ATE301707T1 - Aus einer mit einem stamm von multiple-sklerosis- virus infizierten zellinie hergestelltes biologisches virusmaterial - Google Patents
Aus einer mit einem stamm von multiple-sklerosis- virus infizierten zellinie hergestelltes biologisches virusmaterialInfo
- Publication number
- ATE301707T1 ATE301707T1 AT99113896T AT99113896T ATE301707T1 AT E301707 T1 ATE301707 T1 AT E301707T1 AT 99113896 T AT99113896 T AT 99113896T AT 99113896 T AT99113896 T AT 99113896T AT E301707 T1 ATE301707 T1 AT E301707T1
- Authority
- AT
- Austria
- Prior art keywords
- virus
- culture
- viral
- cell line
- infected
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 6
- 201000006417 multiple sclerosis Diseases 0.000 title abstract 5
- 239000012620 biological material Substances 0.000 title 1
- 230000003612 virological effect Effects 0.000 abstract 4
- 239000001963 growth medium Substances 0.000 abstract 2
- 102000003996 Interferon-beta Human genes 0.000 abstract 1
- 108090000467 Interferon-beta Proteins 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
- 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10051—Methods of production or purification of viral material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9204322A FR2689519B1 (fr) | 1992-04-03 | 1992-04-03 | Procédé de culture in vitro de cellules infectées par un virus associé à la sclérose en plaques et lignées cellulaires obtenues. |
| FR9213443A FR2689520B1 (fr) | 1992-04-03 | 1992-11-03 | Procede et milieu de culture pour l'obtention de cellules infectees par un virus associe a la sclerose en plaques. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE301707T1 true ATE301707T1 (de) | 2005-08-15 |
Family
ID=26229388
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99113896T ATE301707T1 (de) | 1992-04-03 | 1993-04-02 | Aus einer mit einem stamm von multiple-sklerosis- virus infizierten zellinie hergestelltes biologisches virusmaterial |
| AT93908989T ATE188993T1 (de) | 1992-04-03 | 1993-04-02 | Herstellungsmethode um multiple-sklerose-virus- assoziierte infizierte zellen zu erhalten |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93908989T ATE188993T1 (de) | 1992-04-03 | 1993-04-02 | Herstellungsmethode um multiple-sklerose-virus- assoziierte infizierte zellen zu erhalten |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US5650318A (de) |
| EP (2) | EP0587873B1 (de) |
| AT (2) | ATE301707T1 (de) |
| CA (1) | CA2110703C (de) |
| DE (2) | DE69333855T2 (de) |
| DK (1) | DK0587873T3 (de) |
| ES (1) | ES2142864T3 (de) |
| FR (1) | FR2689520B1 (de) |
| WO (1) | WO1993020188A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2715939B1 (fr) * | 1994-02-04 | 1996-08-02 | Bio Merieux | Virus MSRV2 associé à la sclérose en plaques, et ses constituants nucléiques. |
| FR2715938B1 (fr) * | 1994-02-04 | 1997-01-10 | Bio Merieux | Constituants nucléiques du virus MSRV1, associé à la sclérose en plaques. |
| FR2715937A1 (fr) * | 1994-02-04 | 1995-08-11 | Bio Merieux | Virus MSRV1 et MSRV2 associés ensemble à la sclérose en plaques et leurs constituants nucléiques. |
| FR2727428B1 (fr) * | 1994-11-24 | 1997-04-30 | Bio Merieux | Virus msrv1 associe a la sclerose en plaques et ses constituants nucleiques |
| FR2715936B1 (fr) * | 1994-02-04 | 1996-04-19 | Bio Merieux | Virus MSRV1 associé à la sclérose en plaques, et ses constituants nucléiques. |
| FR2728585A1 (fr) * | 1994-12-23 | 1996-06-28 | Bio Merieux | Virus msrv1 et agent pathogene et/ou infectant msrv2 associes a la sclerose en plaques et leurs constituants nucleiques |
