WO2006107903A2 - Polymeric micelles for drug delivery - Google Patents
Polymeric micelles for drug delivery Download PDFInfo
- Publication number
- WO2006107903A2 WO2006107903A2 PCT/US2006/012382 US2006012382W WO2006107903A2 WO 2006107903 A2 WO2006107903 A2 WO 2006107903A2 US 2006012382 W US2006012382 W US 2006012382W WO 2006107903 A2 WO2006107903 A2 WO 2006107903A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chain
- group
- nitrogen
- optionally substituted
- protected
- Prior art date
Links
- 0 CCC(C)(CCO)ON* Chemical compound CCC(C)(CCO)ON* 0.000 description 8
- MREICTHRFCQNJR-UHFFFAOYSA-N C#CCOCCOCCOCCN Chemical compound C#CCOCCOCCOCCN MREICTHRFCQNJR-UHFFFAOYSA-N 0.000 description 1
- VLNGAWLXTMFVPW-UHFFFAOYSA-N CC(C)(C(N[I](C)C)=O)Br Chemical compound CC(C)(C(N[I](C)C)=O)Br VLNGAWLXTMFVPW-UHFFFAOYSA-N 0.000 description 1
- BMNTUAGBVADDDK-YFKPBYRVSA-N CC(C)(C)OC(C[C@@H](C(O1)=O)NC1=O)=O Chemical compound CC(C)(C)OC(C[C@@H](C(O1)=O)NC1=O)=O BMNTUAGBVADDDK-YFKPBYRVSA-N 0.000 description 1
- RTUDQBPZFFIRAD-JTQLQIEISA-N CC([C@H](Cc1ccccc1)N)=O Chemical compound CC([C@H](Cc1ccccc1)N)=O RTUDQBPZFFIRAD-JTQLQIEISA-N 0.000 description 1
- JVKXRDUBMZCFDT-UHFFFAOYSA-N CC(c1c2cccc1)(c1ccccc11)[Si]21C#CCOCCOCCOCCN Chemical compound CC(c1c2cccc1)(c1ccccc11)[Si]21C#CCOCCOCCOCCN JVKXRDUBMZCFDT-UHFFFAOYSA-N 0.000 description 1
- XOYKIUZWCICSAK-UHFFFAOYSA-N C[IH]N(Cc(cc1)ccc1Br)Cc(cc1)ccc1Br Chemical compound C[IH]N(Cc(cc1)ccc1Br)Cc(cc1)ccc1Br XOYKIUZWCICSAK-UHFFFAOYSA-N 0.000 description 1
- GQBIVYSGPXCELZ-QMMMGPOBSA-N O=C([C@H](Cc1ccccc1)N1)OC1=O Chemical compound O=C([C@H](Cc1ccccc1)N1)OC1=O GQBIVYSGPXCELZ-QMMMGPOBSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
- A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/40—Polyamides containing oxygen in the form of ether groups
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
- C08G73/028—Polyamidoamines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Nanotechnology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Virology (AREA)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ562064A NZ562064A (en) | 2005-04-01 | 2006-04-03 | Polymeric micelles for drug delivery |
CA2603853A CA2603853C (en) | 2005-04-01 | 2006-04-03 | Polymeric micelles for drug delivery |
DE602006008625T DE602006008625D1 (de) | 2005-04-01 | 2006-04-03 | Polymermicellen für die arzneistoffzufuhr |
JP2008504516A JP4390845B2 (ja) | 2005-04-01 | 2006-04-03 | 薬物送達のためのポリマーミセル |
MX2007012157A MX2007012157A (es) | 2005-04-01 | 2006-04-03 | Micelas polimericas para suministro de farmacos. |
EP06749187A EP1907444B1 (en) | 2005-04-01 | 2006-04-03 | Polymeric micelles for drug delivery |
AU2006231452A AU2006231452B2 (en) | 2005-04-01 | 2006-04-03 | Polymeric micelles for drug delivery |
AT06749187T ATE440117T1 (de) | 2005-04-01 | 2006-04-03 | Polymermicellen für die arzneistoffzufuhr |
KR1020077024561A KR101288729B1 (ko) | 2005-04-01 | 2006-04-03 | 약물 전달용 중합체성 마이셀 |
IL186254A IL186254A (en) | 2005-04-01 | 2007-09-25 | Polymeric drugs for drug delivery |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66726005P | 2005-04-01 | 2005-04-01 | |
US60/667,260 | 2005-04-01 | ||
US74178005P | 2005-12-01 | 2005-12-01 | |
US60/741,780 | 2005-12-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006107903A2 true WO2006107903A2 (en) | 2006-10-12 |
WO2006107903A3 WO2006107903A3 (en) | 2007-02-15 |
Family
ID=36951510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/012382 WO2006107903A2 (en) | 2005-04-01 | 2006-04-03 | Polymeric micelles for drug delivery |
