TR200102168T2 - BHV-1 geni silinmiş virüs aşısı. - Google Patents
BHV-1 geni silinmiş virüs aşısı.Info
- Publication number
- TR200102168T2 TR200102168T2 TR2001/02168T TR200102168T TR200102168T2 TR 200102168 T2 TR200102168 T2 TR 200102168T2 TR 2001/02168 T TR2001/02168 T TR 2001/02168T TR 200102168 T TR200102168 T TR 200102168T TR 200102168 T2 TR200102168 T2 TR 200102168T2
- Authority
- TR
- Turkey
- Prior art keywords
- animals
- bhv
- virus vaccine
- infected
- gal
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 5
- 230000029812 viral genome replication Effects 0.000 abstract 2
- 101000807236 Human cytomegalovirus (strain AD169) Membrane glycoprotein US3 Proteins 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 241001529453 unidentified herpesvirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16741—Use of virus, viral particle or viral elements as a vector
- C12N2710/16743—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16761—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Pulmonology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Sigir herpesvirüs 1'in (BHV-1) glikoprotein E(gE) kodlayan tabii bölgesinin bir bölümünün silinmesini müteatip islevsel bir yabanci B-gal'yi ihtiva eden bir plasmitin gE lokusuna yerlestirilmesi ile emniyetli canli bir rekombinan virüs ve bir asili hayvanlarla enfekte olmus hayvanlarin birbbirlerinde ayrit edilebilmeleri için immünolojik bir isaret olarak kullanilmaktadir. Ayrica B-gal üretimi sayesinde asilanmis hayvanlarda gE3 1IBRB virüs replikasyonu kolaylikla degerlendirilmakta ve bir fenotip isaretleyici olarak, bu hayvanlarin enfekte hayvanlarda olusan yabani tipe virüs replikasyonundan ayirt edilmeleri saglanmaktadir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/240,173 US6284251B1 (en) | 1996-02-26 | 1999-01-29 | BHV-1 gene-deleted virus vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200102168T2 true TR200102168T2 (tr) | 2001-12-21 |
Family
ID=22905424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/02168T TR200102168T2 (tr) | 1999-01-29 | 2000-01-18 | BHV-1 geni silinmiş virüs aşısı. |
Country Status (26)
Country | Link |
---|---|
US (1) | US6284251B1 (tr) |
EP (1) | EP1155119B1 (tr) |
JP (2) | JP2002535000A (tr) |
CN (1) | CN1197961C (tr) |
AT (1) | ATE342731T1 (tr) |
AU (1) | AU776261B2 (tr) |
BG (1) | BG105701A (tr) |
BR (1) | BR0007855A (tr) |
CA (1) | CA2359177C (tr) |
CZ (1) | CZ20012589A3 (tr) |
DE (1) | DE60031374T2 (tr) |
DK (1) | DK1155119T3 (tr) |
EA (1) | EA005736B1 (tr) |
EE (1) | EE200100396A (tr) |
ES (1) | ES2269101T3 (tr) |
HK (1) | HK1042512B (tr) |
HR (1) | HRP20010476B1 (tr) |
HU (1) | HUP0200560A2 (tr) |
NO (1) | NO20013697L (tr) |
NZ (1) | NZ512125A (tr) |
PT (1) | PT1155119E (tr) |
SK (1) | SK10702001A3 (tr) |
TR (1) | TR200102168T2 (tr) |
UA (1) | UA75035C2 (tr) |
WO (1) | WO2000044884A1 (tr) |
YU (1) | YU45601A (tr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2193842B1 (es) * | 2001-06-28 | 2005-06-01 | Consejo Superior De Investigaciones Cientificas | Virus recombinante de la fiebre aftosa que carece del sitio antigenico a y su utilizacion como vacuna marcada. |
CN101353670B (zh) * | 2007-07-27 | 2012-07-04 | 中国农业科学院哈尔滨兽医研究所 | 牛传染性鼻气管炎病毒重组毒株、其构建方法及应用 |
