CY1106848T1 - Τροποποιημενος ιος vaccinia ankara για τον εμβολιασμο νεογνων - Google Patents
Τροποποιημενος ιος vaccinia ankara για τον εμβολιασμο νεογνωνInfo
- Publication number
- CY1106848T1 CY1106848T1 CY20071101154T CY071101154T CY1106848T1 CY 1106848 T1 CY1106848 T1 CY 1106848T1 CY 20071101154 T CY20071101154 T CY 20071101154T CY 071101154 T CY071101154 T CY 071101154T CY 1106848 T1 CY1106848 T1 CY 1106848T1
- Authority
- CY
- Cyprus
- Prior art keywords
- virus
- vaccination
- newborn
- relates
- antigens
- Prior art date
Links
- 238000002255 vaccination Methods 0.000 title abstract 5
- 241001183012 Modified Vaccinia Ankara virus Species 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 abstract 8
- 239000000427 antigen Substances 0.000 abstract 6
- 102000036639 antigens Human genes 0.000 abstract 6
- 108091007433 antigens Proteins 0.000 abstract 6
- 241001465754 Metazoa Species 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- 102000014150 Interferons Human genes 0.000 abstract 2
- 108010050904 Interferons Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 210000004443 dendritic cell Anatomy 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 229940079322 interferon Drugs 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 2
- 230000001413 cellular effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
- A61K39/285—Vaccinia virus or variola virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
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- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2710/24011—Poxviridae
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- C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2710/00011—Details
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- C12N2710/24161—Methods of inactivation or attenuation
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
Η εφεύρεση αφορά στη χρήση ενός ιού για την παρασκευή ενός φαρμάκου για τον εμβολιασμό ή το χειρισμό ενός νεογέννητου ή σε εμβρυακή μορφή ζώου, συμπεριλαμβανομένου του ανθρώπου, όπου ο ιός είναι ικανός να μολύνει τα κύτταρα του νεογέννητου ή σε εμβρυακή μορφή ζώου, συμπεριλαμβανομένου του ανθρώπου, αλλά ανίκανος ν' αντιγράφεται σε μολυσματικό ιό απογόνων στο νεογέννητο ή σε εμβρυακή μορφή ζώο, συμπεριλαμβανομένου του ανθρώπου. Ο ιός είναι κατά προτίμηση ένας Τροποποιημένος Ιός Vaccinia Ankara. Συγκεκριμένα, η εφεύρεση αφορά στον εμβολιασμό των νεογνών ενάντια σε μολύνσεις με ιούς που ανήκουν στην ίδια ιική ομάδα με τον ιό που χρησιμοποιείται για τον εμβολιασμό. Επιπλέον, η εφεύρεση αφορά στον εμβολιασμό των νεογνών ενάντια σε αντιγόνα που επιλέγονται από ξενικά αντιγόνα και καρκινικά αντιγόνα, όπου το καρκινικό αντιγόνο και/ή το ξενικό αντιγόνο είναι διαφορετικά από τα αντιγόνα που συνδέονται με τον ιό. Η εφεύρεση περαιτέρω αφορά στη χρήση ιών, όπως ορίστηκαν παραπάνω, προκειμένου να αυξηθεί το επίπεδο των παραγόντων, οι οποίοι ενεργοποιούν τα δενδριτικά κύτταρα ή τα πρόδρομα κύτταρα τους, και/ή να αυξηθεί ο αριθμός των δενδριτικών κυττάρων ή των προδρόμων κυττάρων τους και/ή να αυξηθεί η παραγωγή και/ή το κυτταρικό περιεχόμενο μίας ιντερφερόνης (ΙFΝ) ή ΙL-12.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200200590 | 2002-04-19 | ||
| PCT/EP2003/003994 WO2003088994A2 (en) | 2002-04-19 | 2003-04-16 | Modified vaccinia virus ankara for the vaccination of neonates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1106848T1 true CY1106848T1 (el) | 2012-05-23 |
Family
ID=29225556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20071101154T CY1106848T1 (el) | 2002-04-19 | 2007-09-07 | Τροποποιημενος ιος vaccinia ankara για τον εμβολιασμο νεογνων |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US7897156B2 (el) |
| EP (4) | EP1839672A3 (el) |
| JP (4) | JP4801880B2 (el) |
| KR (2) | KR101028937B1 (el) |
| CN (1) | CN100540051C (el) |
| AT (1) | ATE366586T2 (el) |
| AU (1) | AU2003239805B2 (el) |
| BR (1) | BR0309339A (el) |
| CA (1) | CA2478009C (el) |
| CY (1) | CY1106848T1 (el) |
| DE (1) | DE60314823T3 (el) |
| DK (1) | DK1420822T4 (el) |