Country Status (13)
Cited By (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008106657A2 (en) * | 2007-03-01 | 2008-09-04 | Intezyne Technologies, Inc. | Encapsulated amyloid-beta peptides |
WO2008134734A2 (en) * | 2007-04-30 | 2008-11-06 | Intezyne Technologies, Inc. | Encapsulated contrast agents |
WO2009147438A1 (en) * | 2008-06-04 | 2009-12-10 | Gw Pharma Limited | Cannabinoids in combination with non -cannabinoid chemotherapeutic agents (e.g. serm or alkylating agents) |
JP2010526183A (ja) * | 2007-04-30 | 2010-07-29 | インテザイン テクノロジーズ, インコーポレイテッド | 疎水性薬物のカプセル化のために混合立体化学を有するハイブリッドブロックコポリマー |
JP2011503067A (ja) * | 2007-11-07 | 2011-01-27 | マリンクロッド・インコーポレイテッド | 生物学的適用のためのフォトニックシェルコアが架橋し、官能化されたナノ構造 |
US8034396B2 (en) | 2008-04-01 | 2011-10-11 | Tyco Healthcare Group Lp | Bioadhesive composition formed using click chemistry |
US8188046B2 (en) | 2006-10-16 | 2012-05-29 | University Of South Florida | Amyloid beta peptides and methods of use |
WO2011143524A3 (en) * | 2010-05-14 | 2012-10-04 | Mallinckrodt Llc | Functional, cross-linked nanostructures for tandem optical imaging and therapy |
WO2013007709A3 (de) * | 2011-07-08 | 2013-04-04 | Cynora Gmbh | Querverknüpfung und stabilisierung von organischen metallkomplexen in netzwerken |
WO2013075394A1 (zh) * | 2011-11-22 | 2013-05-30 | 原创生医股份有限公司 | 具有螯合型复合微胞的药物载体及其应用 |
US8512728B2 (en) | 2009-02-21 | 2013-08-20 | Sofradim Production | Method of forming a medical device on biological tissue |
US8535477B2 (en) | 2009-02-21 | 2013-09-17 | Sofradim Production | Medical devices incorporating functional adhesives |
EP2660255A1 (en) * | 2012-04-11 | 2013-11-06 | Intezyne Technologies Inc. | Block copolymers for stable micelles |
US8632825B2 (en) | 2008-06-04 | 2014-01-21 | Gw Pharma Limited | Anti-tumoural effects of cannabinoid combinations |
US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
US8663689B2 (en) | 2009-02-21 | 2014-03-04 | Sofradim Production | Functionalized adhesive medical gel |
US8790719B2 (en) | 2010-03-12 | 2014-07-29 | Gw Pharma Limited | Phytocannabinoids in the treatment of cancer |
US8865857B2 (en) | 2010-07-01 | 2014-10-21 | Sofradim Production | Medical device with predefined activated cellular integration |
US8877170B2 (en) | 2009-02-21 | 2014-11-04 | Sofradim Production | Medical device with inflammatory response-reducing coating |
US8968733B2 (en) | 2009-02-21 | 2015-03-03 | Sofradim Production | Functionalized surgical adhesives |
US9084771B2 (en) | 2007-05-17 | 2015-07-21 | Sutter West Bay Hospitals | Methods and compositions for treating cancer |
US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
US9247931B2 (en) | 2010-06-29 | 2016-02-02 | Covidien Lp | Microwave-powered reactor and method for in situ forming implants |
US9775928B2 (en) | 2013-06-18 | 2017-10-03 | Covidien Lp | Adhesive barbed filament |
US9901616B2 (en) | 2011-08-31 | 2018-02-27 | University Of Georgia Research Foundation, Inc. | Apoptosis-targeting nanoparticles |
US9944752B2 (en) | 2012-04-11 | 2018-04-17 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
US10143689B2 (en) | 2017-02-08 | 2018-12-04 | Interzyne Technologies, Inc. | SN-38 loaded iron crosslinked micelle and methods thereof |
CN109111582A (zh) * | 2018-06-14 | 2019-01-01 | 哈尔滨工业大学无锡新材料研究院 | 一种聚醚胺-戊二酸共聚物胶团及其制备方法 |
US10398663B2 (en) | 2014-03-14 | 2019-09-03 | University Of Georgia Research Foundation, Inc. | Mitochondrial delivery of 3-bromopyruvate |
