WO2009031295A1 - 薬剤徐放性ステント - Google Patents

薬剤徐放性ステント Download PDF

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Publication number
WO2009031295A1
WO2009031295A1 PCT/JP2008/002410 JP2008002410W WO2009031295A1 WO 2009031295 A1 WO2009031295 A1 WO 2009031295A1 JP 2008002410 W JP2008002410 W JP 2008002410W WO 2009031295 A1 WO2009031295 A1 WO 2009031295A1
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WO
WIPO (PCT)
Prior art keywords
stent
polymer
coating layer
weight
argatoroban
Prior art date
Application number
PCT/JP2008/002410
Other languages
English (en)
French (fr)
Inventor
Ikuo Omura
Zhen Yu Jin
Shuzo Yamashita
Hiroo Iwata
Akira Mochizuki
Original Assignee
Japan Stent Technology Co., Ltd.
Tokai University Educational System
Toyo Advanced Technologies Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Stent Technology Co., Ltd., Tokai University Educational System, Toyo Advanced Technologies Co., Ltd. filed Critical Japan Stent Technology Co., Ltd.
Priority to AU2008294278A priority Critical patent/AU2008294278C1/en
Priority to EP08829751.0A priority patent/EP2201966A4/en
Priority to US12/733,460 priority patent/US8409272B2/en
Priority to JP2009531112A priority patent/JP5368991B2/ja
Priority to CN200880105243.4A priority patent/CN101795719B/zh
Publication of WO2009031295A1 publication Critical patent/WO2009031295A1/ja
Priority to US12/801,307 priority patent/US20100249914A1/en
Priority to AU2010202640A priority patent/AU2010202640B2/en
Priority to US13/492,290 priority patent/US8641756B2/en
Priority to US13/561,828 priority patent/US8968392B2/en
Priority to US13/729,630 priority patent/US9040111B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • A61F2002/91541—Adjacent bands are arranged out of phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/08—Coatings comprising two or more layers

Abstract

　本発明により、外表面と内表面とを有する円筒形状のステント本体と、前記ステント本体の少なくとも外表面を被覆している第１被覆層と、前記第１被覆層を実質的に完全に覆うように被覆している第２被覆層と、を具備しており、前記第１被覆層は、ポリマーと内皮細胞の増殖を阻害しない血管内膜肥厚抑制剤（好ましくは、アルガトロバン）とを含み、前記ポリマーと前記血管内膜肥厚抑制剤の重量構成比率が、ポリマー８～３対血管内膜肥厚抑制剤２～７の範囲にある第１組成物により形成されており、前記第２被覆層は、ポリマー単独により形成されているか、または、ポリマーと薬剤を含み、ポリマー８０重量％に対する薬剤の重量構成比率が２０重量％未満である第２組成物により形成されているステント、およびその製造方法が提供される。 　また、本発明のアルガトロバン担持ステントからアルガトロバンの放出速度の調整方法が提供される。
PCT/JP2008/002410 2007-09-04 2008-09-03 薬剤徐放性ステント WO2009031295A1 (ja)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AU2008294278A AU2008294278C1 (en) 2007-09-04 2008-09-03 Stent for controlled drug release
EP08829751.0A EP2201966A4 (en) 2007-09-04 2008-09-03 STENT FOR THE CONTROLLED RELEASE OF MEDICAMENTS
US12/733,460 US8409272B2 (en) 2007-09-04 2008-09-03 Sustained drug-releasing stent
JP2009531112A JP5368991B2 (ja) 2007-09-04 2008-09-03 薬剤徐放性ステント
CN200880105243.4A CN101795719B (zh) 2007-09-04 2008-09-03 药物缓释性支架
US12/801,307 US20100249914A1 (en) 2007-09-04 2010-06-02 Sustained drug-releasing stent
AU2010202640A AU2010202640B2 (en) 2007-09-04 2010-06-24 Sustained drug-releasing stent
US13/492,290 US8641756B2 (en) 2007-09-04 2012-06-08 Sustained drug-releasing stent
US13/561,828 US8968392B2 (en) 2007-09-04 2012-07-30 Method of inhibiting vascular intimal hyperplasia using stent
US13/729,630 US9040111B2 (en) 2007-09-04 2012-12-28 Method of making a stent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007228788 2007-09-04
JP2007-228788 2007-09-04

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US12/733,460 A-371-Of-International US8409272B2 (en) 2007-09-04 2008-09-03 Sustained drug-releasing stent
US73346010A Continuation 2007-09-04 2010-03-03
US12/801,307 Continuation US20100249914A1 (en) 2007-09-04 2010-06-02 Sustained drug-releasing stent
US13/492,290 Continuation US8641756B2 (en) 2007-09-04 2012-06-08 Sustained drug-releasing stent
US13/729,630 Division US9040111B2 (en) 2007-09-04 2012-12-28 Method of making a stent

