BR0007855A - Vacina de vìrus eliminado o gene bhv-1 - Google Patents

Vacina de vìrus eliminado o gene bhv-1

Info

Publication number
BR0007855A
BR0007855A BR0007855-7A BR0007855A BR0007855A BR 0007855 A BR0007855 A BR 0007855A BR 0007855 A BR0007855 A BR 0007855A BR 0007855 A BR0007855 A BR 0007855A
Authority
BR
Brazil
Prior art keywords
virus
bhv
gene
serves
animals
Prior art date
Application number
BR0007855-7A
Other languages
English (en)
Inventor
Shafiqul I Chowdhury
Original Assignee
Univ Kansas State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kansas State filed Critical Univ Kansas State
Publication of BR0007855A publication Critical patent/BR0007855A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16741—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16743—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16761—Methods of inactivation or attenuation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Patente de Invenção: "VACINA DE VìRUS ELIMINADO O GENE BHV-1". é produzido um vírus recombinante vivo seguro bem como uma vacina por meio da eliminação de uma porção da região codificante de glicoproteína E (gE) nativa de herpesvírus bovino 1 (BHV-1) seguida pela inserção de um plasmídeo incluindo um <225>-gal funcional estranho no lócus da gE. A eliminação do gene da gE atenua o vírus de modo estável e serve como um marcador imunológico diferenciando animais vacinados de animais infectados. Além disso, a produção de <225>-gal possibilita a fácil avaliação de replicação de vírus gE<30>3.1[BR<225> em animais vacinados e serve como um marcador fenotípico o qual a distingue da replicação de vírus do típo selvagem em animais infectados.
BR0007855-7A 1999-01-29 2000-01-18 Vacina de vìrus eliminado o gene bhv-1 BR0007855A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/240,173 US6284251B1 (en) 1996-02-26 1999-01-29 BHV-1 gene-deleted virus vaccine
PCT/US2000/001085 WO2000044884A1 (en) 1999-01-29 2000-01-18 Bhv-1 gene-deleted virus vaccine

Publications (1)

Publication Number Publication Date
BR0007855A true BR0007855A (pt) 2001-10-23

Family

ID=22905424

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0007855-7A BR0007855A (pt) 1999-01-29 2000-01-18 Vacina de vìrus eliminado o gene bhv-1

Country Status (26)

