WO2008130008A1 - 緑内障発症リスクの判定方法 - Google Patents

緑内障発症リスクの判定方法 Download PDF

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Publication number
WO2008130008A1
WO2008130008A1 PCT/JP2008/057527 JP2008057527W WO2008130008A1 WO 2008130008 A1 WO2008130008 A1 WO 2008130008A1 JP 2008057527 W JP2008057527 W JP 2008057527W WO 2008130008 A1 WO2008130008 A1 WO 2008130008A1
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WO
WIPO (PCT)
Prior art keywords
glaucoma
allele
risk
genotype
nucleotide sequence
Prior art date
Application number
PCT/JP2008/057527
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English (en)
French (fr)
Inventor
Shigeru Kinoshita
Kei Tashiro
Masakazu Nakano
Tomohito Yagi
Kazuhiko Mori
Yoko Ikeda
Takazumi Taniguchi
Masaaki Kageyama
Original Assignee
Santen Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co., Ltd. filed Critical Santen Pharmaceutical Co., Ltd.
Priority to BRPI0810071-3A2A priority Critical patent/BRPI0810071A2/pt
Priority to CN200880020560A priority patent/CN101679970A/zh
Priority to JP2009510856A priority patent/JPWO2008130008A1/ja
Priority to CA002683691A priority patent/CA2683691A1/en
Priority to US12/596,258 priority patent/US20100196895A1/en
Priority to MX2009011079A priority patent/MX2009011079A/es
Priority to AU2008241867A priority patent/AU2008241867A1/en
Priority to EP08751865A priority patent/EP2147975A4/en
Publication of WO2008130008A1 publication Critical patent/WO2008130008A1/ja
Priority to US13/546,674 priority patent/US20130012408A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

　被検者由来のサンプルにおいて、配列番号203～514で示される塩基配列からなる群より選択される、少なくとも１つの塩基配列又はその相補的配列における、各塩基配列の31番目に存在する一塩基多型のアレル及び／又は遺伝子型をin vitroで検出する工程(工程Ａ)、ならびに、前記工程Ａで検出されたアレル及び／又は遺伝子型を、配列番号203～514で示される塩基配列におけるハイリスクアレルを含むアレル及び／又は遺伝子型の少なくとも１つと比較する工程(工程Ｂ)を含む、緑内障リスクの有無の判定方法。本発明の方法により、サンプル上の本発明の一塩基多型のアレル又は遺伝子型を分析することにより、サンプル提供者の緑内障の発症リスクの高低を判定することができ、このリスクに基づきサンプル提供者は緑内障の予防措置を講じ、又は適切な治療を受けることができる。
PCT/JP2008/057527 2007-04-17 2008-04-17 緑内障発症リスクの判定方法 WO2008130008A1 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
BRPI0810071-3A2A BRPI0810071A2 (pt) 2007-04-17 2008-04-17 Método para determinação do risco inicial de glaucoma
CN200880020560A CN101679970A (zh) 2007-04-17 2008-04-17 青光眼发病风险的判定方法
JP2009510856A JPWO2008130008A1 (ja) 2007-04-17 2008-04-17 緑内障発症リスクの判定方法
CA002683691A CA2683691A1 (en) 2007-04-17 2008-04-17 Method for determination of onset risk of glaucoma
US12/596,258 US20100196895A1 (en) 2007-04-17 2008-04-17 Method for determination of onset risk of glaucoma
MX2009011079A MX2009011079A (es) 2007-04-17 2008-04-17 Metodo para la determinacion del riesgo del inicio de glaucoma.
AU2008241867A AU2008241867A1 (en) 2007-04-17 2008-04-17 Method for determination of onset risk of glaucoma
EP08751865A EP2147975A4 (en) 2007-04-17 2008-04-17 METHOD FOR DETERMINING THE RISK OF APPEARANCE OF GLAUCOMA
US13/546,674 US20130012408A1 (en) 2007-04-17 2012-07-11 Method for determination of onset risk of glaucoma

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-108688 2007-04-17
JP2007108688 2007-04-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/546,674 Division US20130012408A1 (en) 2007-04-17 2012-07-11 Method for determination of onset risk of glaucoma

Publications (1)

Publication Number Publication Date
WO2008130008A1 true WO2008130008A1 (ja) 2008-10-30

Family

ID=39875536

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/JP2008/057527 WO2008130008A1 (ja) 2007-04-17 2008-04-17 緑内障発症リスクの判定方法
PCT/JP2008/057533 WO2008130009A1 (ja) 2007-04-17 2008-04-17 緑内障進行リスクの判定方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/057533 WO2008130009A1 (ja) 2007-04-17 2008-04-17 緑内障進行リスクの判定方法

Country Status (12)

Country Link
US (4) US8431345B2 (ja)
EP (4) EP2548961A1 (ja)
JP (5) JP5624763B2 (ja)
KR (2) KR20100016568A (ja)
CN (2) CN101679970A (ja)
AU (2) AU2008241867A1 (ja)
BR (2) BRPI0810071A2 (ja)
CA (2) CA2683836A1 (ja)
MX (2) MX2009011080A (ja)
RU (2) RU2009142225A (ja)
SG (2) SG177960A1 (ja)
WO (2) WO2008130008A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG158776A1 (en) * 2008-07-25 2010-02-26 Univ Kaohsiung Medical Using genetic polymorphisms of the bicd1 gene as a method for diagnosing and treating myopia
WO2010061697A1 (ja) * 2008-11-27 2010-06-03 株式会社メニコン 正常眼圧緑内障疾患感受性遺伝子及びその利用
WO2011001135A3 (en) * 2009-07-03 2011-06-30 University College Cardiff Consultants Limited Diagnosis and treatment of alzheimer's disease
WO2011152098A1 (ja) * 2010-06-04 2011-12-08 コニカミノルタエムジー株式会社 イムノクロマトグラフ法のための展開液およびそれを用いた測定法
JP2017000006A (ja) * 2015-06-04 2017-01-05 シスメックス株式会社 関節リウマチ患者におけるメトトレキサートの有効性の診断を補助する方法
WO2018003523A1 (ja) * 2016-06-30 2018-01-04 京都府公立大学法人 広義原発開放隅角緑内障の発症リスクの判定方法

