WO2011046023A1 - 貼付剤を製造するための方法及び装置 - Google Patents
貼付剤を製造するための方法及び装置 Download PDFInfo
- Publication number
- WO2011046023A1 WO2011046023A1 PCT/JP2010/067129 JP2010067129W WO2011046023A1 WO 2011046023 A1 WO2011046023 A1 WO 2011046023A1 JP 2010067129 W JP2010067129 W JP 2010067129W WO 2011046023 A1 WO2011046023 A1 WO 2011046023A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sheet
- forming
- release sheet
- continuous
- continuous sheet
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 30
- 239000000853 adhesive Substances 0.000 title abstract description 21
- 230000001070 adhesive effect Effects 0.000 title abstract description 21
- 239000012790 adhesive layer Substances 0.000 claims abstract description 42
- 239000010410 layer Substances 0.000 claims description 50
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 45
- 238000004519 manufacturing process Methods 0.000 claims description 40
- 238000005304 joining Methods 0.000 claims description 33
- 230000004927 fusion Effects 0.000 claims description 29
- 239000004744 fabric Substances 0.000 claims description 21
- 230000003313 weakening effect Effects 0.000 claims description 17
- 238000005520 cutting process Methods 0.000 claims description 14
- 238000003892 spreading Methods 0.000 claims description 11
- 230000007480 spreading Effects 0.000 claims description 11
- 230000015572 biosynthetic process Effects 0.000 claims description 10
- 238000000926 separation method Methods 0.000 claims description 10
- 238000009825 accumulation Methods 0.000 claims description 9
- 230000006870 function Effects 0.000 claims description 7
- 238000007500 overflow downdraw method Methods 0.000 claims description 7
- 238000011144 upstream manufacturing Methods 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 2
- -1 polyethylene terephthalate Polymers 0.000 description 37
- 239000000835 fiber Substances 0.000 description 21
- 210000003491 skin Anatomy 0.000 description 16
- 239000000463 material Substances 0.000 description 13
- 239000004743 Polypropylene Substances 0.000 description 12
- 229920001155 polypropylene Polymers 0.000 description 12
- 239000002562 thickening agent Substances 0.000 description 12
- 229940079593 drug Drugs 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- 238000003860 storage Methods 0.000 description 11
- 150000003839 salts Chemical class 0.000 description 10
- 229920000139 polyethylene terephthalate Polymers 0.000 description 9
- 239000005020 polyethylene terephthalate Substances 0.000 description 9
- 229920001577 copolymer Polymers 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 238000004049 embossing Methods 0.000 description 8
- 239000011505 plaster Substances 0.000 description 8
- 238000007789 sealing Methods 0.000 description 8
- 239000000499 gel Substances 0.000 description 7
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 239000000123 paper Substances 0.000 description 6
- 229920002472 Starch Polymers 0.000 description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 5
- 239000002585 base Substances 0.000 description 5
- 239000003431 cross linking reagent Substances 0.000 description 5
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 5
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 229920003169 water-soluble polymer Polymers 0.000 description 5
- LVYLCBNXHHHPSB-UHFFFAOYSA-N 2-hydroxyethyl salicylate Chemical compound OCCOC(=O)C1=CC=CC=C1O LVYLCBNXHHHPSB-UHFFFAOYSA-N 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 description 4
- 229920002125 Sokalan® Polymers 0.000 description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 4
- 239000004745 nonwoven fabric Substances 0.000 description 4
- 239000004584 polyacrylic acid Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 description 4
- 238000003825 pressing Methods 0.000 description 4
- 229920006132 styrene block copolymer Polymers 0.000 description 4
- 230000037303 wrinkles Effects 0.000 description 4
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 3
- 229920002633 Kraton (polymer) Polymers 0.000 description 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 3
- 235000006679 Mentha X verticillata Nutrition 0.000 description 3
- 235000002899 Mentha suaveolens Nutrition 0.000 description 3
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 238000005452 bending Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 229920001971 elastomer Polymers 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 229920000058 polyacrylate Polymers 0.000 description 3
- 229920000728 polyester Polymers 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 229920000915 polyvinyl chloride Polymers 0.000 description 3
- 239000004800 polyvinyl chloride Substances 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 239000005060 rubber Substances 0.000 description 3
- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 229920003051 synthetic elastomer Polymers 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- WDQMWEYDKDCEHT-UHFFFAOYSA-N 2-ethylhexyl 2-methylprop-2-enoate Chemical compound CCCCC(CC)COC(=O)C(C)=C WDQMWEYDKDCEHT-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 229920003043 Cellulose fiber Polymers 0.000 description 2
- 229920002085 Dialdehyde starch Polymers 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 229920002367 Polyisobutene Polymers 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 235000010419 agar Nutrition 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 239000000783 alginic acid Substances 0.000 description 2
- 229960001126 alginic acid Drugs 0.000 description 2
- 150000004781 alginic acids Chemical class 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 229960002537 betamethasone Drugs 0.000 description 2
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 2
- CIWBQSYVNNPZIQ-PKWREOPISA-N dexamethasone dipropionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CIWBQSYVNNPZIQ-PKWREOPISA-N 0.000 description 2
- 229950000250 dexamethasone dipropionate Drugs 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000003193 general anesthetic agent Substances 0.000 description 2
- 229960002389 glycol salicylate Drugs 0.000 description 2
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 238000010030 laminating Methods 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 229960001047 methyl salicylate Drugs 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- RGOVYLWUIBMPGK-UHFFFAOYSA-N nonivamide Chemical compound CCCCCCCCC(=O)NCC1=CC=C(O)C(OC)=C1 RGOVYLWUIBMPGK-UHFFFAOYSA-N 0.000 description 2
- 229940060184 oil ingredients Drugs 0.000 description 2
- 239000012985 polymerization agent Substances 0.000 description 2
- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229920002994 synthetic fiber Polymers 0.000 description 2
- 239000012209 synthetic fiber Substances 0.000 description 2
- 229920001059 synthetic polymer Polymers 0.000 description 2
- 239000005061 synthetic rubber Substances 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 239000002759 woven fabric Substances 0.000 description 2
- 239000011787 zinc oxide Substances 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- MDKGKXOCJGEUJW-VIFPVBQESA-N (2s)-2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid Chemical compound C1=CC([C@@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-VIFPVBQESA-N 0.000 description 1
- LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 description 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- JALUUBQFLPUJMY-UHFFFAOYSA-N 2-(4-phenylphenyl)propanoic acid Chemical compound C1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 JALUUBQFLPUJMY-UHFFFAOYSA-N 0.000 description 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 1
- IEKLVCVEJCEIJD-LYRWTKHRSA-N 4-[2-[(8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)COC(=O)CCC(O)=O)(O)[C@@]1(C)C[C@@H]2O IEKLVCVEJCEIJD-LYRWTKHRSA-N 0.000 description 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
- TZZAKSLHHIJRLL-UHFFFAOYSA-N 4-hydroxy-3-methoxybenzamide Chemical compound COC1=CC(C(N)=O)=CC=C1O TZZAKSLHHIJRLL-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 1
- 229920002972 Acrylic fiber Polymers 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- VAUBWHIQMRKGBN-BHHHYXKXSA-N C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)CC2=O Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)CC2=O VAUBWHIQMRKGBN-BHHHYXKXSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 240000000491 Corchorus aestuans Species 0.000 description 1
- 235000011777 Corchorus aestuans Nutrition 0.000 description 1
- 235000010862 Corchorus capsularis Nutrition 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- WYQPLTPSGFELIB-JTQPXKBDSA-N Difluprednate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2CC[C@@](C(=O)COC(C)=O)(OC(=O)CCC)[C@@]2(C)C[C@@H]1O WYQPLTPSGFELIB-JTQPXKBDSA-N 0.000 description 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- GXBYFVGCMPJVJX-UHFFFAOYSA-N Epoxybutene Chemical compound C=CC1CO1 GXBYFVGCMPJVJX-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 241000219146 Gossypium Species 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- MUQNGPZZQDCDFT-JNQJZLCISA-N Halcinonide Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CCl)[C@@]1(C)C[C@@H]2O MUQNGPZZQDCDFT-JNQJZLCISA-N 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 229920000057 Mannan Polymers 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical class COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 240000000907 Musa textilis Species 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 1
- TVQZAMVBTVNYLA-UHFFFAOYSA-N Pranoprofen Chemical compound C1=CC=C2CC3=CC(C(C(O)=O)C)=CC=C3OC2=N1 TVQZAMVBTVNYLA-UHFFFAOYSA-N 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 206010050637 Skin tightness Diseases 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- FBRAWBYQGRLCEK-UHFFFAOYSA-N [17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6h-cyclopenta[a]phenanthren-17-yl] butanoate Chemical compound C1CC2=CC(=O)C=CC2(C)C2(F)C1C1CC(C)C(C(=O)CCl)(OC(=O)CCC)C1(C)CC2=O FBRAWBYQGRLCEK-UHFFFAOYSA-N 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- 229940124532 absorption promoter Drugs 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- 150000001241 acetals Chemical class 0.000 description 1
- 229940022663 acetate Drugs 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000003522 acrylic cement Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940023476 agar Drugs 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 229940030600 antihypertensive agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000004760 aramid Substances 0.000 description 1
- 229920006231 aramid fiber Polymers 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 229960001102 betamethasone dipropionate Drugs 0.000 description 1
- CIWBQSYVNNPZIQ-XYWKZLDCSA-N betamethasone dipropionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CIWBQSYVNNPZIQ-XYWKZLDCSA-N 0.000 description 1
- 229960004311 betamethasone valerate Drugs 0.000 description 1
- SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 description 1
- QRZAKQDHEVVFRX-UHFFFAOYSA-N biphenyl-4-ylacetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1C1=CC=CC=C1 QRZAKQDHEVVFRX-UHFFFAOYSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 229960001889 buprenorphine hydrochloride Drugs 0.000 description 1
- UAIXRPCCYXNJMQ-RZIPZOSSSA-N buprenorphine hydrochlorie Chemical compound [Cl-].C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)C[NH+]2CC1CC1 UAIXRPCCYXNJMQ-RZIPZOSSSA-N 0.000 description 1
- GMTYREVWZXJPLF-AFHUBHILSA-N butorphanol D-tartrate Chemical compound OC(=O)[C@@H](O)[C@H](O)C(O)=O.N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 GMTYREVWZXJPLF-AFHUBHILSA-N 0.000 description 1
- 229960001590 butorphanol tartrate Drugs 0.000 description 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 229940001468 citrate Drugs 0.000 description 1
- 229960005465 clobetasone butyrate Drugs 0.000 description 1
- 229920006026 co-polymeric resin Polymers 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- BMCQMVFGOVHVNG-TUFAYURCSA-N cortisol 17-butyrate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)CO)(OC(=O)CCC)[C@@]1(C)C[C@@H]2O BMCQMVFGOVHVNG-TUFAYURCSA-N 0.000 description 1
- FZCHYNWYXKICIO-FZNHGJLXSA-N cortisol 17-valerate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O FZCHYNWYXKICIO-FZNHGJLXSA-N 0.000 description 1
- DNTGGZPQPQTDQF-XBXARRHUSA-N crotamiton Chemical compound C/C=C/C(=O)N(CC)C1=CC=CC=C1C DNTGGZPQPQTDQF-XBXARRHUSA-N 0.000 description 1
- 229960003338 crotamiton Drugs 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- 229950006825 dexamethasone valerate Drugs 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 229960004875 difluprednate Drugs 0.000 description 1
- 125000005442 diisocyanate group Chemical group 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- 125000005594 diketone group Chemical group 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 125000003700 epoxy group Chemical group 0.000 description 1
- BXOUVIIITJXIKB-UHFFFAOYSA-N ethene;styrene Chemical group C=C.C=CC1=CC=CC=C1 BXOUVIIITJXIKB-UHFFFAOYSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 229960005293 etodolac Drugs 0.000 description 1
- XFBVBWWRPKNWHW-UHFFFAOYSA-N etodolac Chemical compound C1COC(CC)(CC(O)=O)C2=N[C]3C(CC)=CC=CC3=C21 XFBVBWWRPKNWHW-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 229960000192 felbinac Drugs 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229960001347 fluocinolone acetonide Drugs 0.000 description 1
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- LRBQNJMCXXYXIU-QWKBTXIPSA-N gallotannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@H]2[C@@H]([C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-QWKBTXIPSA-N 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229940015043 glyoxal Drugs 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 229960002383 halcinonide Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Substances CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 229960001524 hydrocortisone butyrate Drugs 0.000 description 1
- 229960000631 hydrocortisone valerate Drugs 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 150000002440 hydroxy compounds Chemical class 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229920000831 ionic polymer Polymers 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
- 229960000991 ketoprofen Drugs 0.000 description 1
- 229960004752 ketorolac Drugs 0.000 description 1
- OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 description 1
