ES2067916T3 - Matriz con celulas fijadas por adherencia y procedimiento de produccion de virus/antigenos de virus. - Google Patents
Matriz con celulas fijadas por adherencia y procedimiento de produccion de virus/antigenos de virus.Info
- Publication number
- ES2067916T3 ES2067916T3 ES91900666T ES91900666T ES2067916T3 ES 2067916 T3 ES2067916 T3 ES 2067916T3 ES 91900666 T ES91900666 T ES 91900666T ES 91900666 T ES91900666 T ES 91900666T ES 2067916 T3 ES2067916 T3 ES 2067916T3
- Authority
- ES
- Spain
- Prior art keywords
- virus
- cells
- matrix
- viruses
- antigens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000700605 Viruses Species 0.000 title abstract 8
- 239000000427 antigen Substances 0.000 title abstract 5
- 102000036639 antigens Human genes 0.000 title abstract 5
- 108091007433 antigens Proteins 0.000 title abstract 5
- 239000011159 matrix material Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010014599 encephalitis Diseases 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 201000011475 meningoencephalitis Diseases 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2531/00—Microcarriers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24151—Methods of production or purification of viral material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
MATRIZ CON CELULAS UNIDAS ADHERENTES A ELLA, ASI COMO PROCEDIMIENTO PARA LA PRODUCCION DE VIRUS/ANTIGENOS DE VIRUS. LA INVENCION CONSTA DE UNA MATRIZ, ES DECIR UN MATERIAL DE SOPORTE, CON CELULAS HUMANAS O ANIMALES UNIDAS ADHERENTEMENTE A ELLA, ESTANDO LAS CELULAS INFECTADAS CON VIRUS. SE HA MOSTRADO QUE LAS CELULAS DEPENDIENTES DE LA SUPERFICIE, QUE SON APROPIADAS PARA LA MULTIPLICACION DE LOS VIRUS, INCLUSO EN ESTADO INFECTADO POR VIRUS PERMANECEN ADHERIDAS A UNA MATRIZ, PRODUCEN ANTIGENOS DE VIRUS DE FORMA CONSTANTE A LO LARGO DE UN TIEMPO RELATIVAMENTE LARGO Y LOS CEDEN AL MEDIO DE CULTIVO. PARA LA PRODUCCION DEL ANTIGENO DEL VIRUS DE LA MENINGOENCEFALITIS ESTIVAL (FSME) MEDIANTE CULTIVO DEL VIRUS FSME EN CULTIVOS CELULARES SE VACUNA CON EL VIRUS FSME UNA LINEA CELULAR PERMANENTE DEPENDIENTE DE LA SUPERFICIE, PREFERENTEMENTE LA LINEA CELULAR VERO ATTC CCL 81, Y LAS CELULAS SE MANTIENEN UNIDAS A SOPORTES CONSERVANDO EL CRECIMIENTO CELULAR EN UN SISTEMA SIN SUERO NO LITICO, PARA CONSERVARLA FORMACION DE ANTIGENOS, SEPARANDO A CONTINUACION EL MEDIO QUE CONTIENE LOS ANTIGENOS DE LAS CELULAS UNIDAS AL SOPORTE Y DE FORMA CONOCIDA MEDIANTE CONCENTRACION, INACTIVACION Y PURIFICACION SE PREPARA UN COMPUESTO GALENICO ACEPTABLE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT2928/89A AT393356B (de) | 1989-12-22 | 1989-12-22 | Verfahren zur herstellung von fsme-virus-antigen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2067916T3 true ES2067916T3 (es) | 1995-04-01 |
Family
ID=3542524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91900666T Expired - Lifetime ES2067916T3 (es) | 1989-12-22 | 1990-12-21 | Matriz con celulas fijadas por adherencia y procedimiento de produccion de virus/antigenos de virus. |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0506714B1 (es) |
| JP (1) | JP2633391B2 (es) |
| AT (2) | AT393356B (es) |
| CA (1) | CA2071954C (es) |
| CZ (1) | CZ281804B6 (es) |
| DE (1) | DE59007659D1 (es) |
| DK (1) | DK0506714T3 (es) |
| ES (1) | ES2067916T3 (es) |
| FI (1) | FI98377C (es) |
| HR (1) | HRP921354A2 (es) |
| HU (1) | HU213886B (es) |
| NO (1) | NO310305B1 (es) |
| RU (1) | RU2082757C1 (es) |
| SK (1) | SK659090A3 (es) |
| WO (1) | WO1991009935A1 (es) |
| YU (1) | YU242390A (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996015231A2 (en) * | 1994-11-10 | 1996-05-23 | Immuno Aktiengesellschaft | Method for producing biologicals in protein-free culture |
| FR2737412B1 (fr) * | 1995-08-01 | 1997-10-24 | Pasteur Merieux Serums Vacc | Procede de production d'un vaccin contre le virus de l'encephalite japonaise et vaccin obtenu par ce procede |
| EP0841942B2 (fr) * | 1995-08-01 | 2007-12-12 | Sanofi Pasteur | Procede de production industrielle d'un vaccin contre l'encephalite japonaise et vaccin obtenu |
