NO931483L - Forbedret fremgangsmaate for fremstilling av cefalosporiner - Google Patents

Forbedret fremgangsmaate for fremstilling av cefalosporiner

Info

Publication number
NO931483L
NO931483L NO93931483A NO931483A NO931483L NO 931483 L NO931483 L NO 931483L NO 93931483 A NO93931483 A NO 93931483A NO 931483 A NO931483 A NO 931483A NO 931483 L NO931483 L NO 931483L
Authority
NO
Norway
Prior art keywords
amino
cephalosporines
manufacturing
cephalosporanic
improved procedure
Prior art date
Application number
NO93931483A
Other languages
English (en)
Other versions
NO931483D0 (no
Inventor
John Paul Gardner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO931483D0 publication Critical patent/NO931483D0/no
Publication of NO931483L publication Critical patent/NO931483L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Det blir beskrevet en forbedret fremgangsmåte for fremstilling av cefalosporiner ved reaksjon av forbindelser slik som 7-amlno-cefalosporlnsyre eller deres derivater med derivater av a-amlnosyrer l nærvær av et passende Immoblllsert penlclllinacylase-enzym under de følgende betingelsene, uavhengig eller i kombinasjon: 1) ved en temperatur i området fra 0*C til +20'C; eller 2) ved omglvelses-pH; med et høyt molart forhold av a-aminosyre til en cefalosporinkjerne.
NO93931483A 1992-04-24 1993-04-22 Forbedret fremgangsmaate for fremstilling av cefalosporiner NO931483L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87425792A 1992-04-24 1992-04-24

Publications (2)

Publication Number Publication Date
NO931483D0 NO931483D0 (no) 1993-04-22
NO931483L true NO931483L (no) 1993-10-25

Family

ID=25363336

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93931483A NO931483L (no) 1992-04-24 1993-04-22 Forbedret fremgangsmaate for fremstilling av cefalosporiner

Country Status (22)

Country Link
US (1) US5801011A (no)
EP (1) EP0567323B1 (no)
JP (1) JPH069649A (no)
KR (1) KR930021643A (no)
CN (1) CN1063491C (no)
AT (1) ATE183778T1 (no)
AU (1) AU664078B2 (no)
BR (1) BR9301627A (no)
CA (1) CA2094686A1 (no)
CZ (1) CZ69593A3 (no)
DE (1) DE69326095T2 (no)
DK (1) DK0567323T3 (no)
ES (1) ES2135446T3 (no)
FI (1) FI931815A (no)
GR (1) GR3031739T3 (no)
HU (1) HUT64352A (no)
IL (1) IL105494A (no)
MX (1) MX9302354A (no)
NO (1) NO931483L (no)
NZ (1) NZ247464A (no)
YU (1) YU27893A (no)
ZA (1) ZA932809B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8799498A (en) * 1997-06-10 1998-12-30 Gist-Brocades B.V. Process for enzymatically preparing a beta-lactam antibiotic and this antibiotic
CZ300467B6 (cs) 2007-01-31 2009-05-27 Mikrobiologický ústav AV CR, v.v.i. Sekvence nukleotidu o velikosti 2646 bp, kódující penicilinacylázu, nové konstrukty rekombinantní nukleové kyseliny a rekombinantní mikroorganismy nesoucí tuto sekvenci
CN101429538B (zh) * 2008-12-12 2011-05-25 河北九派制药有限公司 7-α-甲氧基-3-去乙酰基头孢噻吩苄星盐的制备方法
CN103805671B (zh) * 2013-11-11 2015-08-26 华北制药河北华民药业有限责任公司 一种制备头孢氨苄的方法
CN105002253B (zh) * 2015-07-09 2019-02-15 山东罗欣药业集团恒欣药业有限公司 一种新型头孢类抗感染药物的酶促合成工艺
US20170101660A1 (en) * 2015-10-07 2017-04-13 Gwangju Institute Of Science And Technology Enzyme-immobilized porous membrane and preparation method of antibiotics using the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5548797B1 (no) * 1971-04-02 1980-12-08
IL39158A (en) * 1971-04-28 1977-08-31 Snam Progetti Enzymatic scission and synthesis of penicillins and cephalosporins
IT1045797B (it) * 1973-12-20 1980-06-10 Snam Progetti Procedimento per la sintesi enzimatica di penicilline e cefalosporine semisintetiche mediante una acilasi insolubile
US4113566A (en) * 1976-11-26 1978-09-12 Pfizer Inc. Process for preparing 6-aminopenicillanic acid
CH640240A5 (en) * 1979-02-09 1983-12-30 I B S A Inst Biochimique Sa Preparation of penicillins and cephalosporins from precursors obtained by hydrolysis of natural penicillins/cephalosporins, using enzymatic complexes immobilised on solid carriers
JPH0791291B2 (ja) * 1985-12-30 1995-10-04 イ−ライ・リリ−・アンド・カンパニ− １−カルバセフアロスポリン抗生物質
CZ381392A3 (en) * 1990-07-04 1993-12-15 Novo Nordisk As Process for preparing beta-lactams
IT1243800B (it) * 1990-08-28 1994-06-28 Sclavo Spa Procedimento migliorato per la preparazione di cefalosporine
SK63894A3 (en) * 1991-12-19 1995-03-08 Novo Nordisk As Method of preparation of beta-lactam antibiotic
GB9204439D0 (en) * 1992-02-27 1992-04-15 Fujisawa Pharmaceutical Co A new cephalosporin c acylase

Also Published As

Publication number Publication date
IL105494A0 (en) 1993-08-18
MX9302354A (es) 1994-05-31
BR9301627A (pt) 1993-10-26
ES2135446T3 (es) 1999-11-01
HU9301188D0 (en) 1993-07-28
ZA932809B (en) 1994-10-21
YU27893A (sh) 1996-07-24
CN1077749A (zh) 1993-10-27
IL105494A (en) 2000-08-13
HUT64352A (en) 1993-12-28
EP0567323A3 (no) 1994-04-27
ATE183778T1 (de) 1999-09-15
AU664078B2 (en) 1995-11-02
US5801011A (en) 1998-09-01
KR930021643A (ko) 1993-11-22
CA2094686A1 (en) 1993-10-25
EP0567323A2 (en) 1993-10-27
NO931483D0 (no) 1993-04-22
JPH069649A (ja) 1994-01-18
FI931815A0 (fi) 1993-04-22
CN1063491C (zh) 2001-03-21
CZ69593A3 (en) 1993-12-15
DK0567323T3 (da) 1999-12-13
GR3031739T3 (en) 2000-02-29
EP0567323B1 (en) 1999-08-25
FI931815A (fi) 1993-10-25
NZ247464A (en) 1994-12-22
DE69326095T2 (de) 2000-01-20
DE69326095D1 (de) 1999-09-30
AU3712593A (en) 1993-10-28

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