WO2008126797A1 - 微粉砕化有機化合物粒子の製造方法 - Google Patents

微粉砕化有機化合物粒子の製造方法 Download PDF

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Publication number
WO2008126797A1
WO2008126797A1 PCT/JP2008/056799 JP2008056799W WO2008126797A1 WO 2008126797 A1 WO2008126797 A1 WO 2008126797A1 JP 2008056799 W JP2008056799 W JP 2008056799W WO 2008126797 A1 WO2008126797 A1 WO 2008126797A1
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WIPO (PCT)
Prior art keywords
organic compound
compound particle
poorly water
producing
medical use
Prior art date
Application number
PCT/JP2008/056799
Other languages
English (en)
French (fr)
Inventor
Takashi Hirokawa
Takahiro Tada
Original Assignee
Activus Pharma Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Activus Pharma Co., Ltd. filed Critical Activus Pharma Co., Ltd.
Priority to JP2009509328A priority Critical patent/JP5317960B2/ja
Priority to EP08739905.1A priority patent/EP2143423B1/en
Priority to CA2679929A priority patent/CA2679929C/en
Priority to KR1020097014759A priority patent/KR101369061B1/ko
Priority to ES08739905.1T priority patent/ES2563979T3/es
Priority to CN2008800084620A priority patent/CN101636150B/zh
Publication of WO2008126797A1 publication Critical patent/WO2008126797A1/ja
Priority to US12/585,786 priority patent/US8226983B2/en
Priority to IL201169A priority patent/IL201169A/en
Priority to US13/484,460 priority patent/US20120237768A1/en
Priority to IL223087A priority patent/IL223087A/en

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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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Abstract

　本発明は、難水溶性であり、かつ、結晶性である有機化合物の微粉砕化粒子の製造方法、及び、該製造方法により製造された微粉砕化有機化合物粒子の提供することを目的とする。特に、本発明は、難水溶性医療用有機化合物を、生理学的に許容される塩及び生理学的に許容されるポリオールと混合して、前記有機化合物を湿式粉砕することを特徴とする、難水溶性医療用有機化合物微粒子の製造方法、及び該製造方法により得られる難水溶性医療用有機化合物微粒子を提供することを目的とする。
PCT/JP2008/056799 2007-04-06 2008-04-04 微粉砕化有機化合物粒子の製造方法 WO2008126797A1 (ja)

Priority Applications (10)

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JP2009509328A JP5317960B2 (ja) 2007-04-06 2008-04-04 微粉砕化有機化合物粒子の製造方法
EP08739905.1A EP2143423B1 (en) 2007-04-06 2008-04-04 Method for producing pulverized organic compound particle
CA2679929A CA2679929C (en) 2007-04-06 2008-04-04 Method for producing finely pulverized organic compound particle
KR1020097014759A KR101369061B1 (ko) 2007-04-06 2008-04-04 미분쇄화 유기 화합물 입자의 제조 방법
ES08739905.1T ES2563979T3 (es) 2007-04-06 2008-04-04 Método para producción de partículas de compuesto orgánico pulverizadas
CN2008800084620A CN101636150B (zh) 2007-04-06 2008-04-04 难水溶性医疗用有机化合物微粒子的制造方法
US12/585,786 US8226983B2 (en) 2007-04-06 2009-09-24 Method for producing pulverized organic compound particle
IL201169A IL201169A (en) 2007-04-06 2009-09-24 A method for producing crushed particles of organic compound
US13/484,460 US20120237768A1 (en) 2007-04-06 2012-05-31 Method for producing pulverized organic compound particle
IL223087A IL223087A (en) 2007-04-06 2012-11-18 Thin crushed organic compound particles

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JP2007-100902 2007-04-06
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JP2007-210370 2007-08-10
JP2007210370 2007-08-10

