WO2006069246A2 - Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides - Google Patents

Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides Download PDF

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Publication number
WO2006069246A2
WO2006069246A2 PCT/US2005/046618 US2005046618W WO2006069246A2 WO 2006069246 A2 WO2006069246 A2 WO 2006069246A2 US 2005046618 W US2005046618 W US 2005046618W WO 2006069246 A2 WO2006069246 A2 WO 2006069246A2
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WO
WIPO (PCT)
Prior art keywords
substituted
alkylene
group
amino acid
alkyl
Prior art date
Application number
PCT/US2005/046618
Other languages
English (en)
French (fr)
Other versions
WO2006069246A3 (en
WO2006069246A9 (en
Inventor
Zhenwei Miao
Junjie Liu
Thea Norman
Russell Driver
Original Assignee
Ambrx, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP05855215.9A priority Critical patent/EP1828224B1/en
Priority to CA2590590A priority patent/CA2590590C/en
Priority to MX2007007590A priority patent/MX2007007590A/es
Priority to GB0713066A priority patent/GB2438982A/en
Priority to EP11177567.2A priority patent/EP2399893B1/en
Priority to KR1020077016540A priority patent/KR101423769B1/ko
Priority to AU2005319125A priority patent/AU2005319125A1/en
Application filed by Ambrx, Inc. filed Critical Ambrx, Inc.
Priority to NZ555308A priority patent/NZ555308A/en
Priority to JP2007548475A priority patent/JP5425398B2/ja
Priority to BRPI0516385-4A priority patent/BRPI0516385B1/pt
Priority to DK05855215.9T priority patent/DK1828224T3/en
Publication of WO2006069246A2 publication Critical patent/WO2006069246A2/en
Publication of WO2006069246A9 publication Critical patent/WO2006069246A9/en
Priority to IL183346A priority patent/IL183346A/en
Priority to HK08102427.1A priority patent/HK1111702A1/zh
Publication of WO2006069246A3 publication Critical patent/WO2006069246A3/en
Priority to AU2010226982A priority patent/AU2010226982B2/en
Priority to IL220740A priority patent/IL220740A/en
Priority to IL227753A priority patent/IL227753A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/04—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
    • C07C225/08—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • C07C225/10—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings with doubly-bound oxygen atoms bound to carbon atoms not being part of rings
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
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    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
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    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
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