- 239000002655 kraft paper Substances 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 229960002373 loxoprofen Drugs 0.000 description 1
- BAZQYVYVKYOAGO-UHFFFAOYSA-M loxoprofen sodium hydrate Chemical compound O.O.[Na+].C1=CC(C(C([O-])=O)C)=CC=C1CC1C(=O)CCC1 BAZQYVYVKYOAGO-UHFFFAOYSA-M 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 240000004308 marijuana Species 0.000 description 1
- 108010090374 matriderm Proteins 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 229940065472 octyl acrylate Drugs 0.000 description 1
- 229960002739 oxaprozin Drugs 0.000 description 1
- OFPXSFXSNFPTHF-UHFFFAOYSA-N oxaprozin Chemical compound O1C(CCC(=O)O)=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 OFPXSFXSNFPTHF-UHFFFAOYSA-N 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229960001639 penicillamine Drugs 0.000 description 1
- UCUUFSAXZMGPGH-UHFFFAOYSA-N penta-1,4-dien-3-one Chemical compound C=CC(=O)C=C UCUUFSAXZMGPGH-UHFFFAOYSA-N 0.000 description 1
- 229960005301 pentazocine Drugs 0.000 description 1
- VOKSWYLNZZRQPF-GDIGMMSISA-N pentazocine Chemical compound C1C2=CC=C(O)C=C2[C@@]2(C)[C@@H](C)[C@@H]1N(CC=C(C)C)CC2 VOKSWYLNZZRQPF-GDIGMMSISA-N 0.000 description 1
- 229940116257 pepper extract Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920001707 polybutylene terephthalate Polymers 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920005996 polystyrene-poly(ethylene-butylene)-polystyrene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920006306 polyurethane fiber Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- 229960003101 pranoprofen Drugs 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229950008480 prednisolone valerate acetate Drugs 0.000 description 1
- DGYSDXLCLKPUBR-SLPNHVECSA-N prednisolone valerate acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(C)=O)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O DGYSDXLCLKPUBR-SLPNHVECSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 1
- 229940032159 propylene carbonate Drugs 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000002964 rayon Substances 0.000 description 1
- 229940077082 red pepper extract Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000004627 regenerated cellulose Substances 0.000 description 1
- 229920006297 regenerated protein fiber Polymers 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940114926 stearate Drugs 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 229960000894 sulindac Drugs 0.000 description 1
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
- 229960004492 suprofen Drugs 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229960001017 tolmetin Drugs 0.000 description 1
- UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229920000428 triblock copolymer Polymers 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 description 1
- 229910021511 zinc hydroxide Inorganic materials 0.000 description 1
- 229940007718 zinc hydroxide Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F13/0289—Apparatus or processes for manufacturing adhesive dressings or bandages manufacturing of adhesive dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00072—Packaging of dressings
- A61F13/00076—Packaging of adhesive dressings
- A61F13/0008—Packaging of adhesive dressings having means for facilitating the removal of the packaging and release liner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00085—Accessories for dressings having means for facilitating the application on the skin, e.g. single hand handling facilities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0259—Adhesive bandages or dressings characterised by the release liner covering the skin adhering layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
- Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/12—Surface bonding means and/or assembly means with cutting, punching, piercing, severing or tearing
Definitions
- the present invention relates to a patch such as a poultice or a plaster, and particularly relates to a production method and apparatus thereof.
- the patch is usually composed of a support made of woven fabric or nonwoven fabric, a pressure-sensitive adhesive layer provided on one surface of the support, and a release sheet that is releasably attached to the pressure-sensitive adhesive layer. ing.
- the adhesive forming the adhesive layer contains a transdermal drug or the like.
- the patches described in Patent Documents 1 and 2 are composed of a support having elasticity and a release sheet that is releasably attached to an adhesive layer on the support, and a perforation is formed in the central portion of the release sheet. It is characterized by being formed.
- this patch first, the patch is pulled right and left to tear the perforation to expose the pressure-sensitive adhesive layer, and the exposed part is attached to the skin, and then the release sheet is removed.
- the patch described in Patent Document 3 has two release sheets placed on the adhesive layer, the inner end of one release sheet is bent, and the inner side of the other release sheet is placed on the folded portion. The ends are overlapped.
- the release sheet can be easily removed from the adhesive layer, thereby facilitating the application to the skin. I am trying.
- the patch described in Patent Document 4 is one in which two release sheets are folded and placed on the pressure-sensitive adhesive layer in a state where the fold lines are butted. Similarly to the patch described in Patent Document 3, this patch can also be easily peeled from the pressure-sensitive adhesive layer by picking a bent portion.
- Patent Document 5 is a wound dressing different from a patch, a so-called adhesive bandage, this is also devised to facilitate the peeling of the release sheet. That is, this wound dressing is placed on the pressure-sensitive adhesive layer in a state in which the ends of the two release sheets are in contact with each other as in the case of Patent Document 4. And the pulling tab which pulls a peeling sheet and peels it is made to adhere on the edge part of the butt
- the patch of Patent Documents 3 and 4 and the wound dressing described in Patent Document 5 have the advantage that it is easy to peel off the release sheet from the adhesive layer because there is a portion to be picked, but the two release sheets are superimposed. There is a problem that the medicinal component in the pressure-sensitive adhesive layer leaks out from the portion and the butted portion.
- the folded part of one release sheet and the end of the other release sheet stacked on the other are oriented in the same direction, and therefore only from one side. It is inconvenient because the release sheet cannot be picked. Furthermore, in order to bend the release sheet, a special sheet bending apparatus is required, and there is a problem that the manufacturing cost of the patch increases.
- the patch described in Patent Document 4 also requires a step of bending the release sheet during production, and in addition, the folding lines of the two release sheets must be matched with high accuracy in order to suppress leakage of medicinal components as much as possible. Therefore, it is extremely difficult to produce the patch.
- JP-A-8-112305 Japanese Utility Model Publication No. 50-133797 JP 2000-219622 A JP 2009-131583 A JP 59-149141 A
- An object of the present invention is to provide a method and apparatus suitable for producing such a novel patch.
- the patch produced by the patch production method or the patch production apparatus according to the present invention includes a support, a pressure-sensitive adhesive layer provided on one surface of the support, and a release sheet attached to the pressure-sensitive adhesive layer in a peelable manner. And a weakening portion formed on the release sheet for facilitating the separation of the release sheet, and further, a knob forming sheet is joined on the release sheet so as to cover the weakened portion.
- the portion of the tab piece forming sheet other than the tab portion functions as a tab piece, and the tab portion forming sheet has a weakening portion that facilitates the division of the release sheet at a position corresponding to the weakened portion of the release sheet. It is characterized by being formed.
- the support preferably has elasticity. This is because the release sheet and the tab piece forming sheet can be divided along the weakened portion by pulling the support.
- the release sheet and the tab piece forming sheet are divided along the weakened portion, whereby a tab piece is formed on each of the divided release sheets.
- the user can easily peel off the release sheet from the adhesive layer using the knob, and can also be used for adjusting the position of the patch.
- the release sheet since the release sheet has a single sheet configuration before use, problems such as leakage of medicinal components and wrinkles of the patch due to the displacement of the release sheet as in the conventional configurations described in Patent Documents 3 to 5 also occur. Absent.
- Such a patch is manufactured by the following method. That is, the method for producing a patch according to the present invention includes a first step of forming an adhesive layer on a support, a second step of joining a knob-forming sheet on the release sheet, a release sheet, and a knob-forming sheet.
- the third step for forming the weakened portion and the release sheet obtained by joining the knob forming sheet obtained in the third step can be peeled to the adhesive layer on the support obtained in the first step.
- a fourth step of attaching The bonding in the second step is preferably performed by heat fusion.
- the present invention also relates to a method for continuously producing a patch, and in that case, the patch, the release sheet, and the tab piece forming sheet are produced from continuous sheets. That is, in the method, the first continuous sheet serving as a support is fed out from the first original fabric, and a first step of forming an adhesive layer on the first continuous sheet, and a second step serving as a release sheet. The continuous sheet is fed out from the second original fabric, and the third continuous sheet to be a tab forming sheet is fed out from the third original fabric, and the third continuous sheet is superposed on the second continuous sheet and joined. The second step, the third step of forming the weakened portion in the joined second continuous sheet and the third continuous sheet, and the second step obtained by joining the third continuous sheet obtained in the third step.
- the bonding in the second step is preferably performed by a heat fusion method.
- a junction part when a junction part is one place, it can be on a junction part, but when a junction part is provided in two places, it is between two junction parts. Is preferable. This is because the weakness can be easily formed between the two joint portions because the rigidity or strength of the joint portion is higher than that of the portion other than the joint portion.
- an adhesive layer is formed by spreading an adhesive on a first continuous sheet serving as a support drawn from the first original fabric.
- the spreading portion to be formed, the second continuous sheet serving as a release sheet fed out from the second original fabric, and the third continuous sheet serving as a tab piece forming sheet fed out from the third original fabric are stacked.
- the third continuous sheet that has passed through the weakened part forming part, the weakened part forming part that forms the weakened part on the second continuous sheet and the third continuous sheet joined by the joined part, and the joined part to be joined together A laminated body forming portion that forms a laminated body by releasably attaching the second continuous sheet bonded to the adhesive layer on the first continuous sheet that has passed through the spreading portion, and a laminated body forming portion.
- the obtained laminate is cut into a predetermined size, and a cut portion for forming a patch is provided. It is characterized in Rukoto.
- the joint is preferably provided with a heat fusion device, and when the heat fusion device is a press type, the first accumulation device capable of accumulating the second continuous sheet and the third continuous sheet.
- the second storage device may be provided on the upstream side of the heat-sealing device and between the heat-sealing device and the laminated body forming unit, respectively.
- the patch according to the present invention has no member that needs to be bent. Therefore, the manufacturing method and apparatus also do not require a special bending apparatus or the like, and are easy to manufacture. Moreover, since the peeling suppression means as described in Patent Document 5 is not necessary, the manufacturing is easy also in this respect. Therefore, manufacturing efficiency can be improved and an increase in manufacturing cost can be suppressed.
- FIG. 1 is a perspective view showing an embodiment of such a patch
- FIG. 2 is a plan view thereof
- FIG. 3 is a side view thereof.
- the illustrated patch 10 is used as a poultice or plaster, etc., and has a stretchable support 12 and an adhesive containing a drug formed on substantially the entire surface of one side of the support 12. It is comprised from the layer 14, the peeling sheet 16 stuck to the surface of the adhesive layer 14 so that peeling was possible, and the knob
- the pick piece forming sheet 18 is not joined to the release sheet 16 on the entire surface, and both left and right end portions are not joined to the release sheet 16.
- substantially central part of the release sheet 16 and the tab-forming sheet 18 which is a substantially central part in the longitudinal direction of the patch 10, and hereinafter referred to as “substantially central part”
- a weakened portion 20 such as a perforation that makes it easy to divide the release sheet 16 and the tab piece forming sheet 18 is formed.
- a suitable sheet-like member such as woven fabric, knitted fabric, non-woven fabric, non-woven paper, film, etc. can be used, and thickness, elongation, tensile strength, sticking can be used. It is selected in consideration of physical properties such as workability, feel at the time of application, skin tightness, transfer of medicinal components to the support 12 and the like.
- the stretchability of the support 12 it is desirable that the 50% modulus in the vertical direction and / or the horizontal direction is 0.5 to 10 N / 50 mm.
