TW201130467A - Adhesive patch - Google Patents
Adhesive patch Download PDFInfo
- Publication number
- TW201130467A TW201130467A TW099134410A TW99134410A TW201130467A TW 201130467 A TW201130467 A TW 201130467A TW 099134410 A TW099134410 A TW 099134410A TW 99134410 A TW99134410 A TW 99134410A TW 201130467 A TW201130467 A TW 201130467A
- Authority
- TW
- Taiwan
- Prior art keywords
- sheet
- patch
- peeling
- adhesive layer
- pick
- Prior art date
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- 239000000853 adhesive Substances 0.000 title claims abstract description 26
- 230000001070 adhesive effect Effects 0.000 title claims abstract description 25
- 239000012790 adhesive layer Substances 0.000 claims abstract description 61
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- 229940079593 drug Drugs 0.000 description 12
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- 230000000694 effects Effects 0.000 description 10
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Landscapes
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- Adhesive Tapes (AREA)
- Adhesives Or Adhesive Processes (AREA)
Description
201130467 六、發明說明: 【發明所屬之技術領域】 本發明係有關泥敷劑及藥膏劑等貼劑,特別係有關可 容易貼上皮膚之貼劑。 【先前技術】 貼劑一般係具備織布或不織布等形成之支持體、設置 於該支持體其中一面的黏著劑層、與可與該黏著劑層剝離 之被黏著的剝離薄片所構成。而於形成黏著劑層之黏著劑 中,含有可經皮吸收之藥物等。 於該等貼劑的領域中’持續追求著貼附於皮膚的容易 性。因此’自以往即提案有例如如下述專利文件1〜4所記 載之貼劑。 專利文件1及2記載之貼劑係由具伸縮性的支持體,與 貼附於支持體上的黏著劑層之可剝離的剝離薄片所構成, 其特徵係於剝離薄片的中央部位形成撕裂線。使用該貼劑 時,首先需藉由左右拉伸貼劑使撕裂線斷裂後,露出黏著 劑層,再將該露出部分貼於皮膚上,之後,再去除剝離薄 另外,專利文件3記載之貼劑,係於黏著劑層上設置 二片剝離薄片,彎折其中一片剝離薄片的內側端部,再使 另一片剝離薄片的內側端部疊合於該彎折部位之上。該等 貼劑由於可自彎折部位或疊合於其上的端部摘取,可容易 地將剝離薄片自黏著劑層去除,以此設計謀求貼附於皮膚 s -5- 201130467 的容易化。 進而專利文件4記載之貼劑,係分別彎 片後,使二片剝離薄片的彎折線以對接的狀 層之上。該貼劑亦與專利文件3記載之貼劑 折部位,可容易地將剝離薄片自黏著劑層剝 另外,專利文件5記載之貼劑,係與貼 包帶,即醫療用膠帶,但其亦對於使剝離薄 足功夫。該創傷包帶亦與專利文件4記載之 使二片剝離薄片的端部以對接的狀態置於黏 然後於各剝離薄片的對接側的端部上,附i 薄片而使其剝離的撕開標籤。相關的創傷隹 件3、4記載之貼劑相同,摘取撕開標籤後, 剝離薄片自黏著劑層剝離。 先前技術文件 專利文件 專利文件1 :特開平8 - 1 1 2 3 0 5號公報 專利文件2 :實開昭5 0 - 1 3 3 7 9 7號公報 專利文件3 :特開2000_219622號公報 專利文件4:特開2009-131583號公報 專利文件5 :特開昭59- 1 49】41號公報 【發明內容】 〔發明欲解決之課題〕 折二片剝離薄 態置於黏著劑 相同,摘取彎 離。 劑不同的創傷 片容易剝離下 貼劑相同,係 著劑層之上。 有可拉伸剝離 帶亦與專利文 即可容易地將 -6 - 201130467 本發明係提高上述以往的各種貼劑以及 附容易性。 然而’專利文件1及2記載之貼劑,沿著 離薄片後’將黏著劑層的露出部分貼於皮膚 難以剝除剝離薄片。 另外’專利文件3及4記載之貼劑以及| 的創傷包帶,雖然因具有可供摘取的部分, 離薄片自黏著劑層剝除的優點,但存在藥效 剝離薄片的疊合部分或對接部分外漏此問題 另外於專利文件3記載之貼劑中,由於 薄片的彎折部分,與疊合於其上的另一片剝 朝向同一個方向,形成了只能從其中一側才 片的構造’相當不便。進而由於彎折剝離薄 的彎折薄片裝置’亦有增加貼劑製造成本之 針對專利文件4記載之貼劑,由於製造 剝離薄片之步驟,再者爲極力抑制藥效成女 離薄片相鄰的彎折線必須以良好的精度對接 上極爲困難。 進而,於如專利文件5記載的構成中,H 載之貼劑相同,必須以極高的精度進行剝離 籤的對接。