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WO2010052896A1 (ja) * 2008-11-04 2010-05-14 日揮株式会社 プロピオン酸フルチカゾンを含む局所投与剤
WO2011001214A1 (en) * 2009-06-30 2011-01-06 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Surface amorphization of phenprobamate
WO2011118960A2 (ko) 2010-03-22 2011-09-29 (주)바이오시네틱스 나노입자 제조방법
WO2013042978A1 (ko) 2011-09-21 2013-03-28 (주)바이오시네틱스 나노입자 제조방법
JP2013525337A (ja) * 2010-04-20 2013-06-20 シプラ・リミテッド 医薬組成物
WO2013168437A1 (ja) 2012-05-11 2013-11-14 株式会社アクティバスファーマ 有機化合物ナノ粉体、その製造方法ならびに懸濁液
JP5536654B2 (ja) * 2008-09-19 2014-07-02 株式会社アクティバスファーマ 医療用複合有機化合物粉体、その製造方法ならびに懸濁液
JP2014518284A (ja) * 2011-07-07 2014-07-28 アーキュール，インコーポレイティド ピロロキノリニル−ピロリジン−２，５−ジオン製剤及びその調製方法及び使用方法
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CN103932988A (zh) 2009-04-24 2014-07-23 伊休蒂卡有限公司 吲哚美辛的新剂型
SG182485A1 (en) * 2010-01-15 2012-08-30 Lithera Inc Lyophilized cake formulations
MX2013004137A (es) 2010-10-12 2013-07-29 Cipla Ltd Composicion farmaceutica.
JOP20120023B1 (ar) 2011-02-04 2022-03-14 Novartis Ag صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية
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Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5817167A (ja) 1981-07-06 1983-02-01 モベイ・コ−ポレ−ション 顔料のコンデイシヨニング方法
JPH0366613A (ja) * 1989-08-04 1991-03-22 Tanabe Seiyaku Co Ltd 難溶性薬物の超微粒子化法
JPH03131355A (ja) * 1989-10-17 1991-06-04 Sankyo Co Ltd 難溶性化合物の湿式粉砕方法
JPH04295420A (ja) * 1991-01-25 1992-10-20 Sterling Winthrop Inc 表面変性薬物微小粒子
JPH06228454A (ja) * 1991-03-07 1994-08-16 Toyo Ink Mfg Co Ltd β型ジオキサジン顔料の製造法
US5626662A (en) 1994-04-21 1997-05-06 Hoechst Aktiengesellschaft Fine division in the preparation of organic pigments
JPH10330799A (ja) * 1997-06-04 1998-12-15 Lion Corp 泡状殺菌洗浄剤組成物
JPH11100317A (ja) 1997-07-26 1999-04-13 Ciba Specialty Chem Holding Inc Ｕｖ−防御剤組成物
US6284282B1 (en) 1998-04-29 2001-09-04 Genentech, Inc. Method of spray freeze drying proteins for pharmaceutical administration
JP2002511398A (ja) 1998-04-09 2002-04-16 エフ．ホフマン−ラ ロシュ アーゲー 圧縮ガス及び界面活性剤に溶解することによって（サブ）ミクロンレベルの大きさの粒子を製造する方法
JP2002518318A (ja) 1998-06-19 2002-06-25 アールティーピー・ファーマ・インコーポレーテッド 水に溶けない化合物のサブミクロン粒子を生成させる方法
JP2003286105A (ja) 2002-03-27 2003-10-07 Kumiai Chem Ind Co Ltd 顆粒状水和剤
JP2003342493A (ja) * 2002-05-27 2003-12-03 Konica Minolta Holdings Inc 有機化合物の精製方法
JP2004330078A (ja) 2003-05-07 2004-11-25 Morinaga Milk Ind Co Ltd 食品の微粉砕方法および飲食物
JP2005008806A (ja) * 2003-06-20 2005-01-13 Toyo Ink Mfg Co Ltd β型銅フタロシアニン顔料の製造方法
JP2006089386A (ja) 2004-09-21 2006-04-06 Nippon Tenganyaku Kenkyusho:Kk ステロイドまたはステロイド誘導体を含有する懸濁性医薬組成物
JP2006182992A (ja) 2004-12-28 2006-07-13 Usm Kenkyusho:Kk 絹微粒子溶液及び絹微粒子粉末の製造方法並びに絹微粒子を含む材料
WO2006087919A1 (ja) * 2005-01-28 2006-08-24 Takeda Pharmaceutical Company Limited 難水溶性物質含有微細化組成物
JP2006255519A (ja) * 2005-03-15 2006-09-28 Masumi Kusunoki 媒体循環型粉砕装置

