WO2006037342A2 - Controlled release pharmaceutical compositions comprising a fumaric acid ester - Google Patents

Controlled release pharmaceutical compositions comprising a fumaric acid ester Download PDF

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Publication number
WO2006037342A2
WO2006037342A2 PCT/DK2005/000648 DK2005000648W WO2006037342A2 WO 2006037342 A2 WO2006037342 A2 WO 2006037342A2 DK 2005000648 W DK2005000648 W DK 2005000648W WO 2006037342 A2 WO2006037342 A2 WO 2006037342A2
Authority
WO
WIPO (PCT)
Prior art keywords
fumaric acid
controlled release
composition according
pharmaceutical composition
acid ester
Prior art date
Application number
PCT/DK2005/000648
Other languages
English (en)
French (fr)
Other versions
WO2006037342A3 (en
Inventor
Henrik Nilsson
Florian SCHÖNHARTING
Bernd W. MÜLLER
Joseph R. Robinson
Original Assignee
Aditech Pharma Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
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Application filed by Aditech Pharma Ab filed Critical Aditech Pharma Ab
Priority to LTEP05789026.1T priority Critical patent/LT1799196T/lt
Priority to PT10182198T priority patent/PT2316430E/pt
Priority to DK05789026.1T priority patent/DK1799196T3/en
Priority to EP10182198A priority patent/EP2316430B8/en
Priority to PCT/DK2005/000648 priority patent/WO2006037342A2/en
Priority to US11/576,871 priority patent/US20140099364A2/en
Priority to EP05789026.1A priority patent/EP1799196B1/en
Priority to PL10182198T priority patent/PL2316430T3/pl
Priority to ES10182198T priority patent/ES2387192T3/es
Priority to HK07114067.2A priority patent/HK1108836B/en
Priority to JP2007535023A priority patent/JP2008515822A/ja
Priority to SI200531565T priority patent/SI2316430T1/sl
Priority to EP18204738.1A priority patent/EP3459532A1/en
Priority to DK10182198.1T priority patent/DK2316430T3/da
Priority to ES05789026.1T priority patent/ES2582942T3/es
Priority to EP18208053.1A priority patent/EP3470064A1/en
Priority to PT57890261T priority patent/PT1799196T/pt
Priority to SI200532086A priority patent/SI1799196T1/sl
Publication of WO2006037342A2 publication Critical patent/WO2006037342A2/en
Publication of WO2006037342A3 publication Critical patent/WO2006037342A3/en
Priority to CNA2006800415268A priority patent/CN101304732A/zh
Priority to EP06791451A priority patent/EP1951206A1/en
Priority to PCT/DK2006/000561 priority patent/WO2007042034A1/en
Priority to JP2008533870A priority patent/JP2009510137A/ja
Priority to US12/089,074 priority patent/US20080299196A1/en
Priority to PCT/DK2006/000563 priority patent/WO2007042035A2/en
Priority to EP06791453A priority patent/EP1940382A2/en
Priority to US12/089,004 priority patent/US20080300217A1/en
Priority to JP2012267572A priority patent/JP2013064007A/ja
Priority to US13/957,117 priority patent/US20140037720A1/en
Priority to US13/957,250 priority patent/US20140037740A1/en
Priority to US13/957,220 priority patent/US20130316003A1/en
Priority to US13/957,147 priority patent/US20130315993A1/en
Priority to US14/209,823 priority patent/US20150024049A1/en
Priority to US14/209,712 priority patent/US20140199386A1/en
Priority to US14/209,651 priority patent/US20140200273A1/en
Priority to US14/209,584 priority patent/US20140200272A1/en
Priority to US14/209,756 priority patent/US20140199393A1/en
Priority to US14/209,480 priority patent/US20170112793A2/en
Priority to US14/212,503 priority patent/US20140199390A1/en
Priority to US14/213,321 priority patent/US20140199387A1/en
Priority to US14/213,673 priority patent/US20140199388A1/en
Priority to US14/213,399 priority patent/US20140205659A1/en
Priority to US14/212,685 priority patent/US20140199392A1/en
Priority to CY20161100847T priority patent/CY1117937T1/el
Priority to US15/581,966 priority patent/US20170231941A1/en
Priority to US15/728,872 priority patent/US20180028483A1/en
Priority to US15/834,870 priority patent/US20180098957A1/en
Priority to US15/988,628 priority patent/US20180263947A1/en
Priority to US16/046,509 priority patent/US20180325855A1/en
Priority to US16/204,503 priority patent/US20190091192A1/en
Priority to US16/204,559 priority patent/US20190091193A1/en
Priority to US16/204,403 priority patent/US20190091191A1/en
Priority to US16/227,287 priority patent/US11229619B2/en
Priority to US16/294,038 priority patent/US20190201368A1/en
Priority to US16/525,392 priority patent/US11052062B2/en
Priority to US17/185,600 priority patent/US20210220318A1/en
Priority to US17/553,367 priority patent/US20220105064A1/en

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    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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Definitions

  • Fumaraat 120® Another marketed composition is Fumaraat 120® containing 120 mg of dimethylfumarate and 95 mg of calcium monoethylfumarate (TioFarma, Oud-Beijerland, Netherlands).
