WO2007099152A1 - Comprimés résistant à l'écrasement destinés à éviter le mésusage involontaire et le détournement illicite - Google Patents

Comprimés résistant à l'écrasement destinés à éviter le mésusage involontaire et le détournement illicite Download PDF

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Publication number
WO2007099152A1
WO2007099152A1 PCT/EP2007/051967 EP2007051967W WO2007099152A1 WO 2007099152 A1 WO2007099152 A1 WO 2007099152A1 EP 2007051967 W EP2007051967 W EP 2007051967W WO 2007099152 A1 WO2007099152 A1 WO 2007099152A1
Authority
WO
WIPO (PCT)
Prior art keywords
tablets
matrix
compression
tablets according
mixture
Prior art date
Application number
PCT/EP2007/051967
Other languages
English (en)
French (fr)
Inventor
Vincent Cailly-Dufestel
Catherine Herry
Jonathan Bacon
Pascal Oury
Original Assignee
Ethypharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37460138&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2007099152(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to KR1020087024049A priority Critical patent/KR101375903B1/ko
Priority to EA200870267A priority patent/EA014652B1/ru
Priority to BRPI0707044A priority patent/BRPI0707044B8/pt
Priority to EP07712415.4A priority patent/EP1996166B1/fr
Priority to EP16183449.4A priority patent/EP3115041B1/fr
Priority to NZ571519A priority patent/NZ571519A/en
Priority to CN2007800071749A priority patent/CN101394839B/zh
Priority to ES07712415.4T priority patent/ES2609469T3/es
Priority to US12/224,374 priority patent/US20100015223A1/en
Priority to AU2007220454A priority patent/AU2007220454B2/en
Application filed by Ethypharm filed Critical Ethypharm
Priority to CA2643328A priority patent/CA2643328C/fr
Priority to MX2008011240A priority patent/MX2008011240A/es
Priority to JP2008556787A priority patent/JP5508722B2/ja
Publication of WO2007099152A1 publication Critical patent/WO2007099152A1/fr
Priority to IL193732A priority patent/IL193732A/en
Priority to US14/699,684 priority patent/US20150246035A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
PCT/EP2007/051967 2006-03-01 2007-03-01 Comprimés résistant à l'écrasement destinés à éviter le mésusage involontaire et le détournement illicite WO2007099152A1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
JP2008556787A JP5508722B2 (ja) 2006-03-01 2007-03-01 事故的誤用および不法転用を防止するための耐破砕性錠剤
AU2007220454A AU2007220454B2 (en) 2006-03-01 2007-03-01 Crush-resistant tablets intended to prevent accidental misuse and unlawful diversion
US12/224,374 US20100015223A1 (en) 2006-03-01 2007-03-01 Crush-Resistant Tablets Intended to Prevent Accidental Misuse and Unlawful Diversion
EP07712415.4A EP1996166B1 (fr) 2006-03-01 2007-03-01 Comprimés résistant à l'écrasement destinés à éviter le mésusage involontaire et le détournement illicite
EA200870267A EA014652B1 (ru) 2006-03-01 2007-03-01 Устойчивые к раздавливанию таблетки, предназначенные для предотвращения случайного неправильного применения и недозволенного употребления
NZ571519A NZ571519A (en) 2006-03-01 2007-03-01 Crush-resistant tablets intended to prevent accidental misuse and unlawful diversion
CN2007800071749A CN101394839B (zh) 2006-03-01 2007-03-01 旨在避免非主观误服和非法滥服的抗张性片剂
KR1020087024049A KR101375903B1 (ko) 2006-03-01 2007-03-01 우발적 오용 및 불법 전환을 방지하기 위한 내분쇄성 정제
BRPI0707044A BRPI0707044B8 (pt) 2006-03-01 2007-03-01 comprimido matricial insolúvel em água e processo de fabricação de comprimidos matriciais
EP16183449.4A EP3115041B1 (fr) 2006-03-01 2007-03-01 Comprimés résistant à l'écrasement destinés à éviter le mésusage involontaire et le détournement illicite
ES07712415.4T ES2609469T3 (es) 2006-03-01 2007-03-01 Comprimidos resistentes al aplastamiento destinados a evitar el mal uso accidental y la desviación de uso ilícita
CA2643328A CA2643328C (fr) 2006-03-01 2007-03-01 Comprimes resistant a l'ecrasement destines a eviter le mesusage involontaire et le detournement illicite
MX2008011240A MX2008011240A (es) 2006-03-01 2007-03-01 Tabletas resistentes al rompimiento destinadas a prevenir un mal uso accidental y la alteracion ilegal en su uso.
IL193732A IL193732A (en) 2006-03-01 2008-08-27 Crush resistant tablets designed to prevent accidental use and illegal change
US14/699,684 US20150246035A1 (en) 2006-03-01 2015-04-29 Crush-resistant tablets intended to prevent accidental misuse and unlawful diversion

