YU13701A - GnRH SREDSTVA KOJA NISU PEPTIDI, POSTUPCI I INTERMEDIJERI ZA NJIHOVO DOBIJANJE - Google Patents

GnRH SREDSTVA KOJA NISU PEPTIDI, POSTUPCI I INTERMEDIJERI ZA NJIHOVO DOBIJANJE

Info

Publication number
YU13701A
YU13701A YU13701A YU13701A YU13701A YU 13701 A YU13701 A YU 13701A YU 13701 A YU13701 A YU 13701A YU 13701 A YU13701 A YU 13701A YU 13701 A YU13701 A YU 13701A
Authority
YU
Yugoslavia
Prior art keywords
preparation
methods
intermediates
peptide gnrh
gnrh agents
Prior art date
Application number
YU13701A
Other languages
English (en)
Inventor
Mark Brian Anderson
Haresh N. Vazir
David Robert Luthin
Genevieve Deguzman Paderes
Ved Pathak
Lance Christopher Christie
Yufeng Hong
Eileen Valenzuela Tompkins
Haitao Li
James Faust
Original Assignee
Agouron Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceuticals Inc. filed Critical Agouron Pharmaceuticals Inc.
Publication of YU13701A publication Critical patent/YU13701A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Opisani su nepeptidni GnRH agensi sposobni za inhibiranje efekta hormona koji oslobadja gonadotropin. Takva jedinjenja i njihove farmaceutski prihvatljive soli, multimeri, ciljni lekovi, i aktivni metaboliti pogodni su za lečenje reproduktivnih poremećaja kod sisara i tumora koji su zavisni od steroidnih hormona kao i za regulisanje plodnosti, kada se pokazuje suzbijanje oslobadjanja gonadotropina. Postupci za sintetizovanje jedinjenja i intermedijera korisnih za njihovo dobijanje takodje su opisani.[Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.
YU13701A 1998-08-20 1999-08-20 GnRH SREDSTVA KOJA NISU PEPTIDI, POSTUPCI I INTERMEDIJERI ZA NJIHOVO DOBIJANJE YU13701A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9752098P 1998-08-20 1998-08-20

Publications (1)

Publication Number Publication Date
YU13701A true YU13701A (sh) 2005-06-10

Family

ID=22263796

Family Applications (1)

Application Number Title Priority Date Filing Date
YU13701A YU13701A (sh) 1998-08-20 1999-08-20 GnRH SREDSTVA KOJA NISU PEPTIDI, POSTUPCI I INTERMEDIJERI ZA NJIHOVO DOBIJANJE

Country Status (33)