  • Fumaraat 120® containing 120 mg of dimethylfumarate and 95 mg of calcium monoethylfumarate (TioFarma, Oud-Beijerland, Netherlands).
  • the pharmacokinetic profile of Fumaraat 120® is described in healthy subjects. The results show that a single oral dose of Fumaraat 120® is followed by a rise in serum monomethylfumarate concentration and only negligible concentrations of dimethylfumarate and fumaric acid is observed.
  • the active substance in a composition of the invention is any fumaric acid ester.
  • the fumaric acid ester is preferably selected from the group consisting of dimethylfumarate, diethylfumarate, dipropylfumarate, dibutylfumarate, dipentylfumarate, methyl-ethylfumarate, methyl-propylfumarate, methyl-butylfumarate, methyl-pentylfumarate, monomethylfumarate, monoethylfumarate, monopropylfumarate, monobutylfumarate and monopentylfumarate, including pharmaceutically acceptable salts thereof.
  • composition of the invention comprises the active substance in the form of micro-crystals with hydroph ilic surfaces.
  • the micro-crystals are filmcoated directly, in order to achieve a sustained release formulation.
  • a controlled release pharmaceutical composition comprising as an active substance one or more fumaric acid esters selected from CJi-(C 1 - C 5 )alkylesters of fumaric acid and mono-(C 1 -C 5 )alkylesters of fumaric acid, or a pharmaceutically acceptable salt thereof, characterized in that it consists of a controlled- release dosage form adapted to release di-(Ci-C 5 )alkylester and/or a mono-(Ci-C 5 )alkylester of fumaric acid or a pharmaceutically acceptable salt thereof over a predetermined time period, according to a in vitro profile of dissolution when measured according to USP in 0.1 N hydrochloric acid during the first 2 hours and then 0.05 M phosphate buffer at a pH 6.5 or 6.8,
  • the most about 85% w/w such as, e.g., from about 50% to about 85% w/w, from about 60% to about 80% w/w, or about 75% w/w of the total amount of the fumaric acid ester contained in the composition is released, and/or within the first 8 hours after start of the test at the most about 92% w/w such as, e.g., from about 30% to about 92% w/w, from about 35% to about 90% w/w, from about 40% to about 85% w/w, from about 45% to about 80% w/w, from about 50% to about 75% w/w, from about 55% to about 75% w/w, from about 60% to about 75% w/w, or about 65% w/w, or about 70% w/w of the total amount of the fumaric acid ester contained in the composition is released, and/or
  • the composition within the first 10 hours after start of the test at the most about 85% w/w such as, e.g., from about 50% to about 85% w/w such as, e.g., from about 60% to about 80% w/w, or about 75% w/w of the total amount of the fumaric acid ester contained in the composition is released, and/or within the first 12 hours after start of the test at least about 80% w/w such as, e.g., about 80% w/w or more such as, e.g., about 85% w/w or more, about 90% w/w or more or about 95% w/w or more of the total amount of the fumaric acid ester contained in the composition is released.
  • 80% w/w such as, e.g., about 80% w/w or more such as, e.g., about 85% w/w or more, about 90% w/w or more or about 95% w/w or more of the total amount of
  • the most about 95% w/w such as, e.g., from about 35% to about 95% w/w, from about 40% to about 90% w/w, from about 45% to about 85% w/w, from about 50% to about 85% w/w, from about 55% to about 85% w/w, from about 60% to about 85% w/w, from about 65% to about 85% w/w, from about 70% to about 85% w/w, from about 75% to about 85% w/w, or about 65% w/w, or about 70% w/w, or about 75% w/w, or about 80% w/w of the total amount of the fumaric acid ester contained in the composition is released, and/or
  • the invention relates to a controlled release pharmaceutical composition for oral use comprising as an active substance one or more fumaric acid esters selected from di-(C 1 -C 5 )alkylesters of fumaric acid and mono-(C 1 -C 5 )alkylesters of fumaric acid, or a pharmaceutically acceptable salt thereof, wherein the release of the fumaric acid ester - when subjected to an in vitro dissolution test according to the "half-change" method - is as follows:
  • One aspect of the invention relates to a zero-order dissolution release profile. Another aspect relates to a first-order dissolution release profile. A further aspect relates to a square-root (Higuchi 's equation) dissolution release profile.
  • an oral anti-psoriatic drug such as 1) an oral retinoid (such as acitretin or etretinate) combined or not combined with PUVA, 2) cyclosporine and other calcineurin inhibitors, such as ISA247, tacrolimus and pimecrolimus, 3) methotrexate, 4) hydroxyurea, 5) azathioprine, 6) sulphasalazine, 7) a fumarate derivative (such as e.g.
