YU242390A - Matrica s celicami, vezanimi nanjo adherentno, kot tudi postopek za proizvodnjo virusa/virusantigena - Google Patents
Matrica s celicami, vezanimi nanjo adherentno, kot tudi postopek za proizvodnjo virusa/virusantigenaInfo
- Publication number
- YU242390A YU242390A YU242390A YU242390A YU242390A YU 242390 A YU242390 A YU 242390A YU 242390 A YU242390 A YU 242390A YU 242390 A YU242390 A YU 242390A YU 242390 A YU242390 A YU 242390A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- virus
- cells
- antigen
- bound
- matrix
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 4
- 239000011159 matrix material Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 5
- 239000000427 antigen Substances 0.000 abstract 4
- 102000036639 antigens Human genes 0.000 abstract 4
- 108091007433 antigens Proteins 0.000 abstract 4
- 241000710771 Tick-borne encephalitis virus Species 0.000 abstract 2
- 230000001419 dependent effect Effects 0.000 abstract 2
- 210000004102 animal cell Anatomy 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000012876 carrier material Substances 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 206010014599 encephalitis Diseases 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 230000000415 inactivating effect Effects 0.000 abstract 1
- 230000002101 lytic effect Effects 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 201000011475 meningoencephalitis Diseases 0.000 abstract 1
- 210000003501 vero cell Anatomy 0.000 abstract 1
- 230000029812 viral genome replication Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2531/00—Microcarriers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24151—Methods of production or purification of viral material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
Izum se nanaša na matrico, torej nosilni material, z nanjo adherentno vezanimi človeškimi ali živalskimi celicami, pri čemer so celice inficirane z virusom. Pokazalo se je, da od površine odvisne celice, primerne za razmnoževanje virusa, ostanejo celo v stanju, inficiranem z virusom, adherentno vezane na matrici, da sorazmerno dolgo časa kontinuirno proizvajajo virusantigen in ga oddajajo v gojilni medij. Za proizvodnjo virusantigena zgodnjega poletnega meningoencefalitisa (FSME) z gojenjem FSME-virusa v celičnih kulturah cepimo od površine odvisno, permanentno celično linijo, prednostno Vero-celično linijo ATTC CCL 81, FSME-virusom ter vzdržujemo celice ob vzdrževanju celične rasti v ne-litičnem sistemu brez seruma vezane na nosilcih, da vzdržujemo tvorbo antigena, nakar ločimo antigen vsebujoči medij od celic, vezanih na nosilcu, ter na znan način obdelamo s koncentriranjem, dezaktiviranjem in čiščenjem v galensko sprejemljiv pripravek.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HRP921354 HRP921354A2 (en) | 1989-12-22 | 1992-11-25 | Matrix with cells adherently bounded to it, and the process for the production of viruses/virus antigenes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT2928/89A AT393356B (de) | 1989-12-22 | 1989-12-22 | Verfahren zur herstellung von fsme-virus-antigen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU242390A true YU242390A (sh) | 1993-05-28 |
Family
ID=3542524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU242390A YU242390A (sh) | 1989-12-22 | 1990-12-21 | Matrica s celicami, vezanimi nanjo adherentno, kot tudi postopek za proizvodnjo virusa/virusantigena |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0506714B1 (sh) |
| JP (1) | JP2633391B2 (sh) |
| AT (2) | AT393356B (sh) |
| CA (1) | CA2071954C (sh) |
| CZ (1) | CZ281804B6 (sh) |
| DE (1) | DE59007659D1 (sh) |
| DK (1) | DK0506714T3 (sh) |
| ES (1) | ES2067916T3 (sh) |
| FI (1) | FI98377C (sh) |
| HR (1) | HRP921354A2 (sh) |
| HU (1) | HU213886B (sh) |
| NO (1) | NO310305B1 (sh) |
| RU (1) | RU2082757C1 (sh) |
| SK (1) | SK659090A3 (sh) |
| WO (1) | WO1991009935A1 (sh) |
| YU (1) | YU242390A (sh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2378409T3 (es) * | 1994-11-10 | 2012-04-12 | Baxter Healthcare S.A. | Método para producir sustancias biológicas en cultivo sin proteínas |
