YU47125B - Postupak za dobijanje novih hidrozida 4-hloro-3-sulfamoilbenzoeve kiseline - Google Patents
Postupak za dobijanje novih hidrozida 4-hloro-3-sulfamoilbenzoeve kiselineInfo
- Publication number
- YU47125B YU47125B YU240188A YU240188A YU47125B YU 47125 B YU47125 B YU 47125B YU 240188 A YU240188 A YU 240188A YU 240188 A YU240188 A YU 240188A YU 47125 B YU47125 B YU 47125B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- group
- carbon atoms
- represents hydrogen
- hydrosides
- chloro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/22—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
POSTUPAK ZA DOBIJANJE NOVIH HIDROZIDA 4-HLORO-3-SULFAMOILBENZOEVE KISELINE, opste formule gde R je atom vodonika ili trifluorometil, karboksi, C2-5alkoksikarbonil, ciano, benzoil, sulfamoil ili C1-4alkilsulfonil grupe; R1 je atom vodonika ili normalnog ili racvastog lanca C1-4alkil, C1-4alkiltio, C1-4alkilsulfonil, bneziltio, benzilsulfonil, fenil, hidroksi ili merkapto grupa; i R2 je atom vodonika ili hlora, kao i njihovih farmaceutski prih-vatljivih soli, naznacen time, sto obuhvata: a) reagovanje 1-aminobenzimidazol derivata opste formule gde R i R1 su isti kao sto je definisano napred, sa derivatom karboksilne kiseline opste formule gde X je atom hlora ili hidroksi, -OCH2CN, metoksi, etoksi, -OCOOCH3 ili -OCOOC2H5 grupa; R2 je isti kao sto je definisano napred i R3 i R4 su atom vodonika ili R3 i R4 zajedno grade -CHN(CH3)2 grupu, i po izboru uklanjanje zastiten grupe u alkalnoj sredini; ili b) reagovanje 2-aminofenilhidrazin derivata opste formule gde R, R2, R3 i R4 su isti kao sto je definisano napred, sa ugljen disulfidom, kalijum etil ksantatom ili tiofosgenom i dodatno kada se dobija jedinjenje opste formule gde R, R1 i R2 su isti kao sto je definisano napred, uklanjanje zastitne grupe u alkalnoj sredini radi dobijanja jedinjenja opste formule gde R i R2 su isti kao sto jedefinisano napred, ili c) reagovanje 2-aminofenilhidrazin derivata opste formule gde R, R2, R3 i R4 su isti kao sto je definisano napred, i R5 je atom vodonika ili acetil, propionil, butiril, izobutiril, pentanoil, 2-metil-butiril, trimetilacetil ili benzoil grupe, sa mravljom ili sircetnom kiselinom i kada se dobija jedinjenje opste formule gde R i R2 su isti kao sto je definisano napred i R1 je kao sto je definisano napred za R5, uklanjanje zastitne grupe u alkalnoj sredini radi dobijanja jedinjenja opste formule (I), gde R, R1 i R2 su isti kao sto je definisano napred ili d) reagovanje 2-aminofenilhidrazin derivata opste formule (IVb) gde R, R2, R3 i R4 su isti kao sto je definisano napred, sa N,N1-dikar-boalkoksi-S-metilizotiureom derivatom opste formule gde R7 je C1-4alkil grupa, i dodatno, kada se dobija jedinjenje opste formule gde R i R2 su isti kao sto je definisano napred uklanjanje zastitne grupe u alkalnoj sredini radi dobijanja jedinjenja opste formule gde R i R2 su isti kao sto je definisano napred, ili e) reagovanje jedinjenja opste formule (Ib) ili (Ie) gde R, R2, R3 i R4 su isti kao sto je definisano napred, sa sredstvom za alkilovanje i dodatno kada se dobija jedinjenje opste formule gde R i R2 su isti kao sto je definisano napred, i R6 je normalnog ili racvastog lanca C1-4alkil ili benzil grupe, uklanjanje zastitne grupe u alkalnoj sredini, radi dobijanja jedinjenja opste formule (Ic) gde R, R2 i R6 su isti kao sto je definisano napred, ili f) reagovanje 2-benzimidazolil tioetra derivata opste formule (Ic) ili (Ih), gde R, R2, R3, R4 i R6 su isti kao sto je definisano napred, sa oksidacionim sredstvom i, ako se zeli, hidrolizu tako dobijenog jedinjenja
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU876131A HU207051B (en) | 1987-12-30 | 1987-12-30 | Process for producing 4-chloro-3-sulfamoylbenzoic acid hydrazides and pharmaceutical compositions comprising such compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU240188A YU240188A (en) | 1990-10-31 |
| YU47125B true YU47125B (sh) | 1994-12-28 |
Family
ID=10971250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU240188A YU47125B (sh) | 1987-12-30 | 1988-12-30 | Postupak za dobijanje novih hidrozida 4-hloro-3-sulfamoilbenzoeve kiseline |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4916149A (sh) |