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165506A (en) * 1998-09-04 2000-12-26 Elan Pharma International Ltd. Solid dose form of nanoparticulate naproxen
US7919119B2 (en) * 1999-05-27 2011-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
DE60133270T2 (de) * 2000-05-10 2009-04-23 Jagotec Ag Zerkleinerung mittels mahlkörper
JP4969761B2 (ja) * 2000-08-31 2012-07-04 オバン・エナジー・リミテッド 所望粒度を持つ固体基材の小粒子および第一材料の小粒状物を含む相乗作用性混合物を製造する方法
ATE419835T1 (de) * 2002-05-06 2009-01-15 Elan Pharma Int Ltd Nystatin-nanopartikelzusammensetzungen
WO2004006959A1 (en) * 2002-07-16 2004-01-22 Elan Pharma International, Ltd Liquid dosage compositions of stable nanoparticulate active agents
CA2604770C (en) * 2005-04-13 2013-09-24 Abbott Gmbh & Co. Kg Method for carefully producing ultrafine particle suspensions and ultrafine particles and use thereof
DE602006009710D1 (de) * 2005-12-15 2009-11-19 Acusphere Inc Verfahren zur herstellung von pharmazeutischen formulierungen auf teilchenbasis zur parenteralen verabreichung

Patent Citations (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5817167A (ja) 1981-07-06 1983-02-01 モベイ・コ−ポレ−ション 顔料のコンデイシヨニング方法
JPH0366613A (ja) * 1989-08-04 1991-03-22 Tanabe Seiyaku Co Ltd 難溶性薬物の超微粒子化法
JP2642486B2 (ja) 1989-08-04 1997-08-20 田辺製薬株式会社 難溶性薬物の超微粒子化法
JPH03131355A (ja) * 1989-10-17 1991-06-04 Sankyo Co Ltd 難溶性化合物の湿式粉砕方法
JP3602546B2 (ja) 1991-01-25 2004-12-15 エラン ファーマ インターナショナル，リミティド 表面変性薬物微小粒子
JPH04295420A (ja) * 1991-01-25 1992-10-20 Sterling Winthrop Inc 表面変性薬物微小粒子
JPH06228454A (ja) * 1991-03-07 1994-08-16 Toyo Ink Mfg Co Ltd β型ジオキサジン顔料の製造法
JP2683458B2 (ja) 1991-03-07 1997-11-26 東洋インキ製造株式会社 β型ジオキサジン顔料の製造法
US5626662A (en) 1994-04-21 1997-05-06 Hoechst Aktiengesellschaft Fine division in the preparation of organic pigments
JPH10330799A (ja) * 1997-06-04 1998-12-15 Lion Corp 泡状殺菌洗浄剤組成物
JPH11100317A (ja) 1997-07-26 1999-04-13 Ciba Specialty Chem Holding Inc Ｕｖ−防御剤組成物
JP2002511398A (ja) 1998-04-09 2002-04-16 エフ．ホフマン−ラ ロシュ アーゲー 圧縮ガス及び界面活性剤に溶解することによって（サブ）ミクロンレベルの大きさの粒子を製造する方法
US6284282B1 (en) 1998-04-29 2001-09-04 Genentech, Inc. Method of spray freeze drying proteins for pharmaceutical administration
JP2002518318A (ja) 1998-06-19 2002-06-25 アールティーピー・ファーマ・インコーポレーテッド 水に溶けない化合物のサブミクロン粒子を生成させる方法
JP2003286105A (ja) 2002-03-27 2003-10-07 Kumiai Chem Ind Co Ltd 顆粒状水和剤
JP2003342493A (ja) * 2002-05-27 2003-12-03 Konica Minolta Holdings Inc 有機化合物の精製方法
JP2004330078A (ja) 2003-05-07 2004-11-25 Morinaga Milk Ind Co Ltd 食品の微粉砕方法および飲食物
JP2005008806A (ja) * 2003-06-20 2005-01-13 Toyo Ink Mfg Co Ltd β型銅フタロシアニン顔料の製造方法
JP2006089386A (ja) 2004-09-21 2006-04-06 Nippon Tenganyaku Kenkyusho:Kk ステロイドまたはステロイド誘導体を含有する懸濁性医薬組成物
JP2006182992A (ja) 2004-12-28 2006-07-13 Usm Kenkyusho:Kk 絹微粒子溶液及び絹微粒子粉末の製造方法並びに絹微粒子を含む材料
WO2006087919A1 (ja) * 2005-01-28 2006-08-24 Takeda Pharmaceutical Company Limited 難水溶性物質含有微細化組成物
JP2006255519A (ja) * 2005-03-15 2006-09-28 Masumi Kusunoki 媒体循環型粉砕装置

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"Apparatus 3 for Dry Powder Inhalers", USP30-NF25, vol. 1, pages 220 - 240
KUWAHARA YOSHITAKA: "Pulverization Process in Fine Pulverization Region and Contamination", CUTTING-EDGE PULVERIZATION TECHNOLOGIES AND APPLICATIONS, 2005, pages 81 - 88
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, vol. 9, no. 1, 2004, pages 1 - 13
See also references of EP2143423A4