Country Link
US (1) US6284251B1 (pt)
EP (1) EP1155119B1 (pt)
JP (2) JP2002535000A (pt)
CN (1) CN1197961C (pt)
AT (1) ATE342731T1 (pt)
AU (1) AU776261B2 (pt)
BG (1) BG105701A (pt)
BR (1) BR0007855A (pt)
CA (1) CA2359177C (pt)
CZ (1) CZ20012589A3 (pt)
DE (1) DE60031374T2 (pt)
DK (1) DK1155119T3 (pt)
EA (1) EA005736B1 (pt)
EE (1) EE200100396A (pt)
ES (1) ES2269101T3 (pt)
HK (1) HK1042512B (pt)
HR (1) HRP20010476B1 (pt)
HU (1) HUP0200560A2 (pt)
NO (1) NO20013697L (pt)
NZ (1) NZ512125A (pt)
PT (1) PT1155119E (pt)
SK (1) SK10702001A3 (pt)
TR (1) TR200102168T2 (pt)
UA (1) UA75035C2 (pt)
WO (1) WO2000044884A1 (pt)
YU (1) YU45601A (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2193842B1 (es) * 2001-06-28 2005-06-01 Consejo Superior De Investigaciones Cientificas Virus recombinante de la fiebre aftosa que carece del sitio antigenico a y su utilizacion como vacuna marcada.
CN101353670B (zh) * 2007-07-27 2012-07-04 中国农业科学院哈尔滨兽医研究所 牛传染性鼻气管炎病毒重组毒株、其构建方法及应用
US8877211B2 (en) 2011-06-27 2014-11-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Bovine herpes virus vaccine with multiple mutations
CN104640991B (zh) * 2012-07-04 2017-09-19 昆士兰州农渔林业部 重组低毒力1型牛疱疹病毒(BoHV‑1)疫苗载体
EP3194968B1 (en) * 2014-08-01 2020-09-02 The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College Bovine herpesvirus detection and treatment
CN107893056B (zh) * 2017-12-13 2019-08-27 江苏省农业科学院 山羊疱疹病毒ⅰ型疫苗株及其应用
CN108690835B (zh) * 2018-05-30 2021-08-31 内蒙古元山生物科技有限公司 一株I型牛疱疹病毒gE缺失毒株及其获取方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8305323D0 (en) 1983-02-25 1983-03-30 Baylor College Medicine Infectious bovine rhinotracheitis vaccine
US4810634A (en) 1985-07-29 1989-03-07 The Upjohn Company Pseudorabies virus mutants incapable of producing glycoprotein X
US4703011A (en) 1985-11-12 1987-10-27 Novagene, Inc. Thymidine kinase deletion mutants of bovine herpesvirus-1
US5593873A (en) * 1986-01-27 1997-01-14 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus
WO1989010965A2 (en) 1988-05-03 1989-11-16 The Upjohn Company Glycoprotein h of herpes viruses
FR2693472B1 (fr) 1992-06-26 1994-12-23 Rhone Merieux Mutants du virus de la rhinotrachéite infectieuse bovine, délétés dans l'un des gènes des glycoprotéines mineures, vaccins préparés à partir de ces souches, méthodes de production et méthodes d'utilisation.
NL9100989A (nl) 1991-06-07 1993-01-04 Stichting Centr Diergeneeskund Bovine herpesvirus type 1 deletiemutanten, daarop gebaseerde vaccins, diagnostische kits voor detectie van bovine herpesvirus type 1.
AU672583B2 (en) 1991-07-18 1996-10-10 Prutech Research And Development Partnership Recombinant infectious bovine rhinotracheitis virus
US5874279A (en) * 1991-07-18 1999-02-23 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus
CA2057387A1 (en) 1991-12-11 1993-06-12 Lorne A. Babiuk Recombinant bovine herpesvirus type 1 polypeptides and vaccines
ES2074965B1 (es) * 1994-01-31 1996-05-01 Hipra Lab Sa Virus mutante recombinante de rinotraqueitis infecciosa bovina y vacunas que lo contienen.

Also Published As

Publication number Publication date
EP1155119A1 (en) 2001-11-21
NO20013697D0 (no) 2001-07-27
AU2615200A (en) 2000-08-18
DE60031374D1 (de) 2006-11-30
NZ512125A (en) 2003-01-31
PT1155119E (pt) 2006-12-29
EE200100396A (et) 2002-10-15
WO2000044884A1 (en) 2000-08-03
EA005736B1 (ru) 2005-06-30
JP2007020574A (ja) 2007-02-01
EP1155119B1 (en) 2006-10-18
EA200100720A1 (ru) 2002-02-28
UA75035C2 (en) 2006-03-15
SK10702001A3 (sk) 2002-01-07
DE60031374T2 (de) 2007-08-30
CA2359177A1 (en) 2000-08-03
CA2359177C (en) 2007-07-03
YU45601A (sh) 2005-06-10
ES2269101T3 (es) 2007-04-01
CZ20012589A3 (cs) 2002-03-13
HRP20010476B1 (en) 2007-09-30
EP1155119A4 (en) 2003-01-02
CN1197961C (zh) 2005-04-20
HK1042512A1 (en) 2002-08-16
HUP0200560A2 (en) 2002-06-29
BG105701A (bg) 2002-03-29
DK1155119T3 (da) 2007-02-05
TR200102168T2 (tr) 2001-12-21
NO20013697L (no) 2001-08-27
US6284251B1 (en) 2001-09-04
HRP20010476A2 (en) 2002-08-31
AU776261B2 (en) 2004-09-02
HK1042512B (zh) 2007-05-11
ATE342731T1 (de) 2006-11-15
CN1364193A (zh) 2002-08-14
JP2002535000A (ja) 2002-10-22

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010.