MX9804850A - Antagonistas de hormona liberadora de gonadotropina. - Google Patents
Antagonistas de hormona liberadora de gonadotropina.Info
- Publication number
- MX9804850A MX9804850A MX9804850A MX9804850A MX9804850A MX 9804850 A MX9804850 A MX 9804850A MX 9804850 A MX9804850 A MX 9804850A MX 9804850 A MX9804850 A MX 9804850A MX 9804850 A MX9804850 A MX 9804850A
- Authority
- MX
- Mexico
- Prior art keywords
- antagonists
- releasing hormone
- gonadotropin releasing
- useful
- gnrh
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
Se describe un compuesto de la formula (I), y sales farmacéuticamente aceptables de los mismos que son utiles como antagonistas de GnRH y como tales pueden serutiles para el tratamiento de una variedad de condiciones relacionadas con las hormonas del sexo y otras tanto en hombres como mujeres.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US863495P | 1995-12-14 | 1995-12-14 | |
GBGB9603369.1A GB9603369D0 (en) | 1996-02-16 | 1996-02-16 | Antagonists of gonadotropin releasing hormone |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9804850A true MX9804850A (es) | 1998-09-30 |
Family
ID=26308742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9804850A MX9804850A (es) | 1995-12-14 | 1998-06-15 | Antagonistas de hormona liberadora de gonadotropina. |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0871624A1 (es) |
JP (2) | JPH11501329A (es) |
KR (1) | KR19990072124A (es) |
CN (1) | CN1208413A (es) |
AU (1) | AU709090B2 (es) |
CA (1) | CA2240048A1 (es) |
CZ (1) | CZ183298A3 (es) |
EA (1) | EA000829B1 (es) |
EE (1) | EE9800181A (es) |
HU (1) | HUP9902121A3 (es) |
IL (1) | IL124613A0 (es) |
MX (1) | MX9804850A (es) |
NO (1) | NO982731L (es) |
NZ (1) | NZ325014A (es) |
PL (1) | PL327132A1 (es) |
SK (1) | SK77598A3 (es) |
WO (1) | WO1997021703A1 (es) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX9501608A (es) | 1994-04-01 | 1997-02-28 | Lilly Co Eli | 1h-indol-3-glioxilamidas inhibidoras de spla2. |
US6200957B1 (en) * | 1995-12-14 | 2001-03-13 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
EP0868178A4 (en) * | 1995-12-14 | 2000-03-29 | Merck & Co Inc | GONADOLIBERIN ANTAGONISTS |
WO1998055123A1 (en) * | 1997-06-05 | 1998-12-10 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US5981550A (en) * | 1997-06-05 | 1999-11-09 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US6004984A (en) * | 1997-06-05 | 1999-12-21 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US6156772A (en) * | 1997-06-05 | 2000-12-05 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US6156767A (en) * | 1997-06-05 | 2000-12-05 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
AU729663B2 (en) * | 1997-06-05 | 2001-02-08 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
CA2292605A1 (en) * | 1997-06-05 | 1998-12-10 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US5985901A (en) * | 1997-06-05 | 1999-11-16 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
AU7806998A (en) * | 1997-06-05 | 1998-12-21 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
GB9718833D0 (en) * | 1997-09-04 | 1997-11-12 | Merck Sharp & Dohme | Therapeutic agents |
CA2308069A1 (en) * | 1997-10-28 | 1999-05-06 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US6159975A (en) * | 1998-02-11 | 2000-12-12 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
EP1062215A4 (en) * | 1998-02-11 | 2001-03-14 | Merck & Co Inc | GONADOTROPHIN RELEASE HORMONE ANTAGONISTS |
US6218426B1 (en) * | 1998-03-05 | 2001-04-17 | Agouron Pharmaceuticals, Inc. | Non-peptide GnRH agents |