| FR2737412B1 (fr) * | 1995-08-01 | 1997-10-24 | Pasteur Merieux Serums Vacc | Procede de production d'un vaccin contre le virus de l'encephalite japonaise et vaccin obtenu par ce procede |
| KR19990036028A (ko) * | 1995-08-01 | 1999-05-25 | 다니엘 케르니 | 일본뇌염 백신의 공업적인 생산방법 및 이에 의한 백신 |
| JP4371343B2 (ja) * | 1998-10-05 | 2009-11-25 | 財団法人阪大微生物病研究会 | 日本脳炎ウイルス群感染症に対する不活化ワクチンのための増強免疫原およびその製造方法 |
| AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| US6855535B2 (en) * | 2001-12-10 | 2005-02-15 | Baxter Healthcare S.A. | Method of large scale production of Hepatitis A virus |
| US6951752B2 (en) * | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
| JP2007068401A (ja) * | 2003-08-07 | 2007-03-22 | Chemo Sero Therapeut Res Inst | 西ナイルウイルスワクチン |
| PT2574677T (pt) * | 2007-12-27 | 2017-10-19 | Baxalta Inc | Processos para cultura de células |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT358167B (de) * | 1978-12-22 | 1980-08-25 | Immuno Ag | Verfahren zur herstellung von fruehsommer- -meningoenzephalitis-virus (fsme-virus)- -vakzinen |
| SE445116B (sv) * | 1979-09-12 | 1986-06-02 | Pharmacia Fine Chemicals Ab | Sett att odla celler pa mikroberare med fibronektinytskikt |
| NO161446C (no) * | 1981-03-13 | 1989-08-16 | Damon Biotech Inc | Fremgangsmaate for dyrking av celler som er avhengige av forankring. |
| SE8103138L (sv) * | 1981-05-19 | 1982-11-20 | Pharmacia Fine Chemicals Ab | Mikroberare for odling av forankringsberoende celler |
| CA1206900A (en) * | 1981-12-21 | 1986-07-02 | Raymond L. Downs | Hollow glass shell microcarrier for growth of cell cultures, and method of shell manufacture |
| AT385203B (de) * | 1985-04-26 | 1988-03-10 | Immuno Ag | Verfahren zur herstellung einer fruehsommermeningoenzephalitis-virus (fsme-virus)-vakzine |
| DD274336A3 (de) * | 1985-10-03 | 1989-12-20 | Npo Biolar | Verfahren zur Gewinnung einer Mikroträgersubstanz für die Zellkultivierung |
-
1989
- 1989-12-22 AT AT2928/89A patent/AT393356B/de not_active IP Right Cessation
-
1990
- 1990-12-21 CA CA 2071954 patent/CA2071954C/en not_active Expired - Lifetime
- 1990-12-21 RU SU905052769A patent/RU2082757C1/ru not_active IP Right Cessation
- 1990-12-21 JP JP50113291A patent/JP2633391B2/ja not_active Expired - Fee Related
- 1990-12-21 EP EP19910900666 patent/EP0506714B1/de not_active Expired - Lifetime
- 1990-12-21 DE DE59007659T patent/DE59007659D1/de not_active Expired - Fee Related
- 1990-12-21 SK SK6590-90A patent/SK659090A3/sk not_active IP Right Cessation
- 1990-12-21 CZ CS906590A patent/CZ281804B6/cs not_active IP Right Cessation
- 1990-12-21 HU HU9202009A patent/HU213886B/hu unknown
- 1990-12-21 WO PCT/AT1990/000128 patent/WO1991009935A1/de active IP Right Grant
- 1990-12-21 DK DK91900666T patent/DK0506714T3/da not_active Application Discontinuation
- 1990-12-21 ES ES91900666T patent/ES2067916T3/es not_active Expired - Lifetime
- 1990-12-21 AT AT91900666T patent/ATE113652T1/de not_active IP Right Cessation
- 1990-12-21 YU YU242390A patent/YU242390A/sh unknown
-
1992
- 1992-06-18 FI FI922851A patent/FI98377C/fi active
- 1992-06-19 NO NO19922422A patent/NO310305B1/no not_active IP Right Cessation
- 1992-11-25 HR HRP921354 patent/HRP921354A2/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0506714T3 (da) | 1995-04-18 |
| DE59007659D1 (de) | 1994-12-08 |
| ATA292889A (de) | 1991-03-15 |
| FI922851A (fi) | 1992-06-18 |
| JP2633391B2 (ja) | 1997-07-23 |
| HU9202009D0 (en) | 1992-10-28 |
| AT393356B (de) | 1991-10-10 |
| ES2067916T3 (es) | 1995-04-01 |
| EP0506714A1 (de) | 1992-10-07 |
| EP0506714B1 (de) | 1994-11-02 |
| RU2082757C1 (ru) | 1997-06-27 |
| CZ659090A3 (en) | 1996-11-13 |
| CA2071954A1 (en) | 1991-06-23 |
| WO1991009935A1 (de) | 1991-07-11 |
| CA2071954C (en) | 1996-06-18 |
| HU213886B (en) | 1997-11-28 |
| FI922851A0 (fi) | 1992-06-18 |
| HRP921354A2 (en) | 1996-02-29 |
| HUT65410A (en) | 1994-06-28 |
| ATE113652T1 (de) | 1994-11-15 |
| FI98377C (fi) | 1997-06-10 |
| SK279236B6 (sk) | 1998-08-05 |
| SK659090A3 (en) | 1998-08-05 |
| FI98377B (fi) | 1997-02-28 |
| NO922422L (no) | 1992-08-17 |
| JPH05502581A (ja) | 1993-05-13 |
| NO922422D0 (no) | 1992-06-19 |
| NO310305B1 (no) | 2001-06-18 |
| CZ281804B6 (cs) | 1997-02-12 |
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