YU43085B - Process for obtaining new phospholipide or sphingolipide amides - Google Patents

Process for obtaining new phospholipide or sphingolipide amides

Info

Publication number
YU43085B
YU43085B YU1689/82A YU168982A YU43085B YU 43085 B YU43085 B YU 43085B YU 1689/82 A YU1689/82 A YU 1689/82A YU 168982 A YU168982 A YU 168982A YU 43085 B YU43085 B YU 43085B
Authority
YU
Yugoslavia
Prior art keywords
sphingolipide
phospholipide
amides
obtaining new
residue
Prior art date
Application number
YU1689/82A
Other languages
English (en)
Other versions
YU168982A (en
Inventor
Valle F Della
R Aurelio
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Spa filed Critical Fidia Spa
Publication of YU168982A publication Critical patent/YU168982A/xx
Publication of YU43085B publication Critical patent/YU43085B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
YU1689/82A 1981-08-03 1982-08-03 Process for obtaining new phospholipide or sphingolipide amides YU43085B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT49031/81A IT1171432B (it) 1981-08-03 1981-08-03 Amidi organiche derivate da lipidi azotati utilizzabili come farmaci

Publications (2)

Publication Number Publication Date
YU168982A YU168982A (en) 1986-02-28
YU43085B true YU43085B (en) 1989-02-28

Family

ID=11269438

Family Applications (3)

Application Number Title Priority Date Filing Date
YU1689/82A YU43085B (en) 1981-08-03 1982-08-03 Process for obtaining new phospholipide or sphingolipide amides
YU735/85A YU42914B (en) 1981-08-03 1985-04-30 Process for obtaining new sphingolipide amides
YU734/85A YU42913B (en) 1981-08-03 1985-04-30 Process for obtaining new sphingolipide amides

Family Applications After (2)

Application Number Title Priority Date Filing Date
YU735/85A YU42914B (en) 1981-08-03 1985-04-30 Process for obtaining new sphingolipide amides
YU734/85A YU42913B (en) 1981-08-03 1985-04-30 Process for obtaining new sphingolipide amides

Country Status (21)

Country Link
US (3) US4757053A (ja)
EP (1) EP0072286B2 (ja)
JP (2) JPS5843942A (ja)
KR (1) KR880000042B1 (ja)
AT (1) ATE23165T1 (ja)
AU (1) AU561811B2 (ja)
DE (1) DE3273983D1 (ja)
DK (1) DK159204C (ja)
ES (3) ES8602616A1 (ja)
FI (1) FI75829C (ja)
GR (1) GR76234B (ja)
HU (1) HU192771B (ja)
IE (1) IE53644B1 (ja)
IL (1) IL66454A0 (ja)
IT (1) IT1171432B (ja)
NO (1) NO161314C (ja)
NZ (1) NZ201439A (ja)
PL (1) PL141417B1 (ja)
PT (1) PT75363B (ja)
YU (3) YU43085B (ja)
ZA (1) ZA825585B (ja)

