YU26102A - Nove farmaceutske smese antituberkuloznih lekova i postupak za njihovo dobijanje - Google Patents

Nove farmaceutske smese antituberkuloznih lekova i postupak za njihovo dobijanje

Info

Publication number
YU26102A
YU26102A YU26102A YUP26102A YU26102A YU 26102 A YU26102 A YU 26102A YU 26102 A YU26102 A YU 26102A YU P26102 A YUP26102 A YU P26102A YU 26102 A YU26102 A YU 26102A
Authority
YU
Yugoslavia
Prior art keywords
rifampicin
drugs
isoniazid
preparation
pharmaceutical compositions
Prior art date
Application number
YU26102A
Other languages
English (en)
Inventor
Amarjit Singh
Rajesh Jain
Original Assignee
Panacea Biotec Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panacea Biotec Limited filed Critical Panacea Biotec Limited
Publication of YU26102A publication Critical patent/YU26102A/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Farmaceutski sastav anti-tuberkuloznih lekova za oralnu upotrebu koji obuhvata Rifampicin i/ili Izonijazid, gde je bioraspoloživost Rifampicina i/ili drugih lekova povećana. Pogodno je bioraspoloživost Rifampicina povećana sprečavanjem njegovog razlaganja prouzrokovanog prisustvom Izonijazida. Rifampicin i/ili Izonijazid mogu da budu prisutni u obliku sa odloženim i/ili produženim otpuštanjem takvom da se minimalna količina leka rastvara izmedju pH 1 i 4. Pogodno se odloženo otpuštanje Rifampicina i/ili Izonijazida postiže tretiranjem lekova sa pH osetljivim polimerima.[A pharmaceutical composition of anti-tubercular drugs for oral use comprising Rifampicin and/or Isoniazid wherein the bioavailability of Rifampicin and/or other drugs is enhanced. Preferably the bioavailability of Rifampicin is enhanced by preventing its degradation caused by presence of Isoniazid. Rifampicin and/or Isoniazid may be present in delayed release and/or extended release form such that minimal amount of the drug is dissolved between pH 1 and 4. preferably delayed release of Rifampicin and/or Isoniazid is achieved by treating the drugs with pH sensitive polymers.
YU26102A 2000-08-09 2001-04-10 Nove farmaceutske smese antituberkuloznih lekova i postupak za njihovo dobijanje YU26102A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN720DE2000 2000-08-09

Publications (1)

Publication Number Publication Date
YU26102A true YU26102A (sh) 2004-12-31

Family

ID=11097078

Family Applications (1)

Application Number Title Priority Date Filing Date
YU26102A YU26102A (sh) 2000-08-09 2001-04-10 Nove farmaceutske smese antituberkuloznih lekova i postupak za njihovo dobijanje

Country Status (22)