| EP (1) | EP0324988B1 (sh) |
| JP (1) | JPH01213269A (sh) |
| CN (1) | CN1037336A (sh) |
| AT (1) | ATE75467T1 (sh) |
| AU (1) | AU609682B2 (sh) |
| CA (1) | CA1332739C (sh) |
| CS (1) | CS277585B6 (sh) |
| DD (1) | DD283383A5 (sh) |
| DE (1) | DE3870601D1 (sh) |
| DK (1) | DK727488A (sh) |
| ES (1) | ES2034149T3 (sh) |
| FI (1) | FI886045A (sh) |
| GR (1) | GR3004471T3 (sh) |
| HU (1) | HU207051B (sh) |
| IE (1) | IE63246B1 (sh) |
| IL (1) | IL88735A (sh) |
| NO (1) | NO172285C (sh) |
| NZ (1) | NZ227481A (sh) |
| PH (1) | PH25739A (sh) |
| PL (2) | PL158049B1 (sh) |
| PT (1) | PT89368B (sh) |
| RU (2) | RU1838303C (sh) |
| SU (1) | SU1736339A3 (sh) |
| UA (1) | UA19123A (sh) |
| YU (1) | YU47125B (sh) |
| ZA (1) | ZA889729B (sh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69220050T2 (de) * | 1991-04-01 | 1998-01-22 | Univ Duke | Verfahren zur inhibierung der fibrose |
| FR2708608B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés de N-sulfonylbenzimidazolone, leur préparation, les compositions pharmaceutiques en contenant. |
| DE10132896A1 (de) * | 2001-07-06 | 2003-01-16 | Bayer Cropscience Ag | Heterocyclische Amidderivate |
| DE102005002130A1 (de) * | 2005-01-17 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Substituierte N-Aminomethylensulfonamide, ihre Herstellung und Verwendung als Arzneimittel |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1122541B (de) * | 1959-12-28 | 1962-01-25 | Hoechst Ag | Verfahren zur Herstellung von Sulfamyl-anthranilsaeuren |
| DE1158927B (de) * | 1961-09-15 | 1963-12-12 | Werner Rahms | Grubenstempel |
| DE2144908C2 (de) * | 1971-09-08 | 1982-12-09 | Hoechst Ag, 6000 Frankfurt | 5-(3- oder 4-Aminobenzolsulfonylamino)-benzimidazolone-(2) und Verfahren zu ihrer Herstellung |
| BE793718A (fr) * | 1972-01-07 | 1973-07-05 | Merck & Co Inc | Aminobenzimidazoles |
| DE2247828A1 (de) * | 1972-09-29 | 1974-04-04 | Hoechst Ag | Sulfamoyl-anthranilsaeuren und verfahren zu ihrer herstellung |
| US4420487A (en) * | 1978-04-10 | 1983-12-13 | The Purdue Frederick Company | Diuretic and antihypertensive benzimidazoles |
-
1987
- 1987-12-30 HU HU876131A patent/HU207051B/hu not_active IP Right Cessation
-
1988
- 1988-12-20 IL IL88735A patent/IL88735A/xx not_active IP Right Cessation
- 1988-12-22 NZ NZ227481A patent/NZ227481A/en unknown
- 1988-12-23 DD DD88323775A patent/DD283383A5/de not_active IP Right Cessation
- 1988-12-28 PH PH37991A patent/PH25739A/en unknown
- 1988-12-29 CA CA000587184A patent/CA1332739C/en not_active Expired - Fee Related
- 1988-12-29 DK DK727488A patent/DK727488A/da not_active Application Discontinuation
- 1988-12-29 ZA ZA889729A patent/ZA889729B/xx unknown
- 1988-12-29 US US07/295,925 patent/US4916149A/en not_active Expired - Fee Related
- 1988-12-29 JP JP63335692A patent/JPH01213269A/ja active Pending
- 1988-12-30 PT PT89368A patent/PT89368B/pt not_active IP Right Cessation
- 1988-12-30 CN CN88108996A patent/CN1037336A/zh active Pending
- 1988-12-30 AT AT88121901T patent/ATE75467T1/de not_active IP Right Cessation
- 1988-12-30 IE IE389288A patent/IE63246B1/en not_active IP Right Cessation
- 1988-12-30 ES ES198888121901T patent/ES2034149T3/es not_active Expired - Lifetime
- 1988-12-30 YU YU240188A patent/YU47125B/sh unknown
- 1988-12-30 NO NO885830A patent/NO172285C/no unknown
- 1988-12-30 PL PL1988282492A patent/PL158049B1/pl unknown
- 1988-12-30 SU SU884613207A patent/SU1736339A3/ru active
- 1988-12-30 DE DE8888121901T patent/DE3870601D1/de not_active Expired - Fee Related
- 1988-12-30 CS CS889108A patent/CS277585B6/cs unknown
- 1988-12-30 FI FI886045A patent/FI886045A/fi not_active Application Discontinuation
- 1988-12-30 AU AU27631/88A patent/AU609682B2/en not_active Ceased
- 1988-12-30 EP EP88121901A patent/EP0324988B1/de not_active Expired - Lifetime
- 1988-12-30 UA UA4613207A patent/UA19123A/uk unknown
- 1988-12-30 PL PL1988276889A patent/PL157971B1/pl unknown
-
1989
- 1989-05-10 RU SU894613991A patent/RU1838303C/ru active
- 1989-10-20 RU SU894742151A patent/RU1830064C/ru active
-
1992
- 1992-04-30 GR GR920400738T patent/GR3004471T3/el unknown
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