另外,即使於使切斷前的撕開標 )附著於切斷前的剝離薄片(薄片素材)後 素材及標籤素材,由於是切斷二者附著後強 ,存在難以切斷的問題。 創傷包帶的貼 撕裂線分斷剝 上時,有時會 ί利文件5記載 而有容易將剝 成分會自二片 點。 其中一片剝離 離薄片的端部 可摘取剝離薄 片而需要特殊 問題。 時必須有彎折 卜外漏,2片剝 ,於貼劑製造 ϋ專利文件4記 薄片與撕開標 籤(標籤素材 ,欲切斷薄片 度提高的部分 201130467 於專利文件5記載的創傷包帶中,拉伸撕開標籤剝除 剝離薄片時,爲使無阻抗可順利進行剝離,於創傷包帶的 邊端設置抑制剝離薄片剝離的抑制剝離裝置,但由於設置 該抑制剝離裝置,增加了 一個以上的製作步驟,而存在製 造時耗費時間及成本之問題。另外,抑制剝離裝置有彎折 式(參照專利文件5之圖5 )及迴紋針式(參照專利文件5 之圖6),該等裝置係於創傷包帶的表面形成突出部位, 可能會於貼於患部時造成妨礙。因此,該等突出部位,並 不適用於泥敷劑及藥膏劑等大型貼劑。 進而於專利文件3〜5記載之構成中,由於並非是使2 片剝離薄片結合在一起,二者間可能出現位置上的偏差、 捲摺等,於該等情況下更容易使藥效成分外漏,而造成製 劑安定性上的問題。另外,剝離薄片的位置產生偏差,拉 伸彎折部分或撕開標籤時會使支持體變形,其結果可能會 發生貼附時弄皺貼劑的問題。該等因位置偏差造成的弊害 ,於僅使端部對接的專利文件4及5所記載的構成特別顯著 〇 本發明有鑑於上述相關情況,以提供容易貼附於皮膚 ,亦容易製造之貼劑爲目的。 〔解決課題之手段〕 爲達成上述目的,本發明之貼劑的特徵係具備支持體 、設置於該支持體其中一面的黏著劑層、可與該黏著劑層 剝離之被黏著的剝離薄片、形成於剝離薄片,且使該剝離 -8- .201130467 薄片容易分斷之弱化部,進而於該剝離薄片上,摘取片形 成薄片以覆蓋前述弱化部之方式接合,該接合部分以外之 摘取片形成薄片之一部分,成爲具功能的摘取片,且摘取 片形成薄片亦於對應於剝離薄片之弱化部的位置上,形成 容易分斷該剝離薄片之弱化部。 特別係支持體具有伸縮性爲佳。其理由係藉由拉伸支 持體,可使剝離薄片與摘取片形成薄片沿著弱化部而分斷 〇 該等貼劑中,藉由使剝離薄片與摘取片形成薄片沿著 弱化部而分斷’被分斷的各剝離薄片上分別形成摘取片。 藉此’使用者可使用該摘取片,容易地將剝離薄片自黏著 劑層剝除’另外,亦可利用爲貼劑的位置調整等。 另外,由於剝離薄片於使用前爲單張構成,亦不會發 生如專利文件3〜5記載之以往的構成,因剝離薄片位置上 的偏差而使藥效成分外漏,或弄皺貼劑等問題。 尙且’剝離薄片與摘取片形成薄片間的接合部分,可 形成於弱化部的左右位置’與該弱化部分隔,或亦可形成 於弱化部之上。 另外’根據本發明之貼劑,適合以下述方法製造。即 爲以包含於支持體上形成黏著劑層之第!步驟、於剝離薄 片上接合摘取片形成薄片之第2步驟、於剝離薄片以及摘 取片形成薄片上形成弱化部之第3步驟、與將第3步驟所得 之已接合摘取片形成薄片之剝離薄片,使其以可剝離的方 式附著於第1步驟所得之支持體上的前述之黏著劑層之第4
S -9 - 201130467 ^ 步驟之方法爲佳。 根據本發明之貼劑,無彎折加工所需要的材料。因此 ,即使於其製造方法中,亦無需特殊的彎折加工裝置等, 易於製造。 且作爲形成弱化部之位置,若接合部分爲1處時則設 置於接合部分之上,若接合部分設置有2處時則以2個接合 部分之間爲佳。理由係接合部分的剛性或強度較接合部分 以外的位置爲高,可容易地於2個接合部分間形成形成弱 化部。 另外,藉由熱融著接合剝離薄片與摘取片形成薄片時 ,由於剝離薄片及/或摘取片形成薄片有收縮的可能性, 接合部分狹窄時,可抑制該等收縮。自相關的觀點,接合 部分有2個位置,且使接合部分寬度縮窄極有效果。 〔發明的效果〕 根據本發明,由形成有摘取片,使貼劑的貼附作業變 爲容易。 另外,由於摘取片係分別形成於分斷部位即弱化部的 兩側,任一片摘取片均容易摘取,且可同時使用2片摘取 片,對使用者而言相當便利。 另外,由於剝離薄片係由單張薄片構成’與以2片薄 片覆蓋於黏著劑層此一形式之貼劑相比,黏著劑層中之藥 效成分以剝離薄片爲界大幅抑制外漏,或可完全防止外漏 -10- 201130467 進而,由於無需彎折剝離薄片等,及無需如專利文件 5記載之抑制剝離裝置’容易製造’且可抑制製造成本升 高。 【實施方式】 以下,藉由圖面針對適合本發明之實施方式加以詳細 說明。 圖1係根據本發明之貼劑的實施方式之立體圖,圖2係 其平面圖,圖3則爲其側視圖。如圖所示,與本實施方式 有關之貼劑(1 〇 ),係可使用爲泥敷劑或藥膏劑等貼劑, 由具有伸縮性之支持體(12) '形成於支持體(12)其中 一面的大部分面積,含有藥物的黏著劑層(14)、設置於 黏著劑層(1 4 )的表面,可剝離之被貼附的剝離薄片(i 6 )、及接合於剝離薄片(1 6 )上之摘取片形成薄片(丨8 ) 所構成。 摘取片形成薄片(1 8 )並非全面性的與剝離薄片(! 6 )接合’左右兩端部分與剝離薄片(1 6 )爲非接合狀態。 進而於剝離薄片(1 6 )及摘取片形成薄片(1 8 )的略 中央部(即貼劑(1 〇 )之較長方向的略中央部位,以下與 稱做「略中央部」之情況時相同),自貼劑(丨〇 )其中一 個長邊至另一個長邊’形成有使剝離薄片(16)及摘取片 形成薄片(〗8 )容易分斷之撕裂線等弱化部(2〇 )。 •^下針對各構成要素進行說明。 支持體(1 2 )可使用具伸縮性者,例如織布、編布、 5 -11 - 201130467 不織布、不織紙、薄膜等適 、伸縮性、張力強度、貼附 觸感、與皮膚的密閉性、藥 1 2 )等而加以選擇。