  • nutritional therapies such as elemental or polymeric formulas or pre- and probiotics
  • Eudragit ® L30D-55 is sprayed at drying temperatures of 6O°C to 80 0 C onto the tablets in an amount of 6 mg polymeric material per mm 2 . Pigments and talc are added in an appropriate amount.
  • a saturated solution of 50 g DMF in 300 ml 2-propanol is prepared at 60 0 C and slowly cooled under permanent stirring.
  • the precipitated crystals are filtered off and dried at 50 0 C.
  • the crystals are sieved and the 315 - 710 ⁇ m fraction is used for a coating process in either a pan coater or a fluid-bed coater (Mini-Glatt).
  • a coating solution of 12 g ethyl cellulose (e.g. Ethocel ® NF premium) and 3 g polyethylene glycole 400 in 500 g ethanol is sprayed at 60 0 C onto the powder surface. After drying, the coated crystals are sieved through a 1.00 mm sieve.
  • Ethylcellulose e.g. Ethocel ® NF premium
  • Polyethylenglycole 400 which is dissolved in 150 ml Ethanol 96%, passed through a 1,0 mm sieve, dried at 50° to 6O 0 C over 30 min and again passed through a sieve 1,0 mm.
  • a placebo granulate is prepared as follows: Tablettose ® and Avicel ® 102 are mixed in equal shares and granulated with 2% povidone (e.g.

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PCT/DK2005/000648 2004-10-08 2005-10-07 Controlled release pharmaceutical compositions comprising a fumaric acid ester WO2006037342A2 (en)

Priority Applications (56)

Application Number Priority Date Filing Date Title
LTEP05789026.1T LT1799196T (lt) 2004-10-08 2005-10-07 Kontroliuojamo atpalaidavimo farmacinė kompozicija, apimanti fumaro rūgšties esterį
PT10182198T PT2316430E (pt) 2004-10-08 2005-10-07 Composições farmacêuticas de libertação controlada compreendendo um éster de ácido fumárico
DK05789026.1T DK1799196T3 (en) 2004-10-08 2005-10-07 Controlled release pharmaceutical compositions comprising a fumaric acid ester
EP10182198A EP2316430B8 (en) 2004-10-08 2005-10-07 Controlled release pharmaceutical compositions comprising a fumaric acid ester
PCT/DK2005/000648 WO2006037342A2 (en) 2004-10-08 2005-10-07 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US11/576,871 US20140099364A2 (en) 2004-10-08 2005-10-07 Controlled release pharmaceutical compositions comprising a fumaric acid ester
EP05789026.1A EP1799196B1 (en) 2004-10-08 2005-10-07 Controlled release pharmaceutical compositions comprising a fumaric acid ester
PL10182198T PL2316430T3 (pl) 2004-10-08 2005-10-07 Kompozycje farmaceutyczne o kontrolowanym uwalnianiu, zawierające ester kwasu fumarowego
ES10182198T ES2387192T3 (es) 2004-10-08 2005-10-07 Composiciones farmacéuticas de liberación controlada que comprenden un éster de ácido fumárico
HK07114067.2A HK1108836B (en) 2004-10-08 2005-10-07 Controlled release pharmaceutical compositions comprising a fumaric acid ester
JP2007535023A JP2008515822A (ja) 2004-10-08 2005-10-07 フマル酸エステルを含む制御放出医薬組成物
SI200531565T SI2316430T1 (sl) 2004-10-08 2005-10-07 Farmacevtski sestavki z nadziranim sproščanjem, ki obsegajo ester fumarne kisline
EP18204738.1A EP3459532A1 (en) 2004-10-08 2005-10-07 Controlled release pharmaceutical compositions comprising a fumaric acid ester
DK10182198.1T DK2316430T3 (da) 2004-10-08 2005-10-07 Farmaceutiske sammensætninger med kontrolleret frigivelse omfattende en fumarsyreester
ES05789026.1T ES2582942T3 (es) 2004-10-08 2005-10-07 Composiciones farmacéuticas de liberación controlada que comprenden un éster de ácido fumárico
EP18208053.1A EP3470064A1 (en) 2004-10-08 2005-10-07 Controlled release pharmaceutical compositions comprising a fumaric acid ester
PT57890261T PT1799196T (pt) 2004-10-08 2005-10-07 Composições farmacêuticas de libertação controlada compreendendo um éster de ácido fumárico
SI200532086A SI1799196T1 (sl) 2004-10-08 2005-10-07 Farmacevtski sestavki z nadzorovanim sproščanjem, obsegajoči ester fumarne kisline
CNA2006800415268A CN101304732A (zh) 2005-10-07 2006-10-06 包含富马酸酯的控释药物组合物
EP06791451A EP1951206A1 (en) 2005-10-07 2006-10-06 Controlled release pharmaceutical compositions comprising a fumaric acid ester
PCT/DK2006/000561 WO2007042034A1 (en) 2005-10-07 2006-10-06 Controlled release pharmaceutical compositions comprising a fumaric acid ester
JP2008533870A JP2009510137A (ja) 2005-10-07 2006-10-06 フマル酸エステルを含む制御放出医薬組成物
US12/089,074 US20080299196A1 (en) 2005-10-07 2006-10-06 Controlled Release Pharmaceutical Compositions Comprising a Fumaric Acid Ester
