WO2011126903A2 - Multisubstituted aromatic compounds as inhibitors of thrombin - Google Patents

Multisubstituted aromatic compounds as inhibitors of thrombin Download PDF

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Publication number
WO2011126903A2
WO2011126903A2 PCT/US2011/030585 US2011030585W WO2011126903A2 WO 2011126903 A2 WO2011126903 A2 WO 2011126903A2 US 2011030585 W US2011030585 W US 2011030585W WO 2011126903 A2 WO2011126903 A2 WO 2011126903A2
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WO
WIPO (PCT)
Prior art keywords
substituted
unsubstituted
pyridin
triazol
amine
Prior art date
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PCT/US2011/030585
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English (en)
French (fr)
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WO2011126903A3 (en
Inventor
Kevin Michael Short
Son Minh Pham
David Charles Williams
Somalee Datta
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Verseon Corp
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Verseon Corp
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Priority to KR1020127028509A priority Critical patent/KR20130053404A/ko
Priority to KR1020197006283A priority patent/KR102113960B1/ko
Priority to BR112012024678A priority patent/BR112012024678A2/pt
Priority to NZ603156A priority patent/NZ603156A/en
Priority to CA2829790A priority patent/CA2829790C/en
Priority to SG2012070892A priority patent/SG184243A1/en
Priority to MX2012011380A priority patent/MX355038B/es
Priority to EP11766507.5A priority patent/EP2560966B1/en
Application filed by Verseon Corp filed Critical Verseon Corp
Priority to AU2011238616A priority patent/AU2011238616B2/en
Priority to CN201180026731.8A priority patent/CN102918034B/zh
Priority to JP2013502815A priority patent/JP6155187B2/ja
Priority to KR1020187005952A priority patent/KR101955691B1/ko
Priority to RU2012146194A priority patent/RU2639876C2/ru
Publication of WO2011126903A2 publication Critical patent/WO2011126903A2/en
Publication of WO2011126903A3 publication Critical patent/WO2011126903A3/en
Priority to IL222019A priority patent/IL222019A/en
Priority to US13/630,201 priority patent/US9533967B2/en
Anticipated expiration legal-status Critical
Priority to US14/989,742 priority patent/US20160122333A1/en
Priority to US15/004,789 priority patent/US9963440B2/en
Priority to IL243989A priority patent/IL243989B/en
Priority to IL243990A priority patent/IL243990B/en
Priority to US15/155,954 priority patent/US20160256440A1/en
Priority to AU2016206247A priority patent/AU2016206247B2/en
Priority to US15/937,475 priority patent/US10653674B2/en
Priority to AU2019200013A priority patent/AU2019200013A1/en
Ceased legal-status Critical Current

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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Definitions

  • the present disclosure relates to compounds, e.g., multisubstituted aromatic compounds, which exhibit biological activity, e.g., inhibitory action, against thrombin (activated blood-coagulation factor II; EC 3.4.21.5).
  • thrombin activated blood-coagulation factor II
  • the cascade includes the Extrinsic and Intrinsic pathways, involving the activation of at least 13 interconnected factors and a variety of co- factors and other regulatory proteins.
  • plasma factor VII interacts with exposed Tissue Factor (TF), and the resultant TF-fVTIa complex initiates a complex series of events.
  • Factor fXa is produced directly 'downstream' from the TF-fVTIa complex, and amplified manifold via the Intrinsic Pathway.
  • FXa then serves as the catalyst for formation of thrombin (flla), which in turn is the direct precursor to fibrinolysis.
  • the outcome is a fibrinolytic clot, which stops the bleeding. Fibrinolysis of the polymeric clot into fibrin monomers leads to dissolution and a return of the system to the pre-clot state.
  • the cascade is a complex balance of factors and co-factors and is tightly regulated.
  • Vitamin K is a ubiquitous cofactor within the coagulation cascade, antagonism results in the simultaneous inhibition of many clotting factors and thus can lead to significant bleeding complications.