Country Link
EP (1) EP1105120B1 (sh)
JP (1) JP2002535244A (sh)
KR (1) KR20010085402A (sh)
CN (1) CN1379666A (sh)
AP (1) AP2001002053A0 (sh)
AT (1) ATE291423T1 (sh)
AU (1) AU759310B2 (sh)
BG (1) BG105362A (sh)
BR (1) BR9913374A (sh)
CA (1) CA2341346A1 (sh)
CZ (1) CZ2001523A3 (sh)
DE (1) DE69924387D1 (sh)
EA (1) EA200100255A1 (sh)
EE (1) EE200100102A (sh)
ES (1) ES2237966T3 (sh)
GE (1) GEP20043315B (sh)
HR (1) HRP20010206A2 (sh)
HU (1) HUP0103622A3 (sh)
ID (1) ID29244A (sh)
IL (1) IL141396A0 (sh)
IS (1) IS5846A (sh)
LT (1) LT4904B (sh)
LV (1) LV12732B (sh)
NO (1) NO20010309L (sh)
NZ (1) NZ509252A (sh)
OA (1) OA11599A (sh)
PL (1) PL356984A1 (sh)
SI (1) SI20746A (sh)
SK (1) SK2262001A3 (sh)
TR (1) TR200100631T2 (sh)
WO (1) WO2000020358A2 (sh)
YU (1) YU13701A (sh)
ZA (1) ZA200100831B (sh)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE307795T1 (de) * 1992-04-22 2005-11-15 Ligand Pharm Inc Verbindungen mit retinoid x rezeptorselektivität
JP2003524620A (ja) * 1999-03-24 2003-08-19 アノーメッド インコーポレイティド ケモカインレセプター結合複素環化合物
CO5370679A1 (es) * 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
MXPA03011002A (es) * 2001-06-06 2004-10-28 Agouron Pharma Agentes gnrh no peptidicos, composiciones farmaceuticas y procedimientos para su uso y procesos para prepararlos a ellos y a sus intermedios.
SK288015B6 (sk) * 2001-06-11 2012-11-05 Virochem Pharma Inc. Thiophene derivatives as antiviral agents for flavivirus infection
WO2003030902A1 (en) 2001-10-09 2003-04-17 Tularik Inc. Imidazole derivates as anti-inflammatory agents
GB0126292D0 (en) * 2001-11-01 2002-01-02 Smithkline Beecham Plc Compounds
JP2005170790A (ja) * 2002-01-09 2005-06-30 Ajinomoto Co Inc Ｎ−アルキルスルフォニル置換アミド誘導体
US6521395B1 (en) * 2002-01-30 2003-02-18 Eastman Kodak Company Infrared couplers for incorporating and recovering metadata
WO2003068769A1 (en) * 2002-02-12 2003-08-21 Pfizer Inc. Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh)
TW200304820A (en) * 2002-03-25 2003-10-16 Avanir Pharmaceuticals Use of benzimidazole analogs in the treatment of cell proliferation
CA2489252A1 (en) * 2002-06-13 2003-12-24 Pfizer Inc. Non-peptide gnrh agents, pharmaceutical compositions and methods for their use
DE60307313T2 (de) * 2002-11-20 2006-12-14 Paradigm Therapeutics Ltd. Heterozyklische siliziumverbindungen und deren verwendung zur behandlung von krankheiten oder zuständen, die mit gnrh (gonadotropinfreisetzendem hormon) assoziiert sind
CN101475528A (zh) * 2003-03-31 2009-07-08 大正制药株式会社 新的喹啉、四氢喹唑啉和嘧啶衍生物以及与其应用有关的治疗方法
EP1464335A3 (en) * 2003-03-31 2007-05-09 Taisho Pharmaceutical Co. Ltd. Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist
US7427683B2 (en) * 2003-04-25 2008-09-23 Ortho-Mcneil Pharmaceutical, Inc. c-fms kinase inhibitors
MXPA05011503A (es) * 2003-04-25 2006-05-31 Johnson & Johnson Inhibidores de la c-fms cinasa.
US20050004133A1 (en) * 2003-06-05 2005-01-06 Makings Lewis R. Modulators of VR1 receptor
US20070111967A1 (en) * 2003-07-09 2007-05-17 Miller David J Organosilicon compounds and their use
EP1644385B1 (en) * 2003-07-10 2007-08-29 Takeda Cambridge Limited Silicon compounds and their use
WO2005039564A1 (en) * 2003-10-02 2005-05-06 Vertex Pharmaceuticals Incorporated Phthalimide compounds useful as protein kinase inhibitors
US20090291915A1 (en) * 2004-12-17 2009-11-26 Graham Andrew Showell Silicon Compounds and Their Use
AP2007004245A0 (en) 2005-05-13 2007-12-31 Virochem Pharma Inc Compounds and methods for the treatment or prevention of flavivirus infections
JP5118029B2 (ja) 2005-06-14 2013-01-16 タイゲン バイオテクノロジー カンパニー，リミテッド ピリミジン化合物
US8193206B2 (en) 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
CA2613162A1 (en) * 2005-06-28 2007-01-04 Takeda Cambridge Limited Heterocyclic non-peptide gnrh antagonists
AU2006278397B2 (en) * 2005-08-04 2013-01-17 Sirtris Pharmaceuticals, Inc. Oxazolopyridine derivatives as sirtuin modulators
JP5255559B2 (ja) 2006-03-31 2013-08-07 アボット・ラボラトリーズ インダゾール化合物
WO2007131996A1 (en) * 2006-05-12 2007-11-22 Genmedica Therapeutics Sl Meta-xylylenediamine vanadate salts
TW200916472A (en) 2007-06-20 2009-04-16 Sirtris Pharmaceuticals Inc Sirtuin modulating compounds
MX2010003866A (es) * 2007-10-11 2010-06-01 Vertex Pharma Heteroaril amidas utiles como inhibidores de canales de sodio dependientes de voltaje.
NZ585587A (en) 2007-10-31 2012-04-27 Res Found Itsuu Lab Retinoid prodrug compound
PT2268635E (pt) 2008-04-21 2015-10-06 Taigen Biotechnology Co Ltd Compostos heterocíclicos
UY31984A (es) * 2008-07-16 2010-02-26 Boehringer Ingelheim Int DERIVADOS DE 1-(3,4-difluorobencil)-6-oxo-1,6-dihidropirimidin-5-carboxamidas N-sustituidas y de 2-(3,4-difluorobencil)-3-oxo-2,3-dihidro-1H-pirazol-4-carboxamidas N-sustituidas.
WO2010056847A2 (en) 2008-11-13 2010-05-20 Taigen Biotechnology Co., Ltd. Lyophilization formulation
EP2611784A4 (en) 2010-08-05 2014-01-08 Amgen Inc BENZIMIDAZOLE AND AZABENEZIMIDAZOLE COMPOUNDS FOR INHIBITING THE ANAPLASTIC LYMPHOMINE KINASE
CN102050823A (zh) * 2010-10-27 2011-05-11 华东理工大学 新型光稳定剂-鸟嘌呤类似物的合成及表征
US9199918B2 (en) * 2011-02-15 2015-12-01 Georgetown University Small molecule inhibitors of AGBL2
JP6254075B2 (ja) 2011-05-16 2017-12-27 バイオノミックス リミテッド カリウムチャネル遮断剤としてのアミン誘導体
EP3037417B1 (en) 2011-07-26 2019-05-22 Sanofi 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
US9586914B2 (en) 2011-11-07 2017-03-07 The University Of Queensland Modulators of C3a receptors
JP2016504270A (ja) * 2012-10-17 2016-02-12 ザ ユニバーシティ オブ ブリストル 眼血管形成（ｏｃｕｌａｒｎｅｏｖａｓｃｕｌａｎ）を治療するのに有用な化合物
GB201300304D0 (en) * 2013-01-08 2013-02-20 Kalvista Pharmaceuticals Ltd Benzylamine derivatives
WO2017070235A1 (en) * 2015-10-19 2017-04-27 Attenua, Inc. Antitussive compositions and methods
CN111315735B (zh) 2017-09-04 2024-03-08 C4医药公司 二氢苯并咪唑酮
EP3935050A4 (en) 2019-03-06 2023-01-04 C4 Therapeutics, Inc. HETEROCYCLIC COMPOUNDS FOR MEDICAL TREATMENT

