DE69231499T2 - Zusammensetzung auf der basis von mikrokristalliner zellulose für die herstellung von kugelförmigen teilchen - Google Patents

Zusammensetzung auf der basis von mikrokristalliner zellulose für die herstellung von kugelförmigen teilchen

Info

Publication number
DE69231499T2
DE69231499T2 DE69231499T DE69231499T DE69231499T2 DE 69231499 T2 DE69231499 T2 DE 69231499T2 DE 69231499 T DE69231499 T DE 69231499T DE 69231499 T DE69231499 T DE 69231499T DE 69231499 T2 DE69231499 T2 DE 69231499T2
Authority
DE
Germany
Prior art keywords
microcrystalline cellulose
composition
production
spherical particles
hydrocolloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69231499T
Other languages
English (en)
Other versions
DE69231499D1 (de
Inventor
David Frank Erkoboni
Scott Allan Fiore
Thomas Albert Wheatley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FMC Corp
Original Assignee
FMC Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FMC Corp filed Critical FMC Corp
Application granted granted Critical
Publication of DE69231499D1 publication Critical patent/DE69231499D1/de
Publication of DE69231499T2 publication Critical patent/DE69231499T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/005—Processes for mixing polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/02—Cellulose; Modified cellulose
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers
    • C08J2300/14—Water soluble or water swellable polymers, e.g. aqueous gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers
DE69231499T 1991-12-30 1992-11-18 Zusammensetzung auf der basis von mikrokristalliner zellulose für die herstellung von kugelförmigen teilchen Expired - Fee Related DE69231499T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81602791A 1991-12-30 1991-12-30
PCT/US1992/009983 WO1993012768A1 (en) 1991-12-30 1992-11-18 Microcrystalline cellulose spheronization composition

Publications (2)

Publication Number Publication Date
DE69231499D1 DE69231499D1 (de) 2000-11-09
DE69231499T2 true DE69231499T2 (de) 2001-05-03

Family

ID=25219497

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69231499T Expired - Fee Related DE69231499T2 (de) 1991-12-30 1992-11-18 Zusammensetzung auf der basis von mikrokristalliner zellulose für die herstellung von kugelförmigen teilchen

Country Status (16)