  • the need for parenteral administration for the heparin-derived therapeutics, and the inconvenient requirements for close supervision for the orally available warfarin, has resulted in a drive to discover and develop orally available drugs with wide therapeutic windows for safety and efficacy.
  • DTIs direct thrombin inhibitors
  • Ring A is substituted or unsubstituted pyrazolyl, or substituted or unsubstituted triazolyl.
  • L 1 , L 2 and L 3 are independently a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, -S-, -SO-, -S0 2 -, -0-, -NHS0 2 -, or -NR 5 -.
  • L 4 is absent, a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, -S-, -SO-, -S0 2 -, -0-, -NHSO 2 -, or -NR 5 -.
  • R 1 , R 2 and R 3 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.
  • R 4 is absent, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or
  • a pharmaceutical composition comprising a compound disclosed herein and a pharmaceutically acceptable excipient.
  • the compound is a compound of any of Formulae (la), (lb), (Ha), (lib), (Ilia), (Illb), (IV) or (V) as disclosed herein, or a compound as set forth in any of Tables A, B or C herein, or pharmaceutically acceptable salt, ester, solvate, or prodrug thereof.
  • a method for treating a disease or disorder in a subject includes administering a compound of any of Formulae (la), (lb), (Ila), (lib), (Ilia), (Illb), (IV) or (V) as disclosed herein, compound as set forth in any of Tables A, B or C herein, pharmaceutically acceptable salt, ester, solvate, or prodrug thereof, or pharmaceutical composition thereof, to a subject in need thereof in an amount effective to treat the disease or disorder.
  • a method for preventing a disease or disorder in a subject includes administering a compound of any of Formulae (la), (lb), (Ha), (lib), (Ilia), (Illb), (IV) or (V) as disclosed herein, compound as set forth in any of Tables A, B or C herein, pharmaceutically acceptable salt, ester, solvate, or prodrug thereof, or pharmaceutical composition thereof, to a subject in need thereof in an amount effective to prevent the disease or disorder.
  • attachment signifies a stable covalent bond, certain preferred points of attachment being apparent to those of ordinary skill in the art.
  • halogen or halo include fluorine, chlorine, bromine, and iodine. Additionally, terms such as “haloalkyl” are meant to include monohaloalkyl and
  • halo(Ci-C4)alkyl includes, but is not limited to, fluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, 4-chlorobutyl, 3- bromopropyl, and the like.
  • alkyl by itself or as part of another substituent, means, unless otherwise stated, a straight (i.e., unbranched) or branched chain, or combination thereof, which may be fully saturated, mono- or polyunsaturated and can include di- and multivalent radicals, having the number of carbon atoms designated (i.e., C1-C10 means one to ten carbons).
  • saturated hydrocarbon radicals include, but are not limited to, groups such as methyl, ethyl, n- propyl, isopropyl, n-butyl, t-butyl, isobutyl, sec-butyl, (cyclohexyl)methyl, homologs and isomers of, for example, n-pentyl, n-hexyl, n-heptyl, n-octyl, and the like.
  • An unsaturated alkyl group is one having one or more double bonds or triple bonds.
  • unsaturated alkyl groups include, but are not limited to, vinyl, 2-propenyl, crotyl, 2-isopentenyl, 2- (butadienyl), 2,4-pentadienyl, 3-(l,4-pentadienyl), ethynyl, 1- and 3-propynyl, 3-butynyl, and the higher homologs and isomers.
  • alkyl can refer to C1-C16 straight chain saturated, C1-C16 branched saturated, C3-C8 cyclic saturated and Q-C16 straight chain or branched saturated aliphatic hydrocarbon groups substituted with C3-C8 cyclic saturated aliphatic hydrocarbon groups having the specified number of carbon atoms.