- Specific materials for the support 12 include bast fibers such as paper, cotton, cannabis and jute, cellulose fibers such as leaf fibers of manila hemp, animal fibers such as wool, and protein fibers such as silk fiber and feather fibers. Natural fibers such as regenerated cellulose fibers such as rayon and cupra, regenerated fibers such as regenerated protein fibers, semi-synthetic fibers such as cellulose acetate fibers and promix, nylon aramid fibers, polyethylene terephthalate fibers, polyester fibers, acrylic fibers, polyethylene, etc.
- bast fibers such as paper, cotton, cannabis and jute
- cellulose fibers such as leaf fibers of manila hemp
- animal fibers such as wool
- protein fibers such as silk fiber and feather fibers.
- Natural fibers such as regenerated cellulose fibers such as rayon and cupra, regenerated fibers such as regenerated protein fibers, semi-synthetic fibers such as cellulose acetate fibers and promix, nylon
- Polyolefin fibers such as polypropylene, polyvinyl alcohol fibers, polyvinyl chloride fibers, polyvinylidene chloride fibers, polyvinyl chloride fibers, polyurethane fibers, polyoxymethylene fibers, polytetrafluoroethylene fibers, polyparaphenylenebenzbisthiazole (PBT) Fiber, polyimide fiber Etc.
- PBT polyparaphenylenebenzbisthiazole
- a nonwoven fabric made of a polyester-based polyethylene terephthalate fiber that has little interaction with the components contained in the pressure-sensitive adhesive layer 14 is preferable.
- the pressure-sensitive adhesive layer 14 is used effectively as a patch 10 such as a poultice or a plaster by containing or adhering a drug to an adhesive base.
- the adhesive component that is a constituent material of the adhesive layer 14 is not particularly limited as long as it has adhesiveness and can be attached to the skin. However, when used as a poultice, the adhesive layer 14 has an adhesiveness to the skin.
- the pressure-sensitive adhesive layer 14 is preferably a water-soluble polymer.
- the thickener is 5 to 20% by weight, preferably 10 to 15% by weight, and the wetting agent is 5 to 40% by weight.
- an agent 10% by weight to 80% by weight of water, 0 to 8% by weight of a solubilizing agent, and 5% by weight or less of a drug, preferably 0.1 to 5% by weight.
- water-soluble polymer examples include gelatin, agar, alginic acid, mannan, carboxymethyl cellulose or a salt thereof, hydroxypropyl cellulose or a salt thereof, polyvinyl alcohol, polyacrylic acid or a salt thereof, or at least one of these. Or what was bridge
- a thickener, a wetting agent, and the like are appropriately added to the adhesive layer 14.
- moisture can be stably maintained at 10% to 80% and that it has water retention.
- Specific examples include guar gum, locust bean gum, carrageenan, alginic acid, sodium alginate, agar, gum arabic, tragacanth gum, karaya gum, pectin, starch, acacia gum and other microbial systems, xanthan gum and other microbial systems, gelatin, collagen and the like.
- Natural polymers such as animal systems, cellulose systems such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose sodium, semi-synthetic polymers such as starch systems such as soluble starch, carboxymethyl starch, and dialdehyde starch, polyvinyl alcohol, polyvinyl pyrrolidone, Vinyl-based materials such as polyvinyl methacrylate, acrylic-based materials such as polyacrylic acid and sodium polyacrylate, other polyethylene oxide, methyl vinyl ether / Water-soluble polymers of a synthetic polymer such as water maleic acid copolymers and the like are suitably used. In particular, sodium polyacrylate is preferable. This is because the gel strength is strong and the water retention is excellent.
- sodium polyacrylate having an average degree of polymerization of 20000 to 70000 is preferred.
- the average degree of polymerization becomes smaller than 20000 the thickening effect tends to be poor and sufficient gel strength cannot be obtained.
- the average degree of polymerization becomes larger than 70000 the thickening effect tends to be too strong and the workability tends to decrease. Appear.
- a polymer complex can be formed with a strong ionic polymer of sodium polyacrylate, and an elastic gel with higher gel strength can be obtained.
- Wetting agents include polyhydric alcohols such as glycerin, propylene glycol and sorbitol, and fillers include kaolin, talc, titanium, bentonite, aluminum silicate, titanium oxide, zinc oxide, aluminum metasilicate, calcium sulfate, calcium phosphate, etc. It may be added. Further, as a solubilizing agent or absorption promoter, propylene carbonate, crotamiton, l-menthol, mint oil, limonene, diisopropyl adipate and the like, and as medicinal aids, methyl salicylate, glycol salicylate, l-menthol, thymol, mint oil, Nonyl acid vanillylamide, pepper extract, etc. may be added.
- solubilizing agent or absorption promoter propylene carbonate, crotamiton, l-menthol, mint oil, limonene, diisopropyl adipate and the like, and as medicinal aids, methyl
- stabilizers antioxidants, emulsifiers and the like may be added as necessary.
- the pressure-sensitive adhesive layer 14 can be strengthened and water retention can be imparted.
- This crosslinking agent and polymerization agent are appropriately selected according to the type of thickener and the like.
- polyacrylic acid or polyacrylate when applied to the thickener, a compound having at least two epoxy groups in the molecule, hydrochloride such as Ca, Mg, Al, sulfate, phosphate, Inorganic acid salts such as carbonate, organic acid salts such as citrate, tartrate, gluconate and stearate, oxides such as zinc oxide and anhydrous silicic acid, hydroxides such as aluminum hydroxide and magnesium hydroxide A polyvalent metal compound such as is preferably used.
- hydrochloride such as Ca, Mg, Al, sulfate, phosphate
- Inorganic acid salts such as carbonate
- organic acid salts such as citrate, tartrate, gluconate and stearate
- oxides such as zinc oxide and anhydrous silicic acid
- hydroxides such as aluminum hydroxide and magnesium hydroxide
- a polyvalent metal compound such as is preferably used.
- polyvinyl alcohol When polyvinyl alcohol is applied as a thickener, adipic acid, thioglycolic acid, epoxy compound (epichlorohydrin), aldehydes, N-methylol compound, Al, Ti, Zr, Sn, V, Cu, B, Cr Complexes such as compounds such as are preferably used.
- polyvinylpyrrolidone When polyvinylpyrrolidone is applied as the thickener, methyl vinyl ether / maleic anhydride copolymer, polyacid compound or alkali metal salt thereof (polyacrylic acid, tannic acid and derivatives thereof), etc. are preferably used.
- polyethylene oxide when polyethylene oxide is applied to the thickener, perchioside, polysulfone azide and the like are preferably used.
- a methyl vinyl ether / maleic anhydride copolymer when applied to the thickener, polyfunctional hydroxy compounds, polyamines, iodine, gelatin, polyvinyl pyrrolidone, iron, mercury, lead salts and the like are preferably used.
- aldehydes such as formaldehyde, glutaraldehyde, and dialdehyde starch
- diepoxides such as glyoxal and butadiene oxide
- diketones such as divinyl ketone
- diisocyanates are preferably used.
- a polyvalent metal salt such as lithium hydroxide, zinc hydroxide, aluminum hydroxide or sodium borate is preferably added as a crosslinking agent. Particularly preferred are zinc salts and aluminum salts.
- the concentration of the polyvalent metal salt added as a crosslinking agent is preferably 0.5 to 1.5 equivalents relative to 1 equivalent of the thickener (or water-soluble polymer). As the concentration of the polyvalent metal salt becomes smaller than 0.5 equivalent, the reaction tends to be too slow and the gel strength tends to be lowered, and as the concentration of the polyvalent metal salt becomes larger than 1.5 equivalent, the reaction becomes too fast. There is a tendency that gelation becomes non-uniform and workability decreases.
- the adhesive base is preferably a rubber-based adhesive component, an acrylic adhesive component, a silicon-based adhesive component, or the like.
- the rubber-based adhesive component either natural rubber or synthetic rubber can be used.
- the synthetic rubber include styrene-based block copolymers and polyisobutylene.
- styrene block copolymers include styrene-butylene-styrene block copolymer (SBS), styrene-isoprene-styrene block copolymer (SIS), styrene-ethylene / butylene-styrene block copolymer (SEBS), styrene-ethylene / propylene- Styrene block copolymer (SEPS) is mentioned.
- styrenic block copolymer examples include Kraton D-1112, D-1111, D-1107 (trade name, manufactured by Kraton Polymer Co., Ltd.), JSR5000 or JSR5002 (trade name, manufactured by Nippon Synthetic Rubber Co., Ltd.), Linear triblock copolymers such as Quintac 3530, 3421 or 3570C (trade name, manufactured by ZEON CORPORATION), Clayton D-KX401CS or D-1107CU (trade name, manufactured by Clayton Polymer Co., Ltd.), Clayton D-1124 (Brand name, manufactured by Kraton Polymer Co., Ltd.), Sorprene 418 (Brand name, manufactured by Philippe Petroleum Co., Ltd.) and the like.
- polymers to low molecular weight compounds are used.
- Opanol B10, B12, B12SF, B15, B15SF, B30SF, B50, B50SF, B80, B100, B120, B150, B200 (trade name, BASF Manufactured by Co., Ltd.), Vistanex LM-MS, LM-MH, LM-H, MM L-80, MM L-100, MM L-120, MM L-150 (trade name, manufactured by Exxon Chemical Co., Ltd.) Etc.
- monomer units may be (meth) acrylic represented by, for example, 2-ethylhexyl acrylate, methyl acrylate, butyl acrylate, hydroxyethyl acrylate, 2-ethylhexyl methacrylate, and the like.
- Polymers or copolymers containing at least one acid ester are used, such as acrylic acid / octyl acrylate ester copolymer, acrylic acid-2-ethylhexyl / N-vinyl-2-pyrrolidone / dimethacrylic acid 1,6-hexane glycol copolymer, 2-ethylhexyl acrylate / vinyl acetate copolymer, 2-ethylhexyl acrylate / vinyl acetate / acrylic acid copolymer, 2-ethylhexyl acrylate / methacrylic acid-2 -Ethylhexyl / dodecyl methacrylate copolymer, Methyl crylate / acrylic acid-2-ethylhexyl copolymer resin emulsion, pressure sensitive adhesive such as acrylic polymer in acrylic resin alkanolamine liquid, Duro-Tak acrylic pressure sensitive adhesive series (manufactured by National Starch and Chemical
- the above rubber-based, acrylic-based, silicon-based and other adhesive bases can be used singly or in combination of two or more.
- a tackifier In the case of a plaster agent, a tackifier, a plasticizer, a filler, and a stabilizer can be appropriately blended.
- the drug contained in the adhesive layer 14 is not particularly limited as long as it is percutaneously absorbed into the body and exerts a pharmacological effect.
- an anti-inflammatory agent for example, an analgesic agent, an antihistamine, Examples include anesthetic agents, blood circulation promoters, anesthetic agents, tranquilizers, antihypertensive agents, antibacterial agents, and vasodilators.
- the drugs include methyl salicylate, glycol salicylate, l-menthol, red pepper extract, nonylic acid vanillylamide, mint oil, diclofenac, ibuprofen, indomethacin, ketoprofen, loxoprofen, sulindac, tolmetine, lobenzalit, penicillamine, fempfen, flurule At least one selected from biprofen, naproxen, pranoprofen, thiaprofen, suprofen, felbinac, ketorolac, oxaprozin, etodolac, zaltoprofin, piroxicam, pentazocine, buprenorphine hydrochloride, butorphanol tartrate, and the like, and ester derivatives or salts thereof
- Non-steroidal anti-inflammatory drugs prednisolone, dexamethasone, hydrocortisone, betamethasone, Osinide, fluocinolone ace
- Two or more kinds of drugs can be used in combination as necessary.
- these drugs may be in the form of an ester derivative, an amide derivative, an acetal derivative, or a medically acceptable inorganic salt or organic salt as necessary. It may be contained or attached to the pressure-sensitive adhesive layer 14.
- the amount of the drug is appropriately selected according to the type and use of the patch 10 such as a patch or plaster so that an effective amount set in advance when applied to the patient can be applied to the skin.
- release sheet 16 examples include polypropylene, for example, unstretched polypropylene and stretched polypropylene, polyethylene terephthalate, polybutylene terephthalate, polyethylene, polyester, polyurethane, polyvinyl chloride, polystyrene and other plastic films, synthetic resins, synthetic paper, synthetic fibers, and the like.
- a non-colored or colored paper such as silicon-treated paper, aluminum foil, and laminated paper obtained by laminating kraft paper with polyethylene or the like is used.
- the thickness of the release sheet 16 is not particularly limited, but it is preferably 10 to 75 ⁇ m, preferably 12 to 50 ⁇ m.
- the thickness of the release sheet 16 is less than 10 ⁇ m, the release sheet 16 becomes too thin, and the release sheet 16 is entangled with the pressure-sensitive adhesive layer 14 at the time of release, or the release sheet 16 is immediately divided at the time of production. Etc., or when the release sheet 16 is stuck on the pressure-sensitive adhesive layer 14, the tendency that the release sheet 16 tends to be wrinkled tends to appear.
- the release sheet 16 and the tab piece forming sheet 18 are divided along the weakening line 20 by pulling left and right.
- the thickness exceeds 75 ⁇ m, it becomes difficult to divide, When manufacturing, it becomes difficult to cut the raw sheet, and the tendency for workability and the like to decrease appears.
- the release sheet 16 is preferably provided with irregularities by embossing or the like.
- a display part such as a figure such as an arrow, a character, a symbol, or the like may be provided on the left and right parts of the release sheet 16 or may be colored. This display part may be formed by embossing.
- the release sheet 16 When the release sheet 16 is embossed, the following effects are obtained. That is, since the unevenness
- the end of the release sheet 16 along the dividing line tends to float naturally from the adhesive layer 14. This also facilitates the peeling of the release sheet 16.
- the exposed portion of the support 12 is bent or the adhesive layers 14 of the portion adhere to each other due to such a floating phenomenon at the end of the release sheet 16. Since the knob forming sheet 18 (the knobs 18 a and 18 b) is joined along the weakened portion 20, it is possible to prevent the end of the release sheet 16 from being carelessly lifted from the pressure-sensitive adhesive layer 14.
- the tab forming sheet 18 is rectangular, and the length D1 of the long side thereof is substantially the same as the length D2 of the short side of the patch 10, and the length D3 of the short side thereof. Is shorter than the length D4 of the long side of the patch 10.
- Such a tab piece forming sheet 18 is arranged at a substantially central portion of the release sheet 16 such that the long side of the tab piece forming sheet 18 is parallel to the short side of the release sheet 16.
- the tab piece forming sheet 18 is peeled at a position at a predetermined interval x (not particularly limited, for example, 0.5 to 25 mm) on each of the left and right sides from the longitudinal central axis (position of the weakened portion 20).
- the sheet 16 is joined substantially inseparably.
- the left and right joining portions 22 of the tab piece forming sheet 18 and the release sheet 16 extend over the entire length of the tab piece forming sheet 18. Further, the tab piece forming sheet 18 is not joined to the release sheet 16 with respect to a portion outside the joining portion 22 (a direction away from the longitudinal central axis of the tab piece forming sheet 18).
- the portion functions as knobs 18a and 18b described later. Since the pick pieces 18a and 18b are for picking with a finger, they are appropriately determined as long as they can be picked with a finger, but the width y of the pick pieces 18a and 18b is preferably about 2 to 4 cm. . This is because if it is less than 2 cm, it is difficult to pick it with a finger, and if it exceeds 4 cm, the pick pieces 18a and 18b are too large to be handled and the material cost increases.
- the width z of the joining portion 22 between the tab piece forming sheet 18 and the release sheet 16 can be determined as long as a minimum dimension is secured so that the joining of the sheets 16 and 18 cannot be separated.
- it is effective to have a certain width. For example, a width of about 0.1 to 10 mm is preferable.
- the long side length D1 is 150 mm and the short side length as the knob forming sheet 18.
- D3 is 70 mm
- the distance x from the longitudinal center axis (position of the weakened portion 20) of the knob-forming sheet 18 to the joint portion 22 is 2.5 mm
- the width z of the joint portion 22 is 1.0 mm. Therefore, it is preferable to use the knobs 18a and 18b having a width y of 31.5 mm.
- any means may be used as long as the two sheets 16 and 18 can be joined substantially inseparablely.
- the heat fusion method is preferred.
- the heat fusion method is preferable because the bonding time can be significantly reduced as compared with the case where an adhesive is used.
- the joint portion 22 has a continuous line shape, but may have a discontinuous line shape such as a dotted line.
- the material of the tab piece forming sheet 18 the same material as that of the release sheet 16 described above can be used.
- polyethylene terephthalate that is not easily torn is effective. is there.
- the release sheet 16 has a single layer structure of polyethylene terephthalate, and the release sheet 16 has at least a surface layer made of polypropylene and has unevenness formed by embossing or the like, it is possible to heat-bond both of them. It can be difficult.
- an adhesive may be used.
- the knob forming sheet 18 may be formed in a two-layer structure as schematically shown in FIG. That is, by laminating polypropylene on the lower surface of the polyethylene terephthalate base layer (the surface on the side of the release sheet 16), thermal fusion can be easily performed on the polypropylene release sheet 16 having irregularities.
- the thickness of the pick piece forming sheet 18 can be determined as appropriate, but is preferably about 10 to 100 ⁇ m in consideration of the strength as a pick piece and the feel when picked.
- the polyethylene terephthalate layer is about 5 to 40 ⁇ m and the unstretched polypropylene layer is about 10 to 60 ⁇ m.
- the thickness of the stretched polypropylene layer is preferably about 10 to 60 ⁇ m.
- the pick pieces 18a and 18b can be easily visually recognized.
- the weakened portion 20 formed at substantially the center of the release sheet 16 and the pick piece forming sheet 18 is for easily dividing the both sheets 16 and 18 and is formed over the entire length of the pick piece forming sheet 18. .
- a so-called perforation is formed by connecting small holes 20 a penetrating the release sheet 16 and the knob-forming sheet 18.
- the length of the small hole 20a is larger than the above range with respect to the length of the connecting portion 20b, there is a possibility that the small hole 20a is divided even when not in use, and the medicinal component is volatilized and the medicinal effect is reduced, The tendency for reliability and convenience to decline appears.
- the escape of medicinal components and moisture from the small holes 20a can be prevented or suppressed by closing the small holes 20a by applying tension to the release sheet 16.
- the length of the small hole 20a is smaller than the above range with respect to the length of the connecting portion 20b, it becomes difficult to divide the release sheet 16, and the tendency for convenience and workability to decrease appears.
- the length of the connecting portion 20b can be determined as appropriate, but the length of the connecting portion 20b is preferably in the range of 0.03 to 10 mm. This is because if the connecting portion 20b is excessively long, it is difficult to divide, but if the connecting portion 20b is short, it is easy to divide, but if the connecting portion 20b is too short, the connecting portion 20b is easily broken except during use.
- the weakening part 20 is for facilitating the division
- This groove is a so-called half cut that penetrates the knob forming sheet 18 and extends partway through the release sheet 16. Therefore, the weakened part 20 by such a groove
- the weakened portion 20 may be variously considered, such as one in which heat is locally applied to the release sheet 16 and the pick-up piece forming sheet 18 by a laser or the like so that the portion can be easily divided, or thin.
- the tensile strength of the release sheet 16 is not particularly limited, but is 1 g / cm to 200 g / cm, preferably 1 g. / Cm to 100 g / cm is preferable. This range is based on the fact that the material of the tab piece forming sheet 18 bonded to the release sheet 16 is preferably polyethylene terephthalate or the like, and has higher rigidity than the release sheet 16. That is, even if the tensile strength of the release sheet 16 having the weakened portion 20 is as low as about 1 g / cm, the knob-forming sheet 18 is bonded to the release sheet 16, so that the release sheet 16 has appropriate splitting properties. become.
- the release sheet 16 becomes smaller than 1 g / cm, the release sheet 16 is cut halfway during the production, and the release sheet 16 is continuously stuck on the pressure-sensitive adhesive layer 14.
- the patch 10 such as a poultice or plaster
- the release sheet 16 is easily divided, and the yield tends to decrease.
- the tensile strength becomes larger than 200 g / cm, it becomes difficult to divide the release sheet 16 easily when used, and the convenience tends to be lowered.
- both ends of the patch 10 are picked, the release sheet 16 is pulled to the left and right together with the support 12, and the release sheet 16 and the handle piece forming sheet 18 are moved along the weakened portion 20. Divide left and right. At this time, when unevenness is formed on the release sheet 16 by embossing or the like, it becomes slippery and the patch 10 is easily pulled.
- the joining portion 22 has a thickness corresponding to both the release sheet 16 and the tab piece forming sheet 18, and the strength or rigidity is increased accordingly. Therefore, when the both ends of the patch 10 are picked and pulled to the left and right, the tensile force is dispersed throughout the joint portion 22. As a result, when a part of the weakened portion 20 starts to break, the break instantly spreads over the entire weakened portion 20 and the sheets 16 and 18 can be divided in an instant.
- the connecting portion 20b between the perforated small holes 20a is instantaneously formed.
- the user can be given a unique feeling of cutting because the cutting is continued.
- this feeling of cutting is also a feeling that the support 12 extends after a momentary division. Is also included. Therefore, when there is no sense that it has been divided and an elongation is felt at the moment when it is pulled, there is a possibility that the release sheet 16 of the patch 10 has been divided once. That is, it is possible to give the user a sense of security that the adhesive layer 14 of the patch 10 is protected until use, and the user's feeling of use becomes good.
- the weakened portion 20 is on the non-joined portion between the release sheet 16 and the tab piece forming sheet 18, so that it is not affected by the joined portion 22, that is, heat fusion or adhesive. Therefore, the separation of the release sheet 16 and the tab piece forming sheet 18 can be performed while controlling the cutting of the weakened portion 20.
- the joined portion 22 between the sheets 16 and 18 is maintained without being separated, so that the shape thereof is slightly curved. Although it occurs, it can maintain a substantially straight or flat state. Due to such shape stability, the shape of the support 12 attached to the joint portion 22 can also be maintained, and wrinkles can be prevented from approaching.
- the pressure-sensitive adhesive layer 14 on the support 12 is exposed.
- the exposed adhesive layer 14 is applied to the skin.
- the patch 10 has a temporary fixing effect on the skin S.
- tab pieces 18a and 18b are formed on the respective release sheets 16. Therefore, after the patch 10 is temporarily fixed, the tab pieces 18a and 18b are picked and pulled.
- the pressure-sensitive adhesive layer 14 can be adhered to the skin S while peeling the separated release sheet 16 from the pressure-sensitive adhesive layer 14 on the support 12.
- the free ends of the knobs 18a and 18b are close to the exposed part of the adhesive layer 14, and the double part of the release sheet 16 and the knobs 18a and 18b has a certain thickness and rigidity. Therefore, the user can arrange the patch 10 at a desired position by tactile sensation. Further, in the state where the knobs 18a and 18b are picked, the finger is close to the exposed portion of the adhesive layer 14, so that the position of the patch 10 can be easily finely adjusted, which is very convenient for the user. To improve.
- the release sheet when temporarily fixed to the skin, the release sheet may be sandwiched between the support and the skin, and it may be difficult to remove the release sheet.
- the tabs 18a and 18b are formed. Therefore, the release sheet 16 can be easily peeled by gripping and pulling the tabs. Moreover, since it can prevent that a fingertip touches the adhesive layer 14, an adhesive does not adhere to a hand.
- both the left and right pick pieces 18a and 18b can be picked and both the left and right pick pieces 18a and 18b can be picked and pulled at the same time, the pasting workability is improved for the user.
- the joining portion 22 between the release sheet 16 and the tabs 18a and 18b has a high rigidity, as in the case of division. Act equally.
- a separation line between the release sheet 16 and the pressure-sensitive adhesive layer 14 (external portion of the adhesion portion between the release sheet 16 and the pressure-sensitive adhesive layer 16) The force acts substantially even on the boundary line between the two. As a result, it is possible to prevent the support 12 from wrinkling and the adhesive layers 14 from adhering to each other.
- the patch 10 according to the present invention may be used other than the above method.