Country Link
US (1) US5725886A (de)
EP (1) EP0619731B1 (de)
JP (1) JP2628230B2 (de)
CN (1) CN1074228A (de)
AT (1) ATE196733T1 (de)
AU (1) AU663146B2 (de)
BR (1) BR9206996A (de)
CA (1) CA2126441C (de)
DE (1) DE69231499T2 (de)
ES (1) ES2150438T3 (de)
FI (1) FI943121A (de)
IL (1) IL104087A (de)
MX (1) MX9207438A (de)
NO (1) NO942457D0 (de)
WO (1) WO1993012768A1 (de)
ZA (1) ZA929161B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567439A (en) * 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
US6471994B1 (en) 1995-01-09 2002-10-29 Edward Mendell Co., Inc. Pharmaceutical excipient having improved compressibility
IL116674A (en) * 1995-01-09 2003-05-29 Mendell Co Inc Edward Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof
US5948438A (en) * 1995-01-09 1999-09-07 Edward Mendell Co., Inc. Pharmaceutical formulations having improved disintegration and/or absorptivity
US6395303B1 (en) 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
US6936277B2 (en) 1995-01-09 2005-08-30 J. Rettenmaier & Soehne Gmbh & Co. Kg Pharmaceutical excipient having improved compressibility
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US6391337B2 (en) 1995-11-15 2002-05-21 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US5733578A (en) * 1995-11-15 1998-03-31 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US6852336B2 (en) 1995-11-15 2005-02-08 J. Rettenmaier & Soehne Gmbh + Co. Kg Directly compressible high load acetaminophen formulations
BR9711148A (pt) * 1996-08-14 1999-08-17 Zamonouchi Europ Bv Granulados compreendendo composto solÚvel em gua e celulose
CN1086189C (zh) * 1997-06-12 2002-06-12 食品机械和化工公司 超细微晶纤维素组合物及其制备方法
US5904937A (en) * 1997-10-03 1999-05-18 Fmc Corporation Taste masked pharmaceutical compositions
US7122207B2 (en) * 1998-05-22 2006-10-17 Bristol-Myers Squibb Company High drug load acid labile pharmaceutical composition
DK1233755T3 (da) 1999-09-29 2007-10-29 Scherer Technologies Inc R P Hydrolyseret cellulosegranuleringer af salte af lægemidler
CN1187052C (zh) 2000-03-30 2005-02-02 布里斯托尔-迈尔斯斯奎布公司 含有司他夫定(stavudine)的持续释放微球
MXPA03006963A (es) * 2001-02-05 2004-07-07 Scherer Technologies Inc R P Metodos y composiciones para reducir el sabor de los agentes farmaceuticamente activos.
BR0209155A (pt) * 2001-04-26 2004-10-05 Bristol Myers Squibb Co Tablete farmacêutico tendo um teor de api elevado
EP1575487B1 (de) 2002-05-14 2019-08-14 DuPont Nutrition USA, Inc. Coattrittierte mikrokristalline zellulose hydrokolloid-zusammensetzungen und verfahren zur herstellung
CN101115409B (zh) * 2005-02-04 2013-03-27 菲利普莫里斯生产公司 具有纤维质滋味添加剂的香烟及过滤嘴
US20070000505A1 (en) * 2005-02-24 2007-01-04 Philip Morris Usa Inc. Smoking article with tobacco beads
US7879382B2 (en) * 2005-09-30 2011-02-01 Fmc Corporation Stabilizers and compositions and products comprising same
FR2898056B1 (fr) * 2006-03-01 2012-01-20 Ethypharm Sa Comprimes resistant a l'ecrasement destines a eviter le detournement illicite
BRPI0714586A2 (pt) * 2006-07-28 2013-05-07 Farmaprojects S A formulaÇço farmacÊutica de liberaÇço prolongada de metropolol e processo para a sua preparaÇço
JP2010507676A (ja) * 2006-10-27 2010-03-11 エフ エム シー コーポレーション 乾式顆粒化結合剤、生成物およびその使用
ATE476176T1 (de) * 2007-03-02 2010-08-15 Farnam Co Inc Wachsähnliches material enthaltende tabletten mit verzögerter freisetzung
US9888712B2 (en) 2007-06-08 2018-02-13 Philip Morris Usa Inc. Oral pouch products including a liner and tobacco beads
US20100055180A1 (en) * 2007-10-10 2010-03-04 Mallinckrodt Baker, Inc. Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof
SG185257A1 (en) * 2007-10-10 2012-11-29 Avantor Performance Mat Inc Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof
JP2012509329A (ja) * 2008-11-19 2012-04-19 アバントール パフォーマンス マテリアルズ， インコーポレイテッド 直接圧縮可能で高機能性な顆粒状の微結晶性セルロースベース賦形剤、それらの製造プロセスおよび使用
US9144625B2 (en) 2008-11-27 2015-09-29 Speciality Fibres And Materials Ltd. Cellulose ethylsulfonate-based absorbent material
US9221963B2 (en) 2008-11-27 2015-12-29 Speciality Fibres And Materials Ltd. Absorbent material
US8377215B2 (en) 2008-12-18 2013-02-19 Philip Morris Usa Inc. Moist botanical pouch processing
US8863755B2 (en) * 2009-02-27 2014-10-21 Philip Morris Usa Inc. Controlled flavor release tobacco pouch products and methods of making
US20110277781A1 (en) 2010-03-26 2011-11-17 Philip Morris Usa Inc. Methods for improving quality of mainstream smoke and multicomponent filters and smoking articles therefor
US10051884B2 (en) 2010-03-26 2018-08-21 Philip Morris Usa Inc. Controlled release mentholated tobacco beads
US9055757B2 (en) 2011-10-05 2015-06-16 Fmc Corporation Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses
BR112014007366B1 (pt) 2011-10-05 2020-09-15 Dupont Nutrition Usa, Inc Processo para fabricar uma composição estabilizadora compreendendo extrusão em duas etapas, composição estabilizadora de celulose microcristalina e produto alimentício comestível e suspensão industrial compreendendo a mesma
WO2013085810A2 (en) 2011-12-09 2013-06-13 Fmc Corporation Co-attrited stabilizer composition
CN105085992B (zh) * 2015-09-16 2017-12-29 珠海市东辰医药科技有限公司 一种改性微晶纤维素的制备工艺
CN105193738B (zh) * 2015-09-21 2018-09-04 珠海市东辰制药有限公司 一种微晶纤维素丸芯的制备工艺
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1010477A (en) * 1962-05-15 1965-11-17 Fmc Corp Method of making cellulose crystallite aggregates in particulate form and product of such method
GB1561204A (en) * 1977-06-01 1980-02-13 Ici Ltd Sustained release pharmaceutical composition
US4421778A (en) * 1982-11-04 1983-12-20 Rich Products Corporation Freezer stable whipped ice cream and milk shake food products
US4744987A (en) * 1985-03-08 1988-05-17 Fmc Corporation Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation
IL81419A0 (en) * 1986-01-30 1987-08-31 Syntex Inc Long acting sustained release pharmaceutical compositions containing dihydropyridines and their preparation
GB8705083D0 (en) * 1987-03-04 1987-04-08 Euro Celtique Sa Spheroids
CA1323833C (en) * 1987-04-28 1993-11-02 Yatindra M. Joshi Pharmaceutical compositions in the form of beadlets and method
US4837030A (en) * 1987-10-06 1989-06-06 American Cyanamid Company Novel controlled release formulations of tetracycline compounds

