DE60031374D1 - Virusimpfstoff charakterisiert durch eine bhv-1-gendeletion - Google Patents

Virusimpfstoff charakterisiert durch eine bhv-1-gendeletion

Info

Publication number
DE60031374D1
DE60031374D1 DE60031374T DE60031374T DE60031374D1 DE 60031374 D1 DE60031374 D1 DE 60031374D1 DE 60031374 T DE60031374 T DE 60031374T DE 60031374 T DE60031374 T DE 60031374T DE 60031374 D1 DE60031374 D1 DE 60031374D1
Authority
DE
Germany
Prior art keywords
bhv
virus
deletion
animals
serves
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60031374T
Other languages
English (en)
Other versions
DE60031374T2 (de
Inventor
I Chowdhury
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kansas State University
Original Assignee
Kansas State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kansas State University filed Critical Kansas State University
Application granted granted Critical
Publication of DE60031374D1 publication Critical patent/DE60031374D1/de
Publication of DE60031374T2 publication Critical patent/DE60031374T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16741—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16743—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16761—Methods of inactivation or attenuation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE60031374T 1999-01-29 2000-01-18 Virusimpfstoff charakterisiert durch eine bhv-1-gendeletion Expired - Fee Related DE60031374T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US240173 1999-01-29
US09/240,173 US6284251B1 (en) 1996-02-26 1999-01-29 BHV-1 gene-deleted virus vaccine
PCT/US2000/001085 WO2000044884A1 (en) 1999-01-29 2000-01-18 Bhv-1 gene-deleted virus vaccine

Publications (2)

Publication Number Publication Date
DE60031374D1 true DE60031374D1 (de) 2006-11-30
DE60031374T2 DE60031374T2 (de) 2007-08-30

Family

ID=22905424

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60031374T Expired - Fee Related DE60031374T2 (de) 1999-01-29 2000-01-18 Virusimpfstoff charakterisiert durch eine bhv-1-gendeletion

Country Status (26)

Country Link
US (1) US6284251B1 (de)
EP (1) EP1155119B1 (de)
JP (2) JP2002535000A (de)
CN (1) CN1197961C (de)
AT (1) ATE342731T1 (de)
AU (1) AU776261B2 (de)
BG (1) BG105701A (de)
BR (1) BR0007855A (de)
CA (1) CA2359177C (de)
CZ (1) CZ20012589A3 (de)
DE (1) DE60031374T2 (de)
DK (1) DK1155119T3 (de)
EA (1) EA005736B1 (de)
EE (1) EE200100396A (de)
ES (1) ES2269101T3 (de)
HK (1) HK1042512B (de)
HR (1) HRP20010476B1 (de)
HU (1) HUP0200560A2 (de)
NO (1) NO20013697L (de)
NZ (1) NZ512125A (de)
PT (1) PT1155119E (de)
SK (1) SK10702001A3 (de)
TR (1) TR200102168T2 (de)
UA (1) UA75035C2 (de)
WO (1) WO2000044884A1 (de)
YU (1) YU45601A (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2193842B1 (es) * 2001-06-28 2005-06-01 Consejo Superior De Investigaciones Cientificas Virus recombinante de la fiebre aftosa que carece del sitio antigenico a y su utilizacion como vacuna marcada.
CN101353670B (zh) * 2007-07-27 2012-07-04 中国农业科学院哈尔滨兽医研究所 牛传染性鼻气管炎病毒重组毒株、其构建方法及应用
US8877211B2 (en) 2011-06-27 2014-11-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Bovine herpes virus vaccine with multiple mutations
CN104640991B (zh) * 2012-07-04 2017-09-19 昆士兰州农渔林业部 重组低毒力1型牛疱疹病毒(BoHV‑1)疫苗载体
PL3194968T3 (pl) * 2014-08-01 2021-04-06 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Wykrywanie i traktowanie bydlęcego wirusa opryszczki
CN107893056B (zh) * 2017-12-13 2019-08-27 江苏省农业科学院 山羊疱疹病毒ⅰ型疫苗株及其应用
CN108690835B (zh) * 2018-05-30 2021-08-31 内蒙古元山生物科技有限公司 一株I型牛疱疹病毒gE缺失毒株及其获取方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8305323D0 (en) 1983-02-25 1983-03-30 Baylor College Medicine Infectious bovine rhinotracheitis vaccine
KR950000887B1 (ko) 1985-07-29 1995-02-03 디 엎죤 캄파니 프로제니터 비루스 왁찐 조성물, 이의 제조방법, 및 이를 사용하여 비루스에 감염된 동물과 왁찐 주사를 맞은 동물을 구별하기 위한 방법
US4703011A (en) 1985-11-12 1987-10-27 Novagene, Inc. Thymidine kinase deletion mutants of bovine herpesvirus-1
US5593873A (en) * 1986-01-27 1997-01-14 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus
WO1989010965A2 (en) 1988-05-03 1989-11-16 The Upjohn Company Glycoprotein h of herpes viruses
FR2693472B1 (fr) 1992-06-26 1994-12-23 Rhone Merieux Mutants du virus de la rhinotrachéite infectieuse bovine, délétés dans l'un des gènes des glycoprotéines mineures, vaccins préparés à partir de ces souches, méthodes de production et méthodes d'utilisation.
NL9100989A (nl) 1991-06-07 1993-01-04 Stichting Centr Diergeneeskund Bovine herpesvirus type 1 deletiemutanten, daarop gebaseerde vaccins, diagnostische kits voor detectie van bovine herpesvirus type 1.
US5874279A (en) * 1991-07-18 1999-02-23 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus
EP0598759A4 (de) 1991-07-18 1998-06-03 Syntro Corp Rekombinanter infektiöser rinder rhinotracheitis virus.
CA2057387A1 (en) 1991-12-11 1993-06-12 Lorne A. Babiuk Recombinant bovine herpesvirus type 1 polypeptides and vaccines
ES2074965B1 (es) * 1994-01-31 1996-05-01 Hipra Lab Sa Virus mutante recombinante de rinotraqueitis infecciosa bovina y vacunas que lo contienen.

Also Published As

Publication number Publication date
HUP0200560A2 (en) 2002-06-29
HK1042512A1 (en) 2002-08-16
SK10702001A3 (sk) 2002-01-07
DE60031374T2 (de) 2007-08-30
JP2002535000A (ja) 2002-10-22
BR0007855A (pt) 2001-10-23
CA2359177C (en) 2007-07-03
CN1364193A (zh) 2002-08-14
CA2359177A1 (en) 2000-08-03
AU2615200A (en) 2000-08-18
HRP20010476B1 (en) 2007-09-30
WO2000044884A1 (en) 2000-08-03
ES2269101T3 (es) 2007-04-01
EA005736B1 (ru) 2005-06-30
UA75035C2 (en) 2006-03-15
EE200100396A (et) 2002-10-15
YU45601A (sh) 2005-06-10
HRP20010476A2 (en) 2002-08-31
DK1155119T3 (da) 2007-02-05
HK1042512B (zh) 2007-05-11
US6284251B1 (en) 2001-09-04
EP1155119B1 (de) 2006-10-18
BG105701A (bg) 2002-03-29
NZ512125A (en) 2003-01-31
AU776261B2 (en) 2004-09-02
NO20013697D0 (no) 2001-07-27
EP1155119A4 (de) 2003-01-02
CZ20012589A3 (cs) 2002-03-13
EP1155119A1 (de) 2001-11-21
EA200100720A1 (ru) 2002-02-28
PT1155119E (pt) 2006-12-29
TR200102168T2 (tr) 2001-12-21
NO20013697L (no) 2001-08-27
JP2007020574A (ja) 2007-02-01
ATE342731T1 (de) 2006-11-15
CN1197961C (zh) 2005-04-20

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee