ES2070101A1 - Procedimiento para la preparacion de derivados de cefem. - Google Patents

Procedimiento para la preparacion de derivados de cefem.

Info

Publication number
ES2070101A1
ES2070101A1 ES9350013A ES9350013A ES2070101A1 ES 2070101 A1 ES2070101 A1 ES 2070101A1 ES 9350013 A ES9350013 A ES 9350013A ES 9350013 A ES9350013 A ES 9350013A ES 2070101 A1 ES2070101 A1 ES 2070101A1
Authority
ES
Spain
Prior art keywords
methyl
thiomethyl
formula
represents hydrogen
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9350013A
Other languages
English (en)
Other versions
ES2070101B1 (es
Inventor
Hyek Lee Kwang
Hyun Ko Dong
Jin Kim Young
Xik Xiang Myung
Sik Yoon Myeong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cheil Foods and Chemicals Inc
Original Assignee
Cheil Foods and Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cheil Foods and Chemicals Inc filed Critical Cheil Foods and Chemicals Inc
Publication of ES2070101A1 publication Critical patent/ES2070101A1/es
Application granted granted Critical
Publication of ES2070101B1 publication Critical patent/ES2070101B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D501/06—Acylation of 7-aminocephalosporanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CEFEM, QUE SON UTILES ANTIBIOTICOS, Y QUE RESPONDE A LA FORMULA (I) *FIG* DONDE R1 REPRESENTA HIDROGENO O UNA SAL METALICA; Y R2 REPRESENTA HIDROGENO ACETOXIMETILO, (2,5-DIHIDRO-2-METIL-6-HIDROXI-5-OSO-AS-TRIAZIN-3-IL) TIOMETILO O (1-METIL-1H-TETRAZOL-5-IL) TIOMETILO. ESTE PROCEDIMIENTO COMPRENDE HACER REACCIONAR UNA MEZCLA DE TRIFENILFOSFINA (PH3P) Y HEXACLOROETANO (C2CL6) CON ACIDO [2-AMINO-{AL-(METOXIIMINO) TIAZOL-4-IL]-ACETICO EN UN DISOLVENTE ORGANICO PARA DAR UN DERIVADO DE CLORURO DE ACILOXIFOSFONIO DE FORMULA (IV), SILILAR 7-ACA Y SUS DERIVADOS (V) CON UN AGENTE SILILANTE EN UN DISOLVENTE ORGANICO, EN PRESENCIA O AUSENCIA DE UNA BASE, Y LUEGO ACILAR CON EL COMPUESTO RESULTANTE.
ES09350013A 1991-11-18 1993-07-16 Procedimiento para la preparacion de derivados de cefem. Expired - Fee Related ES2070101B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019910020505A KR950014571B1 (ko) 1991-11-18 1991-11-18 세펨 유도체의 제조방법

Publications (2)

Publication Number Publication Date
ES2070101A1 true ES2070101A1 (es) 1995-05-16
ES2070101B1 ES2070101B1 (es) 1996-02-16

Family

ID=19322986

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09350013A Expired - Fee Related ES2070101B1 (es) 1991-11-18 1993-07-16 Procedimiento para la preparacion de derivados de cefem.

Country Status (13)

Country Link
US (1) US5317099A (es)
EP (1) EP0613480B1 (es)
JP (1) JPH0811755B2 (es)
KR (1) KR950014571B1 (es)
AT (1) AT403048B (es)
CH (1) CH684091A5 (es)
DE (2) DE4293959C2 (es)
DK (1) DK56694A (es)
ES (1) ES2070101B1 (es)
GB (1) GB2275927B (es)
NL (1) NL9220025A (es)
SE (1) SE505050C2 (es)
WO (1) WO1993010123A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5402609A (en) * 1992-08-13 1995-04-04 Kelley, Jr.; Michael L. Concrete building block system
TW369530B (en) * 1993-06-10 1999-09-11 Lucky Ltd Process for preparing cephalosporin compounds from reactive organic acid derivatives
KR100197788B1 (ko) * 1995-06-30 1999-06-15 김충환 세펨 유도체의 제조방법
IN181459B (es) * 1995-12-26 1998-06-20 Lupin Lab Ltd
WO2005076694A2 (en) * 2004-01-16 2005-08-25 Wockhardt Limited Improved process for the production of cefotaxime sodium
CN108383857B (zh) * 2018-05-04 2021-02-05 山东四环药业股份有限公司 一种盐酸头孢甲肟的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2022090A (en) * 1978-05-30 1979-12-12 Hoffmann La Roche 7-[2-(2-amino-4-thiazolyl)-2- methoxyimino-acetamido]-3- heterocyclyl(thiomethyl)-cephems
EP0037380A2 (en) * 1980-03-28 1981-10-07 BIOCHEMIE Gesellschaft m.b.H. New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
ES2023550A6 (es) * 1989-05-23 1992-01-16 Synthetic Biolog Dev Procedimiento mejorado para la preparacion de ceftriaxona.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196205A (en) * 1976-01-23 1980-04-01 Roussel Uclaf 3-Acetoxymethyl-7-(iminoacetamido)-cephalosporanic acid derivatives
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
US4304770A (en) * 1976-04-12 1981-12-08 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
US4331664A (en) * 1976-04-12 1982-05-25 Fujisawa Pharmaceutical Co., Ltd. Syn isomer of 7-[2-cyclo(lower) alkoxyimino-2-(2-amino-or substituted aminothiazol-4-yl)acetamido]-3-lower alkanoyloxymethyl or heterocyclicthiomethyl-3-cephem-4-carboxylic acid compounds
DE2760484C2 (es) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp
US4370326A (en) * 1977-09-13 1983-01-25 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and composition
DE2758000A1 (de) * 1977-12-24 1979-07-05 Hoechst Ag Verfahren zur herstellung von penicillinen und cephalosporinen
CH641468A5 (de) * 1978-05-30 1984-02-29 Hoffmann La Roche Cephemderivate.
GB2025933B (en) * 1978-06-13 1982-10-27 Fujisawa Pharmaceutical Co Cephem and cepham compounds
FR2462439A1 (fr) * 1979-07-26 1981-02-13 Roussel Uclaf Nouveau procede de preparation de produits derives de l'acide 7-/(2-aryl) 2-hydroxyimino acetamido/cephalosporanique
KR870001332B1 (ko) * 1984-09-27 1987-07-18 한미약품공업 주식회사 세펨 유도체의 간단한 제조방법
CN1022837C (zh) * 1988-03-16 1993-11-24 卫材株式会社 制备头孢烯衍生物的方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2022090A (en) * 1978-05-30 1979-12-12 Hoffmann La Roche 7-[2-(2-amino-4-thiazolyl)-2- methoxyimino-acetamido]-3- heterocyclyl(thiomethyl)-cephems
EP0037380A2 (en) * 1980-03-28 1981-10-07 BIOCHEMIE Gesellschaft m.b.H. New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
ES2023550A6 (es) * 1989-05-23 1992-01-16 Synthetic Biolog Dev Procedimiento mejorado para la preparacion de ceftriaxona.