- the picking piece forming sheet 18 is pulled by holding the portions that become the picking pieces 18a and 18b, and the separation sheet 16 and the picking piece forming sheet 18 are divided, and then one of the picking pieces 18a and 18b is picked,
- the peeling sheet 16 may be peeled to expose half of the pressure-sensitive adhesive layer 14 on the support 12 and then attached to the skin.
- the knobs 18a and 18b are formed symmetrically, the user can freely select the knobs 18a and 18b which are easier to pick, which is convenient.
- the support 12 is a non-woven fabric and the pressure-sensitive adhesive layer 14 is an aqueous gel.
- the adhesive layer agent 14 is an aqueous gel, it has sufficient thickness and weight, so that it has an appropriate peel strength and the release sheet 16 does not peel off too easily. Therefore, since it is not necessary to dare to provide a peeling suppression means such as the wound dressing described in Patent Document 5, manufacturing is easy and cost is low.
- the method according to the present invention for producing the patch 10 having an excellent effect as described above is basically performed in the steps shown in FIG. That is, first, the support 12 is prepared, and the pressure-sensitive adhesive layer 14 is formed on one surface thereof. Further, the tab forming sheet 18 is joined to the release sheet 16, and then the weakened portion 20 such as a perforation is formed. And the peeling sheet 16 which has this picking piece formation sheet 18 is affixed on the adhesive layer 14 on the support body 12.
- FIG. As described above, as described above, there are a method using an adhesive and a method using a heat fusion method.
- the continuous patch manufacturing method the first step of feeding the first continuous sheet serving as the support 12 from the first original fabric and forming the adhesive layer 14 on the first continuous sheet;
- the second continuous sheet serving as the release sheet 16 is fed out from the second original fabric, and the third continuous sheet serving as the tab-forming sheet 18 is fed out from the third original fabric, so that the second continuous sheet is placed on the second continuous sheet.
- the second step of superposing and joining the three continuous sheets, the third step of forming the weakened portion in the joined second continuous sheet and the third continuous sheet, and the third step obtained in the third step, A fourth step of forming a laminate by releasably attaching the second continuous sheet to which the continuous sheet is bonded to the adhesive layer 14 on the first continuous sheet obtained in the first step; Predetermining the laminate obtained in the fourth step And cut into size, characterized in that it comprises a fifth step and the color forming a patch 10.
- the illustrated apparatus 100 includes a spreader 110 for spreading a pressure-sensitive adhesive on the first continuous sheet 12 ⁇ / b> A serving as a support 12 to form a pressure-sensitive adhesive layer 14, and a second continuous sheet 16 ⁇ / b> A serving as a release sheet 16.
- a joint 120 that joins the third continuous sheet 18A to be the knob-forming sheet 18, and a weakened part that forms the weakened part 20 in the second and third continuous sheets 16A and 18A that have passed through the joint 120.
- the forming unit 140 and the second and third continuous sheets 16A and 18A that have passed through the weakening unit forming unit 140 are attached to the adhesive layer 14 of the first continuous sheet 12A that has passed through the spreading unit 110 and laminated.
- the laminated body forming part 150 that forms the body 24 and the laminated body 24 of the first to third continuous sheets 12A, 16A, and 18A that have passed through the laminated body forming part 150 are cut into the patch 10 as the final product. Cutting section 160 and It is al configuration.
- the first continuous sheet 12 ⁇ / b> A is fed from the roll-shaped first raw fabric 12 ⁇ / b> B rotatably held on the upstream side of the spreading section 110 and supplied to the spreading section 110.
- the spreading part 110 has a conventionally known configuration, and spreads an adhesive on the upper surface of the first continuous sheet 12 ⁇ / b> A to form the adhesive layer 14.
- the second continuous sheet 16A and the third continuous sheet 18A are respectively a roll-shaped second raw fabric 16B and a roll-shaped third raw sheet that are rotatably held on the upstream side of the joint 120.
- the two continuous sheets 16A and 18A are fed out from the opposite side 18B and fed into the joint 120 in a state of being overlapped.
- a heat fusion apparatus there is a roller type having a pair of heat sealing rollers, but a press type is preferable for reliable heat fusion.
- FIG. 9 is a side view schematically showing the joint 120 having the press-type fusing device 122.
- the illustrated thermal fusion apparatus 122 includes a fixed seal bar 124 and a movable seal bar 126 disposed above the fixed seal bar 124 so as to be movable up and down.
- the fixed seal bar 124 and the movable seal bar 126 come into contact with each other.
- the second and third portions are interposed between the fixed seal bar 124 and the movable seal bar 126 in a heated state.
- the continuous sheets 16A and 18A are fed and the continuous sheets 16A and 18A are pressed between the seal bars 124 and 126, the continuous sheets 16A and 18A are heat-sealed at the portion where the seal bars 124 and 126 are in contact with each other. Is done.
- the bonding strength of the bonding portion 22 by this heat fusion can be adjusted by appropriately changing parameters such as pressing time, pressing pressure, and heating temperature. Even when the second continuous sheet 16A is uneven by embossing or the like, a sufficient pressing time and pressing pressure can be secured by using the press-type heat fusion apparatus 122. Therefore, there is an advantage that the second continuous sheet 16A and the third continuous sheet 18A can be reliably heat-sealed.
- a flat plate that is, a so-called anvil may be used.
- two pairs of fixed / movable seal bars 124 and 126 are provided in parallel with the feeding direction of the continuous sheets 16A and 18A, thereby forming two joint portions 22. It is like that.
- the 9 has a first storage device 128 and a second storage device 130 that can store or retain the second and third continuous sheets 16A and 18A, respectively.
- the second and third continuous sheets 16A and 18A are provided on the upstream side and the downstream side of the dressing device 122 so as to continuously feed the second and third continuous sheets 16A and 18A.
- the illustrated mechanism includes a plurality of guide rollers 132 that are rotatably attached to a fixed portion, and a movable roller 134 that is disposed between adjacent guide rollers 132.
- the movable roller 134 can be moved toward and away from the guide roller 132.
- the movable roller 134 is separated from the guide roller 132 by a spring or the like when no load is applied.
- the second and third continuous sheets 16A and 18A are alternately wound around the guide roller 132 and the movable roller 134, and a tension exceeding a predetermined value is applied to the continuous sheets 16A and 18A.
- the movable roller 134 approaches the guide roller 132, and conversely, when the tension falls below a predetermined value, the movable roller 134 moves away from the guide roller 132.
- the second and third continuous sheets 16A and 18A are continuously guided by the guide roller 132 and the movable roller 134 with a predetermined tension. .
- the second and third continuous sheets 16A and 18A are heat-sealed by the heat-sealing device 122, the second and third continuous sheets 16A and 18A are continuously joined from the original fabrics 16B and 18B.
- the tension of the second and third continuous sheets 16A and 18A is lowered, so that the movable roller 134 is separated from the guide roller 132 and the first accumulation is performed.
- the sheet path length in the device 128 increases. Since the second and third continuous sheets 16A and 18A are stored in the first storage device 128 by the stretched amount, it is not necessary to stop the continuous sheets 16A and 18A from being fed from the raw fabrics 16B and 18B. .
- the second and third continuous sheets 16A and 18A are sent to the laminate forming unit 150 as they are on the downstream side of the thermal fusion device 122 at the time of thermal fusion, the second storage device 130 on the downstream side. Then, since the tension of the second and third continuous sheets 16 ⁇ / b> A and 18 ⁇ / b> A increases, the movable roller 134 approaches the guide roller 132. As a result, the second and third continuous sheets 16A and 18A that have been stored in the second storage device 130 are sent out.
- the second and third continuous sheets 16A and 18A are intermittently fed by the heat fusion device 122, the feeding to the joining portion 120 and the joining portion 120 are caused by the presence in the storage devices 128 and 130. Therefore, the second and third continuous sheets 16A, 18A and the first continuous sheet 12A can be continuously overlapped without stagnation.
- the second and third continuous sheets 16 ⁇ / b> A and 18 ⁇ / b> A that are doubled at the joint 120 are sent to the weakened part forming part 140 to form the weakened part 20.
- Conventionally known devices can be used as the weakened portion forming portion 140.
- the weakened portion forming portion 140 includes a roller having a blade for forming a perforation, a groove, or the like, or a perforation, a groove, Examples include those that form weak parts.
- the weakened portion 20 is formed at the center between the two joint portions 22 formed previously.
- the second and third continuous sheets 16A and 18A in which the weakened portions 20 such as perforations are formed in the weakened portion forming unit 140 are then used in the laminated body forming unit 150 to form the adhesive layer of the first continuous sheet 12A.
- 14 is laminated to form a laminate 24 and fed into the cutting section 160.
- the laminate 24 is cut at a predetermined size and timing, and the desired patch 10 is completed.
- the second and third continuous sheets 16 ⁇ / b> A and 18 ⁇ / b> A that become the release sheet 16 and the tab-forming sheet 18 need not be bent, and the second and second Since the joining of the three continuous sheets 16A and 18A and the formation of the weakened portion 20 can be carried out continuously along the sheet feeding direction, the production can be performed efficiently.
- the second and third continuous sheets 16A and 18A are joined using the press-type heat fusion device 122, the second continuous sheet 16A is surely formed even if unevenness such as embossing is formed. It can be joined to the third continuous sheet 18A.
- the present invention also copes with intermittent feeding when the press-type heat fusion device 122 is used, and the first and second continuous sheets 12A, 12A, and 130 are supported by the storage devices 128 and 130. It is possible to achieve an effect that the overlapping with the continuous sheets 16A and 18A and the final cutting can be continuously performed.
- the support 12 is stretchable. However, if it is not necessary to split the release sheet 16 by pulling the patch 10 left and right, the stretchability of the support 12 is not necessary. is there.
- the left and right joint portions 22 are separated from the weakened portion 20, but are formed at a position relatively close to the weakened portion 20, so that the handle is separated after the sheet is cut. It is difficult to pick the inner part of the sheet 18 (the part on the side opposite to the knobs 18a and 18b). Therefore, as shown in FIG. 10, a mode in which the left and right joint portions 22 are formed at a position relatively away from the weakened portion 20, for example, a position about 15 to 25 mm away is also conceivable.
- the release sheet 16 and the pick piece forming sheet 18 are divided along the weakening line 20, not only the outer portions 18 a and 18 b but also the inner portions 18 c and 18 d are pick pieces. Will function as.
- the release sheet 16 can be peeled by picking the inner knob 18 c for the left side and the outer knob 18 b for the right side.
- the shape of the joint portion 22 is not limited to a straight line as shown in FIG. 2, but may be other shapes, for example, a curved line as shown in FIG. Such a non-linear joining portion 22 is preferable because it can be easily joined by a thermal fusion method.
- the cut piece forming sheet 18 is cut along the weakening line 20, and then the pick pieces 18 a and 18 b are pulled to the left and right, the exposed surface (the drug surface) of the adhesive layer 14 of the patch 10. ) Can be curved in a three-dimensional manner so that the patch 10 can be easily applied without causing wrinkles on the applied body surface.
- the joining portion 22 it is not necessary to form the joining portion 22 at two places on the left and right, and as shown in FIG. 13, the release sheet 16 and the tab piece forming sheet 18 are joined at one place in the substantially central portion.
- the weakened portion 20 may be formed on the joint portion 22. In this case, there is only one pair of the fixed seal bar 124 and the movable seal bar 126 in the press-type heat fusion apparatus 122.
- knob forming sheet 18 may be joined at a position shifted from the center of the release sheet 16.
- the weakening portion 20 is not limited to a straight line, but may be a waveform or a sawtooth shape as shown in FIG.
- the shape of the joint portion 22 can be a waveform or a sawtooth shape in accordance with the shape of the weakened portion 20.