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* Cited by examiner, † Cited by third party
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IT1171432B (it) * 1981-08-03 1987-06-10 Fidia Farmaceutici Amidi organiche derivate da lipidi azotati utilizzabili come farmaci
US5334583A (en) * 1982-07-23 1994-08-02 Ciba-Geigy Corp. Use of sugar derivatives for the prophylaxis and treatment of virus infections
US5189017A (en) * 1982-07-23 1993-02-23 Ciba-Geigy Corporation Use of sugar derivatives for the prophylaxis and treatment of virus infections
EP0169812B1 (de) * 1984-07-25 1989-08-23 Ciba-Geigy Ag Phosphatidylverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung
US4885285A (en) * 1984-09-13 1989-12-05 Ciba-Geigy Corporation Phosphorus compounds, processes for their manufacture, and their use
LU85971A1 (fr) * 1985-06-25 1987-01-13 Oreal Nouveaux composes lipidiques amphiphiles, leur procede de preparation et leurs applications,notamnent en cosmetique et en dermopharmacie
US4873322A (en) * 1986-01-24 1989-10-10 Ciba-Geigy Corporation Saccharide derivatives and processes for their manufacture
US5434190A (en) * 1986-08-08 1995-07-18 Colgate-Palmolive Co. N-aryl and N-cycloalkyl neoalkanamide insect repellents
EP0299201A3 (de) * 1987-06-12 1990-08-22 Wilhelm Dr. Hoerrmann Fett-Aminoalkohol enthaltendes Arzneimittel
US5534553A (en) * 1987-06-12 1996-07-09 Hoerrmann; Wilhelm Drug containing fatty amino alcohols or derivatives thereof
DE3819870A1 (de) * 1987-06-12 1988-12-29 Hoerrmann Wilhelm Arzneimittel auf der basis von fett-amino-alkoholen
JP2588729B2 (ja) * 1987-10-05 1997-03-12 塩野義製薬株式会社 スフィンゴシン誘導体
IT1235162B (it) * 1988-12-02 1992-06-22 Fidia Farmaceutici Derivati di lisosfingolipidi
IT1238346B (it) * 1989-11-14 1993-07-13 Gangliosidi modificati e loro derivati funzionali.
US6509192B1 (en) * 1992-02-24 2003-01-21 Coulter International Corp. Quality control method
US6362003B1 (en) 1992-02-24 2002-03-26 Coulter Corporation Hematological reference control composition containing leukocyte analogs, methods of making, and uses thereof
DE4229877C2 (de) * 1992-09-04 1994-09-15 Max Delbrueck Centrum Phospho- bzw. Phosphono-(N-acyl)-serine und ihre Herstellung
US5346914A (en) * 1993-05-14 1994-09-13 Abbott Laboratories (4-alkoxypyran-4-yl) substituted arylalkylaryl-, arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase
US5635536A (en) * 1994-12-07 1997-06-03 Pharmacia & Upjohn Aktiebolag Emulsion suitable for administering a sphingolipid
JP3874215B2 (ja) * 1997-08-07 2007-01-31 Ｎｓｋワーナー株式会社 ワンウェイクラッチおよびワンウェイクラッチ用外輪・ 保持器組立体
US6092636A (en) * 1997-08-07 2000-07-25 Nsk-Warner K.K. Oneway clutch
WO2001079152A1 (en) * 2000-04-19 2001-10-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem Sphingolipids
US6756504B2 (en) 2000-04-19 2004-06-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Sphingolipids
CN1649600A (zh) 2002-02-28 2005-08-03 A&D生物科学公司 氟西汀及类似物的糖醛酰胺、苷和原酸酯苷及其应用
WO2003079980A2 (en) * 2002-03-19 2003-10-02 A & D Bioscience, Inc. Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
AU2003223510B2 (en) 2002-04-12 2008-05-08 Merck Sharp & Dohme Corp. Bicyclic amides
US20050255038A1 (en) * 2002-04-12 2005-11-17 A And D Bioscience, Inc. Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents and uses thereof
FR2839310A1 (fr) * 2002-05-03 2003-11-07 Pasteur Institut Nouveau procede de preparation d' alpha-glycosylceramides, nouveaux derives alpha-glycosylceramide et leurs applications
WO2003094842A2 (en) * 2002-05-07 2003-11-20 A & D Bioscience, Inc. Conjugates comprising central nervous system active drug
KR100496566B1 (ko) * 2002-06-11 2005-06-23 주식회사 포스코 탈황능이 향상된 무연탄을 이용한 용선용 탈황제
US20050215487A1 (en) * 2002-06-27 2005-09-29 Holick Michael F Conjugates comprising an nsaid and a sugar and uses thereof
CN107434814B (zh) * 2017-07-14 2019-05-03 中国科学院化学研究所 改性共轭聚合物及其制备方法和应用
JP2019161542A (ja) * 2018-03-15 2019-09-19 オンキヨー株式会社 振動板およびこれを用いたスピーカーユニット、ヘッドホン、並びにイヤホン、振動板の製造方法
KR102503769B1 (ko) * 2020-07-10 2023-02-27 솔루스바이오텍 주식회사 측쇄 지방산을 포함하는 신규한 스핑고지질과 그의 용도
CN115260091A (zh) * 2022-08-05 2022-11-01 深圳市迪克曼生物科技有限公司 含环状羧酸的神经酰胺类化合物及其制备方法和应用

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CH349592A (de) * 1956-06-06 1960-10-31 Ciba Geigy Verfahren zur Herstellung von ungesättigten, aliphatischen Aminodiolen
BE569345A (ja) * 1957-07-12
GB1064293A (en) * 1963-07-15 1967-04-05 Bellon Labor Sa Roger Substituted 2-pyrrylketones
US3418325A (en) * 1965-12-23 1968-12-24 Bofors Ab Method of producing a product between meso-inositol and nicotinic acid
US3901893A (en) * 1970-05-18 1975-08-26 Richter Gedeon Vegyeszet New dihydro-lysergic acid derivative
US4064249A (en) * 1974-05-28 1977-12-20 Richter Gedeon Vegyeszeti Gyar Rt. Compounds with ergoline skeleton
HU169073B (ja) * 1974-05-28 1976-09-28
DE2629135A1 (de) * 1976-06-29 1978-01-12 Nattermann A & Cie Neue phospholipid-derivate von prostaglandinen und verfahren zu ihrer herstellung
JPS565491A (en) * 1979-06-19 1981-01-20 Nattermann A & Cie Nnoleyl derivative of phosphatidylethanolamine* its manufacture and medicine containing same for lipemia and arteriosclerosis
IT1171432B (it) * 1981-08-03 1987-06-10 Fidia Farmaceutici Amidi organiche derivate da lipidi azotati utilizzabili come farmaci

Also Published As

Publication number Publication date
GR76234B (ja) 1984-08-04
ES8501735A1 (es) 1984-12-16
IT1171432B (it) 1987-06-10
DE3273983D1 (en) 1986-12-04
NO161314B (no) 1989-04-24
IE53644B1 (en) 1989-01-04
DK346282A (da) 1983-02-04
FI75829C (fi) 1988-08-08
YU168982A (en) 1986-02-28
US4897381A (en) 1990-01-30
FI822672L (fi) 1983-02-04
ATE23165T1 (de) 1986-11-15
PL141417B1 (en) 1987-07-31
YU42914B (en) 1988-12-31
ES533004A0 (es) 1985-12-16
AU8672682A (en) 1983-02-10
JPS5843942A (ja) 1983-03-14
ES514683A0 (es) 1984-12-16
DK159204C (da) 1991-03-11
NO822631L (no) 1983-02-04
IE821863L (en) 1983-02-03
PT75363B (en) 1984-12-10
AU561811B2 (en) 1987-05-21
US4897382A (en) 1990-01-30
JPH0558976A (ja) 1993-03-09
FI75829B (fi) 1988-04-29
NZ201439A (en) 1986-02-21
HU192771B (en) 1987-07-28
EP0072286A1 (en) 1983-02-16
EP0072286B2 (en) 1992-12-09
ES545241A0 (es) 1986-07-16
KR880000042B1 (ko) 1988-02-20
PL237756A1 (en) 1985-05-07
US4757053A (en) 1988-07-12
FI822672A0 (fi) 1982-07-30
EP0072286B1 (en) 1986-10-29
ES8602616A1 (es) 1985-12-16
YU73485A (en) 1986-02-28
ES8608480A1 (es) 1986-07-16
DK159204B (da) 1990-09-17
ZA825585B (en) 1983-06-29
IL66454A0 (en) 1982-12-31
IT8149031A0 (it) 1981-08-03
KR840001170A (ko) 1984-03-28
JPH0512329B2 (ja) 1993-02-17
PT75363A (en) 1982-09-01
YU42913B (en) 1988-12-31
YU73585A (en) 1986-02-28
NO161314C (no) 1989-08-02

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