Also Published As

Publication number Publication date
JPH0811755B2 (ja) 1996-02-07
SE9401706D0 (sv) 1994-05-18
NL9220025A (nl) 1994-12-01
DE4293959T1 (de) 1995-01-26
EP0613480A1 (en) 1994-09-07
US5317099A (en) 1994-05-31
KR950014571B1 (ko) 1995-12-08
AT403048B (de) 1997-10-27
GB2275927B (en) 1995-10-04
ES2070101B1 (es) 1996-02-16
GB2275927A (en) 1994-09-14
EP0613480B1 (en) 1999-03-31
DE4293959C2 (de) 1996-08-29
ATA903092A (de) 1997-03-15
WO1993010123A1 (en) 1993-05-27
SE9401706L (sv) 1994-07-07
KR930010043A (ko) 1993-06-21
SE505050C2 (sv) 1997-06-16
CH684091A5 (de) 1994-07-15
JPH07501072A (ja) 1995-02-02
DK56694A (da) 1994-05-18
GB9409758D0 (en) 1994-07-20

Similar Documents

Publication Publication Date Title
SE8403896L (sv) Antibiotika
KR870001986B1 (ko) 세팔로스포린 유도체의 제조방법
ES2070101A1 (es) Procedimiento para la preparacion de derivados de cefem.
AU1866388A (en) New process for the preparation of cephem compounds and new cephalosporin derivatives
IL103109A (en) Anhydrous process for preparing cefepime dihydrochloride hydrate
AU581046B2 (en) Process for the manufacture of aminothiazole acetic acid derivatives
ES8703401A1 (es) Procedimiento para la obtencion de esteres del acido 4-aci- loxi-3-oxo-butirico
ES471964A1 (es) Un procedimiento para la preparacion de un tiofeno
ES484380A1 (es) Un procedimiento no catalitico para la preparacion de deri- vados de cefalosporina
YU27893A (sh) Postupak za dobijanje cefalosporina
ATE244248T1 (de) Herstellung von amino cephalosporansäurederivaten
SE8703494L (sv) Mellanprodukter anvendbara vid framstellning av 2-tiofen-ettiksyraderivat
KR930016427A (ko) 세프트리악손 디소디움염 헤미헵타하이드레이트의 제조방법
YU44630B (en) Process for preparing 6-/d(-)-alpha(4-ethyl-2,3-dioxo-1-piperazincarboxamido)-phenylacetamido/phenicilanic acid
ES8206536A1 (es) Procedimiento para preparar derivados de 1-oxido de acido 7-acilamino-3-(tio-sustituido)metil-3-cefem-4-carboxilico
IE890128L (en) Method of producing 2-substituted oximino-3-oxobutyric¹acids.
ES2002912A6 (es) Procedimiento para la produccion de antibioticos de cefalosporina
JPS57116048A (en) Novel quinoline derivative
KR880003957A (ko) 세팔로스포린 유도체의 제조방법
JPS57169457A (en) Chlorinated azetidinone derivative and its preparation
KR960037687A (ko) 경구용 세팔로스포린 유도체의 제조방법
ES8603894A1 (es) Un procedimiento para la preaparacion de acido-7-amino-3-metil-3-cefem-4-carboxilico.
KR870010062A (ko) 세파로스포린 유도체의 제조방법
ES8704501A1 (es) Procedimiento de preparacion de cafadroxilo
KR890005125A (ko) 결정성 세팔로스포린 유도체

Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20180806