| AU743546B2 (en) * | 1998-10-05 | 2002-01-31 | Research Foundation For Microbial Diseases Of Osaka University, The | Enhanced immunogen for inactivated vaccine for infection with Japanese encephalitis viruses and process for producing the same |
| AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| US6951752B2 (en) | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
| US6855535B2 (en) * | 2001-12-10 | 2005-02-15 | Baxter Healthcare S.A. | Method of large scale production of Hepatitis A virus |
| JP2007068401A (ja) * | 2003-08-07 | 2007-03-22 | Chemo Sero Therapeut Res Inst | 西ナイルウイルスワクチン |
| DK2235197T3 (en) * | 2007-12-27 | 2017-10-09 | Baxalta GmbH | Methods of cell culture |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT358167B (de) * | 1978-12-22 | 1980-08-25 | Immuno Ag | Verfahren zur herstellung von fruehsommer- -meningoenzephalitis-virus (fsme-virus)- -vakzinen |
| SE445116B (sv) * | 1979-09-12 | 1986-06-02 | Pharmacia Fine Chemicals Ab | Sett att odla celler pa mikroberare med fibronektinytskikt |
| NO161446C (no) * | 1981-03-13 | 1989-08-16 | Damon Biotech Inc | Fremgangsmaate for dyrking av celler som er avhengige av forankring. |
| SE8103138L (sv) * | 1981-05-19 | 1982-11-20 | Pharmacia Fine Chemicals Ab | Mikroberare for odling av forankringsberoende celler |
| CA1206900A (en) * | 1981-12-21 | 1986-07-02 | Raymond L. Downs | Hollow glass shell microcarrier for growth of cell cultures, and method of shell manufacture |
| AT385203B (de) * | 1985-04-26 | 1988-03-10 | Immuno Ag | Verfahren zur herstellung einer fruehsommermeningoenzephalitis-virus (fsme-virus)-vakzine |
| DD274336A3 (de) * | 1985-10-03 | 1989-12-20 | Npo Biolar | Verfahren zur Gewinnung einer Mikroträgersubstanz für die Zellkultivierung |
-
1989
- 1989-12-22 AT AT2928/89A patent/AT393356B/de not_active IP Right Cessation
-
1990
- 1990-12-21 DE DE59007659T patent/DE59007659D1/de not_active Expired - Fee Related
- 1990-12-21 JP JP50113291A patent/JP2633391B2/ja not_active Expired - Fee Related
- 1990-12-21 CZ CS906590A patent/CZ281804B6/cs not_active IP Right Cessation
- 1990-12-21 ES ES91900666T patent/ES2067916T3/es not_active Expired - Lifetime
- 1990-12-21 YU YU242390A patent/YU242390A/sh unknown
- 1990-12-21 CA CA 2071954 patent/CA2071954C/en not_active Expired - Lifetime
- 1990-12-21 RU SU905052769A patent/RU2082757C1/ru not_active IP Right Cessation
- 1990-12-21 EP EP19910900666 patent/EP0506714B1/de not_active Expired - Lifetime
- 1990-12-21 AT AT91900666T patent/ATE113652T1/de not_active IP Right Cessation
- 1990-12-21 SK SK6590-90A patent/SK659090A3/sk not_active IP Right Cessation
- 1990-12-21 WO PCT/AT1990/000128 patent/WO1991009935A1/de active IP Right Grant
- 1990-12-21 DK DK91900666T patent/DK0506714T3/da not_active Application Discontinuation
- 1990-12-21 HU HU9202009A patent/HU213886B/hu unknown
-
1992
- 1992-06-18 FI FI922851A patent/FI98377C/fi active
- 1992-06-19 NO NO19922422A patent/NO310305B1/no not_active IP Right Cessation
- 1992-11-25 HR HRP921354 patent/HRP921354A2/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE59007659D1 (de) | 1994-12-08 |
| EP0506714A1 (de) | 1992-10-07 |
| AT393356B (de) | 1991-10-10 |
| HU9202009D0 (en) | 1992-10-28 |
| SK279236B6 (sk) | 1998-08-05 |
| WO1991009935A1 (de) | 1991-07-11 |
| HUT65410A (en) | 1994-06-28 |
| CZ281804B6 (cs) | 1997-02-12 |
| EP0506714B1 (de) | 1994-11-02 |
| FI98377C (fi) | 1997-06-10 |
| RU2082757C1 (ru) | 1997-06-27 |
| ATA292889A (de) | 1991-03-15 |
| NO922422D0 (no) | 1992-06-19 |
| FI922851A0 (fi) | 1992-06-18 |
| HRP921354A2 (en) | 1996-02-29 |
| NO310305B1 (no) | 2001-06-18 |
| SK659090A3 (en) | 1998-08-05 |
| CA2071954C (en) | 1996-06-18 |
| NO922422L (no) | 1992-08-17 |
| FI98377B (fi) | 1997-02-28 |
| JPH05502581A (ja) | 1993-05-13 |
| ATE113652T1 (de) | 1994-11-15 |
| CZ659090A3 (en) | 1996-11-13 |
| CA2071954A1 (en) | 1991-06-23 |
| HU213886B (en) | 1997-11-28 |
| FI922851A (fi) | 1992-06-18 |
| JP2633391B2 (ja) | 1997-07-23 |
| YU242390A (sh) | 1993-05-28 |
| DK0506714T3 (da) | 1995-04-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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