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3499002A (en) * 1968-06-20 1970-03-03 Robins Co Inc A H 1-carbamoyl-3-aroylpyrrolidines
NL6913261A (sh) * 1968-09-09 1970-03-11
US3932444A (en) * 1972-04-28 1976-01-13 E. I. Du Pont De Nemours & Co. 4-Imidazolylsulfonylimidazoles
US4013647A (en) * 1976-03-23 1977-03-22 American Home Products Corporation Morpholine containing tetrazole-5-carboxamide derivatives
GB1491776A (en) * 1976-09-08 1977-11-16 Pfizer Ltd Thiadiazoles
US4076718A (en) * 1977-01-21 1978-02-28 American Home Products Corporation 2,6-Pyridinediyl-bis-tetrazol-5-carboxamides
US5236928A (en) * 1991-03-19 1993-08-17 Merck & Co., Inc. Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists
EP0592512A1 (en) 1991-07-01 1994-04-20 University Technologies International Inc. (Uti) NON-DESENSITIZING ANALOGS OF GnRH AND OTHER BIOLOGICALLY ACTIVE LIGANDS
US5622976A (en) * 1991-12-31 1997-04-22 Fujisawa Pharmaceutical Co., Ltd. Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity
EP0761654B1 (en) * 1995-08-24 2003-06-18 Basf Aktiengesellschaft Isoxazole- and isothiazole-5-carboxamide derivatives, their preparation and their use as herbicides
WO1997021707A1 (en) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
JP2000511532A (ja) * 1996-05-20 2000-09-05 メルク エンド カンパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモンのアンタゴニスト
US5878393A (en) * 1996-09-09 1999-03-02 Matsushita Electric Industrial Co., Ltd. High quality concatenative reading system