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US9708664B2 (en) 2012-04-20 2017-07-18 University Of Virginia Patent Foundation Compositions and methods for identifying and diagnosing salt sensitivity of blood pressure
WO2014031086A1 (en) 2012-08-24 2014-02-27 Agency For Science, Technology And Research Methods and systems for automatic location of optic structures in an image of an eye, and for automatic retina cup-to-disc ratio computation
US10648035B2 (en) 2012-11-26 2020-05-12 The Johns Hopkins University Methods and compositions for diagnosing and treating gastric cancer
RU2508043C1 (ru) * 2012-12-20 2014-02-27 федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Способ прогнозирования развития открытоугольной глаукомы у пациентов с глазными проявлениями псевдоэксфолиативного синдрома
EP3140422A1 (en) * 2014-05-03 2017-03-15 The Regents of The University of California Methods of identifying biomarkers associated with or causative of the progression of disease, in particular for use in prognosticating primary open angle glaucoma
RU2580306C1 (ru) * 2015-03-26 2016-04-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ прогнозирования риска развития первичной открытоугольной глаукомы у индивидуумов в зависимости от наличия/отсутствия сопутствующих неинфекционных заболеваний глаз
RU2585381C1 (ru) * 2015-03-27 2016-05-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ прогнозирования показателей гидродинамики у больных первичной открытоугольной глаукомой
JP7064215B2 (ja) * 2016-08-05 2022-05-10 京都府公立大学法人 落屑症候群又は落屑緑内障の発症リスクの判定方法
CN113444788B (zh) * 2021-08-27 2021-11-02 中国医学科学院北京协和医院 青光眼诊断产品及应用

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG158776A1 (en) * 2008-07-25 2010-02-26 Univ Kaohsiung Medical Using genetic polymorphisms of the bicd1 gene as a method for diagnosing and treating myopia
WO2010061697A1 (ja) * 2008-11-27 2010-06-03 株式会社メニコン 正常眼圧緑内障疾患感受性遺伝子及びその利用
WO2011001135A3 (en) * 2009-07-03 2011-06-30 University College Cardiff Consultants Limited Diagnosis and treatment of alzheimer's disease
EP2891723A1 (en) * 2009-07-03 2015-07-08 University College Cardiff Consultants Limited Diagnosis and treatment of Alzheimer's disease
WO2011152098A1 (ja) * 2010-06-04 2011-12-08 コニカミノルタエムジー株式会社 イムノクロマトグラフ法のための展開液およびそれを用いた測定法
JP2017000006A (ja) * 2015-06-04 2017-01-05 シスメックス株式会社 関節リウマチ患者におけるメトトレキサートの有効性の診断を補助する方法
WO2018003523A1 (ja) * 2016-06-30 2018-01-04 京都府公立大学法人 広義原発開放隅角緑内障の発症リスクの判定方法
JPWO2018003523A1 (ja) * 2016-06-30 2019-04-18 京都府公立大学法人 広義原発開放隅角緑内障の発症リスクの判定方法
JP7072803B2 (ja) 2016-06-30 2022-05-23 京都府公立大学法人 広義原発開放隅角緑内障の発症リスクの判定方法

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US20110207122A1 (en) 2011-08-25
EP2161334A4 (en) 2010-11-10
EP2147975A4 (en) 2010-11-10
JP5624763B2 (ja) 2014-11-12
SG177960A1 (en) 2012-02-28
BRPI0810425A2 (pt) 2014-10-07
RU2009142225A (ru) 2011-05-27
KR20100016568A (ko) 2010-02-12
CA2683836A1 (en) 2008-10-30
US20100196895A1 (en) 2010-08-05
SG177968A1 (en) 2012-02-28
JP2013150628A (ja) 2013-08-08
CN101679971A (zh) 2010-03-24
AU2008241868A1 (en) 2008-10-30
JPWO2008130008A1 (ja) 2010-07-22
EP2548961A1 (en) 2013-01-23
JPWO2008130009A1 (ja) 2010-07-22
MX2009011080A (es) 2010-03-10
CN101679970A (zh) 2010-03-24
US20130210668A1 (en) 2013-08-15
JP2017201995A (ja) 2017-11-16
MX2009011079A (es) 2010-03-10
EP2161334A1 (en) 2010-03-10
JP5759500B2 (ja) 2015-08-05
EP2147975A1 (en) 2010-01-27
US20130012408A1 (en) 2013-01-10
CA2683691A1 (en) 2008-10-30
BRPI0810071A2 (pt) 2014-10-14
EP2565270A1 (en) 2013-03-06
WO2008130009A1 (ja) 2008-10-30
RU2009142223A (ru) 2011-05-27
US8431345B2 (en) 2013-04-30
AU2008241867A1 (en) 2008-10-30
KR20100016525A (ko) 2010-02-12
JP2015180219A (ja) 2015-10-15
JP6203217B2 (ja) 2017-09-27

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