PCT/DK2006/000563 WO2007042035A2 (en) 2005-10-07 2006-10-06 Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders
EP06791453A EP1940382A2 (en) 2005-10-07 2006-10-06 Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders
US12/089,004 US20080300217A1 (en) 2005-10-07 2006-10-09 Combination Therapy with Fumaric Acid Esters for the Treatment of Autoimmune and/or Inflammatory Disorders
JP2012267572A JP2013064007A (ja) 2004-10-08 2012-12-06 フマル酸エステルを含む制御放出医薬組成物
US13/957,117 US20140037720A1 (en) 2004-10-08 2013-08-01 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US13/957,250 US20140037740A1 (en) 2004-10-08 2013-08-01 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US13/957,220 US20130316003A1 (en) 2004-10-08 2013-08-01 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US13/957,147 US20130315993A1 (en) 2004-10-08 2013-08-01 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/209,823 US20150024049A1 (en) 2004-10-08 2014-03-13 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/209,712 US20140199386A1 (en) 2004-10-08 2014-03-13 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/209,651 US20140200273A1 (en) 2004-10-08 2014-03-13 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/209,584 US20140200272A1 (en) 2004-10-08 2014-03-13 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/209,756 US20140199393A1 (en) 2004-10-08 2014-03-13 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/209,480 US20170112793A2 (en) 2004-10-08 2014-03-13 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/212,503 US20140199390A1 (en) 2004-10-08 2014-03-14 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/213,321 US20140199387A1 (en) 2004-10-08 2014-03-14 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/213,673 US20140199388A1 (en) 2004-10-08 2014-03-14 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/213,399 US20140205659A1 (en) 2004-10-08 2014-03-14 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/212,685 US20140199392A1 (en) 2004-10-08 2014-03-14 Controlled release pharmaceutical compositions comprising a fumaric acid ester
CY20161100847T CY1117937T1 (el) 2004-10-08 2016-08-30 Φαρμακευτικες συνθεσεις ελεγχομενης αποδεσμευσης που περιλαμβανουν εστερα φουμαρικου οξεος
US15/581,966 US20170231941A1 (en) 2004-10-08 2017-04-28 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US15/728,872 US20180028483A1 (en) 2004-10-08 2017-10-10 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US15/834,870 US20180098957A1 (en) 2004-10-08 2017-12-07 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US15/988,628 US20180263947A1 (en) 2004-10-08 2018-05-24 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US16/046,509 US20180325855A1 (en) 2004-10-08 2018-07-26 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US16/204,503 US20190091192A1 (en) 2004-10-08 2018-11-29 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US16/204,559 US20190091193A1 (en) 2004-10-08 2018-11-29 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US16/204,403 US20190091191A1 (en) 2004-10-08 2018-11-29 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US16/227,287 US11229619B2 (en) 2004-10-08 2018-12-20 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US16/294,038 US20190201368A1 (en) 2004-10-08 2019-03-06 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US16/525,392 US11052062B2 (en) 2004-10-08 2019-07-29 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US17/185,600 US20210220318A1 (en) 2004-10-08 2021-02-25 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US17/553,367 US20220105064A1 (en) 2004-10-08 2021-12-16 Controlled release pharmaceutical compositions comprising a fumaric acid ester

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DKPA200401546 2004-10-08
DKPA200401546 2004-10-08
DKPA200401736 2004-11-10
DKPA200401736 2004-11-10
DKPA200500211 2005-02-11
DKPA200500211 2005-02-11
DKPA200500419 2005-03-23
DKPA200500419 2005-03-23
US69151305P 2005-06-16 2005-06-16
US60/691,513 2005-06-16
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US11/576,871 A-371-Of-International US20140099364A2 (en) 2004-10-08 2005-10-07 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US13/957,220 Continuation US20130316003A1 (en) 2004-10-08 2013-08-01 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US13/957,117 Continuation US20140037720A1 (en) 2004-10-08 2013-08-01 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US13/957,147 Continuation US20130315993A1 (en) 2004-10-08 2013-08-01 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US13/957,250 Continuation US20140037740A1 (en) 2004-10-08 2013-08-01 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/209,756 Continuation US20140199393A1 (en) 2004-10-08 2014-03-13 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/209,584 Continuation US20140200272A1 (en) 2004-10-08 2014-03-13 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/209,712 Continuation US20140199386A1 (en) 2004-10-08 2014-03-13 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/209,480 Continuation US20170112793A2 (en) 2004-10-08 2014-03-13 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/209,823 Continuation US20150024049A1 (en) 2004-10-08 2014-03-13 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/209,651 Continuation US20140200273A1 (en) 2004-10-08 2014-03-13 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/212,685 Continuation US20140199392A1 (en) 2004-10-08 2014-03-14 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/213,321 Continuation US20140199387A1 (en) 2004-10-08 2014-03-14 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/212,503 Continuation US20140199390A1 (en) 2004-10-08 2014-03-14 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/213,399 Continuation US20140205659A1 (en) 2004-10-08 2014-03-14 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US14/213,673 Continuation US20140199388A1 (en) 2004-10-08 2014-03-14 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US16/204,403 Division US20190091191A1 (en) 2004-10-08 2018-11-29 Controlled release pharmaceutical compositions comprising a fumaric acid ester
US16/204,503 Division US20190091192A1 (en) 2004-10-08 2018-11-29 Controlled release pharmaceutical compositions comprising a fumaric acid ester
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Cited By (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007042034A1 (en) * 2005-10-07 2007-04-19 Aditech Pharma Ab Controlled release pharmaceutical compositions comprising a fumaric acid ester
WO2007042035A3 (en) * 2005-10-07 2007-06-14 Aditech Pharma Ab Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders
EP1799196A2 (en) 2004-10-08 2007-06-27 Aditech Pharma AB Controlled release pharmaceutical compositions comprising a fumaric acid ester
US7320999B2 (en) 1998-11-19 2008-01-22 Fumapharm Ag Dimethyl fumarate for the treatment of multiple sclerosis
WO2008097596A2 (en) 2007-02-08 2008-08-14 Biogen Idec Ma Inc. Nrf2 screening assays and related methods and compositions
WO2010079221A1 (en) * 2009-01-09 2010-07-15 Forward Pharma A/S Pharmaceutical composition comprising one or more fumaric acid esters
WO2010079222A1 (en) * 2009-01-09 2010-07-15 Forward Pharma A/S Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
EP2424357A1 (en) 2009-04-29 2012-03-07 Biogen Idec MA Inc. Treatment of neurodegeneration and neuroinflammation
US8148414B2 (en) 2008-08-19 2012-04-03 Xenoport, Inc. Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use
WO2013092269A1 (en) 2011-12-19 2013-06-27 Ares Trading S.A. Pharmaceutical compositions comprising glitazones and nrf2 activators
WO2013119677A1 (en) 2012-02-07 2013-08-15 Biogen Idec Ma Inc. Pharmaceutical compositions containing dimethyl fumarate
WO2013119791A1 (en) 2012-02-07 2013-08-15 Xenoport, Inc. Morpholinoalkyl fumarate compounds, pharmaceutical compositions, and methods of use
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
WO2014100728A1 (en) 2012-12-21 2014-06-26 Biogen Idec Ma Inc. Deuterium substituted fumarate derivatives
WO2014152494A1 (en) 2013-03-14 2014-09-25 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various deseases
WO2014160633A1 (en) 2013-03-24 2014-10-02 Xenoport, Inc. Pharmaceutical compositions of dimethyl fumarate
WO2014197860A1 (en) 2013-06-07 2014-12-11 Xenoport, Inc. Method of making monomethyl fumarate
US8980832B2 (en) 2003-09-09 2015-03-17 Biogen Idec International Gmbh Use of fumaric acid derivatives for treating cardiac insufficiency, and asthma
WO2015086467A1 (en) * 2013-12-12 2015-06-18 Almirall, S.A. Pharmaceutical compositions comprising dimethyl fumarate
US9132082B2 (en) 2005-05-11 2015-09-15 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
WO2015138917A1 (en) 2014-03-14 2015-09-17 Biogen Ma Inc. Dimethyl fumarate and vaccination regimens
US9233092B2 (en) 2006-07-25 2016-01-12 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with PPI
EP2982371A1 (en) 2010-02-12 2016-02-10 Biogen MA Inc. Dimethyl fumarate with glatiramer acetate or interferon-beta for treating multiple sclerosis