  • this definition shall include but is not limited to methyl (Me), ethyl (Et), propyl (Pr), butyl (Bu), pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, isopropyl (i-Pr), isobutyl (i-Bu), tert- butyl (t-Bu), sec-butyl (s-Bu), isopentyl, neopentyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclopropylmethyl, and the like.
  • alkylene by itself or as part of another substituent, means, unless otherwise stated, a divalent radical derived from an alkyl, as exemplified, but not limited by, -CH 2 CH 2 CH 2 CH 2 -.
  • an alkyl (or alkylene) group will have from 1 to 24 carbon atoms, with those groups having 10 or fewer carbon atoms being preferred in the compounds disclosed herein.
  • a “lower alkyl” or “lower alkylene” is a shorter chain alkyl or alkylene group, generally having eight or fewer carbon atoms.
  • heteroalkyl by itself or in combination with another term, means, unless otherwise stated, a stable straight or branched chain, or combinations thereof, consisting of at least one carbon atom and at least one heteroatom selected from the group consisting of O, N, P, Si, and S, and wherein the nitrogen and sulfur atoms may optionally be oxidized, and the nitrogen heteroatom may optionally be quaternized.
  • the heteroatom(s) O, N, P, S, and Si may be placed at any interior position of the heteroalkyl group or at the position at which the alkyl group is attached to the remainder of the molecule. Examples include, but are not limited to: -CH 2 -CH 2 -0-CH 3 , -CH 2 -CH 2 -NH-CH 3 , -CH 2 -CH 2 -N(CH 3 )-CH 3 ,
  • heteroalkylene by itself or as part of another substituent, means, unless otherwise stated, a divalent radical derived from heteroalkyl, as exemplified, but not limited by, -CH 2 -CH 2 -S-CH 2 -CH 2 - and -CH 2 -S-CH 2 -CH 2 -NH-CH 2 -.
  • heteroatoms can also occupy either or both of the chain termini (e.g., alkyleneoxy, alkylenedioxy, alkyleneamino, alkylenediamino, and the like).
  • heteroalkyl groups include those groups that are attached to the remainder of the molecule through a heteroatom, such as -C(0)R * , -C(0)NR, -NR'R", -OR * , -SR, and/or -S0 2 R.
  • heteroalkyl is recited, followed by recitations of specific heteroalkyl groups, such as -NR'R” or the like, it will be understood that the terms heteroalkyl and -NR'R" are not redundant or mutually exclusive. Rather, the specific heteroalkyl groups are recited to add clarity. Thus, the term “heteroalkyl” should not be interpreted herein as excluding specific heteroalkyl groups, such as -NR'R” or the like.
  • cycloalkyl and heterocycloalkyl by themselves or in combination with other terms, mean, unless otherwise stated, cyclic versions of “alkyl” and “heteroalkyl,” respectively. Additionally, for heterocycloalkyl, a heteroatom can occupy the position at which the heterocycle is attached to the remainder of the molecule. Examples of cycloalkyl include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, 1- cyclohexenyl, 3-cyclohexenyl, cycloheptyl, and the like.
  • heterocycloalkyl examples include, but are not limited to, l-(l,2,5,6-tetrahydropyridyl), 1-piperidinyl, 2-piperidinyl, 3- piperidinyl, 4-morpholinyl, 3-morpholinyl, tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, tetrahydrothien-2-yl, tetrahydrothien-3-yl, 1-piperazinyl, 2-piperazinyl, and the like.
  • a "cycloalkylene” and a "heterocycloalkylene,” alone or as part of another substituent, means a divalent radical derived from a cycloalkyl and heterocycloalkyl, respectively.
  • alkenyl includes C 2 -Ci 6 straight chain unsaturated, C 2 -Cn branched unsaturated, Cs-Cg unsaturated cyclic, and C 2 -Ci 6 straight chain or branched unsaturated aliphatic hydrocarbon groups substituted with C3-C8 cyclic saturated and unsaturated aliphatic hydrocarbon groups having the specified number of carbon atoms. Double bonds may occur in any stable point along the chain and the carbon-carbon double bonds may have either the cis or trans configuration.