| FR2689521B1 (fr) * | 1992-04-03 | 1996-07-19 | Bio Merieux | Procede d'obtention et maintien d'une culture cellulaire viable, infectee par un virus associe a la sclerose en plaques, et produits biologiques derives de ladite culture. |
| FR2689520B1 (fr) | 1992-04-03 | 1996-07-19 | Bio Merieux | Procede et milieu de culture pour l'obtention de cellules infectees par un virus associe a la sclerose en plaques. |
| DE69533863T2 (de) * | 1994-02-04 | 2006-02-16 | Bio Merieux | MSRV1 Virus der mit Multipler Sklerose verbunden ist, seine nukleären Bestandteile und Verwendungen |
| FR2716198B1 (fr) * | 1994-02-15 | 1996-04-19 | Bio Merieux | Facteur cytotoxique tel qu'associé à la sclérose en plaques, sa détection et sa quantification. |
| FR2731356B1 (fr) * | 1995-03-09 | 1997-04-30 | Bio Merieux | Virus msrv-1 et agent pathogene et/ou infectant msrv-2 associes a la polyarthrite rhumatoide |
| FR2737500B1 (fr) | 1995-08-03 | 1997-08-29 | Bio Merieux | Materiel viral et fragments nucleotidiques associes a la sclerose en plaques, a des fins de diagnostic, prophylactiques et therapeutiques |
| US5840565A (en) | 1995-08-22 | 1998-11-24 | The Regents Of The University Of California | Methods for enhancing the production of viral vaccines in PKR-deficient cell culture |
| JP4226657B2 (ja) | 1996-11-26 | 2009-02-18 | ベーイーオー メリュー | 診断、予防、及び治療のための、多発性硬化症に関連するウイルス性物質及びヌクレオチド断片 |
| FR2762601B3 (fr) | 1997-04-29 | 1999-06-04 | Bio Merieux | Polypeptide capable de reagir avec les anticorps de patients atteints de sclerose en plaques et utilisations |
| ES2276468T3 (es) * | 1997-07-07 | 2007-06-16 | Bio Merieux | Secuencias retroviricas endogeneticas, asociados con efermedades autoinmunitarias y/o con transtornos del embarazo. |
| FR2765588A1 (fr) | 1997-07-07 | 1999-01-08 | Bio Merieux | Materiel nucleique retroviral et fragments nucleotidiques notamment associes a la sclerose en plaques et/ou la polyarthrite rhumatoide, a des fins de diagnostic, prophylactiques et therapeutiques |
| BR9804283B1 (pt) * | 1998-03-18 | 2010-11-30 | processo para a produção de flavivìrus em baixa densidade de células em cultura e processo para a produção de flavivìrus recombinante em baixa densidade de células em cultura. | |
| FR2788784A1 (fr) * | 1999-01-21 | 2000-07-28 | Bio Merieux | Fragment nucleique endogene associe a une maladie auto-immune, procede de marquage et reactif |
| EP1029917A1 (de) | 1999-02-15 | 2000-08-23 | Bio Merieux | Die LTR-Region von MSRV und die durch sie kodierten Proteine, und Sonden und Methoden für Detektion des MSRV-1 Retrovirus |
| CA2403815A1 (en) * | 2000-03-21 | 2001-09-27 | Ms Research A/S | An infective endogenous retrovirus in association with demyelinating diseases e.g. multiple sclerosis |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1133829A (en) * | 1978-08-24 | 1982-10-19 | Neil J.L. Gilmour | Pasteurellosis vaccines |
| US4311686A (en) * | 1979-04-30 | 1982-01-19 | The Immunology Development Corporation | Methodology for the immunodiagnosis of multiple sclerosis and/or malignant diseases from blood sample analysis |
| US4396600A (en) * | 1980-12-18 | 1983-08-02 | Gus Gallucci | Adult schistosome worm-derived antigenic substance and method of obtaining same |
| US4388298A (en) | 1982-07-14 | 1983-06-14 | The United States Of America As Represented By The Secretary Of Agriculture | Propagation of hemorrhagic enteritis virus in a turkey cell line and vaccine produced |
| GB8324800D0 (en) * | 1983-09-15 | 1983-10-19 | Pasteur Institut | Antigens |
| US4647773A (en) | 1984-04-23 | 1987-03-03 | The United States Of America As Represented By The Department Of Health And Human Services | Method of continuous production of retroviruses (HTLV-III) from patients with AIDS and pre-AIDS |