Country Link
US (1) US7195769B2 (sh)
EP (1) EP1307199A2 (sh)
JP (2) JP4098620B2 (sh)
KR (1) KR100620404B1 (sh)
CN (1) CN1388758A (sh)
AU (1) AU778389C (sh)
BG (1) BG65848B1 (sh)
BR (1) BR0107147A (sh)
CA (1) CA2386725A1 (sh)
CZ (1) CZ20021319A3 (sh)
HU (1) HUP0203451A3 (sh)
IL (2) IL149030A0 (sh)
MX (1) MXPA02003596A (sh)
NO (1) NO322503B1 (sh)
NZ (1) NZ518216A (sh)
PL (1) PL355844A1 (sh)
RU (1) RU2240795C9 (sh)
TR (1) TR200200966T1 (sh)
UA (1) UA74164C2 (sh)
WO (1) WO2002011728A2 (sh)
YU (1) YU26102A (sh)
ZA (1) ZA200202637B (sh)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7300670B2 (en) * 2002-04-03 2007-11-27 Unilab Pharmatech, Ltd. Oral suspension formulation
US20050084455A1 (en) * 2003-10-16 2005-04-21 Council Of Scientific & Industrial Research Inhalable biodegradable microparticles for target-specific drug delivery in tuberculosis and a process thereof
CN1319525C (zh) * 2004-09-16 2007-06-06 北京圣医耀科技发展有限责任公司 紫杉醇－海藻酸钠微球血管栓塞剂及其制备
EP1824458A1 (en) * 2004-11-18 2007-08-29 Bristol-Myers Squibb Company Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof
PE20061058A1 (es) * 2004-11-18 2006-10-13 Bristol Myers Squibb Co Composicion farmaceutica que comprende ixabepilona y proceso de preparacion
GB0516604D0 (en) * 2005-08-12 2005-09-21 Sandoz Ag Rapidly dispersing/disintegrating compositions
CN1857220B (zh) * 2006-04-04 2010-10-06 济南康泉医药科技有限公司 一种抗结核病药物缓释剂
RU2327457C1 (ru) * 2007-06-26 2008-06-27 Автономная некоммерческая организация "Институт молекулярной диагностики" (АНО "ИнМоДи") Лекарственное средство на основе рифабутина, препарат противомикробного действия, содержащий наночастицы, и способ его получения
US20090280173A1 (en) * 2008-05-09 2009-11-12 Ishwar Chauhan Multilayer Omeprazole Tablets
US20090280175A1 (en) * 2008-05-09 2009-11-12 Ishwar Chauhan Multilayer Proton Pump Inhibitor Tablets
US20100160363A1 (en) * 2008-12-19 2010-06-24 Aaipharma Services Corp. Extended-release pharmaceutical formulations
US20100159001A1 (en) * 2008-12-19 2010-06-24 Cardinal John R Extended-Release Pharmaceutical Formulations
KR101197277B1 (ko) * 2009-02-05 2012-11-05 (주) 벡스코아 경구용 결핵의 치료용 또는 예방용 고형 제형
SG10201402158VA (en) * 2009-02-10 2014-07-30 Celgene Corp Methods Of Using And Compositions Comprising PDE4 Modulators For Treatment, Prevention And Management Of Tuberculosis
WO2011010214A1 (en) * 2009-07-23 2011-01-27 Cadila Pharmaceuticals Ltd. Pharmaceutical composition of rifampicin
AP2012006119A0 (en) * 2009-07-31 2012-02-29 Cadila Pharmaceuticals Ltd Pharmaceutical composition of isoniazid.
WO2011126352A2 (ru) * 2010-04-07 2011-10-13 Товарищество С Ограниченной Ответственностью "Фармацевтическая Компания "Ромат" Противотуберкулезный препарат на основе комплекса включения циклодекстрина с рифампицином и способ его получения
IT1400989B1 (it) * 2010-07-13 2013-07-05 Segix Italia S R L Ora Istituto Biochimico Naz Savio S R L Forme di somministrazione orale a rilascio controllato di rifampicina per il trattamento di infezioni batteriche dell' apparato intestinale.
TWI391134B (zh) * 2010-07-29 2013-04-01 Taiwan Biotech Co Ltd 製備抗結核病之組合的改良方法及由其製得之醫藥組合物
US8470365B2 (en) 2010-07-29 2013-06-25 Taiwan Biotech Co., Ltd. Process for preparation of anti-tubercular combination and pharmaceutical composition prepared therefrom
EA016410B1 (ru) * 2010-11-13 2012-04-30 Ооо "Нпк Наносистема" Фармацевтическая композиция на основе наночастиц циклодекстрина, содержащих рифабутин, способ ее получения, способ лечения микобактериоза и геликобактерной инфекции (варианты)
CN102727496A (zh) * 2011-04-12 2012-10-17 上海双健现代药物技术咨询有限公司 一种复方抗结核药口服固体制剂及其制备方法
CN102228439B (zh) * 2011-06-21 2013-01-02 中国人民解放军第三0九医院 可注射利福霉素类抗生素凝胶微球及其制备方法
CN102552204B (zh) * 2011-12-30 2014-04-02 沈阳药科大学 复方抗结核包芯片及制备方法
CN102579447B (zh) * 2011-12-31 2014-10-15 沈阳药科大学 抗结核药物复方制剂的制备方法
PL2844233T3 (pl) * 2012-05-01 2020-09-07 Althera Life Sciences, Llc Preparat w postaci tabletki do stosowania doustnego składający się ze stałego połączenia rosuwastatyny i ezetymibu w leczeniu hiperlipidemii i chorób sercowo-naczyniowych
WO2013166114A1 (en) * 2012-05-01 2013-11-07 Althera Life Sciences, Llc Oral tablet formulation consisting of fixed combination of atorvastatin and ezetimibe
KR101301700B1 (ko) * 2012-11-14 2013-08-30 (주)비씨월드제약 용해도 및 안정성이 개선된 리팜피신을 포함하는 결핵 치료용 약학 조성물 및 이의 제조방법
RU2672064C2 (ru) * 2013-03-20 2018-11-09 Департамент Биотехнологии Антибактериальные соединения против лекарственно-устойчивых бактерий
EP3024445B1 (en) * 2013-07-26 2019-01-09 Sanofi Antitubercular composition comprising rifampicin, isoniazid, ethambutol and pyrazinamide and its process of preparation
CN105407876B (zh) * 2013-07-26 2019-08-30 赛诺菲 抗结核病的稳定的包含异烟肼颗粒和利福喷汀颗粒的可分散的片剂及其制备方法
WO2015011161A1 (en) * 2013-07-26 2015-01-29 Sanofi Anti-tuberculosis stable pharmaceutical composition in a form of a coated tablet comprising granules of isoniazid and granules of rifapentine and its process of preparation
WO2016105238A1 (ru) * 2014-12-22 2016-06-30 Анатолий Викторович ЗАЗУЛЯ Изготовление двухслойных таблеток объединяющих механизмы повышения терапевтической эффективности и коррекции побочных действий
CN106619702A (zh) * 2016-12-07 2017-05-10 郑州郑先医药科技有限公司 一种治疗肺结核的药物
US11717519B2 (en) * 2017-04-21 2023-08-08 Washington University In St. Louis Use of fatty acid oxidation inhibitors as antimicrobials
US20200179273A1 (en) * 2017-06-06 2020-06-11 Merck Sharp & DohmeCorp Long-action implant for treatment of infectious diseases
CN108272766B (zh) * 2018-03-21 2020-07-07 江苏四环生物制药有限公司 一种甲钴胺分散迟释片及其制备方法
EP3578167A1 (en) * 2018-06-04 2019-12-11 Universitat de Barcelona Suspension formulation for the treatment of tuberculosis
KR102304069B1 (ko) 2020-01-20 2021-09-23 인제대학교 산학협력단 항결핵제 치료 효과 증진용 조성물
CN112472702A (zh) * 2020-12-14 2021-03-12 卓和药业集团有限公司 一种治疗肺结核的药物组合物及其制备方法
CN114053229B (zh) * 2022-01-17 2022-04-22 山东国邦药业有限公司 一种盐酸沙拉沙星水溶性颗粒剂及其制备方法
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5817442B2 (ja) * 1977-04-25 1983-04-07 第一製薬株式会社 溶出の良いリフアンピシン固形製剤
GB2135879B (en) 1983-03-07 1986-05-21 Ciba Geigy Ag Pharmaceutical preparations with uniform elution properties
JPH0498620A (ja) * 1990-08-15 1992-03-31 Nec Ibaraki Ltd 磁気記録媒体製造装置
US5358502A (en) * 1993-02-25 1994-10-25 Pfizer Inc PH-triggered osmotic bursting delivery devices
EP0650728B1 (en) * 1993-10-29 2002-02-27 Council of Scientific and Industrial Research Pharmaceutical compositions containing piperine and an antituberculosis or antileprosydrug
IT1289883B1 (it) 1996-10-09 1998-10-19 Lupin Lab Ltd Composizione farmaceutica antitubercolare e procedimento per la sua produzione
DE19710009A1 (de) * 1997-03-12 1998-09-24 Knoll Ag Mehrphasige wirkstoffhaltige Zubereitungsformen
US6235311B1 (en) * 1998-03-18 2001-05-22 Bristol-Myers Squibb Company Pharmaceutical composition containing a combination of a statin and aspirin and method
US6264991B1 (en) * 1998-08-18 2001-07-24 Southern Research Institute Compositions and methods for treating intracellular infections
ES2179729B1 (es) * 2000-03-23 2003-12-16 Dreiman Lab Farmaceuticos S A Forma farmaceutica solida de administracion oral dispersable en agua, que comprende rifampicina, isoniazida y piridoxina hidrocloruro, procedimiento para su obtencion y forma de presentacion de dicha forma farmaceutica.