US9278080B2 (en) 2005-05-11 2016-03-08 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
WO2016061393A1 (en) 2014-10-15 2016-04-21 Xenoport, Inc. Fumarate compounds, pharmaceutical compositions, and methods of use
US9326965B2 (en) 2014-02-28 2016-05-03 Banner Life Sciences Llc Controlled release fumarate esters
US9326947B1 (en) 2014-02-28 2016-05-03 Banner Life Sciences Llc Controlled release fumarate esters
KR20160076928A (ko) 2014-12-23 2016-07-01 한미약품 주식회사 푸마르산 에스테르를 함유하는 미니-정제 형태의 약제학적 제제
EP3038605A1 (en) * 2013-08-26 2016-07-06 Forward Pharma A/S Pharmaceutical composition containing dimethyl fumarate for administration at a low daily dose
WO2016124960A1 (en) 2015-02-08 2016-08-11 Alkermes Pharma Ireland Limited Monomethylfumarate prodrug compositions
US9422226B2 (en) 2011-06-08 2016-08-23 Biogen Ma Inc. Process for preparing high purity and crystalline dimethyl fumarate
WO2016113754A3 (en) * 2015-01-14 2016-10-06 Leiutis Pharmaceuticals Pvt, Ltd. Novel oral dosage forms of dimethyl fumarate
WO2016153957A3 (en) * 2015-03-20 2016-11-10 Biogen Ma Inc. Methods and compositions for the intravenous administration of fumarates for the treatment of neurological diseases
US9504679B2 (en) 2011-12-19 2016-11-29 Bjoern Colin Kahrs Pharmaceutical compositions comprising glitazones and Nrf2 activators
WO2016194004A1 (en) * 2015-06-01 2016-12-08 Sun Pharmaceutical Industries Ltd. Pharmaceutical compositions of dimethyl fumarate
WO2016205270A1 (en) * 2015-06-17 2016-12-22 Biogen Ma Inc. Dimethyl fumarate particles and pharmaceutical compositions thereof
US9566259B1 (en) 2015-08-31 2017-02-14 Banner Life Sciences Llc Fumarate ester dosage forms
EP3135282A1 (en) 2007-02-08 2017-03-01 Biogen MA Inc. Neuroprotection in demyelinating diseases
US9604922B2 (en) 2014-02-24 2017-03-28 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
WO2017060420A1 (en) 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Protected fumaric acid-based metabolites for the treatment of autoimmune diseases
US9682057B2 (en) 2013-09-06 2017-06-20 Xenoport, Inc. Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use
WO2017129370A1 (en) * 2016-01-28 2017-08-03 Zaklady Farmaceutyczne Polpharma S.A. Process for preparation of a granulate comprising dimethyl fumarate
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
US10098863B2 (en) 2014-02-28 2018-10-16 Banner Life Sciences Llc Fumarate esters
WO2018234584A1 (en) 2017-06-23 2018-12-27 Almirall, S.A. PHARMACEUTICAL COMPOSITIONS CONTAINING DIMETHYL FUMARATE
US10238615B2 (en) 2002-11-13 2019-03-26 Bracco S.P.A. 3,5,3′-triiodothyronine sulfate as thyromimetic agent and pharmaceutical formulations thereof
US10457635B2 (en) 2011-04-08 2019-10-29 Bracco Imaging S.P.A. Process for the preparation of a sulfated derivative of 3,5-diiodo-o-[3-iodophenyl]-l-tyrosine
US10716760B2 (en) 2012-08-22 2020-07-21 Arbor Pharmaceuticals, Llc Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
US10945984B2 (en) 2012-08-22 2021-03-16 Arbor Pharmaceuticals, Llc Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
US10959972B2 (en) 2014-11-17 2021-03-30 Biogen Ma Inc. Methods of treating multiple sclerosis
WO2021144478A2 (en) 2020-05-06 2021-07-22 Imcyse Sa Combination treatment for fumarate-related diseases
EP3886835A4 (en) * 2018-11-30 2022-08-10 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi DELAYED RELEASE CAPSULE CONTAINING DIMETHYL FUMARATE

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006333151B2 (en) * 2005-12-16 2010-03-04 Merck Sharp & Dohme Llc Pharmaceutical compositions of combinations of dipeptidyl peptidase-4 inhibitors with metformin
US20070142905A1 (en) * 2005-12-16 2007-06-21 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
HK1252751A1 (en) * 2009-01-09 2019-05-31 Fwp Ip Aps Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
US20110223244A1 (en) * 2010-03-09 2011-09-15 Elan Pharma International Limited Alcohol resistant enteric pharmaceutical compositions
AU2012238665B2 (en) * 2011-04-08 2016-09-29 Bracco Imaging Spa Process for the preparation of a sulfated derivative of 3,5-diiodo-O-[3-iodophenyl]-L-tyrosine
RU2014125430A (ru) 2011-11-24 2015-12-27 Синтон Бв Контролируемое высвобождение частиц, содержащих диметилфумарат
EP2782561A1 (en) * 2011-11-24 2014-10-01 Synthon BV Controlled release particles comprising dimethyl fumarate
US9421182B2 (en) 2013-06-21 2016-08-23 Xenoport, Inc. Cocrystals of dimethyl fumarate
CA2919381A1 (en) * 2013-08-01 2015-02-05 Xenoport, Inc. Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