- knob-forming sheet 18 can have a shape other than a rectangle, for example, various shapes as shown in FIGS. Further, as shown in (a) to (c) of FIG. 15, it is possible to adopt a shape in which the tab piece forming sheet 18 does not cross the entire patch 10. In FIG. 15, the joining portion is not shown.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Adhesive Tapes (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
Description
まず、本発明による貼付剤製造方法ないしは貼付剤製造装置によって製造される貼付剤について説明する。図1はかかる貼付剤の一実施形態を示す斜視図であり、図2はその平面図、図3はその側面図である。図示の貼付剤10は、パップ剤又はプラスター剤等として用いられるものであり、伸縮性を有する支持体12と、支持体12の一方の面の略全面に形成された、薬物を含有する粘着剤層14と、粘着剤層14の表面に剥離可能に貼付された剥離シート16と、剥離シート16に接合された摘み片形成シート18とから構成されている。
製造に際して原反のシートを切断することが困難となり、作業性等が低下する傾向が現れ出す。
上述したような優れた効果を有する貼付剤10を製造するための本発明による方法は、基本的には、図7に示す工程で行われる。すなわち、まず支持体12を用意し、その一方の面に粘着剤層14を形成する。また、剥離シート16に摘み片形成シート18を接合し、この後、ミシン目等の弱化部20を形成する。そして、この摘み片形成シート18を有する剥離シート16を、支持体12上の粘着剤層14に貼り付けるのである。接合方法としては、前述したように、接着剤を用いる方法や、熱融着法による方法がある。
以上、本発明の好適な実施形態について詳細に説明したが、本発明は上記実施形態に限定されないことはいうまでもない。
Claims (13)
- 支持体と、前記支持体の一面に設けられた粘着剤層と、前記粘着剤層に剥離可能に付着された剥離シートと、前記剥離シートに形成された、該剥離シートの分断を容易化する弱化部とを備える貼付剤であって、前記剥離シート上には摘み片形成シートが前記弱化部を覆うようにして接合され、当該接合部分以外の前記摘み片形成シートの部分が摘み片として機能するようになっており、前記摘み片形成シートには、前記剥離シートの前記弱化部に対応する位置に、該剥離シートの分断を容易化する弱化部が形成されている、貼付剤を製造するための方法において、
支持体上に粘着剤層を形成する第1ステップと、
剥離シート上に摘み片形成シートを接合する第2ステップと、
前記剥離シート及び前記摘み片形成シートに弱化部を形成する第3ステップと、
前記第3ステップで得られた、前記摘み片形成シートが接合された前記剥離シートを、前記第1ステップで得られた、前記支持体上の前記粘着剤層に剥離可能に付着させる第4ステップと
を含むことを特徴とする貼付剤の製造方法。 - 前記第2ステップで得られる前記剥離シートと前記摘み片形成シートとの接合部分が、前記弱化部の左右に、該弱化部から離隔されて位置されることを特徴とする請求項1に記載の方法。
- 前記第2ステップで得られる前記剥離シートと前記摘み片形成シートとの接合部分が、前記弱化部上に位置されることを特徴とする請求項1に記載の方法。
- 前記第2ステップにおける接合が熱融着法によることを特徴とする請求項1~3のいずれか一項に記載の方法。
- 支持体と、前記支持体の一面に設けられた粘着剤層と、前記粘着剤層に剥離可能に付着された剥離シートと、前記剥離シートに形成された、該剥離シートの分断を容易化する弱化部とを備える貼付剤であって、前記剥離シート上には摘み片形成シートが前記弱化部を覆うようにして接合され、当該接合部分以外の前記摘み片形成シートの部分が摘み片として機能するようになっており、前記摘み片形成シートには、前記剥離シートの前記弱化部に対応する位置に、該剥離シートの分断を容易化する弱化部が形成されている、貼付剤を製造するための方法において、
前記支持体となる第1の連続シートを第1の原反から繰り出し、該第1の連続シート上に粘着剤層を形成する第1ステップと、
前記剥離シートとなる第2の連続シートを第2の原反から繰り出すと共に、前記摘み片形成シートとなる第3の連続シートを第3の原反から繰り出して、前記第2の連続シート上に前記第3の連続シートを重ね合わせ、接合する第2ステップと、
接合された前記第2の連続シート及び前記第3の連続シートに弱化部を形成する第3ステップと、
前記第3ステップで得られた、前記第3の連続シートが接合された前記第2の連続シートを、前記第1ステップで得られた、前記第1の連続シート上の前記粘着剤層に剥離可能に付着させて積層体を形成する第4ステップと、
第4ステップで得られた前記積層体を所定の寸法に裁断して、前記貼付剤を形成する第5ステップと
を含むことを特徴とする方法。 - 前記第2ステップで得られる前記第2の連続シートと前記第3の連続シートとの接合部分が、前記弱化部の左右に、該弱化部から離隔されて位置されることを特徴とする請求項5に記載の方法。
- 前記第2ステップで得られる前記第2の連続シートと前記第3の連続シートとの接合部分が、前記弱化部上に位置されることを特徴とする請求項4に記載の方法。
- 前記第2ステップにおける接合が熱融着法によることを特徴とする請求項5~7のいずれか一項に記載の方法。
- 支持体と、前記支持体の一面に設けられた粘着剤層と、前記粘着剤層に剥離可能に付着された剥離シートと、前記剥離シートに形成された、該剥離シートの分断を容易化する弱化部とを備える貼付剤であって、前記剥離シート上には摘み片形成シートが前記弱化部を覆うようにして接合され、当該接合部分以外の前記摘み片形成シートの部分が摘み片として機能するようになっており、前記摘み片形成シートには、前記剥離シートの前記弱化部に対応する位置に、該剥離シートの分断を容易化する弱化部が形成されている、貼付剤を製造するための装置において、
第1の原反から繰り出された前記支持体となる第1の連続シート上に粘着剤を展着して粘着剤層を形成する展着部と、
第2の原反から繰り出された前記剥離シートとなる第2の連続シートと、第3の原反から繰り出された前記摘み片形成シートとなる第3の連続シートとを重ね合わせ、接合する接合部と、
前記接合部により接合された前記第2の連続シート及び前記第3の連続シートに弱化部を形成する弱化部形成部と、
前記弱化部形成部を通過した、前記第3の連続シートが接合された前記第2の連続シートを、前記展着部を通過した前記第1の連続シート上の前記粘着剤層に剥離可能に付着させて積層体を形成する積層体形成部と、
前記積層体形成部により得られた前記積層体を所定の寸法に裁断して、前記貼付剤を形成する裁断部と
を備えることを特徴とする装置。 - 前記接合部により得られる前記第2の連続シートと前記第3の連続シートとの接合部分が、前記弱化部形成部により形成される前記弱化部の左右に、該弱化部から離隔されて位置されるように、前記接合部が構成されていることを特徴とする請求項9に記載の装置。
- 前記接合部により得られる前記第2の連続シートと前記第3の連続シートとの接合部分が、前記弱化部形成部により形成される前記弱化部上に位置されるように、前記接合部が構成されていることを特徴とする請求項9に記載の装置。
- 前記接合部が熱融着装置を備えることを特徴とする請求項9~11のいずれか一項に記載の方法。
- 前記熱融着装置がプレス式であり、
前記第2の連続シート及び前記第3の連続シートを蓄積することのできる第1の蓄積装置及び第2の蓄積装置が、それぞれ、前記熱融着装置の上流側、及び、前記熱融着装置と前記積層体形成部との間に設けられ、もって、前記熱融着装置による前記第2の連続シート及び前記第3の連続シートの接合中、前記第2の原反及び前記第3の原反から連続的に送られてくる前記第2の連続シート及び前記第3の連続シートを前記第1の蓄積装置により一時的に蓄積すると共に、前記第2の蓄積装置により蓄積されていた前記第2の連続シート及び前記第3の連続シートを下流側に連続的に送るよう構成されていることを特徴とする請求項12に記載の装置。
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10823291.9A EP2489339B1 (en) | 2009-10-14 | 2010-09-30 | Method and device for producing adhesive patch |
ES10823291.9T ES2523727T3 (es) | 2009-10-14 | 2010-09-30 | Procedimiento y dispositivo para producir parche adhesivo |
BR112012008892A BR112012008892B8 (pt) | 2009-10-14 | 2010-09-30 | método e aparelho para fabricação de curativo adesivo |
RU2012119568/12A RU2552241C2 (ru) | 2009-10-14 | 2010-09-30 | Способ и устройство для изготовления клейкой накладки |
CA2777676A CA2777676C (en) | 2009-10-14 | 2010-09-30 | Method and apparatus for manufacturing adhesive patch |
US13/501,764 US9314378B2 (en) | 2009-10-14 | 2010-09-30 | Method and apparatus for manufacturing adhesive patch |
CN201080045907.XA CN102573722B (zh) | 2009-10-14 | 2010-09-30 | 制造贴剂的方法及装置 |
JP2011536091A JP5352677B2 (ja) | 2009-10-14 | 2010-09-30 | 貼付剤を製造するための装置 |
KR1020127009847A KR101554383B1 (ko) | 2009-10-14 | 2010-09-30 | 첩부제를 제조하기 위한 방법 및 장치 |
AU2010307797A AU2010307797B2 (en) | 2009-10-14 | 2010-09-30 | Method and device for producing adhesive patch |
HK13100341.1A HK1173640A1 (en) | 2009-10-14 | 2013-01-09 | Method and device for producing adhesive patch |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009-237571 | 2009-10-14 | ||
JP2009237571 | 2009-10-14 | ||
JP2009-261314 | 2009-11-16 | ||
JP2009261314 | 2009-11-16 | ||
JP2010-134407 | 2010-06-11 | ||
JP2010134407 | 2010-06-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2011046023A1 true WO2011046023A1 (ja) | 2011-04-21 |
Family
ID=43876075
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2010/067140 WO2011046024A1 (ja) | 2009-10-14 | 2010-09-30 | 貼付剤 |
PCT/JP2010/067129 WO2011046023A1 (ja) | 2009-10-14 | 2010-09-30 | 貼付剤を製造するための方法及び装置 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2010/067140 WO2011046024A1 (ja) | 2009-10-14 | 2010-09-30 | 貼付剤 |
Country Status (18)
Country | Link |
---|---|
US (2) | US20120253255A1 (ja) |
EP (2) | EP2489339B1 (ja) |
JP (3) | JP5460726B2 (ja) |
KR (2) | KR101511414B1 (ja) |
CN (2) | CN102573722B (ja) |
AU (2) | AU2010307798A1 (ja) |
BR (2) | BR112012008775B8 (ja) |
CA (2) | CA2777676C (ja) |
ES (1) | ES2523727T3 (ja) |
HK (2) | HK1171936A1 (ja) |
HU (1) | HUE027594T2 (ja) |
IN (1) | IN2012DN03451A (ja) |
MY (2) | MY165470A (ja) |
PL (1) | PL2489340T3 (ja) |
PT (1) | PT2489340T (ja) |
RU (2) | RU2552241C2 (ja) |
TW (2) | TW201129346A (ja) |
WO (2) | WO2011046024A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021106214A1 (ja) * | 2019-11-29 | 2021-06-03 | 小林製薬株式会社 | 貼付剤 |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8021347B2 (en) | 2008-07-21 | 2011-09-20 | Tyco Healthcare Group Lp | Thin film wound dressing |
US20100324516A1 (en) | 2009-06-18 | 2010-12-23 | Tyco Healthcare Group Lp | Apparatus for Vacuum Bridging and/or Exudate Collection |
WO2012029127A1 (ja) * | 2010-08-31 | 2012-03-08 | ニチバン株式会社 | 貼付体シート、及び、その使用、並びに、貼付体シートの貼付方法 |
RU2607749C2 (ru) * | 2011-10-24 | 2017-01-10 | Хисамицу Фармасьютикал Ко., Инк. | Способ производства упаковки восприимчивой к давлению адгезивной ленты |
USD757950S1 (en) * | 2013-01-30 | 2016-05-31 | Mölnlycke Health Care Ab | Wound pad |
DE102013008727A1 (de) | 2013-05-23 | 2014-11-27 | Amw Gmbh | Pflaster mit gekerbter Abziehfolie |
DE102013008726A1 (de) | 2013-05-23 | 2014-11-27 | Amw Gmbh | Plaster mit Abziehhilfe |
CN103263318B (zh) * | 2013-05-27 | 2015-01-21 | 施敬东 | 一种睾丸冷敷贴及其制备方法 |
KR200477166Y1 (ko) * | 2013-07-11 | 2015-05-18 | 강유빈 | 일회용 의료 밴드 |
CN105287440A (zh) * | 2014-06-18 | 2016-02-03 | 杨宁正 | 渗透式药用薄膜贴片 |
JP5767417B1 (ja) * | 2015-02-05 | 2015-08-19 | 久光製薬株式会社 | 貼付剤 |
USD773059S1 (en) * | 2015-03-16 | 2016-11-29 | Covidien Lp | Sacral wound dressing |
USD774200S1 (en) * | 2015-03-16 | 2016-12-13 | Covidien Lp | Sacral wound dressing |
USD774201S1 (en) * | 2015-03-16 | 2016-12-13 | Covidien Lp | Sacral wound dressing |
JP6872308B2 (ja) | 2015-04-14 | 2021-05-19 | セイコーエプソン株式会社 | 記録方法及び記録装置 |
USD791957S1 (en) * | 2015-05-19 | 2017-07-11 | Brian Shawn Freshwater | Wound dressing |
USD791331S1 (en) * | 2015-05-19 | 2017-07-04 | Brian Shawn Freshwater | Wound dressing |
USD804677S1 (en) * | 2015-09-30 | 2017-12-05 | 3M Innovative Properties Company | Surgical drape with a retraction member |
USD804678S1 (en) * | 2015-09-30 | 2017-12-05 | 3M Innovative Properties Company | Oval surgical drape with a retraction member |
EP3167855A1 (en) * | 2015-11-13 | 2017-05-17 | Mölnlycke Health Care AB | Medical dressing |
USD773060S1 (en) * | 2015-12-21 | 2016-11-29 | Covidien Lp | Sacral wound dressing |
CN105476752A (zh) * | 2015-12-30 | 2016-04-13 | 孙硕 | 一种耐久性创可贴 |
USD790715S1 (en) * | 2016-12-16 | 2017-06-27 | Jason Camper | Nutritional adhesive |
JP7114271B2 (ja) * | 2018-02-26 | 2022-08-08 | 久光製薬株式会社 | 貼付剤貼付用補助具 |
WO2019181349A1 (ja) * | 2018-03-23 | 2019-09-26 | 株式会社共和 | 皮膚貼付用シート |
USD890231S1 (en) * | 2018-05-04 | 2020-07-14 | Irobot Corporation | Debris container |
CN108670498B (zh) * | 2018-05-25 | 2024-08-27 | 海口市人民医院(中南大学湘雅医学院附属海口医院) | 一种血管内用支架及其使用方法 |
US11007083B2 (en) * | 2018-08-28 | 2021-05-18 | Aatru Medical, LLC | Dressing |
US11666680B2 (en) | 2018-08-28 | 2023-06-06 | Aatru Medical, LLC | Dressing |
US20200100539A1 (en) * | 2018-10-01 | 2020-04-02 | Jim MENDOZA | Smokable shells and methods for their preparation |
CN110051825B (zh) * | 2019-05-29 | 2022-09-09 | 中国人民解放军陆军军医大学第一附属医院 | 带状疱疹治疗贴 |
US20230181570A1 (en) * | 2020-05-20 | 2023-06-15 | Medrx Co., Ltd. | Transdermal Formulation Containing Apomorphine |
EP4356885A1 (en) * | 2022-10-17 | 2024-04-24 | Mölnlycke Health Care AB | A dressing comprising a skin and/or wound beneficial coating |
EP4356884A1 (en) * | 2022-10-17 | 2024-04-24 | Mölnlycke Health Care AB | A dressing comprising a patterned release liner |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50133797U (ja) | 1974-04-18 | 1975-11-04 | ||
JPS59149141A (ja) | 1983-02-15 | 1984-08-27 | フアイザ−.ホスピタル.プロダクツ.グル−プ.インコ−ポレ−テツド | 創傷包帯 |
JPH08112305A (ja) | 1994-10-14 | 1996-05-07 | Hisamitsu Pharmaceut Co Inc | 貼付剤 |
JPH09238975A (ja) * | 1996-03-01 | 1997-09-16 | Kyowa:Kk | 粘着フィルム |
JP2000219622A (ja) | 1999-01-29 | 2000-08-08 | Toko Yakuhin Kogyo Kk | パップ剤の構造 |
JP2002531221A (ja) * | 1998-12-09 | 2002-09-24 | メールンリユーケ ヘルス ケアー アーベー | グリップタブを含む接着性表面保護シートを作る方法 |
JP2008264170A (ja) * | 2007-04-19 | 2008-11-06 | Nitto Denko Corp | フィルムドレッシング |
JP2009131583A (ja) | 2007-11-30 | 2009-06-18 | Hideya Nishimura | 貼付剤用剥離シート(ライナー) |
WO2010044152A1 (ja) * | 2008-10-15 | 2010-04-22 | 日東電工株式会社 | フィルムドレッシング |
Family Cites Families (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2233209A (en) | 1939-10-24 | 1941-02-25 | Duke Lab Inc | Surgical dressing |
US2280506A (en) | 1941-03-10 | 1942-04-21 | Richard T Betts | Surgical dressing |
US2992644A (en) | 1959-01-02 | 1961-07-18 | Johnson & Johnson | Dressing |
US3156242A (en) | 1962-03-29 | 1964-11-10 | Johnson & Johnson | Flexible absorbent sheet |
US3260260A (en) | 1964-09-16 | 1966-07-12 | Morgan Adhesives Co | Surgical drape or laminate |
US3367329A (en) | 1965-08-27 | 1968-02-06 | Gen Electric | Surgical bandage and method of fabrication |
US3416524A (en) | 1966-12-16 | 1968-12-17 | Parke Davis & Co | Surgical dressing |
NO134790C (no) | 1968-07-09 | 1984-03-22 | Smith & Nephew | Klebende,; trykkfoelsomt, vanndamp-permeabelt produkt for bruk paa hud hos mennesker. |
US3811438A (en) | 1972-03-30 | 1974-05-21 | G Economou | Adhesive tapes and bandages |
US3885559A (en) | 1972-07-24 | 1975-05-27 | George J Economou | Process for the reduction of pain in the removal of adhesive tapes and bandages |
JPS5331719B2 (ja) | 1974-04-09 | 1978-09-04 | ||
US3989040A (en) | 1975-03-17 | 1976-11-02 | Kimberly-Clark Corporation | Patient extremity surgical drape |
US4265234A (en) | 1979-11-14 | 1981-05-05 | The Kendall Company | Dressing composite |
US4374520A (en) | 1980-09-11 | 1983-02-22 | American Hospital Supply Corporation | System and method for bandaging a patient |
US4649909A (en) | 1981-12-11 | 1987-03-17 | Johnson & Johnson Products, Inc. | Composite surgical dressing |
NZ206837A (en) | 1983-01-27 | 1986-08-08 | Johnson & Johnson Prod Inc | Thin film adhesive dressing:backing material in three sections |
US4600001A (en) | 1984-08-15 | 1986-07-15 | The Kendall Company | Combined wound dressing and delivery means composite |
US4685455A (en) | 1984-10-16 | 1987-08-11 | Akzo Nv | Watervapor-permeable, pressure sensitive, antiseptic wound covering material |
US4780168A (en) | 1984-10-22 | 1988-10-25 | Genetic Laboratories, Inc. | Wound closure strips |
US4950282A (en) | 1984-10-22 | 1990-08-21 | Genetic Laboratories, Inc. | Wound closure strips |
USRE33353E (en) | 1985-01-24 | 1990-09-25 | Minnesota Mining And Manufacturing Company | Thin film surgical dressing with delivery system |
US5153040A (en) | 1985-03-11 | 1992-10-06 | Minnesota Mining And Manufacturing Co. | Wound dressing |
US4664106A (en) | 1985-12-20 | 1987-05-12 | Labeltape Meditect Inc. | Wound dressing |
US4744355A (en) | 1986-05-23 | 1988-05-17 | Faasse Jr Adrian L | Hinged end wound dressing |
US5009224A (en) | 1986-09-30 | 1991-04-23 | Minnesota Mining And Manufacturing Company | Method for attaching a pressure-sensitive film article having high moisture vapor transmission rate |
US5147698A (en) | 1986-09-30 | 1992-09-15 | Minnesota Mining And Manufacturing Company | Pressure sensitive adhesive film article having high moisture vapor transmission rate |
US4743232A (en) | 1986-10-06 | 1988-05-10 | The Clinipad Corporation | Package assembly for plastic film bandage |
US4781293A (en) | 1987-12-23 | 1988-11-01 | Pfizer Hospital Products Group, Inc. | One step dressing delivery system |
US4915228A (en) | 1987-12-23 | 1990-04-10 | Smith & Nephew United, Inc. | One step dressing delivery system |
US4915227A (en) | 1987-12-23 | 1990-04-10 | Smith & Nephew United, Inc. | One step dressing delivery system |
US4832008A (en) | 1988-02-09 | 1989-05-23 | The Kendall Company | Wound dressing with release sheets strip |
US5042466A (en) | 1988-02-09 | 1991-08-27 | The Kendall Company | Wound dressing with treated release sheet |
US5088483A (en) | 1988-11-04 | 1992-02-18 | Minnesota Mining And Manufacturing Co. | Adhesive frame bandage |
US5074293A (en) * | 1988-11-30 | 1991-12-24 | Sherwood Medical Company | Wound dressing having peeling-force varying release liners |
US4917928A (en) | 1988-12-02 | 1990-04-17 | Minnesota Mining And Manufacturing Company | Folded adhesive film dressing |
US4917929A (en) | 1989-01-18 | 1990-04-17 | Minnesota Mining And Manufacturing Company | One piece adhesive bandage and package unit |
US5052381A (en) * | 1990-03-19 | 1991-10-01 | The B. F. Goodrich Company | Adhesive wound dressing and perforated shield |
US5160315A (en) | 1991-04-05 | 1992-11-03 | Minnesota Mining And Manufacturing Company | Combined adhesive strip and transparent dressing delivery system |
AU3057792A (en) | 1991-11-06 | 1993-06-07 | Bioderm, Inc. | Occlusive wound dressing and applicator |
US5360393A (en) | 1992-10-19 | 1994-11-01 | California Medical Products, Inc. | Dual adhesive strap for head immobilization |
DE69432108T2 (de) | 1993-05-04 | 2003-12-04 | Lisa Fernandez Geng | Wundverband |
GB9310185D0 (en) | 1993-05-18 | 1993-06-30 | Giltech Ltd | Wound dressing |
US5683354A (en) | 1993-07-06 | 1997-11-04 | Levy; Raymond H. | Adhesive bandage for a digit of a human hand or foot |
CA2127173A1 (en) | 1993-07-20 | 1995-01-21 | Frank S. Castellana | Medical dressing with semi-peripheral delivery system and methods therefor |
US5527271A (en) | 1994-03-30 | 1996-06-18 | Bristol-Myers Squibb Co. | Thermoplastic hydrogel impregnated composite material |
AU123466S (en) | 1994-04-05 | 1995-05-16 | Astra Ab | Topical dressing containing active substance |
US5653699A (en) | 1994-09-13 | 1997-08-05 | Polymedica Industries, Inc. | Spyrosorbent wound dressings for exudate management |
US5840052A (en) | 1995-01-27 | 1998-11-24 | Bertek, Inc. | Adhesive dressing applicator |
NL1001019C2 (nl) * | 1995-08-22 | 1997-02-25 | Lamers Beheer Bv | Pleisterlaminaat. |
USD385038S (en) | 1995-11-02 | 1997-10-14 | Tecnol Medical Products, Inc. | Wound closure dressing |
US5820578A (en) | 1996-02-05 | 1998-10-13 | Johansen; Christen | Bandage |
WO1997042904A2 (en) * | 1996-05-16 | 1997-11-20 | Minnesota Mining And Manufacturing Company | Surgical incise drape |
USD410087S (en) | 1996-07-02 | 1999-05-18 | Dunshee Wayne K | Adhesive bandage |
CA2259370C (en) | 1996-07-02 | 2007-10-23 | Minnesota Mining And Manufacturing Company | Medical adhesive composite and package |
US5733251A (en) | 1996-08-20 | 1998-03-31 | Medical Device Designs, Inc. | Pop top dressing applicator |
US5823977A (en) | 1997-03-13 | 1998-10-20 | Dalyea; Lorraine | Waterproof protective covering for medical uses |
KR100532521B1 (ko) | 1997-05-16 | 2005-12-02 | 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 | 수술용 절개 드레이프 |
USD408541S (en) | 1998-04-13 | 1999-04-20 | Dunshee Wayne K | Bandage and bandage with carrier |
USD409754S (en) | 1998-04-13 | 1999-05-11 | Dunshee Wayne K | Bandage |
US6120792A (en) | 1998-04-29 | 2000-09-19 | Juni; Jack E. | Medicated skin patch and method for its use |
US6607799B1 (en) | 1998-10-15 | 2003-08-19 | 3M Innovative Properties Company | Surgical dressing with delivery system and method of manufacture |
US6159497A (en) | 1998-10-30 | 2000-12-12 | Noven Pharmaceuticals, Inc. | Patch applicator |
JP3135535B2 (ja) | 1998-11-20 | 2001-02-19 | パイオニア株式会社 | 光ディスク及びその駆動装置 |
USD433140S (en) | 1998-12-03 | 2000-10-31 | Coloplast A/S | Wound care dressing |
EP1137763A1 (en) | 1998-12-07 | 2001-10-04 | Novozymes A/S | Glucoamylases with n-terminal extensions |
USD430674S (en) | 2000-01-07 | 2000-09-05 | 3M Innovative Properties Company | Adhesive bandage |
