WO2011037936A3 - Detection of dna methylation of tal1, erg and/or cd40 to diagnose prostate cancer - Google Patents

Detection of dna methylation of tal1, erg and/or cd40 to diagnose prostate cancer Download PDF

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Publication number
WO2011037936A3
WO2011037936A3 PCT/US2010/049708 US2010049708W WO2011037936A3 WO 2011037936 A3 WO2011037936 A3 WO 2011037936A3 US 2010049708 W US2010049708 W US 2010049708W WO 2011037936 A3 WO2011037936 A3 WO 2011037936A3
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WO
WIPO (PCT)
Prior art keywords
prostate cancer
erg
subject
tal1
sample
Prior art date
Application number
PCT/US2010/049708
Other languages
French (fr)
Other versions
WO2011037936A2 (en
Inventor
Joshi Alumkal
Original Assignee
Oregon Health & Science University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oregon Health & Science University filed Critical Oregon Health & Science University
Publication of WO2011037936A2 publication Critical patent/WO2011037936A2/en
Publication of WO2011037936A3 publication Critical patent/WO2011037936A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Abstract

Disclosed herein are methods for diagnosing and/or prognosing a subject with prostate cancer. In some embodiments, the methods include obtaining a biological sample comprising genomic DNA from the subject, and measuring the level of one or more methylated genomic CpG dinucleotides in one or more of the genomic targets TAL1. ERG or CD40, or a combination of two or more thereof, in the sample, wherein an increase in the level of methylation of the one or more genomic CpG dinucleotides in the sample compared to a control indicates a subject with prostate cancer. In some embodiments, the method also includes detecting presence of a TMPRSS2-ERG gene fusion in the sample from the subject.
PCT/US2010/049708 2009-09-24 2010-09-21 Detection of dna methylation of tal1, erg and/or cd40 to diagnose prostate cancer WO2011037936A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US27752309P 2009-09-24 2009-09-24
US61/277,523 2009-09-24
US36434610P 2010-07-14 2010-07-14
US61/364,346 2010-07-14

Publications (2)

Publication Number Publication Date
WO2011037936A2 WO2011037936A2 (en) 2011-03-31
WO2011037936A3 true WO2011037936A3 (en) 2011-08-18

Family

ID=43796452

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/049708 WO2011037936A2 (en) 2009-09-24 2010-09-21 Detection of dna methylation of tal1, erg and/or cd40 to diagnose prostate cancer

Country Status (1)

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WO (1) WO2011037936A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2876252A1 (en) 2012-06-14 2013-12-19 Aarhus Universitet Biomarkers for prostate cancer
US20140274757A1 (en) 2013-03-14 2014-09-18 Marie K. Kirby Differential Methylation Level of CpG Loci That Are Determinative of a Biochemical Reoccurrence of Prostate Cancer
EP3008396B1 (en) * 2013-06-12 2019-10-23 7AC Technologies, Inc. Liquid desiccant air conditioning system
DE102016005947B3 (en) * 2016-05-16 2017-06-08 Dimo Dietrich A method for estimating the prognosis and predicting the response to immunotherapy of patients with malignant diseases
US11685955B2 (en) 2016-05-16 2023-06-27 Dimo Dietrich Method for predicting response of patients with malignant diseases to immunotherapy
US10934592B2 (en) 2017-02-28 2021-03-02 Mayo Foundation For Medical Education And Research Detecting prostate cancer
US20220275461A1 (en) * 2019-08-21 2022-09-01 H. Lee Moffitt Cancer Center And Research Institute, Inc. Diagnostics and methods for prognosing response to immunotherapy based on the methylation status of immune synapse gene signature

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552277A (en) * 1994-07-19 1996-09-03 The Johns Hopkins University School Of Medicine Genetic diagnosis of prostate cancer
US20070048738A1 (en) * 2003-07-14 2007-03-01 Mayo Foundation For Medical Education And Research Methods and compositions for diagnosis, staging and prognosis of prostate cancer
US20080254455A1 (en) * 2007-04-12 2008-10-16 Haiying Wang Detecting prostate cancer
WO2009012387A2 (en) * 2007-07-18 2009-01-22 Gen-Probe Incorporated Compositions and methods to detect tmprss2/erg transcript variants in prostate cancer
US20090170075A1 (en) * 2004-05-07 2009-07-02 Gyorgy Petrovics Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552277A (en) * 1994-07-19 1996-09-03 The Johns Hopkins University School Of Medicine Genetic diagnosis of prostate cancer
US20070048738A1 (en) * 2003-07-14 2007-03-01 Mayo Foundation For Medical Education And Research Methods and compositions for diagnosis, staging and prognosis of prostate cancer
US20090170075A1 (en) * 2004-05-07 2009-07-02 Gyorgy Petrovics Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer
US20080254455A1 (en) * 2007-04-12 2008-10-16 Haiying Wang Detecting prostate cancer
WO2009012387A2 (en) * 2007-07-18 2009-01-22 Gen-Probe Incorporated Compositions and methods to detect tmprss2/erg transcript variants in prostate cancer

Also Published As

Publication number Publication date
WO2011037936A2 (en) 2011-03-31

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