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0601842A FR2898056B1 (fr) 2006-03-01 2006-03-01 Comprimes resistant a l'ecrasement destines a eviter le detournement illicite
FR0601842 2006-03-01

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/224,374 A-371-Of-International US20100015223A1 (en) 2006-03-01 2007-03-01 Crush-Resistant Tablets Intended to Prevent Accidental Misuse and Unlawful Diversion
US14/699,684 Continuation US20150246035A1 (en) 2006-03-01 2015-04-29 Crush-resistant tablets intended to prevent accidental misuse and unlawful diversion

Publications (1)

Publication Number Publication Date
WO2007099152A1 true WO2007099152A1 (fr) 2007-09-07

Family

ID=37460138

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2007/051967 WO2007099152A1 (fr) 2006-03-01 2007-03-01 Comprimés résistant à l'écrasement destinés à éviter le mésusage involontaire et le détournement illicite
PCT/EP2007/051969 WO2007099154A1 (fr) 2006-03-01 2007-03-01 Comprimes d'oxycodone resistant a l'ecrasement destines a eviter le mesusage involontaire et le detournement illicite.

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/051969 WO2007099154A1 (fr) 2006-03-01 2007-03-01 Comprimes d'oxycodone resistant a l'ecrasement destines a eviter le mesusage involontaire et le detournement illicite.

Country Status (18)

Country Link
US (3) US8501160B2 (ja)
EP (4) EP2010157B2 (ja)
JP (3) JP2009528329A (ja)
KR (2) KR101445884B1 (ja)
CN (3) CN101394839B (ja)
AU (2) AU2007220454B2 (ja)
BR (2) BRPI0707043C8 (ja)
CA (2) CA2643330C (ja)
EA (3) EA020550B1 (ja)
ES (3) ES2609695T5 (ja)
FR (1) FR2898056B1 (ja)
HK (1) HK1165263A1 (ja)
IL (2) IL193732A (ja)
MX (2) MX2008011240A (ja)
NZ (3) NZ594935A (ja)
SG (1) SG175666A1 (ja)
WO (2) WO2007099152A1 (ja)
ZA (2) ZA200807571B (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010142814A1 (fr) * 2009-06-12 2010-12-16 Ethypharm Réduction des fluctuations plasmatiques d'opioides
FR2983409A1 (fr) * 2011-12-06 2013-06-07 Ethypharm Sa Comprime susceptible de lutter contre le detournement par voie injectable
EP1996166B1 (fr) 2006-03-01 2016-10-05 Ethypharm Comprimés résistant à l'écrasement destinés à éviter le mésusage involontaire et le détournement illicite

Families Citing this family (77)

* Cited by examiner, † Cited by third party
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KR101045144B1 (ko) 2000-10-30 2011-06-30 유로-셀티크 소시에떼 아노뉨 서방성 하이드로코돈 제형
US20030068375A1 (en) 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
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