WO2013105800A3 - L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법 - Google Patents

L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법 Download PDF

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WO2013105800A3
WO2013105800A3 PCT/KR2013/000214 KR2013000214W WO2013105800A3 WO 2013105800 A3 WO2013105800 A3 WO 2013105800A3 KR 2013000214 W KR2013000214 W KR 2013000214W WO 2013105800 A3 WO2013105800 A3 WO 2013105800A3
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tryptophan
escherichia coli
producing
microorganisms
enhanced
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PCT/KR2013/000214
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English (en)
French (fr)
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WO2013105800A2 (ko
WO2013105800A9 (ko
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이광호
박혜민
이효형
황영빈
이석명
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씨제이제일제당(주)
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Priority to JP2014552128A priority Critical patent/JP6449653B2/ja
Priority to MX2014008470A priority patent/MX351721B/es
Priority to EP13735653.1A priority patent/EP2803720B1/en
Priority to US14/371,465 priority patent/US9587261B2/en
Priority to DK13735653.1T priority patent/DK2803720T3/da
Priority to BR112014017074-6A priority patent/BR112014017074B1/pt
Priority to RU2014132889/10A priority patent/RU2593957C2/ru
Priority to CA2860974A priority patent/CA2860974C/en
Application filed by 씨제이제일제당(주) filed Critical 씨제이제일제당(주)
Priority to CN201380010032.3A priority patent/CN104204189B/zh
Priority to ES13735653T priority patent/ES2910377T3/es
Publication of WO2013105800A2 publication Critical patent/WO2013105800A2/ko
Publication of WO2013105800A9 publication Critical patent/WO2013105800A9/ko
Publication of WO2013105800A3 publication Critical patent/WO2013105800A3/ko
Priority to PH12014501590A priority patent/PH12014501590A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227—Tryptophan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
    • H10K59/00—Integrated devices, or assemblies of multiple devices, comprising at least one organic light-emitting element covered by group H10K50/00
    • H10K59/10—OLED displays
    • H10K59/12—Active-matrix OLED [AMOLED] displays
    • H10K59/131—Interconnections, e.g. wiring lines or terminals
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
    • H10K50/00—Organic light-emitting devices
    • H10K50/80—Constructional details
    • H10K50/805—Electrodes
    • H10K50/82—Cathodes
    • H10K50/826—Multilayers, e.g. opaque multilayers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
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  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 L-트립토판을 생산하는 방법에 관한 것이다. 보다 상세하게는, 본 발명은 트립토판 오페론의 억제 및 감쇠조절이 해제되고 안스라닐산염의 축적이 감소되어 L-트립토판 생산능이 강화된 대장균 변이주 및 이를 이용하여 L-트립토판을 생산하는 방법에 관한 것이다. [대표도] 도 1
PCT/KR2013/000214 2012-01-10 2013-01-10 L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법 WO2013105800A2 (ko)

Priority Applications (11)

Application Number Priority Date Filing Date Title
RU2014132889/10A RU2593957C2 (ru) 2012-01-10 2013-01-10 МИКРООРГАНИЗМ ИЗ РОДА Escherichia, ОБЛАДАЮЩИЙ УСИЛЕННОЙ СПОСОБНОСТЬЮ К ПРОДУКЦИИ L-ТРИПТОФАНА, И СПОСОБ ПОЛУЧЕНИЯ L-ТРИПТОФАНА С ЕГО ИСПОЛЬЗОВАНИЕМ
EP13735653.1A EP2803720B1 (en) 2012-01-10 2013-01-10 Microorganisms of escherichia coli having enhanced l-tryptophan production and method for producing l-tryptophan using same
US14/371,465 US9587261B2 (en) 2012-01-10 2013-01-10 Microorganism of the genus Escherichia having enhanced L-tryptophan productivity and a method for producing L-tryptophan using the same
DK13735653.1T DK2803720T3 (da) 2012-01-10 2013-01-10 Mikroorganismer fra escherichia coli med forbedret produktion af l-tryptofan og fremgangsmåde til fremstilling af l-tryptofan dermed
BR112014017074-6A BR112014017074B1 (pt) 2012-01-10 2013-01-10 Escherichia coli recombinante tendo uma produtividade acentuada de l-triptofano e método para a produção de l-triptofano
JP2014552128A JP6449653B2 (ja) 2012-01-10 2013-01-10 Ｌ−トリプトファン産生能が強化されたエシェリキア属微生物及びこれを用いてｌ−トリプトファンを産生する方法
CA2860974A CA2860974C (en) 2012-01-10 2013-01-10 A microorganism of the genus escherichia having enhanced l-tryptophan productivity and a method for producing l-tryptophan using the same
MX2014008470A MX351721B (es) 2012-01-10 2013-01-10 Un microorganismo del género escherichia que tiene productividad aumentada de l-triptófano y un método para producir l-triptófano utilizando el mismo.
CN201380010032.3A CN104204189B (zh) 2012-01-10 2013-01-10 具有增强的l-色氨酸生产力的埃希氏菌属微生物以及使用其生产l-色氨酸的方法
ES13735653T ES2910377T3 (es) 2012-01-10 2013-01-10 Microorganismos de Escherichia coli que tienen la producción de L-triptófano mejorada y método para producir L-triptófano mediante el uso de los mismos
PH12014501590A PH12014501590A1 (en) 2012-01-10 2014-07-10 A microorganism of the genus escherichia having enhanced l-tryptophan productivity and method for producing l-tryptophan using the same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2012-0002906 2012-01-10
KR20120002906 2012-01-10
KR1020130002913A KR101532129B1 (ko) 2012-01-10 2013-01-10 L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법
KR10-2013-0002913 2013-01-10

Publications (3)

Publication Number Publication Date
WO2013105800A2 WO2013105800A2 (ko) 2013-07-18
WO2013105800A9 WO2013105800A9 (ko) 2013-08-29
WO2013105800A3 true WO2013105800A3 (ko) 2013-10-17

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PCT/KR2013/000214 WO2013105800A2 (ko) 2012-01-10 2013-01-10 L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법

Country Status (14)

Country Link
US (1) US9587261B2 (ko)
EP (1) EP2803720B1 (ko)
JP (2) JP6449653B2 (ko)
KR (3) KR101532129B1 (ko)
BR (1) BR112014017074B1 (ko)
CA (1) CA2860974C (ko)
DK (1) DK2803720T3 (ko)
ES (1) ES2910377T3 (ko)
HU (1) HUE057864T2 (ko)
MX (1) MX351721B (ko)
MY (1) MY173848A (ko)
PH (1) PH12014501590A1 (ko)
RU (1) RU2593957C2 (ko)
WO (1) WO2013105800A2 (ko)

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CA2860974C (en) * 2012-01-10 2019-03-05 Cj Cheiljedang Corporation A microorganism of the genus escherichia having enhanced l-tryptophan productivity and a method for producing l-tryptophan using the same
KR101835173B1 (ko) * 2014-06-23 2018-03-07 씨제이제일제당 (주) L-트립토판 생산능을 갖는 에스케리키아속 미생물 및 이를 이용한 l-트립토판의 제조 방법
KR101835935B1 (ko) * 2014-10-13 2018-03-12 씨제이제일제당 (주) L-아르기닌을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-아르기닌의 제조 방법
KR101704199B1 (ko) * 2015-05-14 2017-02-08 씨제이제일제당 (주) L-트립토판 생산능을 갖는 에스케리키아속 미생물 및 이를 이용한 l-트립토판의 제조 방법
KR101704198B1 (ko) * 2015-05-14 2017-02-08 씨제이제일제당 (주) L-트립토판 생산능을 갖는 에스케리키아속 미생물 및 이를 이용한 l-트립토판의 제조 방법
WO2017136795A1 (en) * 2016-02-04 2017-08-10 Synlogic, Inc. Bacteria engineered to treat diseases associated with tryptophan metabolism
CN111406111A (zh) 2017-11-15 2020-07-10 汉堡工业大学 一种改进的生物技术生产l-色氨酸的方法
KR102035844B1 (ko) * 2018-02-23 2019-10-23 씨제이제일제당 주식회사 L-트립토판을 생산하는 재조합 코리네형 미생물 및 이를 이용한 l-트립토판을 생산하는 방법
WO2019182413A1 (ko) 2018-03-23 2019-09-26 씨제이제일제당 (주) L-아미노산을 포함하는 과립 및 이의 제조방법
US11053526B2 (en) 2018-08-09 2021-07-06 Evonik Operations Gmbh Process for preparing L amino acids using improved strains of the enterobacteriaceae family
KR101991206B1 (ko) 2018-11-29 2019-06-19 씨제이제일제당 (주) cAMP 수용 단백질 변이체 및 이를 이용한 L-아미노산 제조방법
KR101991207B1 (ko) 2018-11-29 2019-06-19 씨제이제일제당 (주) cAMP 수용 단백질 변이체 및 이를 이용한 L-아미노산 제조방법
KR101996767B1 (ko) 2018-11-29 2019-07-04 씨제이제일제당 (주) cAMP 수용 단백질 변이체 및 이를 이용한 L-아미노산 제조방법
EP3677594A1 (en) * 2019-01-07 2020-07-08 Evonik Operations GmbH Method for producing l-tryptophan using improved strains of the enterobacteriaceae family
KR102205717B1 (ko) * 2019-04-05 2021-01-22 씨제이제일제당 주식회사 신규 l-트립토판 배출 단백질 변이체 및 이를 이용한 l-트립토판을 생산하는 방법
KR102134418B1 (ko) * 2019-06-17 2020-07-16 씨제이제일제당 주식회사 L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법
TW202205966A (zh) 2020-06-26 2022-02-16 南韓商Ｃｊ第一製糖股份有限公司 由發酵液製備胺基酸顆粒之方法

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RU2014132889A (ru) 2016-02-27
DK2803720T3 (da) 2022-04-04
ES2910377T3 (es) 2022-05-12
KR20130082121A (ko) 2013-07-18
CA2860974C (en) 2019-03-05
MX2014008470A (es) 2014-11-10
EP2803720A4 (en) 2016-04-06
KR101532129B1 (ko) 2015-06-29
US20150147788A1 (en) 2015-05-28
JP6475668B2 (ja) 2019-02-27
JP2017018094A (ja) 2017-01-26
US9587261B2 (en) 2017-03-07
EP2803720B1 (en) 2022-03-09
KR20160058077A (ko) 2016-05-24
BR112014017074A2 (pt) 2020-10-27
KR101629159B1 (ko) 2016-06-09
CA2860974A1 (en) 2013-07-18
JP2015503358A (ja) 2015-02-02
EP2803720A2 (en) 2014-11-19
RU2593957C2 (ru) 2016-08-10
JP6449653B2 (ja) 2019-01-09
WO2013105800A2 (ko) 2013-07-18
KR20150061626A (ko) 2015-06-04
PH12014501590A1 (en) 2014-10-08
KR101886480B1 (ko) 2018-08-07
CN104204189A (zh) 2014-12-10
MX351721B (es) 2017-10-25
WO2013105800A9 (ko) 2013-08-29
HUE057864T2 (hu) 2022-06-28
BR112014017074B1 (pt) 2022-05-10
MY173848A (en) 2020-02-24

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