ES2042828T3 - Procedimiento de preparacion de vacunas contra tumores modificadas por virus para la inmunoterapia de metastasis de tumores. - Google Patents
Procedimiento de preparacion de vacunas contra tumores modificadas por virus para la inmunoterapia de metastasis de tumores.Info
- Publication number
- ES2042828T3 ES2042828T3 ES89103480T ES89103480T ES2042828T3 ES 2042828 T3 ES2042828 T3 ES 2042828T3 ES 89103480 T ES89103480 T ES 89103480T ES 89103480 T ES89103480 T ES 89103480T ES 2042828 T3 ES2042828 T3 ES 2042828T3
- Authority
- ES
- Spain
- Prior art keywords
- immunotherapy
- tumor
- preparation procedure
- vaccine preparation
- virus modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 241000700605 Viruses Species 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 206010027476 Metastases Diseases 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 230000009401 metastasis Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000005855 radiation Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18133—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
LA PATENTE MUESTRA VACUNAS DE VIRUS MODIFICADOS, ESPECIFICAS DE TUMORES QUE CONSTAN DE LAS CORRESPONDIENTES CELULAS TUMORALES INACTIVADAS MEDIANTE RADIACION SEPARADAS, INCUBADAS CON VIRUS NDV BAJO CONDICIONES ESTERILES EN UN MEDIO SIN SUERO, IRRADIANDOSE DE NUEVO -EN SU CASO- LA VACUNA ANTES DE SU APLICACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3806565A DE3806565A1 (de) | 1988-03-01 | 1988-03-01 | Virusmodifizierte tumorvakzinen fuer die immuntherapie von tumormetastasen |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2042828T3 true ES2042828T3 (es) | 1993-12-16 |
Family
ID=6348527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89103480T Expired - Lifetime ES2042828T3 (es) | 1988-03-01 | 1989-02-27 | Procedimiento de preparacion de vacunas contra tumores modificadas por virus para la inmunoterapia de metastasis de tumores. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5273745A (es) |
EP (1) | EP0331102B1 (es) |
JP (1) | JPH02504034A (es) |
KR (1) | KR900700130A (es) |
AT (1) | ATE90877T1 (es) |
AU (1) | AU3188989A (es) |
DE (2) | DE3806565A1 (es) |
DK (1) | DK541889D0 (es) |
ES (1) | ES2042828T3 (es) |
WO (1) | WO1989007946A1 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3922444A1 (de) * | 1988-03-01 | 1991-01-10 | Deutsches Krebsforsch | Virusmodifizierte tumorvakzine fuer die immuntherapie von tumormetastasen |
DE4204132C2 (de) * | 1991-02-12 | 1997-12-18 | Rudolf Dr Pekar | Aufbereitung für die Gewinnung von Vakzinen für eine Immuntherapie |
DE69232890T2 (de) * | 1991-10-04 | 2003-10-09 | Whitehead Biomedical Inst | Regulierung der systemischen immunantworten mittels zytokinen und antigenen |
WO1994025627A1 (en) | 1993-04-30 | 1994-11-10 | Lorence Robert M | Methods of treating and detecting cancer using viruses |
DE19506483A1 (de) * | 1995-02-24 | 1996-08-29 | Jens Dr Dr Atzpodien | Lyophilisat-Vakzine |
US6406689B1 (en) | 1995-10-03 | 2002-06-18 | Frank W. Falkenberg | Compositions and methods for treatment of tumors and metastatic diseases |
EP0805207A1 (en) * | 1996-05-02 | 1997-11-05 | Gesellschaft für Biotechnologische Forschung mbH (GBF) | Polycistronic expression plasmid for tumor rejection |
ATE245163T1 (de) * | 1996-05-03 | 2003-08-15 | Univ Jefferson | Impfstoff gegen metastasierenden kolorektalkrebs. |
IL125747A0 (en) * | 1996-10-04 | 1999-04-11 | Univ Jefferson | T cells mediating an immune response and methods of use |
EP0904786B1 (en) * | 1997-08-22 | 2004-12-15 | Science Park Raf S.p.A. | Tumor vaccination by use of autologous or HLA-related antigen presenting cell (APC) transduced with a tumour antigen and a foreign antigen capable of causing an immune reaction |
TW575420B (en) * | 1997-09-22 | 2004-02-11 | Kirin Brewery | Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides |
US7780962B2 (en) * | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
US7470426B1 (en) | 1997-10-09 | 2008-12-30 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
US20030044384A1 (en) * | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
HUP0302278A3 (en) * | 1999-04-15 | 2011-01-28 | Pro Virus | Treatment of neoplasms with viruses |
US8147822B1 (en) | 1999-09-17 | 2012-04-03 | Wellstat Biologics Corporation | Oncolytic virus |
EP1092439A1 (en) * | 1999-10-13 | 2001-04-18 | Thorsten Dr. Ahlert | Activation of antigen-specific T cells by virus/antigen-treated dendritic cells |
RU2172182C1 (ru) * | 2000-07-27 | 2001-08-20 | Бритов Василий Александрович | Способ профилактики и лечения заболеваний иммунной системы и средство для его осуществления |
WO2004096244A1 (en) * | 2003-05-02 | 2004-11-11 | Md Bioalpha Co. Ltd. | Method of preparing tumor vaccine for the inducement of anti-tumor activity and a pharmaceutical composition containing the same |
PT2529747T (pt) | 2005-12-02 | 2018-05-09 | Icahn School Med Mount Sinai | Vírus da doença de newcastle quiméricos que apresentam proteínas de superfície não nativas e suas utilizações |
US9283266B2 (en) * | 2008-02-28 | 2016-03-15 | University Of Notre Dame | Metastasis inhibition preparations and methods |
JPWO2010030002A1 (ja) | 2008-09-12 | 2012-02-02 | 国立大学法人三重大学 | 外来性gitrリガンド発現細胞 |
WO2010036652A1 (en) * | 2008-09-23 | 2010-04-01 | Thomas Jefferson University | Cancer vaccines against mucosal antigens and methods of making and using the same |
ES2380289T3 (es) | 2009-11-30 | 2012-05-10 | United Cancer Research Institute | Nuevo clon del virus de la enfermedad de Newcastle, su fabricación y aplicación en el tratamiento médico del cáncer |
GEP20196976B (en) | 2013-03-14 | 2019-06-10 | Sloan Kettering Cancer Center Memorial | Newcastle disease viruses and uses thereof |
EP3441084A1 (en) | 2014-02-27 | 2019-02-13 | Viralytics Limited | Oncolytic virus and immuno-stimulatory agent for combined use in the treatment of cancer |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2918927A1 (de) * | 1979-05-10 | 1980-11-20 | Hans Prof Dr Limburg | Arzneipraeparat zur behandlung von carcinomen und verfahren zu dessen herstellung |
DE3432714A1 (de) * | 1984-09-06 | 1986-04-24 | Behringwerke Ag, 3550 Marburg | Tumortherapeutikum und verfahren zu seiner herstellung |
HU197517B (en) * | 1984-07-30 | 1989-04-28 | Laszlo Csatary | Process for production of terapeutical composition applicable against virus infection |
-
1988
- 1988-03-01 DE DE3806565A patent/DE3806565A1/de active Granted
-
1989
- 1989-02-27 AT AT89103480T patent/ATE90877T1/de active
- 1989-02-27 DE DE8989103480T patent/DE58904760D1/de not_active Expired - Fee Related
- 1989-02-27 US US07/449,851 patent/US5273745A/en not_active Expired - Fee Related
- 1989-02-27 EP EP19890103480 patent/EP0331102B1/de not_active Expired - Lifetime
- 1989-02-27 ES ES89103480T patent/ES2042828T3/es not_active Expired - Lifetime
- 1989-02-27 KR KR1019890702004A patent/KR900700130A/ko not_active Application Discontinuation
- 1989-02-27 WO PCT/EP1989/000186 patent/WO1989007946A1/de unknown
- 1989-02-27 AU AU31889/89A patent/AU3188989A/en not_active Abandoned
- 1989-02-27 JP JP1502563A patent/JPH02504034A/ja active Pending
- 1989-10-31 DK DK541889A patent/DK541889D0/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1989007946A1 (en) | 1989-09-08 |
US5273745A (en) | 1993-12-28 |
AU3188989A (en) | 1989-09-22 |
DK541889A (da) | 1989-10-31 |
KR900700130A (ko) | 1990-08-11 |
DE3806565C2 (es) | 1991-04-25 |
DK541889D0 (da) | 1989-10-31 |
ATE90877T1 (de) | 1993-07-15 |
DE3806565A1 (de) | 1989-09-14 |
EP0331102A1 (de) | 1989-09-06 |
EP0331102B1 (de) | 1993-06-23 |
DE58904760D1 (de) | 1993-07-29 |
JPH02504034A (ja) | 1990-11-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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