WO2011037936A3 - Detection of dna methylation of tal1, erg and/or cd40 to diagnose prostate cancer - Google Patents
Detection of dna methylation of tal1, erg and/or cd40 to diagnose prostate cancer Download PDFInfo
- Publication number
- WO2011037936A3 WO2011037936A3 PCT/US2010/049708 US2010049708W WO2011037936A3 WO 2011037936 A3 WO2011037936 A3 WO 2011037936A3 US 2010049708 W US2010049708 W US 2010049708W WO 2011037936 A3 WO2011037936 A3 WO 2011037936A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- prostate cancer
- erg
- subject
- tal1
- sample
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Disclosed herein are methods for diagnosing and/or prognosing a subject with prostate cancer. In some embodiments, the methods include obtaining a biological sample comprising genomic DNA from the subject, and measuring the level of one or more methylated genomic CpG dinucleotides in one or more of the genomic targets TAL1. ERG or CD40, or a combination of two or more thereof, in the sample, wherein an increase in the level of methylation of the one or more genomic CpG dinucleotides in the sample compared to a control indicates a subject with prostate cancer. In some embodiments, the method also includes detecting presence of a TMPRSS2-ERG gene fusion in the sample from the subject.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27752309P | 2009-09-24 | 2009-09-24 | |
US61/277,523 | 2009-09-24 | ||
US36434610P | 2010-07-14 | 2010-07-14 | |
US61/364,346 | 2010-07-14 |
Publications (2)
Publication Number | Publication Date |
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WO2011037936A2 WO2011037936A2 (en) | 2011-03-31 |
WO2011037936A3 true WO2011037936A3 (en) | 2011-08-18 |
Family
ID=43796452
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/049708 WO2011037936A2 (en) | 2009-09-24 | 2010-09-21 | Detection of dna methylation of tal1, erg and/or cd40 to diagnose prostate cancer |
Country Status (1)
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WO (1) | WO2011037936A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013185779A2 (en) * | 2012-06-14 | 2013-12-19 | Aarhus Universitet | Biomarkers for prostate cancer |
US20140274757A1 (en) | 2013-03-14 | 2014-09-18 | Marie K. Kirby | Differential Methylation Level of CpG Loci That Are Determinative of a Biochemical Reoccurrence of Prostate Cancer |
ES2759926T3 (en) * | 2013-06-12 | 2020-05-12 | 7Ac Tech Inc | Liquid Desiccant Air Conditioning System |
US11685955B2 (en) | 2016-05-16 | 2023-06-27 | Dimo Dietrich | Method for predicting response of patients with malignant diseases to immunotherapy |
DE102016005947B3 (en) * | 2016-05-16 | 2017-06-08 | Dimo Dietrich | A method for estimating the prognosis and predicting the response to immunotherapy of patients with malignant diseases |
KR20190140901A (en) | 2017-02-28 | 2019-12-20 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | Detection of prostate cancer |
US20220275461A1 (en) * | 2019-08-21 | 2022-09-01 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Diagnostics and methods for prognosing response to immunotherapy based on the methylation status of immune synapse gene signature |
CN116987186B (en) * | 2023-08-08 | 2024-05-03 | 武汉爱博泰克生物科技有限公司 | Rabbit monoclonal antibody aiming at human ERG protein and application thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5552277A (en) * | 1994-07-19 | 1996-09-03 | The Johns Hopkins University School Of Medicine | Genetic diagnosis of prostate cancer |
US20070048738A1 (en) * | 2003-07-14 | 2007-03-01 | Mayo Foundation For Medical Education And Research | Methods and compositions for diagnosis, staging and prognosis of prostate cancer |
US20080254455A1 (en) * | 2007-04-12 | 2008-10-16 | Haiying Wang | Detecting prostate cancer |
WO2009012387A2 (en) * | 2007-07-18 | 2009-01-22 | Gen-Probe Incorporated | Compositions and methods to detect tmprss2/erg transcript variants in prostate cancer |
US20090170075A1 (en) * | 2004-05-07 | 2009-07-02 | Gyorgy Petrovics | Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer |
-
2010
- 2010-09-21 WO PCT/US2010/049708 patent/WO2011037936A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5552277A (en) * | 1994-07-19 | 1996-09-03 | The Johns Hopkins University School Of Medicine | Genetic diagnosis of prostate cancer |
US20070048738A1 (en) * | 2003-07-14 | 2007-03-01 | Mayo Foundation For Medical Education And Research | Methods and compositions for diagnosis, staging and prognosis of prostate cancer |
US20090170075A1 (en) * | 2004-05-07 | 2009-07-02 | Gyorgy Petrovics | Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer |
US20080254455A1 (en) * | 2007-04-12 | 2008-10-16 | Haiying Wang | Detecting prostate cancer |
WO2009012387A2 (en) * | 2007-07-18 | 2009-01-22 | Gen-Probe Incorporated | Compositions and methods to detect tmprss2/erg transcript variants in prostate cancer |
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Publication number | Publication date |
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WO2011037936A2 (en) | 2011-03-31 |
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