US5998432A (en) * | 1998-04-02 | 1999-12-07 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US6110931A (en) * | 1998-04-02 | 2000-08-29 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US5985892A (en) * | 1998-04-02 | 1999-11-16 | Merck & Co., Ltd. | Antagonists of gonadotropin releasing hormone |
US6025366A (en) * | 1998-04-02 | 2000-02-15 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US6077847A (en) * | 1998-04-02 | 2000-06-20 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US6228867B1 (en) | 1998-04-02 | 2001-05-08 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US6346534B1 (en) | 1998-09-23 | 2002-02-12 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
EP1171135A4 (en) | 1999-03-10 | 2002-05-15 | Merck & Co Inc | 6-AZAINDOLE COMPOUNDS FOR USE AS GONADOTROPIN RELEASING HORMONE ANTAGONISTS |
JP2003526618A (ja) | 1999-03-10 | 2003-09-09 | メルク エンド カムパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモン拮抗薬としての6−アザインドール化合物 |
WO2000053602A1 (en) * | 1999-03-10 | 2000-09-14 | Merck & Co., Inc. | 6-azaindole compounds as antagonists of gonadotropin releasing hormone |
AU3395000A (en) | 1999-03-10 | 2000-09-28 | Merck & Co., Inc. | 6-azaindole compounds as antagonists of gonadotropin releasing hormone |
US6537998B1 (en) | 1999-10-15 | 2003-03-25 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
MXPA02006848A (es) | 2000-01-25 | 2002-12-13 | Neurocrine Bioscience Inc | Antagonistas del receptor de la hormona liberadora de gonadotropina. |
GB0022670D0 (en) | 2000-09-15 | 2000-11-01 | Astrazeneca Ab | Molecules |
US6583153B2 (en) | 2000-12-12 | 2003-06-24 | Ortho-Mcneil Pharmaceutical, Inc. | 7-heterocyclyl quinoline and thieno[2,3-b]yridine derivatives useful as antagonists of gonadotropin releasing hormone |
SE0100566D0 (sv) | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | Compounds |
SE0101692D0 (sv) | 2001-05-14 | 2001-05-14 | Astrazeneca Ab | Compounds |
AU2002324586B2 (en) | 2001-08-02 | 2008-04-24 | Neurocrine Biosciences, Inc. | 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists |
AU2002321878A1 (en) | 2001-08-02 | 2003-02-17 | Neurocrine Biosciences, Inc. | Pyridinone and pyridazinone derivatives as gonadotropin-releasing hormone receptor antagonists |
CA2455235A1 (en) | 2001-08-02 | 2003-02-13 | Joseph Pontillo | 1,2,4-triazin-3,5-diones as gonadotropin-releasing hormone receptor (gnrh) antagonists |
MXPA04000985A (es) | 2001-08-02 | 2005-02-17 | Neurocrine Biosciences Inc | Piridin-4-onas sustituidas y su uso como antagonistas del receptor de hormona de liberacion de gonadotropina. |
JP2005500356A (ja) | 2001-08-02 | 2005-01-06 | ニューロクライン バイオサイエンシーズ, インコーポレイテッド | ゴナドトロピン放出ホルモンレセプターアンタゴニスト |
WO2003068769A1 (en) | 2002-02-12 | 2003-08-21 | Pfizer Inc. | Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh) |
BR0312123A (pt) | 2002-06-13 | 2005-03-29 | Pfizer | Agentes de gnrh não peptìdicos, composições farmacêuticas e métodos para o seu uso |
TW200407127A (en) | 2002-08-21 | 2004-05-16 | Astrazeneca Ab | Chemical compounds |
AU2003267551A1 (en) | 2002-08-21 | 2004-03-11 | Astrazeneca Ab | Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone |
US7253290B2 (en) | 2002-08-21 | 2007-08-07 | Astrazeneca Ab | Pyrazole derivatives as GnRH inhibitors |
GB0219472D0 (en) * | 2002-08-21 | 2002-10-02 | Astrazeneca Ab | Chemical compounds |
TW200413351A (en) | 2002-08-21 | 2004-08-01 | Astrazeneca Ab | Chemical compounds |
BRPI0412327A (pt) | 2003-07-07 | 2006-09-05 | Neurocrine Biosciences Inc | derivados de pirimidina-2,4-diona como antagonistas de receptor de hormÈnio liberador de gonadotropina |
MXPA06000297A (es) | 2003-07-07 | 2006-03-28 | Neurocrine Biosciences Inc | Derivados de pirimidina-2,4-diona como antagonistas del receptor de la hormona de liberacion de gonadotropina. |