  • this definition shall include but is not limited to ethenyl, propenyl, butenyl, pentenyl, hexenyl, heptenyl, octenyl, nonenyl, decenyl, undecenyl, 1,5-octadienyl, 1,4,7-nonatrienyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, cyclooctenyl, ethylcyclohexenyl, butenylcyclopentyl, l-pentenyl-3 -cyclohexenyl, and the like.
  • heteroalkenyl refers to heteroalkyl having one or more double bonds.
  • alkynyl refers in the customary sense to alkyl additionally having one or more triple bonds.
  • cycloalkenyl refers to cycloalkyl additionally having one or more double bonds.
  • heterocycloalkenyl refers to heterocycloalkyl additionally having one or more double bonds.
  • acyl means, unless otherwise stated, -C(0)R where R is a substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.
  • R', R", R", and R" each preferably independently refer to hydrogen, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl (e.g., aryl substituted with 1-3 halogens), substituted or unsubstituted alkyl, alkoxy, or thioalkoxy groups, or arylalkyl groups.
  • each of the R groups is independently selected as are each R, R", R", and R"" group when more than one of these groups is present.
  • R' and R" When R' and R" are attached to the same nitrogen atom, they can be combined with the nitrogen atom to form a 4-, 5-, 6-, or 7-membered ring.
  • -NRR includes, but is not limited to, 1-pyrrolidinyl and 4-morpholinyl.
  • alkyl is meant to include groups including carbon atoms bound to groups other than hydrogen groups, such as haloalkyl (e.g., -CF 3 and -CH 2 CF 3 ) and acyl (e.g., -C(0)CH 3 , -C(0)CF 3 , -C(0)CH 2 OCH 3 , and the like).
  • each of the R groups is independently selected as are each R, R", R", and R"" groups when more than one of these groups is present.
  • Two or more substituents may optionally be joined to form aryl, heteroaryl, cycloalkyl, or heterocycloalkyl groups.
  • Such so-called ring-forming substituents are typically, though not necessarily, found attached to a cyclic base structure.
  • the ring-forming substituents are attached to adjacent members of the base structure.
  • two ring-forming substituents attached to adjacent members of a cyclic base structure create a fused ring structure.
  • the ring-forming substituents are attached to a single member of the base structure.
  • two ring- forming substituents attached to a single member of a cyclic base structure create a spirocyclic structure.
  • the ring-forming substituents are attached to non-adjacent members of the base structure.
  • Two of the substituents on adjacent atoms of the aryl or heteroaryl ring may optionally form a ring of the formula -T-C(0)-(CRR') q -U-, wherein T and U are
  • q is an integer of from 0 to 3.
  • two of the substituents on adjacent atoms of the aryl or heteroaryl ring may optionally be replaced with a substituent of the formula -A-(CH 2 ) r -B-, wherein A and B are independently -CRR-, -0-, -NR-, -S-, -S(O) -, -S(0) 2 -, -S(0) 2 NR-, or a single bond, and r is an integer of from 1 to 4.
  • One of the single bonds of the new ring so formed may optionally be replaced with a double bond.
  • two of the substituents on adjacent atoms of the aryl or heteroaryl ring may optionally be replaced with a substituent of the formula -(CRR') s -X'- (C"R"') d -, where s and d are independently integers of from 0 to 3, and X' is -0-, -NR-, -S-, -S(O)-, -S(0) 2 -, or -S(0) 2 NR * -.
  • R, R * , R", and R' are preferably independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl.
  • heteroatom or "ring heteroatom” are meant to include oxygen (O), nitrogen (N), sulfur (S), phosphorus (P), and silicon (Si).
  • alkyloxy e.g. methoxy, ethoxy, propyloxy, allyloxy, cyclohexyloxy
  • alkyloxy represents an alkyl group as defined above having the indicated number of carbon atoms attached through an oxygen bridge (-0-).
