ES2150438T3 - Composicion de esferonizacion a base de celulosa microcristalina. - Google Patents

Composicion de esferonizacion a base de celulosa microcristalina.

Info

Publication number
ES2150438T3
ES2150438T3 ES93900553T ES93900553T ES2150438T3 ES 2150438 T3 ES2150438 T3 ES 2150438T3 ES 93900553 T ES93900553 T ES 93900553T ES 93900553 T ES93900553 T ES 93900553T ES 2150438 T3 ES2150438 T3 ES 2150438T3
Authority
ES
Spain
Prior art keywords
composition
microcrystalline cellulose
spheronization
cellulose based
hydrocoloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93900553T
Other languages
English (en)
Inventor
David Frank Erkoboni
Scott Allan Fiore
Thomas Albert Wheatley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FMC Corp
Original Assignee
FMC Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FMC Corp filed Critical FMC Corp
Application granted granted Critical
Publication of ES2150438T3 publication Critical patent/ES2150438T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/005—Processes for mixing polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/02—Cellulose; Modified cellulose
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers
    • C08J2300/14—Water soluble or water swellable polymers, e.g. aqueous gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UNA CELULOSA MICROCRISTALINA NO FROTADA COPROCESADA DE MACROPARTICULAS: COMPOSICION HIDROCOLOIDAL EN LA QUE LOS COMPONENTES RESPECTIVOS ESTAN PRESENTES EN UNA PROPORCION DE PESOS ENTRE 99:1 A 70:30. LA COMPOSICION ES UTIL COMO AGENTE DE ESFERONIZACION PARA PRODUCIR ESFEROIDES DE TAMAÑO UNIFORME Y ESFERICIDAD, Y TENIENDO CARGAS CONSIDERABLES DE MEDICINAS. LA COMPOSICION SE PRODUCE SECANDO UNA MEZCLA PASTOSA DE LA CELULOSA MICROCRISTALINA EN UNA SOLUCION ACUOSA DEL HIDROCOLOIDE. EL HIDROCOLOIDE PREFERIDO ES CELULOSA DE METILO.
ES93900553T 1991-12-30 1992-11-18 Composicion de esferonizacion a base de celulosa microcristalina. Expired - Lifetime ES2150438T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81602791A 1991-12-30 1991-12-30
PCT/US1992/009983 WO1993012768A1 (en) 1991-12-30 1992-11-18 Microcrystalline cellulose spheronization composition

Publications (1)

Publication Number Publication Date
ES2150438T3 true ES2150438T3 (es) 2000-12-01

Family

ID=25219497

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93900553T Expired - Lifetime ES2150438T3 (es) 1991-12-30 1992-11-18 Composicion de esferonizacion a base de celulosa microcristalina.

Country Status (16)

Country Link
US (1) US5725886A (es)
EP (1) EP0619731B1 (es)
JP (1) JP2628230B2 (es)
CN (1) CN1074228A (es)
AT (1) ATE196733T1 (es)
AU (1) AU663146B2 (es)
BR (1) BR9206996A (es)
CA (1) CA2126441C (es)
DE (1) DE69231499T2 (es)
ES (1) ES2150438T3 (es)
FI (1) FI943121A0 (es)
IL (1) IL104087A (es)
MX (1) MX9207438A (es)
NO (1) NO942457D0 (es)
WO (1) WO1993012768A1 (es)
ZA (1) ZA929161B (es)

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US5567439A (en) * 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
US6936277B2 (en) 1995-01-09 2005-08-30 J. Rettenmaier & Soehne Gmbh & Co. Kg Pharmaceutical excipient having improved compressibility
US6395303B1 (en) 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
US5948438A (en) * 1995-01-09 1999-09-07 Edward Mendell Co., Inc. Pharmaceutical formulations having improved disintegration and/or absorptivity
IL139728A (en) * 1995-01-09 2003-06-24 Penwest Pharmaceuticals Compan Aqueous slurry composition containing microcrystalline cellulose for preparing a pharmaceutical excipient
US6471994B1 (en) 1995-01-09 2002-10-29 Edward Mendell Co., Inc. Pharmaceutical excipient having improved compressibility
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US5733578A (en) 1995-11-15 1998-03-31 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US6391337B2 (en) 1995-11-15 2002-05-21 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US6852336B2 (en) 1995-11-15 2005-02-08 J. Rettenmaier & Soehne Gmbh + Co. Kg Directly compressible high load acetaminophen formulations
CN1139377C (zh) * 1996-08-14 2004-02-25 山之内欧洲有限公司 含有水溶性化合物和纤维素的颗粒
CN1086189C (zh) * 1997-06-12 2002-06-12 食品机械和化工公司 超细微晶纤维素组合物及其制备方法
US5904937A (en) * 1997-10-03 1999-05-18 Fmc Corporation Taste masked pharmaceutical compositions
US7122207B2 (en) * 1998-05-22 2006-10-17 Bristol-Myers Squibb Company High drug load acid labile pharmaceutical composition
DK1233755T3 (da) 1999-09-29 2007-10-29 Scherer Technologies Inc R P Hydrolyseret cellulosegranuleringer af salte af lægemidler
PL366089A1 (en) 2000-03-30 2005-01-24 Bristol-Myers Squibb Company Sustained release beadlets containing stavudine
HUP0303178A3 (en) * 2001-02-05 2008-03-28 R P Scherer Technologies Methods and compositions for reducing the taste of pharmaceutically active agents
MXPA03009676A (es) * 2001-04-26 2004-02-12 Bristol Myers Squibb Co CONTROL DE COMPACTIBILIDAD A TRAVeS DE CRISTALIZACION.
ES2752452T3 (es) 2002-05-14 2020-04-06 Dupont Nutrition Usa Inc Composiciones de hidrocoloides de celulosa microcristalinas codesgastadas por atrición y método para su fabricación
AU2006211047B2 (en) * 2005-02-04 2011-03-24 Philip Morris Products S.A. Cigarette and filter with cellulosic flavor addition
US20070000505A1 (en) * 2005-02-24 2007-01-04 Philip Morris Usa Inc. Smoking article with tobacco beads
US7879382B2 (en) * 2005-09-30 2011-02-01 Fmc Corporation Stabilizers and compositions and products comprising same
ZA200807571B (en) * 2006-03-01 2009-08-26 Ethypharm Sa Crush-resistant tablets intended to prevent accidental misuse and unlawful diversion
WO2008012346A1 (en) * 2006-07-28 2008-01-31 Farmaprojects, S. A. Extended release pharmaceutical formulation of metoprolol and process for its preparation
JP2010507676A (ja) * 2006-10-27 2010-03-11 エフ エム シー コーポレーション 乾式顆粒化結合剤、生成物およびその使用
CA2678367C (en) * 2007-03-02 2014-07-08 Farnam Companies, Inc. Sustained release compositions using wax-like materials
US9888712B2 (en) 2007-06-08 2018-02-13 Philip Morris Usa Inc. Oral pouch products including a liner and tobacco beads
US20100055180A1 (en) * 2007-10-10 2010-03-04 Mallinckrodt Baker, Inc. Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof
WO2009048557A1 (en) * 2007-10-10 2009-04-16 Mallinckrodt Baker, Inc. Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof
CA2744142A1 (en) * 2008-11-19 2010-05-27 Avantor Performance Materials, Inc. Directly compressible granular microcrystalline cellulose based excipient, manufacturing process and use thereof
US9144625B2 (en) 2008-11-27 2015-09-29 Speciality Fibres And Materials Ltd. Cellulose ethylsulfonate-based absorbent material
US9221963B2 (en) 2008-11-27 2015-12-29 Speciality Fibres And Materials Ltd. Absorbent material
US8377215B2 (en) 2008-12-18 2013-02-19 Philip Morris Usa Inc. Moist botanical pouch processing
US8863755B2 (en) * 2009-02-27 2014-10-21 Philip Morris Usa Inc. Controlled flavor release tobacco pouch products and methods of making
US10051884B2 (en) * 2010-03-26 2018-08-21 Philip Morris Usa Inc. Controlled release mentholated tobacco beads
US20110277781A1 (en) 2010-03-26 2011-11-17 Philip Morris Usa Inc. Methods for improving quality of mainstream smoke and multicomponent filters and smoking articles therefor
CN103842425B (zh) 2011-10-05 2017-05-24 Fmc有限公司 微晶纤维素和羧甲基纤维素的稳定剂组合物、制备方法和应用
EP2764045B1 (en) 2011-10-05 2017-03-01 FMC Corporation Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses
CN104010522A (zh) 2011-12-09 2014-08-27 Fmc有限公司 共磨碎稳定剂组合物
CN105085992B (zh) * 2015-09-16 2017-12-29 珠海市东辰医药科技有限公司 一种改性微晶纤维素的制备工艺
CN105193738B (zh) * 2015-09-21 2018-09-04 珠海市东辰制药有限公司 一种微晶纤维素丸芯的制备工艺
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1010477A (en) * 1962-05-15 1965-11-17 Fmc Corp Method of making cellulose crystallite aggregates in particulate form and product of such method
GB1561204A (en) * 1977-06-01 1980-02-13 Ici Ltd Sustained release pharmaceutical composition
US4421778A (en) * 1982-11-04 1983-12-20 Rich Products Corporation Freezer stable whipped ice cream and milk shake food products
US4744987A (en) * 1985-03-08 1988-05-17 Fmc Corporation Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation
IL81419A0 (en) * 1986-01-30 1987-08-31 Syntex Inc Long acting sustained release pharmaceutical compositions containing dihydropyridines and their preparation
GB8705083D0 (en) * 1987-03-04 1987-04-08 Euro Celtique Sa Spheroids
CA1323833C (en) * 1987-04-28 1993-11-02 Yatindra M. Joshi Pharmaceutical compositions in the form of beadlets and method
US4837030A (en) * 1987-10-06 1989-06-06 American Cyanamid Company Novel controlled release formulations of tetracycline compounds

Also Published As

Publication number Publication date
EP0619731B1 (en) 2000-10-04
JP2628230B2 (ja) 1997-07-09
MX9207438A (es) 1993-06-01
AU663146B2 (en) 1995-09-28
ZA929161B (en) 1993-05-25
IL104087A (en) 1998-10-30
AU3179393A (en) 1993-07-28
DE69231499D1 (de) 2000-11-09
NO942457L (no) 1994-06-29
BR9206996A (pt) 1995-12-05
US5725886A (en) 1998-03-10
WO1993012768A1 (en) 1993-07-08
CA2126441C (en) 1999-12-21
DE69231499T2 (de) 2001-05-03
FI943121A (fi) 1994-06-29
EP0619731A4 (en) 1995-05-03
CA2126441A1 (en) 1993-07-08
EP0619731A1 (en) 1994-10-19
FI943121A0 (fi) 1994-06-29
ATE196733T1 (de) 2000-10-15
JPH06511255A (ja) 1994-12-15
IL104087A0 (en) 1993-05-13
CN1074228A (zh) 1993-07-14
NO942457D0 (no) 1994-06-29

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