WO2005007633A1 (en) | 2003-07-07 | 2005-01-27 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
DE102004033902A1 (de) | 2004-07-14 | 2006-02-16 | Zentaris Gmbh | Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's) |
EP1873144B1 (en) * | 2005-04-20 | 2014-07-23 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
AU2006257815A1 (en) * | 2005-06-10 | 2006-12-21 | Bipar Sciences, Inc. | PARP modulators and treatment of cancer |
EP2095818A1 (en) | 2008-02-29 | 2009-09-02 | AEterna Zentaris GmbH | Use of LHRH antagonists at non-castrating doses |
TW201130854A (en) | 2009-12-22 | 2011-09-16 | Bayer Schering Pharma Ag | Pyridinone derivatives and pharmaceutical compositions thereof |
WO2012175514A1 (en) | 2011-06-21 | 2012-12-27 | Bayer Intellectual Property Gmbh | Pyridinone derivatives and pharmaceutical compositions thereof |
US9586957B2 (en) * | 2013-03-27 | 2017-03-07 | VIIV Healthcare UK (No.5) Limited | 2-keto amide derivatives as HIV attachment inhibitors |
CN113527254B (zh) * | 2021-07-07 | 2022-05-03 | 北京华氏信华科生物科技有限公司 | 7-甲氧基-1h-吲哚类化合物、制备方法、药物组合物及应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA795239B (en) * | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
US4544663A (en) * | 1984-05-07 | 1985-10-01 | Sandoz, Inc. | Indolamine derivatives as anti-fertility agents |
US5030640A (en) * | 1989-01-05 | 1991-07-09 | Merck & Co., Inc. | Novel β-adrenergic agonists and pharmaceutical compositions thereof |
TW449600B (en) * | 1994-04-19 | 2001-08-11 | Takeda Chemical Industries Ltd | Condensed-ring thiophene derivatives, their production and use |
-
1996
- 1996-12-10 CN CN96199901A patent/CN1208413A/zh active Pending
- 1996-12-10 EP EP96943624A patent/EP0871624A1/en not_active Withdrawn
- 1996-12-10 PL PL96327132A patent/PL327132A1/xx unknown
- 1996-12-10 SK SK775-98A patent/SK77598A3/sk unknown
- 1996-12-10 JP JP9522123A patent/JPH11501329A/ja active Pending
- 1996-12-10 EE EE9800181A patent/EE9800181A/xx unknown
- 1996-12-10 HU HU9902121A patent/HUP9902121A3/hu unknown
- 1996-12-10 IL IL12461396A patent/IL124613A0/xx unknown
- 1996-12-10 EA EA199800564A patent/EA000829B1/ru not_active IP Right Cessation
- 1996-12-10 CA CA002240048A patent/CA2240048A1/en not_active Abandoned
- 1996-12-10 KR KR1019980704442A patent/KR19990072124A/ko not_active Application Discontinuation
- 1996-12-10 NZ NZ325014A patent/NZ325014A/en unknown
- 1996-12-10 AU AU12819/97A patent/AU709090B2/en not_active Ceased
- 1996-12-10 WO PCT/US1996/019443 patent/WO1997021703A1/en not_active Application Discontinuation
- 1996-12-10 CZ CZ981832A patent/CZ183298A3/cs unknown
-
1998
- 1998-06-12 NO NO982731A patent/NO982731L/no not_active Application Discontinuation
- 1998-06-15 MX MX9804850A patent/MX9804850A/es unknown
-
2000
- 2000-02-08 JP JP2000030819A patent/JP2000186039A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0871624A1 (en) | 1998-10-21 |
HUP9902121A3 (en) | 2001-05-28 |
KR19990072124A (ko) | 1999-09-27 |
WO1997021703A1 (en) | 1997-06-19 |
EA199800564A1 (ru) | 1998-12-24 |
IL124613A0 (en) | 1998-12-06 |
EA000829B1 (ru) | 2000-04-24 |
CN1208413A (zh) | 1999-02-17 |
JPH11501329A (ja) | 1999-02-02 |
JP2000186039A (ja) | 2000-07-04 |
AU709090B2 (en) | 1999-08-19 |
SK77598A3 (en) | 1999-01-11 |
NZ325014A (en) | 2000-06-23 |
NO982731L (no) | 1998-08-13 |
HUP9902121A2 (hu) | 1999-10-28 |
EE9800181A (et) | 1998-12-15 |
PL327132A1 (en) | 1998-11-23 |
AU1281997A (en) | 1997-07-03 |
CZ183298A3 (cs) | 1998-09-16 |
CA2240048A1 (en) | 1997-06-19 |
NO982731D0 (no) | 1998-06-12 |
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