Also Published As

Publication number Publication date
ZA929161B (en) 1993-05-25
BR9206996A (pt) 1995-12-05
EP0619731A4 (de) 1995-05-03
CN1074228A (zh) 1993-07-14
IL104087A0 (en) 1993-05-13
NO942457L (no) 1994-06-29
EP0619731A1 (de) 1994-10-19
FI943121A0 (fi) 1994-06-29
JPH06511255A (ja) 1994-12-15
AU663146B2 (en) 1995-09-28
AU3179393A (en) 1993-07-28
FI943121A (fi) 1994-06-29
CA2126441A1 (en) 1993-07-08
CA2126441C (en) 1999-12-21
MX9207438A (es) 1993-06-01
ES2150438T3 (es) 2000-12-01
ATE196733T1 (de) 2000-10-15
IL104087A (en) 1998-10-30
EP0619731B1 (de) 2000-10-04
WO1993012768A1 (en) 1993-07-08
NO942457D0 (no) 1994-06-29
US5725886A (en) 1998-03-10
DE69231499D1 (de) 2000-11-09
JP2628230B2 (ja) 1997-07-09

Similar Documents

Publication Publication Date Title
DE69231499T2 (de) Zusammensetzung auf der basis von mikrokristalliner zellulose für die herstellung von kugelförmigen teilchen
FI862602A0 (fi) Foerfarande foer framstaellning av produkt innehaollande guar-gummi.
DE69228197D1 (de) Silikondioxid enthaltendes produkt und seine herstellung
GB1498086A (en) High bulking clay pigments and methods of making same
KR880000597A (ko) 바이오폴리머 입자 및 그의 제법
KR890003292A (ko) 안정화된 사료 첨가제 및 이의 제조방법
ES321056A1 (es) Un metodo para preparar particulas con forma para material de filtro de cigarrillos.
FI881769A0 (fi) Foerfarande foer framstaellning av stabila sukralfatsuspensioner, vilka icke innehaoller suspenderingsmedel.
ES422710A1 (es) Procedimiento para la produccion de granulos pesticidas dispersables en agua.
IE41923L (en) Suspension of xanthan gum
IE41924L (en) Suspension of alginate
JPS5455054A (en) Water-despersible compound
JPS5474855A (en) Preparation of finely divided soluble cellulose derivative
ATE38236T1 (de) Steroidderivate.
GB896439A (en) Cellulose derivatives useful as anion-exchange materials and their application
ES225054A1 (es) PROCEDIMIENTO DE OBTENCIoN DE PERoXIDO DE HIDRoGENO
ES441516A1 (es) Procedimiento para la preparacion de una suspension de acidosilicico de precipitacion pobre en granos de elevada concen-tracion.
JPS5547616A (en) Preparation of solid drug
GB893499A (en) Nitrocelluose particles
SU614558A1 (ru) Способ изготовлени диффузора электродинамического громкоговорител
GB2619237A (en) Composition of cellulose nanocrystals and carboxymethyl cellulose
KR930001932A (ko) 정화제 겸 탈취제의 제조방법
JPS52133089A (en) Production of fluorescent substance coated with pigment
Bolt One Night stand (1985)
DE3777570D1 (de) Agglomeriertes produkt, seine herstellung und seine anwendung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee