WO2007056332A3 - Molecular diagnosis of autoimmune diseases - Google Patents

Molecular diagnosis of autoimmune diseases Download PDF

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Publication number
WO2007056332A3
WO2007056332A3 PCT/US2006/043272 US2006043272W WO2007056332A3 WO 2007056332 A3 WO2007056332 A3 WO 2007056332A3 US 2006043272 W US2006043272 W US 2006043272W WO 2007056332 A3 WO2007056332 A3 WO 2007056332A3
Authority
WO
WIPO (PCT)
Prior art keywords
subject
genes
methods
uncharacterized
populations
Prior art date
Application number
PCT/US2006/043272
Other languages
French (fr)
Other versions
WO2007056332A2 (en
Inventor
Thomas M Aune
Nancy J Olsen
Iii Philip S Crooke
Cindy L Vnencak-Jones
Sallyanne C Fossey
Original Assignee
Univ Vanderbilt
Thomas M Aune
Nancy J Olsen
Iii Philip S Crooke
Cindy L Vnencak-Jones
Sallyanne C Fossey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vanderbilt, Thomas M Aune, Nancy J Olsen, Iii Philip S Crooke, Cindy L Vnencak-Jones, Sallyanne C Fossey filed Critical Univ Vanderbilt
Publication of WO2007056332A2 publication Critical patent/WO2007056332A2/en
Publication of WO2007056332A3 publication Critical patent/WO2007056332A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods for detecting a multiple sclerosis (MS) syndrome in a subject. In some embodiments, the methods include the steps of obtaining a biological sample from the subject; determining expression levels for two or more genes in the biological sample, wherein the two or more genes are selected from among the genes represented by SEQ ID NOs: 1-9; and calculating a ratio of the expression levels of the two or more genes determined in step (b) to thereby detect the presence of a multiple sclerosis syndrome in the subject. The presently disclosed subject matter also provides reagents and kits that can be used in the practice of the disclosed methods. Also provided are methods for assigning an uncharacterized subject to one of two populations of subjects and computer program products for identifying one or more ratio values that can be employed for assigning an uncharacterized subject to one of two populations of subjects.
PCT/US2006/043272 2005-11-07 2006-11-07 Molecular diagnosis of autoimmune diseases WO2007056332A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73436905P 2005-11-07 2005-11-07
US60/734,369 2005-11-07
US73613105P 2005-11-10 2005-11-10
US60/736,131 2005-11-10

Publications (2)

Publication Number Publication Date
WO2007056332A2 WO2007056332A2 (en) 2007-05-18
WO2007056332A3 true WO2007056332A3 (en) 2009-05-14

Family

ID=38023913

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/043272 WO2007056332A2 (en) 2005-11-07 2006-11-07 Molecular diagnosis of autoimmune diseases

Country Status (1)

Country Link
WO (1) WO2007056332A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100209914A1 (en) * 2007-05-25 2010-08-19 Ore Pharmaceuticals , Inc. Methods, systems, and kits for evaluating multiple sclerosis
WO2010024405A1 (en) * 2008-08-28 2010-03-04 独立行政法人理化学研究所 Ifn type-1 production inhibitor and method for searching for same
CA2743590A1 (en) 2008-11-12 2010-05-20 Yeda Research And Development Co. Ltd. Diagnosis of multiple sclerosis
WO2013040062A2 (en) * 2011-09-12 2013-03-21 Vanderbilt University Characterizing multiple sclerosis
US11053550B2 (en) 2014-10-14 2021-07-06 The University Of North Carolina At Chapel Hill Gene-expression based subtyping of pancreatic ductal adenocarcinoma
EP3443125B1 (en) * 2016-04-15 2023-09-06 Octave Bioscience, Inc. Methods for assessment of multiple sclerosis activity
WO2020205993A1 (en) 2019-04-01 2020-10-08 The University Of North Carolina At Chapel Hill Purity independent subtyping of tumors (purist), a platform and sample type independent single sample classifier for treatment decision making in pancreatic cancer
EP4338170A1 (en) * 2021-05-12 2024-03-20 Genentech, Inc. Logic-based typing of multiple sclerosis subjects based on coded data

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020068707A1 (en) * 1996-12-05 2002-06-06 Tetsuyoshi Ishiwata Iga nephropathy-related genes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020068707A1 (en) * 1996-12-05 2002-06-06 Tetsuyoshi Ishiwata Iga nephropathy-related genes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ACHIRON ET AL., AMERICAN NEUROLOGICAL ASSOCIATON, 2004, pages 410 - 417 *

Also Published As

Publication number Publication date
WO2007056332A2 (en) 2007-05-18

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