且針對 向及/或橫向50%係數爲0.5 支持體(12)的具體材 麻等之韌皮纖維、馬尼拉麻 羊毛等獸毛纖維、絹纖維、 纖維、嫘縈、人造銅銨酸纖 白質纖維等人造纖維、醋酸 等半合成纖維、尼龍聚醯胺 、聚酯纖維、丙烯酸纖維等 維、聚乙烯醇纖維、聚氯乙 乙烯系纖維、聚胺基甲酸乙 氟乙烯纖維、PBT纖維、聚 著劑層(14)所含成分交互 二乙酯纖維所構成之不織布 黏著劑層(14 )係藉由 劑上,而可有效利用作爲泥 而黏著劑層(14)的構成材 性可貼附於皮膚者則無特別 劑層(1 4 )以滿足對皮膚的 效成分、儘可能含有水分、 時會帶走皮膚的熱度,但該 當的薄片狀材料,並考 作業性等物理性質或貼 效成分是否會轉移至支 支持體(12 )之伸縮性 〜10N/50mm爲佳。 料爲可利用紙、棉、大 等之葉脈纖維之纖維素 羽毛纖維等蛋白質纖維 維等人造纖維素纖維或 纖維素纖維或蛋白質共 纖維 '聚對苯二甲二乙 、聚乙烯及聚丙烯等聚 烯纖維、聚偏二氯乙嫌 酯纖維、聚氧甲烯纖維 亞酿胺纖維等。特別係 作用少’聚酯系之聚對 爲佳。 使藥物含有或附著等於 敷劑及藥膏劑等貼劑( 料之黏著成分,若爲具 限定’使用爲泥敷劑時 密著性佳、可提高皮膚 黏著劑層(1 4 )中的水 散熱量會造成清涼感, 慮厚度 附時的 持體( ,以縱 麻、黃 纖維、 等天然 人造蛋 聚纖維 酯纖維 烯烴纖 、聚氯 、聚四 由與黏 苯二甲 黏著基 10) ° 有黏著 ,黏著 吸收有 分蒸發 及角質 -12- 201130467 層因持續自內部蒸散的水分子而被水和化,可促進藥物吸 收、於常溫或接近常溫的溫度下不會鬆弛、剝除時無痛且 不會殘留污漬、不會有黏腻感等條件爲佳。因此,黏著劑 層(1 4 )以使用水溶性高分子爲佳,增黏劑以5重量%〜2 0 重量%爲佳,重量%〜15重量%更佳,濕潤劑以5重量% 〜4 0重量%爲佳,充塡劑爲2 0重量%以下,水爲1 〇重量%〜 8 0重量%,溶解輔助劑爲0〜8重量%,藥物爲5重量%以下 爲佳,〇.1重量%〜5重量%更佳。 上述水溶性高分子可使用明膠、洋菜、海藻酸、甘露 聚糖、羧甲基纖維素或其鹽、羥基丙基纖維素或其鹽、聚 丙烯醇、聚丙烯酸或其鹽等,或爲前述之物質中之至少一 種經有機或無機之交聯劑進行交聯者。 於上述之黏著基劑以外,黏著劑層(14)可適當的添 加增黏劑、濕潤劑等。 例如增黏劑以可安定地保持水分爲1 0%〜80%,且具 有保水性者爲佳。其具體例爲可使用關華豆膠、刺槐豆膠 、卡拉膠、海藻酸、海藻酸鈉、洋菜、阿拉伯膠、黃耆膠 、印度樹膠、果膠、澱粉 '阿拉伯橡膠樹膠等植物系、三 仙膠等微生物系、明膠、膠原蛋白等動物系天然高分子、 甲基纖維素、乙基纖維素、羥乙基纖維素、羧甲基纖維素 鈉等纖維素系可溶性澱粉、羧甲基澱粉 '雙醛澱粉等殿 粉系之半合成高分子、聚丙烯醇、聚丙烯吡咯烷酮、聚丙 烯丙烯酸甲酯等丙烯系、聚丙烯酸、聚丙烯酸鈉等丙烯酸 系、其他聚乙烯過氧化物、甲基丙烯基醚/無水馬來酸共 -13- 201130467 聚合物等合成高分子等之水溶性高分子等。其中以聚丙烯 酸鈉特佳。理由係凝膠強度大,且具優異的保水性。進而 以平均聚合度20000〜70000之聚丙烯酸鈉爲佳。平均聚合 度小於20000伴隨著增黏效果變差,出現無法獲得充分凝 膠強度之傾向,平均聚合度大於70000伴隨著增黏效果過 強,而出現降低作業性之傾向。另外,藉由倂用前述之水 溶性高分子2種以上,例如形成聚丙烯酸鈉之強離子性高 分子與高分子錯合物,可獲得凝膠強度更大之彈性凝膠。 亦可添加濕潤劑爲甘油、丙二醇、山梨醇等多元醇等 ,充塡劑可爲高嶺土、滑石、鈦、膨潤土、矽酸鋁、氧化 鈦、氧化錫、甲基矽酸鋁、硫酸鈣、磷酸鈣等。另外亦可 添加溶解輔助劑或促進吸收劑爲碳酸丙烯酯、克羅米通( crotamiton )、薄荷醇、辣薄荷油、檸檬烯、二異丙醇脂 肪鹽等,藥效輔助劑爲甲基水楊酸、乙二醇水楊酸、薄荷 醇、麝香草酚、辣薄荷油、壬酸香草醯胺、辣椒萃取物等 〇 進而可因應需要,添加安定化劑及抗氧化劑、乳化劑 等。其他也可因應需要,添加交聯劑及聚合劑等。可強固 黏著劑層(!4)同時使其具有保水性。該交聯劑及聚合劑 可因應增黏劑等之種類適當地加以選擇。例如增黏劑使用 聚丙烯酸或聚丙烯酸鹽時,以使用分子中至少具有2個環 氧基之化合物、Ca、Mg、A1等之鹽酸鹽、硫酸鹽、磷酸 鹽 '碳酸鹽等無機酸鹽、檸檬酸鹽、酒石酸鹽、葡萄糖酸 鹽、硬酯酸鹽等有機酸鹽、氧化錫、無水矽酸等氧化物、 -14 - 201130467 氫氧化鋁、氫氧化鎂等氫氧化物等之多價金屬化合物等爲 佳。另外,增黏劑使用聚丙烯醇時,以使用己二酸、乙硫 醇酸、環氧化合物(環氧氯丙烷)、醛類、N-甲醇基化合 物、Al、Ti ' Zr、Sn、V、Cu、B、Cr等化合物等之錯化 物等爲佳。增黏劑使用聚丙烯吡咯烷酮時,以使用甲基丙 烯基醚/無水馬來酸共聚合物、聚酸化合物或其之鹼金屬 鹽(聚丙烯酸或單寧酸及其衍生物)等爲佳。另外,增黏 劑使用聚乙烯過氧化物時,以使用過氧化氫、聚過氧化硫 等爲佳。另外,增黏劑使用甲基丙烯基醚/無水馬來酸共 聚合物時,以使用多官能羥基化合物、聚胺、碘、明膠、 聚丙烯吡咯烷酮、鐵 '水銀、鉛鹽等爲佳。增黏劑使用明 膠時,以使用甲醛、戊二醛、雙醛澱粉等醛類、乙二醛、 丁二烯丙烯過氧化物等二環氧化物類、二丙烯酮等雙酮類 、二異氰酸酯類等爲佳。另外,增黏劑使用聚丙輝酸鈉時 ,交聯劑以添加氫氧化鋰、氫氧化錫 '氫氧化鋁、硼酸鈉 等之多價金屬鹽爲佳。特別係以錫鹽、鋁鹽爲佳。添加於 交聯劑之多價金屬鹽之濃度以相對於1當量之增黏劑(或 水溶性高分子)爲〇·5〜1.5當量爲佳。多價金屬鹽之濃度 較0 · 5當量小時’伴隨著反應過慢,且出現凝膠強度變低 之傾向,多價金屬鹽之濃度較1.5當量爲大時,伴隨著反 應過快且使凝膠化不均勻,出現降低作業性之傾向。 另一方面’藥膏劑之黏著基劑可使用橡膠系黏著成分 、丙烯酸系黏著成分、二氧化矽系黏著成分等。 上述橡膠系黏著成分可使用天然橡膠' 合成橡膠之任 3 -15- 201130467 一種,合成橡膠可舉出例如苯乙烯系嵌段共聚合物及聚異 丁烯。