US8877211B2 (en) | 2011-06-27 | 2014-11-04 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Bovine herpes virus vaccine with multiple mutations |
CN104640991B (zh) * | 2012-07-04 | 2017-09-19 | 昆士兰州农渔林业部 | 重组低毒力1型牛疱疹病毒(BoHV‑1)疫苗载体 |
ES2847203T3 (es) * | 2014-08-01 | 2021-08-02 | The Board Of Supervisors Of Louisiana State Univ And Agricultural And Mechanical College | Detección y tratamiento de herpesvirus bovino |
CN107893056B (zh) * | 2017-12-13 | 2019-08-27 | 江苏省农业科学院 | 山羊疱疹病毒ⅰ型疫苗株及其应用 |
CN108690835B (zh) * | 2018-05-30 | 2021-08-31 | 内蒙古元山生物科技有限公司 | 一株I型牛疱疹病毒gE缺失毒株及其获取方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8305323D0 (en) | 1983-02-25 | 1983-03-30 | Baylor College Medicine | Infectious bovine rhinotracheitis vaccine |
WO1987000862A1 (en) | 1985-07-29 | 1987-02-12 | The Upjohn Company | Virus vaccine |
US4703011A (en) | 1985-11-12 | 1987-10-27 | Novagene, Inc. | Thymidine kinase deletion mutants of bovine herpesvirus-1 |
US5593873A (en) * | 1986-01-27 | 1997-01-14 | Syntro Corporation | Recombinant infectious bovine rhinotracheitis virus |
AU3579089A (en) | 1988-05-03 | 1989-11-29 | Upjohn Company, The | Glycoprotein h of herpes viruses |
FR2693472B1 (fr) | 1992-06-26 | 1994-12-23 | Rhone Merieux | Mutants du virus de la rhinotrachéite infectieuse bovine, délétés dans l'un des gènes des glycoprotéines mineures, vaccins préparés à partir de ces souches, méthodes de production et méthodes d'utilisation. |
NL9100989A (nl) * | 1991-06-07 | 1993-01-04 | Stichting Centr Diergeneeskund | Bovine herpesvirus type 1 deletiemutanten, daarop gebaseerde vaccins, diagnostische kits voor detectie van bovine herpesvirus type 1. |
US5874279A (en) * | 1991-07-18 | 1999-02-23 | Syntro Corporation | Recombinant infectious bovine rhinotracheitis virus |
WO1993002104A1 (en) | 1991-07-18 | 1993-02-04 | Syntro Corporation | Recombinant infectious bovine rhinotracheitis virus |
CA2057387A1 (en) | 1991-12-11 | 1993-06-12 | Lorne A. Babiuk | Recombinant bovine herpesvirus type 1 polypeptides and vaccines |
ES2074965B1 (es) * | 1994-01-31 | 1996-05-01 | Hipra Lab Sa | Virus mutante recombinante de rinotraqueitis infecciosa bovina y vacunas que lo contienen. |
-
1999
- 1999-01-29 US US09/240,173 patent/US6284251B1/en not_active Expired - Fee Related
-
2000
- 2000-01-18 UA UA2001075409A patent/UA75035C2/uk unknown
- 2000-01-18 DK DK00904385T patent/DK1155119T3/da active
- 2000-01-18 DE DE60031374T patent/DE60031374T2/de not_active Expired - Fee Related
- 2000-01-18 CZ CZ20012589A patent/CZ20012589A3/cs unknown
- 2000-01-18 EA EA200100720A patent/EA005736B1/ru not_active IP Right Cessation
- 2000-01-18 HU HU0200560A patent/HUP0200560A2/hu unknown
- 2000-01-18 EP EP00904385A patent/EP1155119B1/en not_active Expired - Lifetime
- 2000-01-18 TR TR2001/02168T patent/TR200102168T2/tr unknown
- 2000-01-18 BR BR0007855-7A patent/BR0007855A/pt not_active IP Right Cessation
- 2000-01-18 YU YU45601A patent/YU45601A/sh unknown
- 2000-01-18 CA CA002359177A patent/CA2359177C/en not_active Expired - Fee Related
- 2000-01-18 AT AT00904385T patent/ATE342731T1/de not_active IP Right Cessation
- 2000-01-18 JP JP2000596128A patent/JP2002535000A/ja active Pending
- 2000-01-18 WO PCT/US2000/001085 patent/WO2000044884A1/en active IP Right Grant
- 2000-01-18 PT PT00904385T patent/PT1155119E/pt unknown
