MYPI91001865A patent/MY109714A/en unknown
- 1991-10-14 YU YU165791A patent/YU48819B/sh unknown
- 1991-10-16 FI FI914875A patent/FI100531B/fi active
- 1991-10-16 NO NO914053A patent/NO179517C/no unknown
- 1991-10-17 GR GR910100427A patent/GR1000997B/el not_active IP Right Cessation
- 1991-10-17 AT AT0206691A patent/AT402501B/de not_active IP Right Cessation
- 1991-10-17 PT PT99268A patent/PT99268B/pt not_active IP Right Cessation
- 1991-10-17 RU SU915010041A patent/RU2049778C1/ru not_active IP Right Cessation
- 1991-10-17 PL PL91292087A patent/PL168831B1/pl not_active IP Right Cessation
- 1991-10-17 HU HU280/91A patent/HU221195B1/hu not_active IP Right Cessation
- 1991-10-17 ES ES09102304A patent/ES2039300B1/es not_active Expired - Fee Related
- 1991-10-17 AR AR91320942A patent/AR247884A1/es active
- 1991-10-18 MX MX9101668A patent/MX9101668A/es unknown
- 1991-10-18 CN CN91110833A patent/CN1038509C/zh not_active Expired - Lifetime
- 1991-10-18 KR KR1019910018376A patent/KR100253047B1/ko not_active IP Right Cessation
-
1994
- 1994-11-22 EE EE9400253A patent/EE03027B1/xx not_active IP Right Cessation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2000185A6 (es) * | 1985-06-28 | 1988-01-01 | Kyorin Seiyaku Kk | Procedimiento para preparar derivados de acidos piridoncaboxilicos |
EP0264050A2 (de) * | 1986-10-16 | 1988-04-20 | Bayer Ag | 7-Amino-1-cyclopropyl-8-chlor-6-fluor-1, 4-dihydro-4-oxo-3-chinolincarbonsäuren, Verfahren zu ihrer Herstellung sowie diese enthaltende antibakterielle Mittel |
JPS6490183A (en) * | 1987-09-30 | 1989-04-06 | Kyorin Seiyaku Kk | Production of quinolonecarboxylic acid derivative |
JPH0196786A (ja) * | 1987-10-09 | 1989-04-14 | Toshiba Corp | 改札装置のデータ集計処理方式 |
EP0341493A2 (en) * | 1988-04-27 | 1989-11-15 | Daiichi Pharmaceutical Co., Ltd. | Optically active pyridonecarboxylic acid derivatives |
EP0357047A1 (en) * | 1988-08-31 | 1990-03-07 | Daiichi Pharmaceutical Co., Ltd. | Spiro compounds |
Non-Patent Citations (2)
Title |
---|
PATENT ABSTRACTS OF JAPAN, Vol. 13, n 302 (C-616) & JP-A-1090183 (KYORIN PHARMACEUT.), 6-4-1989. * Resumen * * |
PATENT ABSTRACTS OF JAPAN, Vol. 14, n 475 (C-770) & JP-A-1096786 (HOKURIKU SEIYAKU), 3-8-1990. * Resumen * * |
Also Published As
Publication number | Publication date |
---|---|
EE03027B1 (et) | 1997-08-15 |
GR910100427A (en) | 1992-09-25 |
HU221195B1 (en) | 2002-08-28 |
AR247884A1 (es) | 1995-04-28 |
AT402501B (de) | 1997-06-25 |
ATA206691A (de) | 1996-10-15 |
NO179517B (no) | 1996-07-15 |
CN1038509C (zh) | 1998-05-27 |
NO914053L (no) | 1992-04-21 |
PL292087A1 (en) | 1992-11-16 |
ES2039300B1 (es) | 1994-05-16 |
NO179517C (no) | 1996-10-23 |
KR100253047B1 (ko) | 2000-05-01 |
HU913280D0 (en) | 1992-01-28 |
PL168831B1 (pl) | 1996-04-30 |
HUT59388A (en) | 1992-05-28 |
GR1000997B (el) | 1993-03-31 |
KR920008007A (ko) | 1992-05-27 |
RU2049778C1 (ru) | 1995-12-10 |
MY109714A (en) | 1997-04-30 |
CN1062906A (zh) | 1992-07-22 |
PT99268A (pt) | 1992-08-31 |
MX9101668A (es) | 1992-06-05 |
FI100531B (fi) | 1997-12-31 |
FI914875A (fi) | 1992-04-19 |
PT99268B (pt) | 1999-04-30 |
YU48819B (sh) | 2001-12-26 |
NO914053D0 (no) | 1991-10-16 |
FI914875A0 (fi) | 1991-10-16 |
YU165791A (sh) | 1994-05-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20100616 |