JP2001198160A (ja) | 2000-01-21 | 2001-07-24 | Uni Charm Corp | 水解性の吸収性物品及びその製造方法 |
DE10007942A1 (de) * | 2000-02-22 | 2001-09-06 | Lohmann Therapie Syst Lts | Verpackung für wirkstoffhaltige Pflaster |
USD458687S1 (en) | 2000-09-29 | 2002-06-11 | Cynthia Mary Dale | Dressing |
US6706940B2 (en) | 2001-02-22 | 2004-03-16 | George Medical, L.L.C. | Transparent film dressing and a method for applying and making the same |
USD473947S1 (en) | 2001-03-12 | 2003-04-29 | 3M Innovative Properties Company | Notched medical dressing |
USD474842S1 (en) | 2001-05-22 | 2003-05-20 | Coloplast A/S | Wound dressing |
USD484602S1 (en) | 2002-02-27 | 2003-12-30 | Bristol-Myers Squibb Company | Wound dressing |
USD484601S1 (en) | 2002-02-27 | 2003-12-30 | Bristol-Myers Squibb Company | Wound dressing |
CA101695S (en) | 2002-06-28 | 2004-04-07 | Bristol Myers Squibb Co | Adhesive dressing |
JP4891547B2 (ja) | 2002-11-26 | 2012-03-07 | コロプラスト アクティーゼルスカブ | 絆創膏 |
USD493230S1 (en) | 2003-02-19 | 2004-07-20 | 3M Innovative Properties Company | Wound dressing |
USD503982S1 (en) | 2003-02-19 | 2005-04-12 | 3M Innovative Properties Company | Wound dressing for heel |
AU154237S (en) | 2003-04-10 | 2004-01-06 | Convatec Technologies Inc | Wound dressing |
NL1023144C2 (nl) | 2003-04-10 | 2004-10-13 | Goyarts B V | Wasbare onderlegger en werkwijze voor het vervaardigen van een dergelijke onderlegger. |
AU154236S (en) | 2003-04-10 | 2004-01-06 | Convatec Technologies Inc | Wound dressing |
US20050034731A1 (en) | 2003-08-13 | 2005-02-17 | Rousseau Robert A. | Surgical wound closure device |
USD495419S1 (en) | 2003-08-15 | 2004-08-31 | 3M Innovative Properties Company | Bandage |
US6920737B2 (en) * | 2003-08-21 | 2005-07-26 | Illinois Tool Works Inc. | Method and apparatus for controlling zipper registration in packaging equipment |
TWI412570B (zh) * | 2004-04-27 | 2013-10-21 | Showa Denko Kk | Adhesive for patch and method for producing the same |
USD557424S1 (en) | 2005-04-20 | 2007-12-11 | Ethicon, Inc. | Wound dressing |
US7812212B2 (en) | 2005-08-23 | 2010-10-12 | Centurion Medical Products Corporation | Window dressing |
USD572824S1 (en) | 2005-08-23 | 2008-07-08 | Tri-State Hospital Supply Corporation | Window dressing |
JP5010829B2 (ja) * | 2005-12-28 | 2012-08-29 | 帝國製薬株式会社 | 貼付剤 |
US7442849B2 (en) | 2005-12-30 | 2008-10-28 | 3M Innovative Properties Company | Thin film delivery system and method of manufacture |
USD578651S1 (en) | 2006-06-12 | 2008-10-14 | 3M Innovative Properties Company | Bandage |
USD611156S1 (en) | 2006-06-12 | 2010-03-02 | 3M Innovative Properties Company | Bandage |
USD604423S1 (en) | 2006-06-12 | 2009-11-17 | 3M Innovative Properties Company | Bandage |
USD573260S1 (en) | 2006-06-12 | 2008-07-15 | 3M Innovative Properties Company | Bandage |
USD605299S1 (en) | 2007-02-08 | 2009-12-01 | Hisamitsu Pharmaceutical Co., Inc. | Medical transdermal patch |
AU318414S (en) | 2007-06-06 | 2008-03-12 | Convatec Technologies Inc | Wound dressing |
JP3135535U (ja) * | 2007-07-06 | 2007-09-20 | 共立薬品工業株式会社 | 創傷保護剤 |
JP5235384B2 (ja) | 2007-11-08 | 2013-07-10 | リンテック株式会社 | 貼付シート |
US8110718B2 (en) | 2008-10-27 | 2012-02-07 | 3M Innovative Properties Company | Thin film delivery system and method of manufacture |
USD625018S1 (en) | 2008-11-05 | 2010-10-05 | Smith & Nephew Plc | Medical dressing |
SE533536C2 (sv) * | 2008-12-22 | 2010-10-19 | Moelnlycke Health Care Ab | Anordning för att underlätta applicering av en plastfilm på hud |
US8212101B2 (en) | 2009-02-03 | 2012-07-03 | Centurion Medical Products Corporation | Window dressing having integral anchor |
USD604424S1 (en) | 2009-02-11 | 2009-11-17 | Pierre Fabre Dermo-Cosmetique | Dressing |
CA134186S (en) | 2009-12-28 | 2010-11-03 | Hisamitsu Pharmaceutical Co | Medical patch |
USD670395S1 (en) | 2010-08-11 | 2012-11-06 | Hisamitsu Pharmaceutical Co., Inc. | Medical transdermal patch |
USD672464S1 (en) | 2012-05-24 | 2012-12-11 | 3M Innovative Properties Company | Wound dressing |
-
2010
- 2010-09-30 BR BR112012008775A patent/BR112012008775B8/pt active IP Right Grant
- 2010-09-30 CA CA2777676A patent/CA2777676C/en active Active
- 2010-09-30 KR KR1020127009846A patent/KR101511414B1/ko active IP Right Grant
- 2010-09-30 EP EP10823291.9A patent/EP2489339B1/en active Active
- 2010-09-30 MY MYPI2012700176A patent/MY165470A/en unknown
- 2010-09-30 RU RU2012119568/12A patent/RU2552241C2/ru active
- 2010-09-30 JP JP2011536092A patent/JP5460726B2/ja active Active
- 2010-09-30 IN IN3451DEN2012 patent/IN2012DN03451A/en unknown
- 2010-09-30 US US13/501,695 patent/US20120253255A1/en not_active Abandoned
- 2010-09-30 HU HUE10823292A patent/HUE027594T2/en unknown
- 2010-09-30 CN CN201080045907.XA patent/CN102573722B/zh active Active
- 2010-09-30 ES ES10823291.9T patent/ES2523727T3/es active Active
- 2010-09-30 WO PCT/JP2010/067140 patent/WO2011046024A1/ja active Application Filing
- 2010-09-30 KR KR1020127009847A patent/KR101554383B1/ko active IP Right Grant
- 2010-09-30 AU AU2010307798A patent/AU2010307798A1/en not_active Abandoned
- 2010-09-30 PL PL10823292.7T patent/PL2489340T3/pl unknown
- 2010-09-30 CN CN201080045908.4A patent/CN102573723B/zh active Active
- 2010-09-30 WO PCT/JP2010/067129 patent/WO2011046023A1/ja active Application Filing
- 2010-09-30 PT PT108232927T patent/PT2489340T/pt unknown
- 2010-09-30 CA CA2777517A patent/CA2777517C/en active Active
- 2010-09-30 AU AU2010307797A patent/AU2010307797B2/en active Active
- 2010-09-30 EP EP10823292.7A patent/EP2489340B1/en active Active
- 2010-09-30 US US13/501,764 patent/US9314378B2/en active Active
- 2010-09-30 JP JP2011536091A patent/JP5352677B2/ja active Active
- 2010-09-30 RU RU2012119543/14A patent/RU2539555C2/ru active
- 2010-09-30 MY MYPI2012700179A patent/MY164418A/en unknown
- 2010-09-30 BR BR112012008892A patent/BR112012008892B8/pt active IP Right Grant
- 2010-10-08 TW TW099134412A patent/TW201129346A/zh unknown
- 2010-10-08 TW TW099134410A patent/TW201130467A/zh unknown
-
2012
- 2012-12-17 HK HK12112997.4A patent/HK1171936A1/xx unknown
-
2013
- 2013-01-09 HK HK13100341.1A patent/HK1173640A1/xx unknown
- 2013-05-31 JP JP2013115446A patent/JP5624175B2/ja active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50133797U (ja) | 1974-04-18 | 1975-11-04 | ||
JPS59149141A (ja) | 1983-02-15 | 1984-08-27 | フアイザ−.ホスピタル.プロダクツ.グル−プ.インコ−ポレ−テツド | 創傷包帯 |
JPH08112305A (ja) | 1994-10-14 | 1996-05-07 | Hisamitsu Pharmaceut Co Inc | 貼付剤 |
JPH09238975A (ja) * | 1996-03-01 | 1997-09-16 | Kyowa:Kk | 粘着フィルム |
JP2002531221A (ja) * | 1998-12-09 | 2002-09-24 | メールンリユーケ ヘルス ケアー アーベー | グリップタブを含む接着性表面保護シートを作る方法 |
JP2000219622A (ja) | 1999-01-29 | 2000-08-08 | Toko Yakuhin Kogyo Kk | パップ剤の構造 |
JP2008264170A (ja) * | 2007-04-19 | 2008-11-06 | Nitto Denko Corp | フィルムドレッシング |
JP2009131583A (ja) | 2007-11-30 | 2009-06-18 | Hideya Nishimura | 貼付剤用剥離シート(ライナー) |
WO2010044152A1 (ja) * | 2008-10-15 | 2010-04-22 | 日東電工株式会社 | フィルムドレッシング |
Non-Patent Citations (1)
Title |
---|
See also references of EP2489339A4 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021106214A1 (ja) * | 2019-11-29 | 2021-06-03 | 小林製薬株式会社 | 貼付剤 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5624175B2 (ja) | 貼付剤を製造するための方法 | |
JP5791774B2 (ja) | 粘着テープ包装袋 | |
EP2380539B1 (en) | Pressure-sensitive adhesive tape package | |
JP4809158B2 (ja) | 簡易剥離可能な剥離シートを備えた貼付剤 | |
KR20140022893A (ko) | 점착 테이프 포장백 | |
AU2015203737B2 (en) | Adhesive patch |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 201080045907.X Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 10823291 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2011536091 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 12012500708 Country of ref document: PH |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2777676 Country of ref document: CA |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 20127009847 Country of ref document: KR Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010307797 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 3455/DELNP/2012 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010823291 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2012119568 Country of ref document: RU |
|
ENP | Entry into the national phase |
Ref document number: 2010307797 Country of ref document: AU Date of ref document: 20100930 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 13501764 Country of ref document: US |
|
REG | Reference to national code |
Ref country code: BR Ref legal event code: B01A Ref document number: 112012008892 Country of ref document: BR |
|
ENP | Entry into the national phase |
Ref document number: 112012008892 Country of ref document: BR Kind code of ref document: A2 Effective date: 20120416 |