Publications (1)

Publication Number Publication Date
WO2009031295A1 true WO2009031295A1 (ja) 2009-03-12

Family

ID=40428619

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/002410 WO2009031295A1 (ja) 2007-09-04 2008-09-03 薬剤徐放性ステント

Country Status (7)

Country Link
US (5) US8409272B2 (ja)
EP (2) EP2201966A4 (ja)
JP (4) JP5368991B2 (ja)
KR (2) KR20100068412A (ja)
CN (2) CN101795719B (ja)
AU (1) AU2010202640B2 (ja)
WO (1) WO2009031295A1 (ja)

Cited By (7)

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WO2010090348A1 (ja) 2009-02-06 2010-08-12 学校法人慶應義塾 生体の管状器官に使用するステント
US8591571B2 (en) 2009-03-02 2013-11-26 Japan Stent Technology Co., Ltd. Drug-eluting stent
US8641756B2 (en) 2007-09-04 2014-02-04 Japan Stent Technology Co., Ltd. Sustained drug-releasing stent
WO2015125320A1 (ja) 2014-02-19 2015-08-27 株式会社Ｗｏｒｌｄ Ｍｅｄｉｓｈ 高柔軟性ステント
JP2016005533A (ja) * 2014-05-30 2016-01-14 株式会社日本ステントテクノロジー ステント
JP2017521114A (ja) * 2014-05-16 2017-08-03 テルモ株式会社 下肢末梢動脈疾患の治療方法
WO2022034905A1 (ja) 2020-08-12 2022-02-17 康宏 正林 ステント

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US20110319987A1 (en) 2009-05-20 2011-12-29 Arsenal Medical Medical implant
US9265633B2 (en) 2009-05-20 2016-02-23 480 Biomedical, Inc. Drug-eluting medical implants
CA3186201A1 (en) * 2009-05-20 2010-11-25 Lyra Therapeutics, Inc. Self-expandable medical device comprising polymeric strands and coatings thereon
US8992601B2 (en) 2009-05-20 2015-03-31 480 Biomedical, Inc. Medical implants
US9309347B2 (en) 2009-05-20 2016-04-12 Biomedical, Inc. Bioresorbable thermoset polyester/urethane elastomers
US8888840B2 (en) * 2009-05-20 2014-11-18 Boston Scientific Scimed, Inc. Drug eluting medical implant
US10166128B2 (en) * 2011-01-14 2019-01-01 W. L. Gore & Associates. Inc. Lattice
EP3060174B1 (en) * 2013-10-22 2020-05-27 Concievalve LLC Methods for inhibiting stenosis, obstruction, or calcification of a stented heart valve or bioprosthesis
JP2015154921A (ja) * 2014-01-17 2015-08-27 株式会社日本ステントテクノロジー 薬剤徐放性ステント
KR102409251B1 (ko) * 2014-10-28 2022-06-14 가부시키가이샤 짐로 약제 용출형 스텐트
JP2016163619A (ja) * 2015-03-06 2016-09-08 株式会社日本ステントテクノロジー 防食効果を利用したマグネシウムの分解速度制御
JP2016165375A (ja) * 2015-03-10 2016-09-15 株式会社日本ステントテクノロジー 防食被覆層を有するステントの製造方法
NZ773822A (en) * 2015-03-16 2022-07-29 Magic Leap Inc Methods and systems for diagnosing and treating health ailments
WO2016163339A1 (ja) * 2015-04-07 2016-10-13 二プロ株式会社 ステント
JP6558569B2 (ja) * 2015-05-21 2019-08-14 ニプロ株式会社 ステント
AU2016361380B2 (en) 2015-11-26 2021-04-08 Japan Medical Device Technology Co., Ltd. Bioabsorbable stent
US11903852B2 (en) 2016-02-17 2024-02-20 Brigham Young University Multi-stage stent devices and associated methods
CN109374558A (zh) * 2018-12-11 2019-02-22 山东吉威医疗制品有限公司 一种无聚合物药物涂层洗脱支架体外释放度的测定方法
TWI794616B (zh) 2019-07-09 2023-03-01 日商大塚醫療器材股份有限公司 藥劑溶出型支架
CN110665072A (zh) * 2019-11-23 2020-01-10 吉林省蔚来生物科技有限公司 一种靶向药物释放介入类医疗器械及其制备方法
JP2023527328A (ja) * 2020-05-26 2023-06-28 エリクシアー メディカル コーポレイション 抗凝固化合物ならびにその使用のための方法およびデバイス
US11654036B2 (en) 2020-05-26 2023-05-23 Elixir Medical Corporation Anticoagulant compounds and methods and devices for their use

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KR20100068412A (ko) 2010-06-23

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