| EA (1) | EA011233B1 (el) |
| ES (1) | ES2288609T5 (el) |
| HK (1) | HK1078777A1 (el) |
| IL (1) | IL163701A0 (el) |
| MX (1) | MXPA04010353A (el) |
| NO (1) | NO336348B1 (el) |
| NZ (2) | NZ536592A (el) |
| PL (1) | PL220781B1 (el) |
| PT (1) | PT1420822E (el) |
| SG (1) | SG173216A1 (el) |
| UA (1) | UA85371C2 (el) |
| WO (1) | WO2003088994A2 (el) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ524661A (en) * | 2000-11-23 | 2005-03-24 | Bavarian Nordic As | Modified vaccinia ankara virus variant |
| US7628980B2 (en) * | 2000-11-23 | 2009-12-08 | Bavarian Nordic A/S | Modified vaccinia virus ankara for the vaccination of neonates |
| EP1839672A3 (en) * | 2002-04-19 | 2007-11-21 | Bavarian Nordic A/S | Modified vaccinia virus Ankara for the vaccination of neonates |
| WO2004043490A1 (en) * | 2002-11-07 | 2004-05-27 | Government Of The United States Of America As Represented By The Sercretary Of The Department Of Health And Human Services National Institutes Of Health | Smallpox vaccine regimen |
| BRPI0608310A2 (pt) | 2005-02-23 | 2009-12-08 | Bavarian Nordic As | uso de um poxvìrus modificado para a indução rápida de imunidade contra um poxvìrus ou outros agentes infecciosos |
| EP1835031A1 (en) * | 2006-03-14 | 2007-09-19 | Paul-Ehrlich-Institut Bundesamt für Sera und Impfstoffe | Use of a recombinant modified vaccinia virus Ankara (MVA) for the treatment of type I hypersensitivity in a living animal including humans |
| US8268327B2 (en) | 2007-04-27 | 2012-09-18 | Bavarian Nordic A/S | Immediate protection against pathogens via MVA |
| US20110052627A1 (en) * | 2008-06-20 | 2011-03-03 | Paul Chaplin | Recombinant modified vaccinia virus measles vaccine |
| ES2617926T3 (es) | 2010-11-05 | 2017-06-20 | Bavarian Nordic A/S | Modulación de respuestas inmunitarias por la proteína K4 poxvírica |
| CN103619350A (zh) | 2011-03-11 | 2014-03-05 | 麦克马斯特大学 | 包含组蛋白去乙酰化酶抑制剂的疫苗接种方法 |
| WO2014037124A1 (en) * | 2012-09-04 | 2014-03-13 | Bavarian Nordic A/S | Methods and compositions for enhancing vaccine immune responses |
| EP2968524A1 (en) | 2013-03-15 | 2016-01-20 | Bavarian Nordic A/S | Single high dose of mva induces a protective immune response in neonates and infants |
| WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
| WO2015085147A1 (en) | 2013-12-05 | 2015-06-11 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
| CA2934073A1 (en) | 2013-12-20 | 2015-06-25 | The Broad Institute, Inc. | Combination therapy with neoantigen vaccine |
| EP3234193B1 (en) | 2014-12-19 | 2020-07-15 | Massachusetts Institute of Technology | Molecular biomarkers for cancer immunotherapy |
| EP3757211A1 (en) | 2014-12-19 | 2020-12-30 | The Broad Institute, Inc. | Methods for profiling the t-cell-receptor repertoire |
| UA113442C2 (xx) | 2015-01-27 | 2017-01-25 | Ентеросорбент | |
| RU2020132040A (ru) | 2015-05-20 | 2020-10-12 | Те Брод Инститьют Инк. | Общие неоантигены |
| TW202241500A (zh) | 2015-06-09 | 2022-11-01 | 美商博德研究所有限公司 | 用於贅瘤疫苗之調配物及其製備方法 |
| FR3042121A1 (fr) | 2015-10-08 | 2017-04-14 | Jean-Marc Limacher | Composition anti-tumorale |
| WO2017184590A1 (en) | 2016-04-18 | 2017-10-26 | The Broad Institute Inc. | Improved hla epitope prediction |
| WO2018140391A1 (en) | 2017-01-24 | 2018-08-02 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
| CN111107872A (zh) | 2017-05-12 | 2020-05-05 | 纪念斯隆-凯特林癌症中心 | 有用于癌症免疫疗法的牛痘病毒突变体 |
| WO2020072700A1 (en) | 2018-10-02 | 2020-04-09 | Dana-Farber Cancer Institute, Inc. | Hla single allele lines |
| US20220062394A1 (en) | 2018-12-17 | 2022-03-03 | The Broad Institute, Inc. | Methods for identifying neoantigens |
| TW202043256A (zh) | 2019-01-10 | 2020-12-01 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| WO2023118508A1 (en) * | 2021-12-23 | 2023-06-29 | Bavarian Nordic A/S | Recombinant mva viruses for intraperitoneal administration for treating cancer |
| WO2024015892A1 (en) | 2022-07-13 | 2024-01-18 | The Broad Institute, Inc. | Hla-ii immunopeptidome methods and systems for antigen discovery |
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