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5536654B2 (ja) * 2008-09-19 2014-07-02 株式会社アクティバスファーマ 医療用複合有機化合物粉体、その製造方法ならびに懸濁液
WO2010052896A1 (ja) * 2008-11-04 2010-05-14 日揮株式会社 プロピオン酸フルチカゾンを含む局所投与剤
WO2011001214A1 (en) * 2009-06-30 2011-01-06 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Surface amorphization of phenprobamate
WO2011118960A2 (ko) 2010-03-22 2011-09-29 (주)바이오시네틱스 나노입자 제조방법
US8828445B2 (en) 2010-03-22 2014-09-09 Bio-Synectics Inc. Method for preparing nano-particles utilizing a saccharide anti-coagulant
JP2013525337A (ja) * 2010-04-20 2013-06-20 シプラ・リミテッド 医薬組成物
JP2014518284A (ja) * 2011-07-07 2014-07-28 アーキュール，インコーポレイティド ピロロキノリニル−ピロリジン−２，５−ジオン製剤及びその調製方法及び使用方法
US9439871B2 (en) 2011-09-21 2016-09-13 Bio-Synectics, Inc. Method for preparing nano particles
WO2013042978A1 (ko) 2011-09-21 2013-03-28 (주)바이오시네틱스 나노입자 제조방법
TWI579004B (zh) * 2012-05-11 2017-04-21 活效製藥股份有限公司 有機化合物奈米粉末、其製造方法及懸浮液
CN104203217A (zh) * 2012-05-11 2014-12-10 株式会社活效制药 有机化合物纳米粉体及其制造方法、以及悬浮液
JPWO2013168437A1 (ja) * 2012-05-11 2016-01-07 株式会社アクティバスファーマ 有機化合物ナノ粉体、その製造方法ならびに懸濁液
US9278071B2 (en) 2012-05-11 2016-03-08 Activus Pharma Co., Ltd. Organic compound nano-powder, method for producing the same and suspension
WO2013168437A1 (ja) 2012-05-11 2013-11-14 株式会社アクティバスファーマ 有機化合物ナノ粉体、その製造方法ならびに懸濁液
RU2613109C2 (ru) * 2012-05-11 2017-03-15 Активус Фарма Ко., Лтд. Нанопорошки органических соединений, способы их получения и их суспензии
JPWO2016181935A1 (ja) * 2015-05-08 2018-02-22 株式会社アクティバスファーマ グルココルチコステロイドのナノ微粒子を含有する水性懸濁液剤
WO2016181935A1 (ja) * 2015-05-08 2016-11-17 株式会社アクティバスファーマ グルココルチコステロイドのナノ微粒子を含有する水性懸濁液剤
US10588913B2 (en) 2015-05-08 2020-03-17 Activus Pharma Co., Ltd. Aqueous suspension agent containing glucocorticosteroid nanoparticles
US11376262B2 (en) 2015-05-08 2022-07-05 Activus Pharma Co., Ltd. Method of treating an inflammatory or infectious disease
IL255452B (en) * 2015-05-08 2022-08-01 Activus Pharma Co Ltd Aqueous suspension containing glucocorticosteroid nanoparticles
JP2018516907A (ja) * 2015-06-04 2018-06-28 クリティテック・インコーポレイテッド タキサン粒子およびその使用
JP2022121532A (ja) * 2015-06-04 2022-08-19 クリティテック・インコーポレイテッド タキサン粒子およびその使用
JP2019502697A (ja) * 2015-12-15 2019-01-31 ホビオネ サイエンティア リミテッド 呼吸域ザフィルルカスト粒子の調製方法
US10987305B2 (en) 2015-12-15 2021-04-27 Cipla Limited Preparation of respirable zafirlukast particles
RU2694221C1 (ru) * 2018-12-14 2019-07-10 Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" Противовоспалительный препарат на основе кетопрофена и способ его получения

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CN101636150A (zh) 2010-01-27
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TW200906450A (en) 2009-02-16
KR20100014315A (ko) 2010-02-10
IL201169A (en) 2013-08-29
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CN101636150B (zh) 2013-12-04
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IL223087A (en) 2014-06-30
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IL201169A0 (en) 2010-05-17
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US20120237768A1 (en) 2012-09-20
IL223087A0 (en) 2012-12-31
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