進而苯乙烯系嵌段共聚合物可舉出苯乙烯-丁二烯-苯乙烯嵌段共聚物(SBS)、苯乙烯-異戊二烯-苯乙烯嵌 段共聚物(SIS)、苯乙烯-乙烯/ 丁二烯-苯乙烯嵌段共聚 物(SEBS)、苯乙烯-乙烯/丙烯-苯乙烯嵌段共聚物( SEPS )。苯乙烯系嵌段共聚合物之具體例可舉出KRATON D-1112、D—1111、D—1107(商品名,KRATON POLYMER (股)製)、JSR5 00 0或JSR5002 (商品名,日本合成橡膠 (股)製)、Quintac3530、3421 或 3570C(商品名,日本 ΖΕΟΝ (股)製)' KRATON D-KX401CS或 D-l 107CU (商 品名’ KRATON POLYMER (股)製)等線性嵌段共聚合 物、及 KRATON D-1124 (商品名 ’KRATON POLYMER ( 股)製)、Solprene 418 (商品名,Phillips Petroleum ( 股)製)等之接枝共聚物等。 聚異丁烯可使用自高分子至低分子物,例如可舉出 Oppanol ΒΙΟ、Β12、B12SF、Β15、B15SF ' B30SF、Β 5 0 、B50SF、 Β80、 Β100、 Β120、 Β150、 Β200(商品名, BASF (股)製)、Vistanex LM-MS、LM-MH、LM-H、 MM L-80、MM L-100、MM L-120、MM L-150 (商品名, Exxon化學(股)製)等。 另外丙烯酸系高分子以單體單位可使用含有例如以丙 烯酸-2-乙基己酯、丙烯酸甲酯、丙烯酸丁酯、丙烯酸羥乙 醋、甲基丙烯酸-2-乙基己酯等之代表(甲基)丙烯酸酯之 至少一種之聚合物或共聚合物等,例如可使用丙烯酸•丙 -16 - 201130467 烯酸辛基酯共聚合物、丙烯酸-2-乙基己酯·Ν_乙烯基-2_ 吡咯烷酮·二甲基丙烯酸-1,6 -己烷乙二醇共聚合物、丙烯 酸-2-乙基己酯•醋酸乙烯共聚合物、丙烯酸·2_乙基己酯 •醋酸乙烯·丙烯酸共聚合物、丙烯酸_2_乙基己酯•甲基 丙烯酸-2-乙基己酯.甲基丙烯酸十二酯共聚合物、丙烯酸 甲酯·丙稀酸-2-乙基己酯共聚合樹脂乳膠、丙烯酸樹脂烷 醇胺液中含有丙嫌酸系高分子等之黏著劑、Duro-Tak丙烯 酸黏著劑系列(National Starch and Chemical 公司製)、 GELVA丙燒酸黏著劑系列(Monsanto公司製)、SK-Dyne (綜硏化學)' Eudragit系列(樋口商會)等。 可將上述之橡膠系、丙烯酸系、二氧化矽系等黏著基 劑之一種或二種以上混合使用。 另外’作爲藥膏劑時’可適當地混合賦予黏著劑、可 塑劑、塡充劑、安定劑。 黏著劑層(1 4 )所含藥物,若爲經皮性可吸收至體內 後發揮藥理效果者則無特別限制,例如可舉出抗發炎齊Ij、 鎭痛劑、抗組織胺劑、局部麻醉劑、血流促進劑、麻醉劑 、精神安定劑、抗高血壓劑、抗菌劑、血管擴張劑等。 具體而言藥物可舉出至少一種選自甲基水楊酸、乙二 醇水楊酸、薄荷醇、辣椒萃取物、壬酸香草醯胺、辣薄荷 油、二氯胺苹乙酸、異丁苯丙酸、吲哚美辛、克特普芬( ketoprofen)、洛索洛芬酸(loxoprofen)、舒達寧( sulindac)、托耳米丁 (tolmetin)、氯苯紮利( lobenzarit)、青黴胺(penicillamine)、聯苯 丁酮酸、富 5. -17- 201130467 帝芬(flurbiprofen )、拿百疼(naproxen )、普拉洛芬( pranoprofen )、泰普菲(tiaproferl )、舒洛芬(supr〇fen )、聯本乙酸(felbinac) 、ketorolac、奧沙普秦 ( oxaprozin )、樂達克定 (etodolac )、扎托洛芬 ( zaltoprofen )、治爾痛(piroxicam )、潘他唑新( pentazocine ) 、鹽酸丁 基唑辛(buprenorphine hydrochloride)、全妥(butorphanol tartrate)等及其之 酯衍生物或鹽之非類固醇類抗發炎藥,及潑尼松龍( prednisolone)、地塞米松(dexamethasone)、皮質醇( hydrocortisone)、美他貝松(betamethasone)、妥膚淨 (fluocinonide)、丙酮化氟新龍(fluocinolone acetonide )、潑尼松龍醋酸醋(prednisolone acetate)、地塞米松 二丙酸醋(dexamethasone dipropionate )、二氣特隆( diflucortolone valerate ) 、倍他米松戊酸酯( betamethasone valerate ) '氣化可的松醋酸醋 ( hydrocortisone acetate)、氯倍他松醋酸醋(clobetasone acetate)、倍他米松醋酸酯(betamethasone acetate)、 氯倍他松丙酸醋(clobetasone propionate)、地塞米松琥 拍酸醋(dexamethasone succinate) ' 潑尼松龍 21- ( 2E,6E )法呢酸醋、氫化可的松(hydrocortisone valerate)戊酸 酯、雙氟拉松醋酸醋(diflorasone acetate)、地塞米松丙 酸醋(dexamethasone propionate)、倍他米松二丙酸醋( betamethasone dipropionate )、安西縮松(amcinonide ) 、地塞米松戊酸醋(dexamethasone valerate)、哈西縮松 -18- 201130467 (halcinonide)、布地奈德(budesonide) ' 阿氯米松二 丙酸酯(alclometasone dipropionate)等類固醇類抗發炎 藥,但並非限定於該等藥物。