WO2015089420A1 (en) * 2013-12-13 2015-06-18 Biogen Idec Ma Inc. Controlled release dosage form for once daily administration of dimethyl fumarate
WO2015161113A1 (en) * 2014-04-16 2015-10-22 Zynga Inc. Systems and methods of incentivizing game play
WO2016057133A1 (en) * 2014-10-08 2016-04-14 Banner Life Sciences Llc Controlled release enteric soft capsules of fumarate esters
MA40982A (fr) * 2014-11-19 2017-09-26 Biogen Ma Inc Formulation de bille pharmaceutique comprenant du fumarate de diméthyle
MA41139A (fr) 2014-12-11 2017-10-17 Actelion Pharmaceuticals Ltd Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1
EA036075B1 (ru) 2014-12-11 2020-09-23 Актелион Фармасьютиклз Лтд Схема дозирования для селективного агониста рецептора s1p1
EP3270911A4 (en) * 2015-03-17 2018-08-29 Hetero Labs Limited Pharmaceutical compositions of dimethyl fumarate
US10213411B2 (en) 2015-08-27 2019-02-26 Vijaykumar Rajasekhar Use of prodrugs of fumarates in treating heart failure diseases
US10463642B2 (en) 2016-02-01 2019-11-05 Vijaykumar Rajasekhar Methods of treating heart failure diseases using prodrugs of methyl hydrogen fumarate
JP6902043B2 (ja) * 2016-02-11 2021-07-14 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． フマル酸ジメチルを含む医薬ビーズ製剤
US11186556B1 (en) 2018-10-16 2021-11-30 Celgene Corporation Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
US11014897B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof
US11013723B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms of a thiazolidinone compound, compositions and methods of use thereof
US11014940B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Thiazolidinone and oxazolidinone compounds and formulations
RU2742745C1 (ru) * 2019-09-24 2021-02-10 Акционерное общество "Исследовательский Институт Химического Разнообразия" Лекарственная форма в виде капсулы, содержащая таблетки с диметилфурмаратом
WO2021142062A1 (en) 2020-01-10 2021-07-15 Banner Life Sciences Llc Fumarate ester dosage forms with enhanced gastrointestinal tolerability
FR3122850A1 (fr) * 2021-05-11 2022-11-18 Faurecia Sièges d'Automobile Siège de véhicule pliable
IL307342A (en) 2021-05-28 2023-11-01 Amgen Inc Formulations of Eframilest
US20250000799A1 (en) * 2021-11-11 2025-01-02 V-Ensure Pharma Technologies Private Limited Reconstitutable, Single Use Antidiabetic Compositions
US20250282721A9 (en) * 2021-12-23 2025-09-11 Gencaps Sàrl Drug delivery system comprising monomethyl fumarate
CN116524199B (zh) * 2023-04-23 2024-03-08 江苏大学 一种基于PReNet渐进式网络的图像去雨方法及装置

Family Cites Families (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2764609A (en) * 1953-07-24 1956-09-25 Monsanto Chemicals Isomerization of dialkyl maleates to dialkyl fumarates
US3078302A (en) * 1958-09-25 1963-02-19 Monsanto Chemicals Production of dialkyl fumarates
GB1153927A (en) 1966-08-25 1969-06-04 Wilhelm Hoerrmann Medicinal Composition Suitable For Treating Diseases Of The Retina
US4952594A (en) * 1973-06-18 1990-08-28 Mercer James B Reagents and method for therapeutic treatment of multiple sclerosis
DE2530372A1 (de) 1975-07-08 1977-01-13 Walter Dr Schweckendiek Pharmazeutische zubereitungen zur behandlung von psoriasis
DE2703964A1 (de) 1975-07-08 1978-08-03 Walter Dr Schweckendiek Pharmazeutische zubereitungen zur behandlung von psoriasis
US4145438A (en) * 1975-09-10 1979-03-20 Fisons Limited Method for treatment of eczema or psoriasis
DE2621214C3 (de) 1976-05-13 1981-11-12 Koronis Gmbh Chemisch-Pharmazeutische Praeparate, 5441 Sassen Verwendung von Stabilisatoren in Arzneimitteln mit Fumarsäuremonoäthylester und desen Mineralsalzen
DE2732131A1 (de) 1977-07-15 1979-01-25 Bayer Ag Verfahren zur herstellung von seitenstaendige hydroxylgruppen aufweisenden isocyanat-polyadditionsprodukten
DE2749188C2 (de) 1977-11-03 1981-11-12 Bayer Ag, 5090 Leverkusen Vorrichtung zum automatischen Einführen eines schnellaufenden Fadens in einen Fadenführungskanal einer Fadenbehandlungsvorrichtung
DE2840498C2 (de) 1978-09-18 1980-04-10 Walter Dr. 6700 Ludwigshafen Schweckendiek Pharmazeutische Zubereitungen zur Behandlung von Psoriasis
US4302440B1 (en) * 1980-07-31 1986-08-05 Easily-swallowed, powder-free and gastric-disintegrable aspirin tablet thinly-coated with hydroxypropyl methylcellulose and aqueous spray-coating preparation thereof
CH664150A5 (de) * 1985-01-15 1988-02-15 Peter Paul Prof Dr Speiser Fumarsaeureprodrug, verfahren zu seiner herstellung und dieses enthaltende darreichungsformen.