  • alkylthio (e.g. methylthio, ethylthio, propylthio, cyclohexylthio and the like) represents an alkyl group as defined above having the indicated number of carbon atoms attached through a sulfur bridge (-S-).
  • alkylamino represents one or two alkyl groups as defined above having the indicated number of carbon atoms attached through an amine bridge.
  • the two alkyl groups maybe taken together with the nitrogen to which they are attached forming a cyclic system containing 3 to 8 carbon atoms with or without one Ci-Ci 6 alkyl, arylCo-Ci 6 alkyl, or Co-Ci 6 alkylaryl substituent.
  • alkylaminoalkyl represents an alkylamino group attached through an alkyl group as defined above having the indicated number of carbon atoms.
  • alkyloxy(alkyl)amino e.g. methoxy(methyl)amine
  • ethoxy(propyl)amine represents an alkyloxy group as defined above attached through an amino group, the amino group itself having an alkyl substituent.
  • alkylcarbonyl e.g. cyclooctylcarbonyl, pentylcarbonyl, 3- hexylcarbonyl
  • alkylcarbonyl represents an alkyl group as defined above having the indicated number of carbon atoms attached through a carbonyl group.
  • alkylcarboxy e.g. heptylcarboxy, cyclopropylcarboxy, 3- pentenylcarboxy
  • alkylcarboxy represents an alkylcarbonyl group as defined above wherein the carbonyl is in turn attached through an oxygen.
  • alkylcarboxyalkyl represents an alkylcarboxy group attached through an alkyl group as defined above having the indicated number of carbon atoms.
  • alkylcarbonylamino e.g. hexylcarbonylamino
  • cyclopentylcarbonylaminomethyl, methylcarbonylaminophenyl represents an alkylcarbonyl group as defined above wherein the carbonyl is in turn attached through the nitrogen atom of an amino group.
  • the nitrogen group may itself be substituted with an alkyl or aryl group.
  • aryl means, unless otherwise stated, a polyunsaturated, aromatic, hydrocarbon substituent, which can be a single ring or multiple rings (preferably from 1 to 3 rings) that are fused together (i.e., a fused ring aryl) or linked covalently.
  • a fused ring aryl refers to multiple rings fused together wherein at least one of the fused rings is an aryl ring.
  • heteroaryl refers to aryl groups (or rings) that contain from one to four heteroatoms selected from N, O, and S, wherein the nitrogen and sulfur atoms are optionally oxidized, and the nitrogen atom(s) are optionally quaternized.
  • heteroaryl includes fused ring heteroaryl groups (i.e., multiple rings fused together wherein at least one of the fused rings is a heteroaromatic ring).
  • a 5,6-fused ring heteroarylene refers to two rings fused together, wherein one ring has 5 members and the other ring has 6 members, and wherein at least one ring is a heteroaryl ring.
  • a 6,6-fused ring heteroarylene refers to two rings fused together, wherein one ring has 6 members and the other ring has 6 members, and wherein at least one ring is a heteroaryl ring.
  • a 6,5-fused ring refers to two rings fused together, wherein one ring has 6 members and the other ring has 6 members, and wherein at least one ring is a heteroaryl ring.
  • heteroarylene refers to two rings fused together, wherein one ring has 6 members and the other ring has 5 members, and wherein at least one ring is a heteroaryl ring.
  • a heteroaryl group can be attached to the remainder of the molecule through a carbon or heteroatom.
  • Non- limiting examples of aryl and heteroaryl groups include phenyl, 1-naphthyl, 2-naphthyl, 4-biphenyl, 1-pyrrolyl, 2-pyrrolyl, 3-pyrrolyl, 3-pyrazolyl, 2-imidazolyl, 4-imidazolyl, pyrazinyl, 2-oxazolyl, 4-oxazolyl, 2-phenyl-4-oxazolyl, 5-oxazolyl, 3-isoxazolyl, 4- isoxazolyl, 5-isoxazolyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidyl, 4-pyrimidyl, 5-benzothiazolyl, purinyl, 2-benzimidazolyl, 5-indolyl, 1-isoquino
  • aryl and heteroaryl ring systems are selected from the group of acceptable substituents described below.