可因應需要倂用2種以上之 藥物。另外,該等藥物可因應需要,以酯體所衍生之化合 物、醯胺體所衍生之化合物、縮醛體所衍生之化合物,或 醫學上容許之無機鹽、有機鹽之型態,包含或附著於黏著 劑層(1 4 )。藥物的用量係使使用於患者時,預先設定的 有效量可適用於皮膚之量可因應泥敷劑及藥膏劑等貼劑( 10)之種類 '用途等適當地加以選擇。 剝離薄片(1 6 )可使用聚丙烯,例如除無延伸聚丙稀 及延伸聚丙烯之外,聚對苯二甲二乙酯、聚對苯二甲二丁 酯、聚乙烯、聚酯、聚胺基甲酸乙酯、聚氯乙烯、聚苯乙 烯等塑膠薄膜,合成樹脂及合成紙、合成纖維等經施以二 氧化矽加工之二氧化矽加工紙,於鋁箔 '牛皮紙以聚乙烯 等進行防水膠膜加工之防水膠膜加工紙等無色或經著色者 〇 並未特別限定剝離薄片(1 6 )的厚度,以形成於1 0从m 〜75/zm爲佳,12/zm〜50ym的範圍更佳。剝離薄片(16 )的厚度低於l〇#m以下時,剝離薄片(16)會過薄,於 進行剝離時剝離薄片(1 6 )會與黏著劑層(1 4 )纏在一起 ,及在製造時剝離薄片(1 6 )會立刻被分斷而降低作業性 等,另外,於黏著劑層(14 )上貼著剝離薄片(1 6 )時, 剝離薄片(1 6 )會出現容易產生皺摺之傾向。另外,於後 述中會詳細說明,使用本發明之貼劑(1 〇 )時,藉由向左
S -19- 201130467 右拉伸’可沿弱化線(20 )分斷剝離薄片(1 6 )與摘取片 形成薄片(18),但剝離薄片(16)的厚度大於75ym時 會難以分斷,且於製造時會變得難以切斷原材薄片,而出 現降低降低作業性之傾向。 進而雖未以圖面表示,但以藉由壓紋加工等對剝離薄 片(16)施加凹凸紋路爲佳。另外爲明確說明分斷方法, 可於剝離薄片(16)的左右部分設計箭頭等圖形或文字、 記號等表示部,亦可施以著色等。該表示部亦可藉由壓紋 加工形成。 對剝離薄片(1 6 )施以壓紋加工時,可獲得以下之作 用效果。亦即,藉由壓紋加工於剝離薄片(1 6 )的表面形 成凹凸,該凹凸可增加與手指及黏著劑層(I4)的摩擦力 。因此,於分斷剝離薄片(16)及摘取片形成薄片(18) 時,剝離薄片(16)上之凹凸,可發揮摩擦而使手指容易 施力之作用。另外,由於剝離薄片(16)與黏著劑層(14 )間的摩擦力變大,向左右拉伸貼劑(1 〇 )時,其力道可 確實傳達至剝離薄片(16),而更爲容易分斷剝離薄片( 16)。進而,由於壓紋加工形成的凹凸使剝離薄片(16) 的厚度因位置而變化,於分斷剝離薄片(I6)後,可發現 沿著分斷線剝離薄片(1 6 )的端部出現自然地從黏著劑層 (14)脫離之傾向,此亦爲可使剝離薄片(16)容易剝離 之設計。 另外藉由剝離薄片(16)的端部出現如上所述之脫離 現象,雖然可能彎摺支持體(12)的露出部分,或沾附該 -20- 201130467 部分的黏著劑層(1 4 ),但由於是沿著剝離薄片(〗6 )的 弱化部(20)與摘取片形成薄片(18)(摘取片(i8a) 、(18b))接合在一起’可抑制剝離薄片(16)的端部 不經意的自黏著劑層(14)脫離。 摘取片形成薄片(18)於圖示實施方式中爲矩形,其 長邊的長度D1實際上與貼劑(1〇)的短邊長度D2相同, 而其短邊的長度D3較貼劑(1〇)的長邊長度D4爲短。該 摘取片形成薄片(18)係於剝離薄片(16)的略中央部, 以使摘取片形成薄片(1 8 )的長邊平行於剝離薄片(丨6 ) 的短邊之方式配置。摘取片形成薄片(18)自其較長方向 中心軸線(弱化部(2 0 )位置)左右兩側,於一定間隔x (並未特別設定,例如0.5〜25mm )位置上,與剝離薄片 (16)以實際上不可分離之方式接合在一起。摘取片形成 薄片(18)與剝離薄片(16)的左右各接合部分(22), 以延伸摘取片形成薄片(1 8 )的全長爲佳。另外,摘取片 形成薄片(1 8 )有關較各接合部分(2 2 )更外側(遠離摘 取片形成薄片(18)的較長方向中心軸線以外的方向)之 部分,並未與剝離薄片(16)接合,該非接合部分係作爲 後述之摘取片(1 8a )、( 1 8b )且具有功能。由於該摘取 片(1 8 a )、( 1 8b )係以手摘取,可適當地決定可供手指 摘取的大小,但摘取片(1 8 a ) 、 ( 1 8 b )的寬度y以2〜 4cm爲佳。較2cm窄不易摘取,而超過4cm則會使摘取片( 1 8a )、( 1 8b )過大不容易使用,亦使材料費增加。 摘取片形成薄片(1 8 )與剝離薄片(1 6 )的接合部分 -21 - 201130467 (22)的寬度z’若爲可確保薄片(16)與薄片(18)的 接合不會分離之最小尺寸,即可適當地加以決定,但爲使 分斷後述之薄片時’力道可有效地自摘取片形成薄片(18 )傳至剝離薄片(1 6 ),需具有一定的寬度。例如以〇. 1 〜10mm左右的寬度爲佳。 短邊的長度D2爲l5〇mm’長邊的長度D4爲200mm之貼 劑(1 〇 )的情況,摘取片形成薄片(1 8 )係使用長邊的長 度D1爲150mm,短邊的長度D3爲7〇mm者,摘取片形成薄 片(1 8 )自其較長方向中心軸線(弱化部(2 〇 )位置)至 接合部分(22)的間隔X爲2.5 mm,接合部分(22)的寬 度z爲1.0mm’因此摘取片(18a) 、(18b)的寬度y以使 用31. 5mm者爲佳。 摘取片形成薄片(18)與剝離薄片(16)的接合方法 ,若爲可使薄片(16)與薄片(18)以實際上不會分離之 方式接合’可爲任一種方法’但以使用接著劑之方法、熱 融著法等爲佳。特別於使用熱融著法之情況,因與使用接 著劑之情況相比可大幅縮短接合時間而爲佳。 另外’圖面上接合部分(22)係以連續線之形式表示 ,但亦可以如虛線等非連續線的型態表示。 摘取片形成薄片(18)的材料可使用與上述之剝離薄 片(1 6 )相同的材料,但考慮摘取片的功能,以不易撕裂 的聚對本一甲—乙醋爲佳。