- 2000-01-18 NZ NZ512125A patent/NZ512125A/xx unknown
- 2000-01-18 AU AU26152/00A patent/AU776261B2/en not_active Ceased
- 2000-01-18 ES ES00904385T patent/ES2269101T3/es not_active Expired - Lifetime
- 2000-01-18 SK SK1070-2001A patent/SK10702001A3/sk unknown
- 2000-01-18 EE EEP200100396A patent/EE200100396A/xx unknown
- 2000-01-18 CN CNB008031363A patent/CN1197961C/zh not_active Expired - Fee Related
-
2001
- 2001-06-25 HR HR20010476A patent/HRP20010476B1/xx not_active IP Right Cessation
- 2001-07-12 BG BG105701A patent/BG105701A/bg unknown
- 2001-07-27 NO NO20013697A patent/NO20013697L/no not_active Application Discontinuation
-
2002
- 2002-03-25 HK HK02102265.2A patent/HK1042512B/zh not_active IP Right Cessation
-
2006
- 2006-08-23 JP JP2006226616A patent/JP2007020574A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Yu et al. | DNA-mediated protection against classical swine fever virus | |
ES2061500T3 (es) | Diagnosis y vacunas de la hepatitis delta su preparacion y uso. | |
CA2334857A1 (en) | Interferon inducing genetically engineered attenuated viruses | |
Hu et al. | Prevention of rabies virus infection in dogs by a recombinant canine adenovirus type-2 encoding the rabies virus glycoprotein | |
ES2070997T3 (es) | Virus de herpes recombinante de pavos y vacunas vector vivas derivadas de los mismos. | |
DE69535359D1 (de) | Rekombinantes herpesvirus aus trufhähnen und seine verwendungen | |
EP0261940A3 (en) | Pseudorabies vaccines and dna vectors for recombination with pox viruses | |
IL77694A (en) | Canine parvovirus vaccines comprising viruses of the canine parvovirus strain 154 or viruses derived therefrom by additional cell culture passaging | |
TR200102168T2 (tr) | BHV-1 geni silinmiş virüs aşısı. | |
CY1106570T1 (el) | Σταθερες, εξασθενημενες μεταλλαγμενες μορφες ιου λυσσας και ζωντανια εμβολια αυτων | |
EA200300215A1 (ru) | Вакцинация против вирусов герпеса, ассоциированных с хозяйской клеткой | |
ES8201020A1 (es) | Un procedimiento para preparar una vacuna de virus vivos de la peritonitis infecciosa de los felinos | |
ATE102650T1 (de) | Mutanten des infektioesen bovinen rhinotracheitisvirus, vakzine die sie enthalten, verfahren zu ihrer herstellung und ihrer verwendung. | |
DE69332264D1 (de) | Mutanten des infektiösen rinder rhinotracheitis-virus und impfstoffe | |
Sobrino et al. | Synthetic peptide vaccines: foot-and-mouth disease virus as a model | |
YU49995A (sh) | Polinukleotidna vakcina za virus herpesa | |
ES2074965A1 (es) | Virus mutante recombinante de rinotraqueitis infecciosa bovina y vacunas que lo contienen. | |
Cavanagh | Viral and bacterial vectors of immunogenes | |
HUP0002374A2 (hu) | Egy diszfunkcionális 71 gén régiót tartalmazó rekombináns 1-es típusú ló herpeszvírus (EHV-1) és alkalmazása vakcinaként | |
ES2012815A6 (es) | Un metodo para producir peptidos antigenicos relacionados con el antigeno p97 asociado a melanoma, y para preparar vacunas que los contienen. | |
Tikhonenko | Prospects and achievements in the development of genetically engineered antiviral vaccines. | |
CA2304991A1 (en) | Synthetic gene of bovine viral diarrhoea virus | |
CY1114437T1 (el) | Εμβολια με βαση πολυνουκλεοτιδιο βελτιστοποιημενου κωδικονιου εναντι μολυνσης ανθρωπινου κυτομεγαλοϊου |