Also Published As

Publication number Publication date
NO20021599L (no) 2002-06-10
CA2386725A1 (en) 2002-02-14
NO322503B1 (no) 2006-10-16
AU778389C (en) 2006-12-14
BG106606A (bg) 2002-12-29
EP1307199A2 (en) 2003-05-07
BG65848B1 (bg) 2010-03-31
HUP0203451A3 (en) 2004-05-28
RU2240795C2 (ru) 2004-11-27
JP2004505918A (ja) 2004-02-26
AU778389B2 (en) 2004-12-02
US7195769B2 (en) 2007-03-27
AU5666101A (en) 2002-02-18
US20030072800A1 (en) 2003-04-17
UA74164C2 (uk) 2005-11-15
TR200200966T1 (tr) 2002-09-23
NZ518216A (en) 2004-11-26
HUP0203451A2 (hu) 2003-02-28
MXPA02003596A (es) 2003-10-14
JP2008056696A (ja) 2008-03-13
KR100620404B1 (ko) 2006-09-13
PL355844A1 (en) 2004-05-31
JP4098620B2 (ja) 2008-06-11
IL149030A (en) 2007-06-17
CZ20021319A3 (cs) 2002-08-14
WO2002011728A2 (en) 2002-02-14
BR0107147A (pt) 2002-06-18
RU2240795C9 (ru) 2005-09-27
KR20020061602A (ko) 2002-07-24
WO2002011728A3 (en) 2002-04-25
NO20021599D0 (no) 2002-04-04
RU2002115283A (ru) 2004-01-27
CN1388758A (zh) 2003-01-01
IL149030A0 (en) 2002-11-10
ZA200202637B (en) 2003-08-20

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