然而,剝離薄片(16)係聚對 本一甲一乙醋的單層構造’於剝離薄片(16)表層至少爲 聚丙烯且經壓紋加工等形成凹凸之情況時,使二者進行熱 -22- .201130467 融著有時會有困難。此時可使用接著劑,但爲進行熱融著 ,可如圖4槪略性所示般,使摘取片形成薄片(〗8 )爲二 層構造。亦即’於聚對苯二甲二乙酯基層的下面(剝離薄 片(16)側之面),藉由層合聚丙烯,而可使對具有凹凸 之聚丙烯的剝離薄片(16)的熱融著容易進行。 可適當決定摘取片形成薄片(18)的厚度,但考慮作 爲摘取片的強度及摘取時之觸感等,以10〜100# m爲佳。 另外’爲聚對苯二甲二乙酯與無延伸聚丙烯此二層構造時 ,聚對苯二甲二乙酯層爲5〜40//m,無延伸聚丙烯層爲10 〜60/z m ’於使用延伸聚丙烯層取代無延伸聚丙烯層之情 況時,延伸聚丙烯層的厚度以10〜60" m爲佳。 另外,藉由將摘取片形成薄片(1 8 )及形成摘取片( 18a) 、(18b)的部分’分開塗上與上述之剝離薄片(16 )不同的顏色,可容易地以視覺分辨摘取片(1 8 a )、( 18b ) ° 形成於剝離薄片(16)與摘取片形成薄片(18)的略 中央部之弱化部(20),係爲容易分斷薄片(16)、薄片 (18)之裝置’且形成爲摘取片形成薄片(18)之全長。 本實施方法中’如圖2所示’有貫通剝離薄片(16)及摘 取片形成薄片(1 8 )的小孔(2 0 a ),即撕裂線。可適當 地決定該撕裂線的構成,但小孔(2 0 a )與小孔(2 0 a )間 的連結部(20b )之間長度的比,以[(20a ) ] : [ ( 20b )] =1 〜1500: 1 〜25 爲佳 ’ [(20a) ] : [(2 0b) ]=1〜1000 :1 〜20 更佳 ’ [(20a) ]: [(20b) ]=1〇〇 〜1000: 1 〜10 -23- 201130467 最佳。小孔(20a)的長度相對於連結部(20b )的長度較 上述範圍大時,可能於使用時以外也會產生分斷,另外, 藥效成分揮發後降低藥效效果等,出現減損信賴性及便利 性之傾向。而自小孔(20a )散失的藥效成分及水分,可 藉由對剝離薄片(1 6 )施加張力而封閉小孔(20a ),可 達到防止或抑制效果。反之,小孔(20a )的長度相對於 連結部(20b)的長度較上述範圍小時,可能會使剝離薄 片(1 6 )難以分斷,出現減損便利性及作業性之傾向。另 外,可適當地決定連結部(20b)的長度,但連結部(20b )的長度以0.03〜10mm的範圍爲佳。連結部(20b)的長 度過長時會變爲不易分斷,反之,連結部(2 0b)的長度 變短雖然容易分斷,但過短時容易於使用時以外破裂。 弱化部(2 0 )係爲容易分斷剝離薄片(1 6 )與摘取片 形成薄片(1 8 )之裝置,可形成如圖5所示的溝以取代撕 裂線。該溝係貫穿摘取片形成薄片(18),並延伸至剝離 薄片(I6)的一半,即爲半切斷。因此,該等溝所構成之 弱化部(2 0 ),不會有如撕裂線般藥效成分漏出的問題。 除此之外’弱化部(2〇)目前有可將雷射等所產生的熱, 加於剝離薄片(16)及摘取片形成薄片(18)的局部位置 ’使該部位容易分斷、變薄等種種做法。 思考沿著弱化部(2 0 )而分斷剝離薄片(丨6 )與摘取 片形成薄片(18)之情況,並未特別限定剝離薄片(16) 的張力強度’但以1 g/ cm〜200 g/cm爲佳,1 g/cm〜 1 〇〇 g/ cm更佳。於該範圍時與剝離薄片(1 6 )接合之摘 -24- .201130467 取片形成薄片(18)的材料以聚對苯二甲二乙酯等爲佳, 理由係基於較剝離薄片(1 6 )剛性爲高。亦即,即使具有 弱化部(20)的剝離薄片(16)其張力強度爲lg/cm之低 者’由於剝離薄片(16)與摘取片形成薄片(丨8)接合在 —起’仍然具有適度的分斷性。另一方面,剝離薄片(16 )的張力強度較lg/cm爲低時’隨之而來係於製造時,剝 離薄片(16)會在中途切斷’無法連續於黏著劑層(14) 上貼著剝離薄片(1 6 ) ’而將泥敷劑及藥膏劑等貼劑(1 〇 )裝入包裝袋中時,剝離薄片(16)亦容易被分斷,容易 出現降低成品率之傾向。反之,張力強度較200g/cm爲大 時’隨之而來係於使用時,難以容易地分斷剝離薄片(16 ),而出現降低便利性之傾向。 如上所述構成之貼劑(1 0 )的製造方法,基本上係採 用如圖6所示之方法。亦即,首先準備其中一面鋪展著黏 著劑層(14 )的支持體(1 2 )。另外,於剝離薄片(1 6 ) 上接合摘取片形成薄片(1 8 ),其後,以撕裂線等形成弱 化部(2 0 )。接著將具有該摘取片形成薄片(1 8 )的剝離 薄片(16),貼附於支持體(12)上的黏著劑層(14)。 當然,於連續性地製造貼劑(1 0 )之情況,係採用如 圖7所示之製造步驟。如圖示可得知,使作爲支持體(1 2 )的第1連續薄片(12A )不斷地自第1滾筒狀原材送出, 於其上方之面藉由鋪展裝置(24)鋪展黏著劑後形成黏著 劑層(14)。於其同時或另外進行其他步驟,即不斷地自 第2滾筒狀原材送出作爲剝離薄片(1 6 )之第2連續薄片( -25- 201130467 16A) ’同時不斷地自第3滾筒狀原材送出作爲摘取片形成 薄片(18)之第3連續薄片(18A),再於第2連續薄片( 16A)上疊合第3連續薄片(18A),以接合裝置(26)將 二者藉由熱融著等方法進行接合。接著,將形成2層的連 續薄片(16A ) 、( 18A )送入弱化部形成裝置(28 ), 於該處形成撕裂線等的弱化部(20)。然後再將已形成有 弱化部(20)的連續薄片(16A) 、( 1 8 A ),疊合於第1 連續薄片(12A)的黏著劑層(14)上,之後送入裁斷裝 置(30)內’依據規定的尺寸及時間點進行裁斷,完成所 期望的貼劑(10)。於該製造步驟中,無需對成爲剝離薄 片(16)及摘取片形成薄片(18)之連續薄片(16A)、 (18A),進行彎摺加工’由於可沿著薄片運送方向連續 地實施第2連續薄片(16A)與第3連續薄片(18A)的接 合,以及形成弱化部(2 0 ),可有效率地進行製造。 其次針對如上所述之貼劑(1 0 )的使用方法加以說明 〇 首先如圖8之(a )所示,摘取貼劑(1 〇 )的兩端部, 同時將支持體(12)及剝離薄片(16)向左右方向拉伸, 再沿著弱化部(20 ),將剝離薄片(1 6 )及摘取片形成薄 片(18)向左右分斷。此時,剝離薄片(16)因壓紋加工 等而形成凹凸之情況時,可造成止滑效果,使貼劑(10) 變爲容易拉伸。 另外,由於接合部分(22)具有剝離薄片(16)及摘 取片形成薄片(18)雙方的厚度,伴隨著可提高其強度及 -26- 201130467 剛性。因此,摘取貼劑(1 ο)的兩端部並向左右方向拉伸 時,其拉伸力可被分散於接合部分(22)的全體上。其結 果當弱化部(2 0 )的一部分開始破斷時,該破斷會瞬間擴 散至弱化部(20)的全體,而可在一瞬間分斷薄片(16) 、薄片(18 )。 特別於弱化部(20 )爲撕裂線,且剝離薄片(〗6 )與 摘取片形成薄片(1 8 )爲如上所述之適合的材料及厚度範 圍之情況時,由於可瞬間連續切斷撕裂線的小孔(20a ) 間的連接部(20b ),而可帶給使用者特殊的切斷感。另 外該切斷感除了給予使用者可確認剝離薄片(1 6 )與摘取 片形成薄片(18)二者已經分開之感覺,加之亦包含在一 瞬間分斷後接著伸展支持體(12)之感覺。因此,沒有已 分斷之感,且於拉伸瞬間感覺到伸展之情況時,貼劑(1〇 )的剝離薄片(1 6 )有一度被分斷的可能性。亦即,可給 予使用者貼劑(10)的黏著劑層(I4)直到使用時均被保 護著的安心感,使用者的使用感亦變佳。 於如圖2所示之方式中,因弱化部(20 )位於剝離薄 片(1 6 )與摘取片形成薄片(1 8 )的非接合部位上,由於 接合部分(2 2 )受到熱融著或接著劑等之影響,控制弱化 部(20)的切斷的同時,可進行剝離薄片(16)與摘取片 形成薄片(1 8 )的分斷。 另外’於剝離薄片(1 6 )與摘取片形成薄片(1 8 )被 分斷後’由於薄片(16)、薄片(18)間的接合部分(22 )並未分離而維持接合狀態,其形狀雖多少產生彎曲,但 5 -27- 201130467 總可維持直線狀態及平面狀態。因該等形狀安定性,附著 於該接合部分(22)之支持體(12)亦可維持形狀,且可 防止皺摺。 剝離薄片(16)與摘取片形成薄片(18)被分斷時, 會露出支持體(12)上的黏著劑層(14)。其次,如圖8 之(b)所示,將該被露出的黏著劑層(Μ)貼附於皮膚 。雖然黏著劑層(1 4 )的露出部分小,但貼劑(1 0 )仍可 獲得對皮膚(S )的暫時貼附效果。摘取片形成薄片(1 8 )被分斷時,由於對各剝離薄片(16)形成摘取片(18a )、(1 8b ),於暫時貼附貼劑(1 0 )後,藉由摘取拉伸 該摘取片(1 8a ) 、( 18b ),被分斷的剝離薄片(1 6 )可 自支持體(12)上的黏著劑層(M)剝離,同時黏著劑層 (1 4 )可貼附於皮膚(S )。 摘取片(18a) 、(18b)的自由端靠近黏著劑層(14 )的露出部分,由於剝離薄片(16)與摘取片(18a)、 (18b)二層重疊的部分因呈現某種程度的厚度而具有剛 性,可根據使用者的觸感,於所期望的位置貼附貼劑(1〇 )。另外於摘取摘取片(18a) 、(18b)的狀態下,由於 手指接近黏著劑層(14)的露出部分,可容易地微調整貼 劑(1 〇 )之位置,更加提升使用者的便利性。 上述專利文件1或2記載之貼劑,若暫時貼附於皮膚時 ,剝離薄片會夾在支持體與皮膚間,而出現難以剝除剝離 薄片之狀況,但由於本發明形成有摘取片(18a) 、 (18b ),藉由摘取撕拉該摘取片,可容易地剝除剝離薄片(16 -28- 201130467 )。另外,由於可防止指尖接觸到黏著劑層(1 4),手指 也不會沾到黏著劑。 進而由於可摘取左右的摘取片(18a) 、(18b)任一 片,加上左右的摘取片(18a) 、 (18b)二者可同時摘取 撕拉,提升使用者的貼附作業性。 另外,摘取撕拉摘取片(ISa) 、(ISb)時,由於與 進行分斷時相同,剝離薄片(16)與摘取片(18a)、( 1 8b )間的接合部分(22 )的剛性高,拉張力可分散於接 合部分(22 )的全體上,略微均等地作用。於該狀態下, 自黏著劑層(14 )剝除剝離薄片(16 )時,於剝離薄片( 1 6 )與黏著劑層(1 4 )間的乖離線(剝離薄片(1 6 )與黏 著劑層(1 4 )的附著部分與外部的界線),力道係略微均 等地作用。其結果可防止支持體(1 2 )產生皺摺,及防止 黏著劑層(1 4 )相互黏在一起。 如此根據本發明,可不污染手部,且不產生皺摺,完 美地將貼劑(1 〇 )貼附於皮膚。 根據本發明之貼劑(1 b)上具有除上述方法以外之使 用法。例如亦可採用撕拉摘取片形成薄片(1 8 )的摘取片 (18a) 、(18b) ’分斷剝離薄片(16)與摘取片形成薄 片(18),之後,摘取摘取片(18a) ' (18b)的其中一 片,剝離該側之剝離薄片(1 6 )後,使支持體(〗2 )上的 黏著劑層(14)的一半露出’再貼附於皮膚之方法。此時 ’由於摘取片(1 8 a )、( 1 8 b )係以左右對稱之方式形成 ,使用者可自由選擇容易摘取側的摘取片(18a) 、 (18b s -29- 201130467 ),相當便利。 可舉出泥敷劑作爲適當地發揮上述效果之本發明的 施方式之一。泥敷劑係以不織布作爲支持體(1 2 ),以 性凝膠作爲黏著劑層(1 4 )。以水性凝膠作爲黏著劑層 14)時,由於具有充分的厚度及重量,而具有適當的剝 強度,但無法過於簡單地剝離剝離薄片(1 6 )。