Also Published As

Publication number Publication date
SK2262001A3 (en) 2002-12-03
SI20746A (sl) 2002-06-30
ID29244A (id) 2001-08-16
CZ2001523A3 (cs) 2002-05-15
NZ509252A (en) 2004-05-28
EE200100102A (et) 2002-06-17
ZA200100831B (en) 2002-08-22
BR9913374A (pt) 2001-05-15
CN1379666A (zh) 2002-11-13
EP1105120A2 (en) 2001-06-13
LV12732B (en) 2002-03-20
WO2000020358B1 (en) 2001-01-04
JP2002535244A (ja) 2002-10-22
EA200100255A1 (ru) 2002-02-28
LT4904B (lt) 2002-04-25
GEP20043315B (en) 2004-02-10
PL356984A1 (en) 2004-07-12
NO20010309D0 (no) 2001-01-19
DE69924387D1 (de) 2005-04-28
AU2470900A (en) 2000-04-26
HUP0103622A2 (hu) 2002-04-29
ES2237966T3 (es) 2005-08-01
EP1105120A4 (en) 2001-12-19
LT2001024A (en) 2001-11-26
CA2341346A1 (en) 2000-04-13
LV12732A (en) 2001-10-20
OA11599A (en) 2004-08-23
EP1105120B1 (en) 2005-03-23
HUP0103622A3 (en) 2003-01-28
KR20010085402A (ko) 2001-09-07
HRP20010206A2 (en) 2004-02-29
WO2000020358A3 (en) 2000-11-16
TR200100631T2 (tr) 2002-08-21
IL141396A0 (en) 2002-03-10
NO20010309L (no) 2001-04-11
IS5846A (is) 2001-02-16
AU759310B2 (en) 2003-04-10
AP2001002053A0 (en) 2001-03-31
WO2000020358A2 (en) 2000-04-13
ATE291423T1 (de) 2005-04-15
BG105362A (en) 2001-12-31

Similar Documents

Publication Publication Date Title
YU13701A (sh) GnRH SREDSTVA KOJA NISU PEPTIDI, POSTUPCI I INTERMEDIJERI ZA NJIHOVO DOBIJANJE
LV12631A (en) Non-peptide gnrh agents
MXPA03001320A (es) Agentes no peptidicos de la gnrh, composiciones farmaceuticas y procedimientos para su uso.
IL124459A0 (en) Antagonists of gonadotropin releasing hormone
MX9804850A (es) Antagonistas de hormona liberadora de gonadotropina.
NZ325060A (en) Non peptide indole derivative and their use as antagonists of gonadotropin releasing hormone
EP1862167A3 (en) Methods and formulations for the treatment of female sexual dysfunction
ES2109995T3 (es) Procedimiento y composiciones de contracepcion y de tratamiento de alteraciones ginecologicas benignas.
WO2002098363A3 (en) NON-PEPTIDE GnRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USES, AND PROCESSES FOR PREPARING THEM
PE55998A1 (es) Derivados 19-nor-pregneno substituidos
MXPA02010066A (es) Estratrienos sustituidos en 8beta-hidrocarbilo para uso como estrogenos selectivos.
GR3030164T3 (en) Treatment of ovarian estrogen dependent conditions
DK279790A (da) Aromatiske steroid-5-alfa-reduktaseinhibitorer
SG188700A1 (en) Use of at-1 receptor antagonist or at-2 receptor modulator for treating diseases associated with an increase of at-1 or at-2 receptors
NO20005145D0 (no) FremgangsmÕte for behandling av fertilitetsproblemer
Leihy et al. Virilization of the urogenital sinus of the tammar wallaby is not unique to 5α-androstane-3α, 17β-diol
WO2003104253A3 (de) 9-alpha-substituierte estratriene als selektiv wirksame estrogene
CA2406846A1 (en) Pharmacotherapeutic process and composition for central nervous system disorders
MX9300677A (es) Procedimiento mejorado para la preparacion de dienos esteroidales substituidos.
JPS5236654A (en) Process for preparation of steroid derivatives