ES2142864T3 - Procedimiento y medio de cultivo para la obtencion de celulas infectadas por un virus asociado a la esclerosis en placas. - Google Patents
Procedimiento y medio de cultivo para la obtencion de celulas infectadas por un virus asociado a la esclerosis en placas.Info
- Publication number
- ES2142864T3 ES2142864T3 ES93908989T ES93908989T ES2142864T3 ES 2142864 T3 ES2142864 T3 ES 2142864T3 ES 93908989 T ES93908989 T ES 93908989T ES 93908989 T ES93908989 T ES 93908989T ES 2142864 T3 ES2142864 T3 ES 2142864T3
- Authority
- ES
- Spain
- Prior art keywords
- culture
- infected
- sclerosis
- plates
- sep
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000034189 Sclerosis Diseases 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000003612 virological effect Effects 0.000 abstract 2
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10051—Methods of production or purification of viral material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PROCESO DE OBTENCION IN VITRO DE UN CULTIVO O LINEA CELULAR INFECTADA POR UNA CEPA VIRAL ASOCIADA A LA ESCLEROSIS EN PLACAS (SEP), SEGUN EL CUAL SE TOMA UNA MUESTRA DE UN INDIVIDUO AFECTADO DE SEP, SE CULTIVA DICHA MUESTRA EN UN MEDIO DE CULTIVO QUE FAVORECE EL CRECIMIENTO DE LAS CELULAS INFECTADAS, PARA OBTENER UN CULTIVO DE CELULAS PRIMARIAS INFECTADAS, Y SE CULTIVA EN SERIE, ES DECIR POR PASOS SUCESIVOS, EN DICHO MEDIO DE CULTIVO, UNA MUESTRA DEL CULTIVO DE CELULAS PRIMARIAS, O DE UN SUBCULTIVO DE ESTA ULTIMA, PARA OBTENER EL CULTIVO O LA DESCENDENCIA CELULAR INFECTADA POR UN VIRUS ASOCIADO A LA SEP, LA INVENCION SE CARACTERIZA QUE EL MEDIO DE CULTIVO CONTIENE ADEMAS UN ANTICUERPO ANTIINTERFERON BETA, O DIRIGIDO CONTRA UNA MOLECULA ANTIGENICAMENTE PROXIMA, JUGANDO UN PAPEL INHIBIDOR EN LA EXPRESION VIRAL, QUE PERMITE EXPRESAR DE MANERA PERSISTENTE Y PROPAGAN LA CEPA VIRAL EN EL CULTIVO O DESCENDENCIA CELULAR.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9204322A FR2689519B1 (fr) | 1992-04-03 | 1992-04-03 | Procédé de culture in vitro de cellules infectées par un virus associé à la sclérose en plaques et lignées cellulaires obtenues. |
FR9213443A FR2689520B1 (fr) | 1992-04-03 | 1992-11-03 | Procede et milieu de culture pour l'obtention de cellules infectees par un virus associe a la sclerose en plaques. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2142864T3 true ES2142864T3 (es) | 2000-05-01 |
Family
ID=26229388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93908989T Expired - Lifetime ES2142864T3 (es) | 1992-04-03 | 1993-04-02 | Procedimiento y medio de cultivo para la obtencion de celulas infectadas por un virus asociado a la esclerosis en placas. |
Country Status (9)
Country | Link |
---|---|
US (3) | US5650318A (es) |
EP (2) | EP0587873B1 (es) |
AT (2) | ATE188993T1 (es) |
CA (1) | CA2110703C (es) |
DE (2) | DE69327623T2 (es) |
DK (1) | DK0587873T3 (es) |
ES (1) | ES2142864T3 (es) |
FR (1) | FR2689520B1 (es) |
WO (1) | WO1993020188A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2715939B1 (fr) * | 1994-02-04 | 1996-08-02 | Bio Merieux | Virus MSRV2 associé à la sclérose en plaques, et ses constituants nucléiques. |
FR2728585A1 (fr) * | 1994-12-23 | 1996-06-28 | Bio Merieux | Virus msrv1 et agent pathogene et/ou infectant msrv2 associes a la sclerose en plaques et leurs constituants nucleiques |
FR2715936B1 (fr) * | 1994-02-04 | 1996-04-19 | Bio Merieux | Virus MSRV1 associé à la sclérose en plaques, et ses constituants nucléiques. |
US5871996A (en) | 1994-02-04 | 1999-02-16 | Bio Merieux | Retrovirus agents MSRV1 and MSRV2 associated with multiple sclerosis |
FR2715938B1 (fr) * | 1994-02-04 | 1997-01-10 | Bio Merieux | Constituants nucléiques du virus MSRV1, associé à la sclérose en plaques. |
FR2727428B1 (fr) * | 1994-11-24 | 1997-04-30 | Bio Merieux | Virus msrv1 associe a la sclerose en plaques et ses constituants nucleiques |
FR2715937A1 (fr) * | 1994-02-04 | 1995-08-11 | Bio Merieux | Virus MSRV1 et MSRV2 associés ensemble à la sclérose en plaques et leurs constituants nucléiques. |
FR2689520B1 (fr) * | 1992-04-03 | 1996-07-19 | Bio Merieux | Procede et milieu de culture pour l'obtention de cellules infectees par un virus associe a la sclerose en plaques. |
FR2689521B1 (fr) * | 1992-04-03 | 1996-07-19 | Bio Merieux | Procede d'obtention et maintien d'une culture cellulaire viable, infectee par un virus associe a la sclerose en plaques, et produits biologiques derives de ladite culture. |
FR2716198B1 (fr) * | 1994-02-15 | 1996-04-19 | Bio Merieux | Facteur cytotoxique tel qu'associé à la sclérose en plaques, sa détection et sa quantification. |
FR2731356B1 (fr) * | 1995-03-09 | 1997-04-30 | Bio Merieux | Virus msrv-1 et agent pathogene et/ou infectant msrv-2 associes a la polyarthrite rhumatoide |
FR2737500B1 (fr) | 1995-08-03 | 1997-08-29 | Bio Merieux | Materiel viral et fragments nucleotidiques associes a la sclerose en plaques, a des fins de diagnostic, prophylactiques et therapeutiques |
US5840565A (en) | 1995-08-22 | 1998-11-24 | The Regents Of The University Of California | Methods for enhancing the production of viral vaccines in PKR-deficient cell culture |
CA2272845C (en) | 1996-11-26 | 2010-01-12 | Bio Merieux | Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes |
FR2762601B3 (fr) | 1997-04-29 | 1999-06-04 | Bio Merieux | Polypeptide capable de reagir avec les anticorps de patients atteints de sclerose en plaques et utilisations |
FR2765588A1 (fr) | 1997-07-07 | 1999-01-08 | Bio Merieux | Materiel nucleique retroviral et fragments nucleotidiques notamment associes a la sclerose en plaques et/ou la polyarthrite rhumatoide, a des fins de diagnostic, prophylactiques et therapeutiques |
ATE346153T1 (de) * | 1997-07-07 | 2006-12-15 | Bio Merieux | Endogene retrovirale sequenzen, verwandten mit auto-immune krankheiten oder mit schwangerschaftsstörungen |
BR9804283B1 (pt) * | 1998-03-18 | 2010-11-30 | processo para a produção de flavivìrus em baixa densidade de células em cultura e processo para a produção de flavivìrus recombinante em baixa densidade de células em cultura. | |
FR2788784A1 (fr) | 1999-01-21 | 2000-07-28 | Bio Merieux | Fragment nucleique endogene associe a une maladie auto-immune, procede de marquage et reactif |
EP1029917A1 (en) * | 1999-02-15 | 2000-08-23 | Bio Merieux | The LTR region of MSRV-1 and the proteins it encodes, and probes and methods for detecting MSRV-1 retrovirus |
CA2403815A1 (en) * | 2000-03-21 | 2001-09-27 | Ms Research A/S | An infective endogenous retrovirus in association with demyelinating diseases e.g. multiple sclerosis |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1980000412A1 (en) * | 1978-08-24 | 1980-03-20 | N Gilmour | Pasteurellosis vaccines |
US4311686A (en) * | 1979-04-30 | 1982-01-19 | The Immunology Development Corporation | Methodology for the immunodiagnosis of multiple sclerosis and/or malignant diseases from blood sample analysis |
US4396600A (en) * | 1980-12-18 | 1983-08-02 | Gus Gallucci | Adult schistosome worm-derived antigenic substance and method of obtaining same |
US4388298A (en) | 1982-07-14 | 1983-06-14 | The United States Of America As Represented By The Secretary Of Agriculture | Propagation of hemorrhagic enteritis virus in a turkey cell line and vaccine produced |
GB8324800D0 (en) * | 1983-09-15 | 1983-10-19 | Pasteur Institut | Antigens |