US10416167B2 (en) | 2012-02-17 | 2019-09-17 | University Of Georgia Research Foundation, Inc. | Nanoparticles for mitochondrial trafficking of agents |
CN111228301A (zh) * | 2020-01-14 | 2020-06-05 | 哈尔滨医科大学 | 一种用于治疗血管生成介导疾病的复方制剂及其制备方法和应用 |
CN111297876A (zh) * | 2020-01-16 | 2020-06-19 | 武汉理工大学 | 一种塞来昔布胶束和和厚朴酚胶束药物联用控释系统及其制备方法 |
US10758514B2 (en) | 2013-06-19 | 2020-09-01 | Gw Pharma Limited | Use of tetrahydrocannabinol and/or cannabidiol for increasing radiosensitivity in the treatment of a brain tumour |
WO2022145486A1 (en) * | 2020-12-28 | 2022-07-07 | Kawasaki Institute Of Industrial Promotion | Poly-ion complex micelle |
US11607384B2 (en) * | 2017-12-08 | 2023-03-21 | Western University Of Health Sciences | Lipid emulsified drug delivery systems for chemoprevention and treatment |
Families Citing this family (160)
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US20080281041A1 (en) | 1999-06-07 | 2008-11-13 | Rozema David B | Reversibly Masked Polymers |
US8137695B2 (en) * | 2006-08-18 | 2012-03-20 | Arrowhead Madison Inc. | Polyconjugates for in vivo delivery of polynucleotides |
US8008355B2 (en) * | 2002-03-11 | 2011-08-30 | Roche Madison Inc. | Endosomolytic poly(vinyl ether) polymers |
US8138383B2 (en) * | 2002-03-11 | 2012-03-20 | Arrowhead Madison Inc. | Membrane active heteropolymers |
AU2003230761A1 (en) * | 2002-03-29 | 2003-10-13 | Abbott Laboratories | Polymeric micelle formulations of hydrophobic compounds and methods |
US9198887B2 (en) | 2003-09-15 | 2015-12-01 | Nanopharmaceuticals Llc | Thyroid hormone analogs and methods of use |
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CA2539288C (en) | 2003-09-15 | 2015-05-12 | Shaker A. Mousa | Thyroid hormone analogs and methods of use |
US20050214379A1 (en) * | 2004-01-02 | 2005-09-29 | Sandro Mecozzi | Encapsulation of chemical compounds in fluorous-core and fluorous-inner-shell micelles formed from semifluorinated-block or fluorinated-block copolymers |
EP2348096A3 (en) | 2005-01-04 | 2011-11-09 | Intezyne Technologies Inc. | Synthesis of hybrid block copolymers and uses thereof |
US10130686B2 (en) | 2005-09-15 | 2018-11-20 | Nanopharmaceuticals Llc | Method and composition of thyroid hormone analogues and nanoformulations thereof for treating inflammatory disorders |
US9220788B2 (en) | 2009-06-17 | 2015-12-29 | Nanopharmaceuticals Llc | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof |
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Also Published As
Publication number | Publication date |
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IL186254A0 (en) | 2008-01-20 |
KR101288729B1 (ko) | 2013-07-23 |
US20060240092A1 (en) | 2006-10-26 |
CA2603853C (en) | 2013-11-19 |
ATE440117T1 (de) | 2009-09-15 |
AU2006231452B2 (en) | 2011-05-26 |
AU2006231452A1 (en) | 2006-10-12 |
EP1907444A2 (en) | 2008-04-09 |
ES2332062T3 (es) | 2010-01-25 |
DE602006008625D1 (de) | 2009-10-01 |
EP1907444B1 (en) | 2009-08-19 |
IL186254A (en) | 2012-04-30 |
MX2007012157A (es) | 2008-03-14 |
US7638558B2 (en) | 2009-12-29 |
US20100159020A1 (en) | 2010-06-24 |
US8426477B1 (en) | 2013-04-23 |
WO2006107903A3 (en) | 2007-02-15 |
US8299128B2 (en) | 2012-10-30 |
JP2008537943A (ja) | 2008-10-02 |
NZ562064A (en) | 2011-03-31 |
US20130195987A1 (en) | 2013-08-01 |
US20110092668A1 (en) | 2011-04-21 |
US20110091534A1 (en) | 2011-04-21 |
US8263665B2 (en) | 2012-09-11 |
US8263663B2 (en) | 2012-09-11 |
US8779008B2 (en) | 2014-07-15 |
KR20080015070A (ko) | 2008-02-18 |
CA2603853A1 (en) | 2006-10-12 |
JP4390845B2 (ja) | 2009-12-24 |
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