  • the aryl substituents are independently selected from the group consisting of halo, nitro, cyano, trihalomethyl, Ci_i 6 alkyl, arylCi_ i 6 alkyl, Co-i 6 alkyloxyCo-i 6 alkyl, arylCo-i 6 alkyloxyCo-i 6 alkyl, Co-i 6 alkylthioCo-i 6 alkyl, arylCo-i 6 alkylthioCo-i 6 alkyl, Co-i 6 alkylaminoCo-i 6 alkyl, arylCo-i 6 alkylaminoCo-i 6 alkyl, di(arylCi-i 6 alkyl)aminoCo-i 6 alkyl, Ci-i 6 alkylcarbonylCo-i 6 alkyl, arylCi_i 6 alkylcarbonylCo- i 6 alkyl, Ci-i 6 alkylcarboxyCo-i 6 alkyl, arylCi-i 6 al
  • R4 are independently selected from hydrogen, Ci- Cnalkyl, arylCo-Cnalkyl, or R5 and R 6 are taken together with the nitrogen to which they are attached forming a cyclic system containing 3 to 8 carbon atoms with or without one Ci_ i 6 alkyl, arylC 0 -Ci 6 alkyl, or C 0 -Cli 6 alkylaryl substituent.
  • Aryl includes but is not limited to pyrazolyl and triazolyl.
  • aryl when used in combination with other terms (e.g., aryloxy, arylthioxy, arylalkyl) includes both aryl and heteroaryl rings as defined above.
  • arylalkyl “aralkyl” and the like are meant to include those radicals in which an aryl group is attached to an alkyl group (e.g., benzyl, phenethyl, pyridylmethyl, and the like) including those alkyl groups in which a carbon atom (e.g., a methylene group) has been replaced by, for example, an oxygen atom (e.g., phenoxymethyl, 2-pyridyloxymethyl, 3-(l- naphthyloxy)propyl, and the like), or a sulfur atom.
  • an oxygen atom e.g., phenoxymethyl, 2-pyridyloxymethyl, 3-(l- naphthyloxy)propyl, and the like
  • sulfur atom e.g
  • arylalkyl e.g. (4-hydroxyphenyl)ethyl, (2-aminonaphthyl)hexyl, pyridylcyclopentyl
  • oxo means an oxygen that is double bonded to a carbon atom.
  • alkylsulfonyl means a moiety having the formula
  • R' is an alkyl group as defined above.
  • R may have a specified number of carbons (e.g., "C 1 -C4 alkylsulfonyl").
  • carbonyloxy represents a carbonyl group attached through an oxygen bridge.
  • alkyl and “alkenyl” may be used
  • linker refers to attachment groups interposed between substituents, e.g., R 1 , R 2 , R 3 or R 4 described herein, e.g., Formula (la) and generically referred to as R n , and the group which is substituted, e.g., "ring A” group of e.g., Formula (la).
  • the linker includes amido (-CONH-R n or -NHCO-R n ), thioamido (-CSNH-R 11 or -NHCS-R n ), carboxyl (-C0 2 -R n or -OCOR n ), carbonyl (-CO-R n ), urea (-NHCONH-R n ), thiourea
  • a "substituent group,” as used herein, means a group selected from the following moieties:
  • heterocycloalkyl unsubstituted aryl, unsubstituted heteroaryl, and (b) alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, substituted with at least one substituent selected from: oxo, -OH, -NH 2 , -SH, -CN, -CF 3 , -NO 2 , halogen, -COOH, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, and unsubstituted heteroaryl.