US4520113A (en) * | 1984-04-23 | 1985-05-28 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Serological detection of antibodies to HTLV-III in sera of patients with AIDS and pre-AIDS conditions |
US4647773A (en) | 1984-04-23 | 1987-03-03 | The United States Of America As Represented By The Department Of Health And Human Services | Method of continuous production of retroviruses (HTLV-III) from patients with AIDS and pre-AIDS |
NZ218050A (en) | 1985-11-13 | 1989-05-29 | Wistar Inst | Test for the presence of htlv-1v |
US4900553A (en) | 1987-09-11 | 1990-02-13 | Case Western Reserve University | Method of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes |
EP0326395A2 (en) | 1988-01-29 | 1989-08-02 | City Of Hope | Method of detecting and identifying certain viral sequences |
FR2651581B1 (fr) | 1989-09-06 | 1994-05-13 | Centre Nal Recherc Scientifique | Moyens pour le diagnostic de neuropathies demyelinisantes, en particulier de la sclerose en plaques. |
US5219837A (en) | 1990-06-21 | 1993-06-15 | Trustees Of The University Of Pennsylvania | Method of stimulating myelination of cells |
US5158976A (en) | 1990-10-29 | 1992-10-27 | The Children's Medical Center Corporation | Controlling glutamine/glutamate related neuronal injury |
DK173091D0 (da) | 1991-10-11 | 1991-10-11 | Schleroseforeningen The Danish | Biologisk materiale |
FR2689520B1 (fr) * | 1992-04-03 | 1996-07-19 | Bio Merieux | Procede et milieu de culture pour l'obtention de cellules infectees par un virus associe a la sclerose en plaques. |
FR2689521B1 (fr) | 1992-04-03 | 1996-07-19 | Bio Merieux | Procede d'obtention et maintien d'une culture cellulaire viable, infectee par un virus associe a la sclerose en plaques, et produits biologiques derives de ladite culture. |
EP0642585B1 (en) | 1992-05-18 | 2005-12-28 | Genentech, Inc. | Activation of oligomerizing receptors by using fused receptor ligands |
GB9310657D0 (en) | 1993-05-24 | 1993-07-07 | Univ London | Retrovirus |
-
1992
- 1992-11-03 FR FR9213443A patent/FR2689520B1/fr not_active Expired - Fee Related
-
1993
- 1993-04-02 EP EP93908989A patent/EP0587873B1/fr not_active Expired - Lifetime
- 1993-04-02 AT AT93908989T patent/ATE188993T1/de active
- 1993-04-02 WO PCT/FR1993/000336 patent/WO1993020188A1/fr active IP Right Grant
- 1993-04-02 AT AT99113896T patent/ATE301707T1/de not_active IP Right Cessation
- 1993-04-02 DK DK93908989T patent/DK0587873T3/da active
- 1993-04-02 CA CA002110703A patent/CA2110703C/fr not_active Expired - Fee Related
- 1993-04-02 DE DE69327623T patent/DE69327623T2/de not_active Expired - Fee Related
- 1993-04-02 EP EP99113896A patent/EP0957162B1/fr not_active Expired - Lifetime
- 1993-04-02 DE DE69333855T patent/DE69333855T2/de not_active Expired - Lifetime
- 1993-04-02 ES ES93908989T patent/ES2142864T3/es not_active Expired - Lifetime
- 1993-04-02 US US08/157,061 patent/US5650318A/en not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/485,145 patent/US6291225B1/en not_active Expired - Fee Related
-
1996
- 1996-11-20 US US08/754,010 patent/US6071736A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2689520A1 (fr) | 1993-10-08 |
US6291225B1 (en) | 2001-09-18 |
US6071736A (en) | 2000-06-06 |
CA2110703A1 (fr) | 1993-10-14 |
DE69327623T2 (de) | 2000-08-31 |
DE69333855D1 (de) | 2005-09-15 |
CA2110703C (fr) | 2001-12-04 |
ATE188993T1 (de) | 2000-02-15 |
WO1993020188A1 (fr) | 1993-10-14 |
DE69327623D1 (de) | 2000-02-24 |
ATE301707T1 (de) | 2005-08-15 |
EP0957162B1 (fr) | 2005-08-10 |
DE69333855T2 (de) | 2006-09-28 |
US5650318A (en) | 1997-07-22 |
EP0587873A1 (fr) | 1994-03-23 |
FR2689520B1 (fr) | 1996-07-19 |
EP0957162A1 (fr) | 1999-11-17 |
DK0587873T3 (da) | 2000-07-17 |
EP0587873B1 (fr) | 2000-01-19 |
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