YU27893A - Postupak za dobijanje cefalosporina - Google Patents
Postupak za dobijanje cefalosporinaInfo
- Publication number
- YU27893A YU27893A YU27893A YU27893A YU27893A YU 27893 A YU27893 A YU 27893A YU 27893 A YU27893 A YU 27893A YU 27893 A YU27893 A YU 27893A YU 27893 A YU27893 A YU 27893A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- amino
- cephalosporanic
- alpha
- derivatives
- cephalosporine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/06—Cephalosporin C; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
POSTUPAK ZA DOBIJANJE CEFALOSPORINA, postupak za dobijanje cefalosporina formule (I) u kojoj je R petočlani ili šestočlani ugljovodonični prsten koji može biti supstituisan ili R je petočlani heterociklični prsten koji sadrži jedan ili više heteroatoma odabranih iz grupe koja se sastoji od azota, kiseonika ili sumpora, koji heterociklični prsten može biti supstituisan; R1 je vodonikov atom, atom halogena, metoksi, metil ili metilen koji je vezan direktno za organski radikal ili preko atoma kiseonika, sumpora ili azota, gde je radikal alkoksi, alkoksikarbonil ili petočlana ili šestočlana heterociklična grupa, koja može biti supstituisana, a pomenuta heterociklična grupa sadrži jedan do četiri hetoroatoma odabranih iz O, S i N; i R2 je vodonik ili karboksi-zaštitna grupa, koja obuhvata reakciju reaktivnog derivata alfa-supstituisane alfa-amino kiseline formule (III): (gde je hidroksi karboksilnog ostatka supstituisan organskom grupom) sa supstratom cefalosporina formule (II): u prisustvu efikasne količine imobilisanog enzima penicilinske acilaze, i izvodjenjem pomenute reakcije na temperaturi u opsegu od oko 0В°C do oko +20В°C.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87425792A | 1992-04-24 | 1992-04-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU27893A true YU27893A (sh) | 1996-07-24 |
Family
ID=25363336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU27893A YU27893A (sh) | 1992-04-24 | 1993-04-23 | Postupak za dobijanje cefalosporina |
Country Status (22)
Country | Link |
---|---|
US (1) | US5801011A (sh) |
EP (1) | EP0567323B1 (sh) |
JP (1) | JPH069649A (sh) |
KR (1) | KR930021643A (sh) |
CN (1) | CN1063491C (sh) |
AT (1) | ATE183778T1 (sh) |
AU (1) | AU664078B2 (sh) |
BR (1) | BR9301627A (sh) |
CA (1) | CA2094686A1 (sh) |
CZ (1) | CZ69593A3 (sh) |
DE (1) | DE69326095T2 (sh) |
DK (1) | DK0567323T3 (sh) |
ES (1) | ES2135446T3 (sh) |
FI (1) | FI931815A (sh) |
GR (1) | GR3031739T3 (sh) |
HU (1) | HUT64352A (sh) |
IL (1) | IL105494A (sh) |
MX (1) | MX9302354A (sh) |
NO (1) | NO931483L (sh) |
NZ (1) | NZ247464A (sh) |
YU (1) | YU27893A (sh) |
ZA (1) | ZA932809B (sh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU8799498A (en) * | 1997-06-10 | 1998-12-30 | Gist-Brocades B.V. | Process for enzymatically preparing a beta-lactam antibiotic and this antibiotic |
CZ200782A3 (cs) | 2007-01-31 | 2009-05-27 | Mikrobiologický ústav AV CR, v.v.i. | Sekvence nukleotidu o velikosti 2646 bp, kódující penicilinacylázu, nové konstrukty rekombinantní nukleové kyseliny a rekombinantní mikroorganismy nesoucí tuto sekvenci |
CN101429538B (zh) * | 2008-12-12 | 2011-05-25 | 河北九派制药有限公司 | 7-α-甲氧基-3-去乙酰基头孢噻吩苄星盐的制备方法 |
CN103805671B (zh) * | 2013-11-11 | 2015-08-26 | 华北制药河北华民药业有限责任公司 | 一种制备头孢氨苄的方法 |
CN105002253B (zh) * | 2015-07-09 | 2019-02-15 | 山东罗欣药业集团恒欣药业有限公司 | 一种新型头孢类抗感染药物的酶促合成工艺 |
US20170101660A1 (en) * | 2015-10-07 | 2017-04-13 | Gwangju Institute Of Science And Technology | Enzyme-immobilized porous membrane and preparation method of antibiotics using the same |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5548797B1 (sh) * | 1971-04-02 | 1980-12-08 | ||
IL39158A (en) * | 1971-04-28 | 1977-08-31 | Snam Progetti | Enzymatic scission and synthesis of penicillins and cephalosporins |
IT1045797B (it) * | 1973-12-20 | 1980-06-10 | Snam Progetti | Procedimento per la sintesi enzimatica di penicilline e cefalosporine semisintetiche mediante una acilasi insolubile |
US4113566A (en) * | 1976-11-26 | 1978-09-12 | Pfizer Inc. | Process for preparing 6-aminopenicillanic acid |
CH640240A5 (en) * | 1979-02-09 | 1983-12-30 | I B S A Inst Biochimique Sa | Preparation of penicillins and cephalosporins from precursors obtained by hydrolysis of natural penicillins/cephalosporins, using enzymatic complexes immobilised on solid carriers |
JPH0791291B2 (ja) * | 1985-12-30 | 1995-10-04 | イ−ライ・リリ−・アンド・カンパニ− | 1−カルバセフアロスポリン抗生物質 |
WO1992001061A1 (en) * | 1990-07-04 | 1992-01-23 | Novo Nordisk A/S | PROCESS FOR PREPARATION OF β-LACTAMS |
IT1243800B (it) * | 1990-08-28 | 1994-06-28 | Sclavo Spa | Procedimento migliorato per la preparazione di cefalosporine |
SK63894A3 (en) * | 1991-12-19 | 1995-03-08 | Novo Nordisk As | Method of preparation of beta-lactam antibiotic |
GB9204439D0 (en) * | 1992-02-27 | 1992-04-15 | Fujisawa Pharmaceutical Co | A new cephalosporin c acylase |
-
1993
- 1993-04-21 ZA ZA932809A patent/ZA932809B/xx unknown
- 1993-04-21 EP EP93303116A patent/EP0567323B1/en not_active Expired - Lifetime
- 1993-04-21 NZ NZ247464A patent/NZ247464A/en unknown
- 1993-04-21 JP JP5094268A patent/JPH069649A/ja not_active Withdrawn
- 1993-04-21 AT AT93303116T patent/ATE183778T1/de not_active IP Right Cessation
- 1993-04-21 ES ES93303116T patent/ES2135446T3/es not_active Expired - Lifetime
- 1993-04-21 CZ CZ93695A patent/CZ69593A3/cs unknown
- 1993-04-21 DK DK93303116T patent/DK0567323T3/da active
- 1993-04-21 DE DE69326095T patent/DE69326095T2/de not_active Expired - Fee Related
- 1993-04-22 BR BR9301627A patent/BR9301627A/pt not_active Application Discontinuation
- 1993-04-22 IL IL10549493A patent/IL105494A/xx not_active IP Right Cessation
- 1993-04-22 AU AU37125/93A patent/AU664078B2/en not_active Ceased
- 1993-04-22 CA CA002094686A patent/CA2094686A1/en not_active Abandoned
- 1993-04-22 FI FI931815A patent/FI931815A/fi not_active Application Discontinuation
- 1993-04-22 MX MX9302354A patent/MX9302354A/es unknown
- 1993-04-22 HU HU9301188A patent/HUT64352A/hu unknown
- 1993-04-22 KR KR1019930006818A patent/KR930021643A/ko not_active Application Discontinuation
- 1993-04-22 NO NO93931483A patent/NO931483L/no unknown
- 1993-04-23 CN CN93104639A patent/CN1063491C/zh not_active Expired - Fee Related
- 1993-04-23 YU YU27893A patent/YU27893A/sh unknown
-
1996
- 1996-01-18 US US08/588,148 patent/US5801011A/en not_active Expired - Fee Related
-
1999
- 1999-11-03 GR GR990402834T patent/GR3031739T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NO931483L (no) | 1993-10-25 |
FI931815A0 (fi) | 1993-04-22 |
HUT64352A (en) | 1993-12-28 |
ES2135446T3 (es) | 1999-11-01 |
CN1063491C (zh) | 2001-03-21 |
AU664078B2 (en) | 1995-11-02 |
CZ69593A3 (en) | 1993-12-15 |
US5801011A (en) | 1998-09-01 |
GR3031739T3 (en) | 2000-02-29 |
CN1077749A (zh) | 1993-10-27 |
DE69326095T2 (de) | 2000-01-20 |
EP0567323A2 (en) | 1993-10-27 |
ATE183778T1 (de) | 1999-09-15 |
NO931483D0 (no) | 1993-04-22 |
FI931815A (fi) | 1993-10-25 |
HU9301188D0 (en) | 1993-07-28 |
NZ247464A (en) | 1994-12-22 |
BR9301627A (pt) | 1993-10-26 |
KR930021643A (ko) | 1993-11-22 |
EP0567323B1 (en) | 1999-08-25 |
ZA932809B (en) | 1994-10-21 |
DE69326095D1 (de) | 1999-09-30 |
AU3712593A (en) | 1993-10-28 |
JPH069649A (ja) | 1994-01-18 |
CA2094686A1 (en) | 1993-10-25 |
MX9302354A (es) | 1994-05-31 |
IL105494A0 (en) | 1993-08-18 |
EP0567323A3 (sh) | 1994-04-27 |
IL105494A (en) | 2000-08-13 |
DK0567323T3 (da) | 1999-12-13 |
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