| US4520113A (en) * | 1984-04-23 | 1985-05-28 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Serological detection of antibodies to HTLV-III in sera of patients with AIDS and pre-AIDS conditions |
| NZ218050A (en) | 1985-11-13 | 1989-05-29 | Wistar Inst | Test for the presence of htlv-1v |
| US4900553A (en) | 1987-09-11 | 1990-02-13 | Case Western Reserve University | Method of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes |
| EP0326395A2 (de) | 1988-01-29 | 1989-08-02 | City Of Hope | Verfahren zum Nachweis und zur Identifizierung von bestimmten viralen Sequenzien |
| FR2651581B1 (fr) | 1989-09-06 | 1994-05-13 | Centre Nal Recherc Scientifique | Moyens pour le diagnostic de neuropathies demyelinisantes, en particulier de la sclerose en plaques. |
| US5219837A (en) | 1990-06-21 | 1993-06-15 | Trustees Of The University Of Pennsylvania | Method of stimulating myelination of cells |
| US5158976A (en) | 1990-10-29 | 1992-10-27 | The Children's Medical Center Corporation | Controlling glutamine/glutamate related neuronal injury |
| DK173091D0 (da) | 1991-10-11 | 1991-10-11 | Schleroseforeningen The Danish | Biologisk materiale |
| FR2689521B1 (fr) | 1992-04-03 | 1996-07-19 | Bio Merieux | Procede d'obtention et maintien d'une culture cellulaire viable, infectee par un virus associe a la sclerose en plaques, et produits biologiques derives de ladite culture. |
| FR2689520B1 (fr) | 1992-04-03 | 1996-07-19 | Bio Merieux | Procede et milieu de culture pour l'obtention de cellules infectees par un virus associe a la sclerose en plaques. |
| WO1993023550A2 (en) | 1992-05-18 | 1993-11-25 | Genentech, Inc. | Activation of oligomerizing receptors by using fused receptor ligands |
| GB9310657D0 (en) | 1993-05-24 | 1993-07-07 | Univ London | Retrovirus |
-
1992
- 1992-11-03 FR FR9213443A patent/FR2689520B1/fr not_active Expired - Fee Related
-
1993
- 1993-04-02 ES ES93908989T patent/ES2142864T3/es not_active Expired - Lifetime
- 1993-04-02 US US08/157,061 patent/US5650318A/en not_active Expired - Fee Related
- 1993-04-02 EP EP93908989A patent/EP0587873B1/de not_active Expired - Lifetime
- 1993-04-02 EP EP99113896A patent/EP0957162B1/de not_active Expired - Lifetime
- 1993-04-02 DK DK93908989T patent/DK0587873T3/da active
- 1993-04-02 WO PCT/FR1993/000336 patent/WO1993020188A1/fr active IP Right Grant
- 1993-04-02 AT AT99113896T patent/ATE301707T1/de not_active IP Right Cessation
- 1993-04-02 DE DE69333855T patent/DE69333855T2/de not_active Expired - Lifetime
- 1993-04-02 CA CA002110703A patent/CA2110703C/fr not_active Expired - Fee Related
- 1993-04-02 DE DE69327623T patent/DE69327623T2/de not_active Expired - Fee Related
- 1993-04-02 AT AT93908989T patent/ATE188993T1/de active
-
1995
- 1995-06-07 US US08/485,145 patent/US6291225B1/en not_active Expired - Fee Related
-
1996
- 1996-11-20 US US08/754,010 patent/US6071736A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69333855D1 (de) | 2005-09-15 |
| EP0957162A1 (de) | 1999-11-17 |
| EP0957162B1 (de) | 2005-08-10 |
| CA2110703A1 (fr) | 1993-10-14 |
| FR2689520A1 (fr) | 1993-10-08 |
| US6071736A (en) | 2000-06-06 |
| DE69327623D1 (de) | 2000-02-24 |
| US6291225B1 (en) | 2001-09-18 |
| ATE188993T1 (de) | 2000-02-15 |
| DE69327623T2 (de) | 2000-08-31 |
| ES2142864T3 (es) | 2000-05-01 |
| EP0587873A1 (de) | 1994-03-23 |
| FR2689520B1 (fr) | 1996-07-19 |
| EP0587873B1 (de) | 2000-01-19 |
| DK0587873T3 (da) | 2000-07-17 |
| DE69333855T2 (de) | 2006-09-28 |
| US5650318A (en) | 1997-07-22 |
| WO1993020188A1 (fr) | 1993-10-14 |
| CA2110703C (fr) | 2001-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |