HUP0302997A2 - alfa4-Integrin antagonista hatású fenilalanin-származékok, azokat tartalmazó gyógyászati készítmények és alkalmazásuk - Google Patents

alfa4-Integrin antagonista hatású fenilalanin-származékok, azokat tartalmazó gyógyászati készítmények és alkalmazásuk

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Publication number
HUP0302997A2
HUP0302997A2 HU0302997A HUP0302997A HUP0302997A2 HU P0302997 A2 HUP0302997 A2 HU P0302997A2 HU 0302997 A HU0302997 A HU 0302997A HU P0302997 A HUP0302997 A HU P0302997A HU P0302997 A2 HUP0302997 A2 HU P0302997A2
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HU
Hungary
Prior art keywords
group
diseases
ring
phenylalanine derivatives
integrin
Prior art date
Application number
HU0302997A
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English (en)
Inventor
Akira Chiba
Hiroyuki Izawa
Shingo Makino
Masahiro Murata
Eiji Nakanishi
Tatsuya Okuzumi
Kazuyuki Sagi
Yuko Satake
Nobuyasu Suzuki
Takashi Tsuji
Toshihiko Yoshimura
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Ajinomoto Co., Inc.
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Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Publication of HUP0302997A2 publication Critical patent/HUP0302997A2/hu
Publication of HUP0302997A3 publication Critical patent/HUP0302997A3/hu
Publication of HU228914B1 publication Critical patent/HU228914B1/hu

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Abstract

A találmány olyan (1) általános képletű fenilalaninszármazékokra ésazok gyógyszerészetileg elfogadható sóikra vonatkozik, ahol aképletben: A jelentése valamely heterociklusos aromás gyűrű; Bjelentése hidroxil-, rövid szénláncú alkoxi- vagyhidroxilaminocsoport; C jelentése hidrogénatom, rövid szénláncúalkil-, alkenil- vagy alkinilcsoport, és az alkilcsoport adott esetbena gyűrűben heteroatomo(ka)t tartalmazó cikloalkilcsoporttal,arilcsoporttal vagy heteroarilcsoporttal lehet szubsztituálva; Djelentése valamely szerves csoport; vagy C és D együtt egy vagy kétoxigén-, nitrogén- vagy kénatomot tartalmazó gyűrűt képezhet; Tjelentése egyszeres kötés, C(=O), C(=S), S(=O), S(=O)2, N(H)-C(=O)vagy N(H)-C(=S)csoport; és J és J' jelentése azonos vagy eltérő,hidrogén- vagy halogénatom, rövid szénláncú alkil-, rövid szénláncúalkiloxicsoport vagy nitrocsoport. A találmány szerinti vegyületekolyan betegségekre használható gyógyászati vagy megelőző szerekkéntalkalmazhatók, amelyek kialakulásában szerepet játszik az a4-integrinfüggő adhéziós folyamat, így gyulladásos betegségekre, reumásarthritisre, gyulladásos bélbetegségekre, szisztémás lupuszeritematozusra, szklerózis multiplexre, Sjögren-szindrómára, asztmára,pszoriázisra, allergiára, cukorbetegségre, szív-érrendszeribetegségekre, artériás szklerózisra, resztenózisra, tumor burjánzásra,tumoráttét képződésre vagy transzplantátum kilökődésre. Ó
HU0302997A 2000-08-18 2001-08-15 Fenilalanin-származékok HU228914B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000248728 2000-08-18
JP2001147451 2001-05-17
PCT/JP2001/007039 WO2002016329A1 (fr) 2000-08-18 2001-08-15 Nouveaux derives de phenylalanine

Publications (3)

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HUP0302997A2 true HUP0302997A2 (hu) 2004-01-28
HUP0302997A3 HUP0302997A3 (en) 2004-03-29
HU228914B1 HU228914B1 (hu) 2013-06-28

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HU0302997A HU228914B1 (hu) 2000-08-18 2001-08-15 Fenilalanin-származékok

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Families Citing this family (54)

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Publication number Priority date Publication date Assignee Title
US6960597B2 (en) 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
YU12203A (sh) * 2000-08-18 2006-03-03 Ajinomoto Co.Inc. Novi derivati fenilalanina
WO2002028830A1 (fr) 2000-09-29 2002-04-11 Ajinomoto Co.,Inc. Nouveaux derives de phenylalanine
JP4164871B2 (ja) * 2001-07-26 2008-10-15 味の素株式会社 新規フェニルプロピオン酸誘導体
EP1454898A4 (en) 2001-12-13 2006-12-13 Ajinomoto Kk NEW PHENYL ALANIDE DERIVATIVES
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