YU12203A - Novi derivati fenilalanina - Google Patents

Novi derivati fenilalanina

Info

Publication number
YU12203A
YU12203A YU12203A YUP12203A YU12203A YU 12203 A YU12203 A YU 12203A YU 12203 A YU12203 A YU 12203A YU P12203 A YUP12203 A YU P12203A YU 12203 A YU12203 A YU 12203A
Authority
YU
Yugoslavia
Prior art keywords
phenylalanine derivatives
new phenylalanine
new
integrin
derivatives
Prior art date
Application number
YU12203A
Other languages
English (en)
Inventor
Shingo Makino
Tatsuya Okuzumi
Toshihiko Yoshimura
Yuko Satake
Nobuyasu Suzuki
Hiroyuki Izawa
Kazuyuki Sagi
Akira Chiba
Eiji Nakanishi
Masahiro Murata
Takashi Tsuji
Original Assignee
Ajinomoto Co.Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co.Inc. filed Critical Ajinomoto Co.Inc.
Publication of YU12203A publication Critical patent/YU12203A/sh

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
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    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Diabetes (AREA)
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  • Biomedical Technology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Navedeni derivati i analozi fenilalanina pokazuju antagonističko dejstvo prema α4 integrinu. Oni se koriste kao terapeutski agensi za razna oboljenja koja su u vezi sa α4 integrinima.[Phenylalanine derivatives (A) and (B) and analogues thereof exhibit an a4 integrin inhibiting activity and are useful as remedies for various a4 integrin-related diseases. (A) (B)
YU12203A 2000-08-18 2001-08-15 Novi derivati fenilalanina YU12203A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000248728 2000-08-18
JP2001147451 2001-05-17

Publications (1)

Publication Number Publication Date
YU12203A true YU12203A (sh) 2006-03-03

Family

ID=26598103

Family Applications (1)

Application Number Title Priority Date Filing Date
YU12203A YU12203A (sh) 2000-08-18 2001-08-15 Novi derivati fenilalanina

Country Status (27)

Country Link
US (4) US7153963B2 (sh)
EP (1) EP1288205B1 (sh)
JP (1) JP3440469B2 (sh)
KR (1) KR100675036B1 (sh)
CN (1) CN1325480C (sh)
AT (1) ATE497385T1 (sh)
AU (2) AU2001278740B9 (sh)
BG (1) BG66085B1 (sh)
BR (1) BRPI0113331B8 (sh)
CA (1) CA2420040C (sh)
CZ (1) CZ302653B6 (sh)
DE (1) DE60143984D1 (sh)
DK (1) DK1288205T3 (sh)
HU (1) HU228914B1 (sh)
IL (2) IL154350A0 (sh)
MX (1) MXPA03001495A (sh)
NO (1) NO325738B1 (sh)
NZ (1) NZ524122A (sh)
PL (1) PL223152B1 (sh)
PT (1) PT1288205E (sh)
RU (1) RU2286340C2 (sh)
SI (1) SI1288205T1 (sh)
SK (1) SK287781B6 (sh)
TW (1) TWI229077B (sh)
UA (1) UA74385C2 (sh)
WO (1) WO2002016329A1 (sh)
YU (1) YU12203A (sh)

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IL154350A0 (en) * 2000-08-18 2003-09-17 Ajinomoto Kk New phenylalanine derivatives
EP1323711B1 (en) 2000-09-29 2006-11-15 Ajinomoto Co., Inc. Novel phenylalanine derivatives
JP4164871B2 (ja) * 2001-07-26 2008-10-15 味の素株式会社 新規フェニルプロピオン酸誘導体
WO2003053926A1 (fr) * 2001-12-13 2003-07-03 Ajinomoto Co.,Inc. Nouveau derive de phenylalanine
AU2003211560A1 (en) * 2002-02-20 2003-09-09 Ajinomoto Co., Inc. Novel phenylalanine derivative
CN101386600B (zh) 2003-02-20 2011-07-06 味之素株式会社 具有喹唑二酮骨架的苯丙氨酸衍生物的制造方法及制造中间体
KR101118930B1 (ko) * 2003-11-14 2012-03-14 아지노모토 가부시키가이샤 페닐알라닌 유도체의 고체 분산체 또는 고체 분산체 의약제제
WO2005046697A1 (ja) * 2003-11-14 2005-05-26 Ajinomoto Co., Inc. フェニルアラニン誘導体の徐放性経口投与製剤
KR101123606B1 (ko) 2003-11-27 2012-03-20 아지노모토 가부시키가이샤 페닐알라닌 유도체의 결정 및 이의 제조방법
KR101194176B1 (ko) 2003-12-22 2012-10-24 아지노모토 가부시키가이샤 신규한 페닐알라닌 유도체
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
SV2006002131A (es) * 2004-06-04 2006-01-26 Genentech Inc Uso de un anticuerpo para el tratamiento de lupus
TWI433682B (zh) * 2004-06-04 2014-04-11 Genentech Inc Cd20抗體於治療多發性硬化症之用途及用於該用途之物品
EP2402326A1 (en) 2005-06-21 2012-01-04 Ajinomoto Co., Inc. Crystals of hydrochloride salts of a Phenylalanine Derivative, Production Method Thereof and Use Thereof as alpha4 integrin Inhibitors
US20090111828A1 (en) * 2005-11-23 2009-04-30 Astrazeneca Ab L-alanine derivatives
NZ568946A (en) 2005-12-29 2010-07-30 Lexicon Pharmaceuticals Inc Multicyclic amino acid derivatives and methods of their use
AR059224A1 (es) 2006-01-31 2008-03-19 Jerini Ag Compuestos para la inhibicion de integrinas y uso de estas
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