ES8604134A1 - Procedimiento para preparar derivados de acidos insaturados sustituidos con carboxialquiltio o carboxiamidoalquiltio. - Google Patents
Procedimiento para preparar derivados de acidos insaturados sustituidos con carboxialquiltio o carboxiamidoalquiltio.Info
- Publication number
- ES8604134A1 ES8604134A1 ES530310A ES530310A ES8604134A1 ES 8604134 A1 ES8604134 A1 ES 8604134A1 ES 530310 A ES530310 A ES 530310A ES 530310 A ES530310 A ES 530310A ES 8604134 A1 ES8604134 A1 ES 8604134A1
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- leukotriene antagonists
- substituted unsaturated
- mercaptocarboxylic acids
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDOS INSATURADOS SUSTITUIDOS CON CARBOXIALQUILTIO O CARBOXIAMIDOALQUILTIO Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE X, R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES; Y M Y P VALEN 0-2 Y 9-13 RESPECTIVAMENTE. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), CON UN COMPUESTO DE FORMULA (III), EN LAS QUE R3, R1 Y R2 SON, RESPECTIVAMENTE R, R1 Y R2 O RADICALES FACILMENTE CONVERTIBLES EN LOS MISMOS, Y M Y P TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA AMINA, A LA TEMPERATURA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES PARA EL TRATAMIENTO DE ENFERMEDADES EN LAS QUE INTERVIENEN LOS LEUCOTRIENOS, COMO EL ASMA.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47277383A | 1983-03-07 | 1983-03-07 | |
US06/472,772 US4533747A (en) | 1983-03-07 | 1983-03-07 | Leukotriene antagonists intermediates |
US06/472,774 US4552893A (en) | 1983-03-07 | 1983-03-07 | Leukotriene antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8604134A1 true ES8604134A1 (es) | 1986-01-16 |
ES530310A0 ES530310A0 (es) | 1986-01-16 |
Family
ID=27413217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530310A Expired ES8604134A1 (es) | 1983-03-07 | 1984-03-06 | Procedimiento para preparar derivados de acidos insaturados sustituidos con carboxialquiltio o carboxiamidoalquiltio. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0121350B1 (es) |
AU (2) | AU569064B2 (es) |
DE (1) | DE3463653D1 (es) |
DK (1) | DK130984A (es) |
ES (1) | ES8604134A1 (es) |
GR (1) | GR79832B (es) |
PT (1) | PT78196B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4623535A (en) * | 1984-01-19 | 1986-11-18 | Smithkline Beckman Corporation | Leukotriene antagonists |
ES8606260A1 (es) * | 1984-06-28 | 1986-04-16 | Ciba Geigy Ag | Procedimiento para la obtencion de tioeteres alifaticos |
US4798842A (en) * | 1984-07-18 | 1989-01-17 | Schering Corporation | Inhibitors of slow reacting substance of anaphylaxis |
US4889873A (en) * | 1984-07-18 | 1989-12-26 | Schering Corporation | Inhibitors of slow reacting substance of anaphylaxis |
US4758594A (en) * | 1984-07-18 | 1988-07-19 | Schering Corporation | Inhibitors of slow reacting substance of anaphylaxis |
US4988716A (en) * | 1984-07-18 | 1991-01-29 | Schering Corporation | Inhibitors of slow reacting substance of anaphylaxis |
FI864901A (fi) * | 1985-12-06 | 1987-06-07 | Ciba Geigy Ag | Hydroxitioetrar. |
FR2660655A1 (fr) * | 1990-04-09 | 1991-10-11 | Fournier Sca Laboratoires | Antagonistes de leucotrienes, leur procede de preparation et leur utilisation en therapeutique. |
AR040956A1 (es) | 2002-07-31 | 2005-04-27 | Schering Ag | Nuevos conjugados de efectores, procedimientos para su preparacion y su uso farmaceutico |
PL374528A1 (en) * | 2002-07-31 | 2005-10-31 | Schering Aktiengesellschaft | New effector conjugates, process for their production and their pharmaceutical use |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4311645A (en) * | 1980-03-24 | 1982-01-19 | Hoffmann-La Roche Inc. | Synthesis of SRS-active compounds |
US4513005A (en) * | 1981-06-18 | 1985-04-23 | Lilly Industries Limited | SRS-A antagonists |
US4461775A (en) * | 1982-08-02 | 1984-07-24 | Mcneilab, Inc. | Hydroxythioether fatty acid derivatives |
US4469705A (en) * | 1982-08-02 | 1984-09-04 | Mcneilab, Inc. | Saturated leukotriene derivatives as antiallergens |
-
1984
- 1984-02-29 DK DK130984A patent/DK130984A/da not_active Application Discontinuation
- 1984-03-02 GR GR73986A patent/GR79832B/el unknown
- 1984-03-02 PT PT7819684A patent/PT78196B/pt unknown
- 1984-03-05 DE DE8484301433T patent/DE3463653D1/de not_active Expired
- 1984-03-05 EP EP19840301433 patent/EP0121350B1/en not_active Expired
- 1984-03-06 ES ES530310A patent/ES8604134A1/es not_active Expired
- 1984-03-07 AU AU25352/84A patent/AU569064B2/en not_active Ceased
-
1987
- 1987-12-04 AU AU82121/87A patent/AU587922B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU2535284A (en) | 1984-09-13 |
EP0121350B1 (en) | 1987-05-13 |
PT78196B (en) | 1986-04-24 |
DK130984D0 (da) | 1984-02-29 |
AU587922B2 (en) | 1989-08-31 |
DE3463653D1 (en) | 1987-06-19 |
EP0121350A2 (en) | 1984-10-10 |
EP0121350A3 (en) | 1985-01-23 |
DK130984A (da) | 1984-09-08 |
GR79832B (es) | 1984-10-31 |
AU8212187A (en) | 1988-03-31 |
ES530310A0 (es) | 1986-01-16 |
PT78196A (en) | 1984-04-01 |
AU569064B2 (en) | 1988-01-21 |
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