  • a “size-limited substituent” or “ size-limited substituent group,” as used herein, means a group selected from all of the substituents described above for a “substituent group,” wherein each substituted or unsubstituted alkyl is a substituted or unsubstituted C 1 -C 20 alkyl, each substituted or unsubstituted heteroalkyl is a substituted or unsubstituted 2 to 20 membered heteroalkyl, each substituted or unsubstituted cycloalkyl is a substituted or unsubstituted C4-C8 cycloalkyl, and each substituted or unsubstituted heterocycloalkyl is a substituted or unsubstituted 4 to 8 membered heterocycloalkyl.
  • a "lower substituent” or " lower substituent group,” as used herein, means a group selected from all of the substituents described above for a “substituent group,” wherein each substituted or unsubstituted alkyl is a substituted or unsubstituted Ci-Cg alkyl, each substituted or unsubstituted heteroalkyl is a substituted or unsubstituted 2 to 8 membered heteroalkyl, each substituted or unsubstituted cycloalkyl is a substituted or unsubstituted C 5 - C 7 cycloalkyl, and each substituted or unsubstituted heterocycloalkyl is a substituted or unsubstituted 5 to 7 membered heterocycloalkyl.
  • Ring A is substituted or unsubstituted pyrazolyl, or substituted or unsubstituted triazolyl.
  • L 1 , L 2 and L 3 are independently a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, -S-, -SO-, -SO 2 -, -0-, -NHSO 2 -, or -NR 5 -.
  • L 4 is absent, a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, -S-, -SO-, -S0 2 -, -0-, -NHSO 2 -, or -NR 5 -.
  • R 1 , R 2 and R 3 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.
  • R 4 is absent, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or
  • the compound is a pharmaceutically acceptable salt, ester, solvate, or prodrug of a compound of Formula (la). In some embodiments, the compound is not an ester, not a solvate, and not a prodrug.
  • L 4 and R 4 are absent, providing a compound with structure of Formula (lb) following.
  • the compound has the structure of Formula (Ila), wherein L 3 is a bond, and R 3 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.
  • the pendant heteroaryl R 3 is substituted or unsubstituted pyridyl, thienyl, or furyl.
  • the R 3 is unsubstituted pyridyl, thienyl, or furyl.
  • R 3 is unsubstituted aryl, preferably phenyl.
  • R 3 is substituted aryl, preferably halogen-substituted phi [0057]
  • a compound is provided with structure of Formula (Ila), wherein L 3 is a bond, substituted or unsubstituted alkylene, and R 3 is substituted or unsubstituted aryl, or substituted or unsubstituted heterocycloalkyl.
  • the compound has the structure of Formula (Ila), wherein L 3 is -C(0)0-, and R 3 is substituted or unsubstituted alkyl, preferably unsubstituted alkyl, more preferably unsubstituted lower alkyl.
  • the compound has the structure of Formula (Ila), wherein L 3 is -C(0)NR 5 -, R 5 is hydrogen or alkyl, and R 3 is substituted or unsubstituted alkyl, or substituted or unsubstituted aryl.
  • L 1 is -S-, -NR 5 -, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene
  • R 1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heterocycloalkyl.
  • L 1 is -NC(O)-.
  • R 3 is substituted or unsubstituted aryl.
  • R 3 is unsubstituted aryl.
  • L 2 is a bond.. In some embodiments, L 2 is a bond and R 2 is hydrogen.
  • L 2 is substituted or unsubstituted alkylene or -C(O)-
  • R 2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heterocycloalkyl.
  • the compound of Formula (Ila) has the structure of Formula (lie) following, wherein L 1 is -NH-(CH 2 ) n -, n is 0 to 6, preferably 1, and R 1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or
  • L 1 is -NHCH 2 - or -NH(CH 2 ) 2 -, and R 1 is substituted or unsubstituted aryl.
  • R 1 is unsubstituted aryl.
  • R 1 is aryl, preferably phenyl, substituted with halogen, -CN or alkyloxy, preferably methoxy.
  • R 1 is unsubstituted alkyl, preferably lower alkyl, more preferably methyl or ethyl.
  • n is 0, and R 1 is hydrogen.
  • the compound of Formula (Ila) has the structure of Formula (lid) following, wherein L 1 is a bond, and R 1 is unsubstituted alkyl, or substituted or unsubstituted aryl. In some embodiments, R 1 is unsubstituted alkyl, preferably lower alkyl. In some embodiments, R 1 is substituted aryl, preferably halogen-substituted phenyl.
  • L 2 is a bond, or substituted or unsubstituted alkylene.
  • L 2 is a bond, and R 2 is alkyl, preferably lower alkyl.
  • L 2 is a substituted alkylene.
  • L 2 is an unsubstituted alkylene, preferably methylene or ethylene.
  • L 2 is an unsubstituted alkylene, and R2 is unsubstituted aryl, preferably phenyl.
  • R 2 is substituted or
  • the compound has the structure of Formula (Ilia).
  • L 3 is a bond, or substituted or unsubstituted alkylene, and R 3 is substituted or unsubstituted aryl, or substituted or unsubstituted heterocycloalkyl.
  • R 3 is substituted or unsubstituted phenyl, or substituted or unsubstituted pyridyl.
  • R 3 is unsubstituted phenyl.
  • R 3 is unsubstituted pyridyl.
  • the compound has the structure of Formula (Ilia) wherein L 3 is -C(0)0-, and R 3 is substituted or unsubstituted alkyl. [0069] In some embodiments, the compound has the structure of Formula (Ilia) wherein L 3 is -C(0)NR 6 , R 6 is hydrogen or alkyl, and R 3 is substituted or unsubstituted alkyl, or substituted or unsubstituted aryl.
  • L 1 is -S-, -NR 4 -, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene, and R 1 is hydrogen, substituted or
  • L 2 is a bond.
  • R 2 is hydrogen.
  • L 2 is substituted or unsubstituted alkylene or -C(O)-, and R 2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heterocycloalkyl.
  • the compound has the structure of Formula (Illb).
  • L 2 is a bond or substituted or unsubstituted alkylene. In some embodiments, L 2 is a bond. In some embodiments, L 2 is unsubstituted alkylene. In some embodiments, L 2 is substituted alkylene. In some embodiments, R 2 is substituted or unsubstituted alkyl, or substituted or unsubstituted aryl. Further to any particular L 2 , in some embodiments R 2 is substituted or unsubstituted alkyl, or substituted or unsubstituted aryl. In some embodiments, R 2 is unsubstituted alkyl. In some embodiments, R 2 is unsubstituted aryl. In some embodiments, R 2 is substituted alkyl. In some embodiments, R 2 is substituted aryl. In some embodiments, R 2 is substituted alkyl. In some embodiments, R 2 is substituted aryl. In some embodiments, R 2
  • L 3 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene, and R 3 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.
  • L 3 is a bond, -NH-, -NHCH 2 - or -NH(CH 2 ) 2 -.
  • L 1 is a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, -C(O)-, -C(0)-NR 6 -.
  • R 1 is hydrogen, -COOH, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or
  • R 6 is hydrogen, or substituted or unsubstituted alkyl.
  • Exemplary compounds, e.g., multisubstituted aromatic compounds, in accordance with the present disclosure are provided herein.
  • compound (Cmpd) number chemical name (i.e., International Union of Pure and Applied Chemistry [IUPAC] name), molecular weight (MW ca i c calculated mass and MW meas measured mass) and biological activity (i.e., inhibition activity in a thrombin assay) are disclosed.
  • IUPAC International Union of Pure and Applied Chemistry
  • the measured chemical species can be the protonated compound, e.g., [M + H] + , whereby the measured mass is 1 atomic unit greater than the calculated mass of the compound, as well known in the art.

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MX2012011380A MX355038B (es) 2010-03-30 2011-03-30 Compuestos aromáticos multisustituidos como inhibidores de trombina.
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