然而, 於並無需設置如專利文件5記載之創傷包帶的抑制剝離 置,容易製造且成本低廉。 以上針對適合本發明之實施方式詳細說明,但本發 並未限定於上述之實施方式。 例如,上述之實施方式中支持體(1 2 )具有伸縮性 但於無需向左右拉伸貼劑(1 〇 )即可使剝離薄片(1 6 ) 斷之情況時,支持體(12)可不具有伸縮性。 另外,圖1〜圖3所示之實施方式中,左右的接合部 (22 )與弱化部(20 )相隔開來,但由於形成於較靠近 化部(20 )的位置,難以於分斷薄片後再摘取摘取片剝 薄片(1 8 )的內側部分(摘取片\ 1 8a ) 、 ( 1 8b )反側 部分)。因此如圖9所示,思考將左右的接合部分(22 形成於較遠離弱化部(20 )的位置,例如於遠離1 5〜 mm之程度。 如圖9所示的實施方式中,沿弱化線(2 0 )分斷剝 薄片(16)與摘取片形成薄片(1S)之後,不僅外側部 的(18a) ' ( 18b),內側部分的(18c) ' ( 18d)亦 有作爲摘取片的功能。藉此可提供適合使用者的各式各 實 水 ( 離 由 裝 明 分 分 弱 離 的 ) 25 離 分 具 樣 -30- 201130467 的使用法。例如如圖1 〇所示,藉由自左側摘取內側的摘取 片(1 8C ),自右側摘取外側的摘取片(1 8b ),可剝離剝 離薄片(16)。 接合部分(22)的形狀不僅可如圖2之直線狀,其他 形狀,亦可如圖1 1所示之彎曲線狀。使用圖Π所示之形狀 時,沿弱化線(20 )分斷摘取片形成薄片(1 8 )後,向左 右拉扯摘取片(1 8 a )、( 1 8b )時,由於貼劑(1 0 )的黏 著劑層(14)的露出面(藥劑面)會呈現脫離般的立體的 彎曲,而可容易地貼付適用於身體面且不會產生皺摺的貼 劑(1 〇 )。另外,由於2條的接合部分(22 )的間隔,在 貼劑(1 〇 )的中央部位變得狹窄,向左右拉扯摘取片( 18a) 、 (18b)時,張力集中於位於貼劑(10)中央部位 的弱化線(2 0 )上,而容易分斷剝離薄片(1 6 )與摘取片 形成薄片(18 )。進而,由於2條的接合部分(22 )的間 隔在貼劑(1 0 )的長邊側變大,藉由摘取該部分而可採用 如圖10所示之使用法。 與圖1〜3之實施方式相反,外側部分的(1 8 a )、( 18b )小或完全沒有時,僅將內側的(18c ) 、 ( 18d )作 爲摘取片亦屬於本發明之範圍。 進而接合部分(22)無需形成左右2個部位,如圖12 所示,可於略中央部之一個位置上,亦即可於弱化部(2 0 )上接合剝離薄片(16)與摘取片形成薄片(18)。 如圖13所示,亦可於偏移剝離薄片(16)的中央部位 之位置上接合摘取片形成薄片(1 8 )。 -31 - 201130467 弱化部(20 )未侷限於直線,可如圖1 3所示’爲波浪 形或鋸齒形。此時接合部分(22 )的形狀亦可配合弱化部 (20 )的形狀爲波浪形或鋸齒形。 進而摘取片形成薄片(1 8 )爲矩形以外之形狀’例如 可爲如圖14之(a)〜(g)所示之各種形狀。另外如圖Μ 之(a)〜(c),亦可採用摘取片形成薄片(18)未橫越 貼劑(10)全體之型態。圖14中未顯示接合部分。 【圖式簡單說明】 [圖1]槪略性地表示根據本發明之貼劑的實施方式之立 體圖。 [圖2]表示圖1之貼劑之平面圖。 [圖3 ]表示圖1之貼劑之側視圖。 [圖4]槪略性地表示2層構造之摘取片形成薄片之剖面 圖。 [圖5 ]表示弱化部的變形例之貼劑的部分剖面圖。 [圖6]表示根據本發明之貼劑基本的製造方法之說明圖 〇 [圖7]表示根據本發明之貼劑於連續製造時的製造方法 之說明圖。 [圖8 ]表示貼劑的貼附順序之說明圖。 [圖9]表示根據本發明之貼劑的變形實施方式之平面圖 〇 [圖1 0]表示圖9之貼劑之側視圖,表示分斷剝離薄片及 -32- 201130467 摘取片形成薄片後之使用方式之一例。 [圖11]表示根據本發明之貼劑的其他變形實施方式之 平面圖。 [圖12]表示根據本發明之貼劑的進而其他的變形實施 方式之平面圖。 [圖13]表示根據本發明之貼劑的進而其他的變形實施 方式之平面圖。 [圖1 4] ( a )〜(g )係分別表示根據本發明之貼劑的 各種變形實施方式之平面圖。 【主要元件符號說明】 1 〇 :貼劑 12 :支持體 12A:支持體的原材薄片 1 4 :黏著劑層 1 6 :剝離薄片 16A :剝離薄片的原材薄片 1 8 :摘取片形成薄片 1 8 a :摘取片 1 8b :摘取片 1 8 c :摘取片 18d :摘取片 18A :摘取片形成薄片的原材薄片 2 0 :弱化部 -33- 201130467 2 0 a :小孔 20b :連結部 22 :接合部分 24 :鋪展裝置 26 :接合裝置 28 :弱化部形成裝置 30 :裁斷裝置 S :皮膚 -34
Claims (1)
- •201130467 七、申請專利範圍: 1.一種貼劑,其特徵係具備:支持體;設置於該支持 體其中一面的黏著劑層;可與該黏著劑層剝離之被黏著的 剝離薄片;形成於該剝離薄片,且使該剝離薄片容易分斷 之弱化部, 於該剝離薄片上,摘取片形成薄片係以覆蓋該弱化部 之方式接合,該接合部分以外之該摘取片形成薄片之一部 分’成爲具功能的摘取片, 該摘取片形成薄片,於對應於該剝離薄片之該弱化部 的位置上’形成容易分斷該剝離薄片之弱化部。 2 ·如申請專利範圍第1項之貼劑,其中該支持體具有 伸縮性。 3 ·如申請專利範圍第1或2項之貼劑,其中該剝離薄片 與該摘取片形成薄片之接合部分,係形成於該弱化部的左 右位置’且與該弱化部分隔。 4.如申請專利範圍第丨或2項之貼劑,其中該剝離薄片 與该摘取片形成薄片之接合部分,係形成於該弱化部上。 S. -35
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