US5149695A (en) * 1985-01-15 1992-09-22 Speiser Peter P Fumaric acid derivatives, process for the production thereof and pharmaceutical compositions containing same
US4693896A (en) 1985-10-07 1987-09-15 Fmc Corporation Ethylcellulose-coated, gastric-disintegrable aspirin tablet
US4855305A (en) 1987-03-23 1989-08-08 Applied Medical Research Compositions and methods of effecting contraception utilizing melatonin
DE3711155A1 (de) * 1987-04-02 1988-10-13 Bayer Ag Verfahren zur herstellung von maleinsaeuredimethylester
IL83775A (en) 1987-09-04 1991-12-15 Dexter Chemical Corp Amino acid esters and amides of fumaric acid and pharmaceutical compositions containing them for use in the treatment of psoriasis
US5214196A (en) * 1987-09-04 1993-05-25 Dexter Chemical Corporation Diethyl ester of di-glycyl fumaramide
US5242905A (en) * 1987-09-04 1993-09-07 Dexter Chemical Corporation Pharmaceutical compositions for the treatment of psoriasis
US4959389A (en) * 1987-10-19 1990-09-25 Speiser Peter P Pharmaceutical preparation for the treatment of psoriatic arthritis
US5424332A (en) * 1987-10-19 1995-06-13 Speiser; Peter P. Pharmaceutical composition and process for the production thereof
US4911917A (en) * 1988-06-28 1990-03-27 Hauser-Kuhrts, Inc. Cholesterol-lowering combination comopsitions of magnesium salt and niacin
US4965252A (en) 1988-06-28 1990-10-23 Hauser-Kuhrts, Inc. Cholesterol-lowering combination compositions of guar gum and niacin
US5023245A (en) * 1987-11-10 1991-06-11 Hauser-Kuhrts, Inc. Improved niacin formulation
DE3834794A1 (de) 1988-10-12 1990-04-19 F Schielein Oral zu verabreichendes mittel zur behandlung von psoriasis
US5484610A (en) 1991-01-02 1996-01-16 Macromed, Inc. pH and temperature sensitive terpolymers for oral drug delivery
GEP19971086B (en) 1991-02-22 1997-12-02 Tillotts Pharma Ag Peroral Pharmaceutically Dispensed Form for Selective Introducing of the Medicine into the Intestine
US5246947A (en) * 1991-09-23 1993-09-21 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1,2-benzisothiazoles and their use for treating depression
FR2694693B1 (fr) 1992-07-28 1994-10-28 Abrax Bio Labs Sa Composition pharmaceutique à base de flavopéréirine et son utilisation dans un traitement contre le virus VIH.
DK0621032T3 (da) * 1993-04-23 2000-10-23 Novartis Ag Lægemiddelform med reguleret afgivelse
US5434185A (en) 1993-05-17 1995-07-18 The University Of Kentucky Research Foundation Method for inhibiting angiogenesis with aurintricarboxylic acid, its analogues or salts
RO114740B1 (ro) 1994-05-06 1999-07-30 Pfizer Compozitie cu eliberare controlata, procedeu de obtinere a acesteia si metoda de tratament
US5589504A (en) * 1994-07-26 1996-12-31 Cornell Research Foundation, Inc. Treatment of newborn jaundice
FR2725623A1 (fr) 1994-10-18 1996-04-19 Flamel Tech Sa Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os
US5716625A (en) * 1994-12-21 1998-02-10 Cosmederm Technologies Formulations and methods for reducing skin irritation
US6139850A (en) * 1994-12-21 2000-10-31 Cosmederm Technologies Formulations and methods for reducing skin irritation
US5804203A (en) * 1994-12-21 1998-09-08 Cosmederm Technologies Topical product formulations containing strontium for reducing skin irritation
EP0737471A3 (fr) * 1995-04-10 2000-12-06 L'oreal Utilisation d'un sel d'une métal alcalino-terreux comme inhibiteur de TNF-alpha dans une composition unique et composition obtenue
AU5787996A (en) 1995-04-19 1996-11-07 Lipoprotein Technologies, Inc. Compositions, kits, and methods for administration of antilipemic and anti-platelet aggregation drugs
FR2749759B1 (fr) * 1996-06-17 1999-11-26 Adir Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
GB9613470D0 (en) * 1996-06-27 1996-08-28 Ciba Geigy Ag Small solid oral dosage form
AU3889197A (en) 1996-07-26 1998-02-20 Douglas V Faller Compositions comprising an inducing agent and an anti-viral agent for the treat ment of blood, viral and cellular disorders
WO1998035666A1 (en) 1997-02-13 1998-08-20 Nanosystems Llc Formulations of nanoparticle naproxen tablets
DE19721099C2 (de) 1997-05-20 1999-12-02 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten
NZ333474A (en) * 1998-01-02 1999-06-29 Mcneil Ppc Inc A chewable tablet containing ibuprofen, fumaric acid and a non hydrocolloid binder e.g. a wax or a fat
DE69804865T2 (de) 1998-01-22 2002-11-07 Zentaris Ag Feste miltefosin enthaltende arzneimittel zur oralen verabreichung bei der behandlung von leishmaniasis
DE19814358C2 (de) 1998-03-31 2002-01-17 Fumapharm Ag Muri Verwendung von Alkylhydrogenfumaraten zur Behandlung von Psoriasis, psoriatischer Arthritis, Neurodermitis und Enteritis regionalis Crohn
DE69917618T2 (de) * 1998-04-03 2005-06-23 Egalet A/S Zusammensetzung mit kontrollierter wirkstoff-freisetzung
US20050220909A1 (en) * 2004-03-30 2005-10-06 Theoharides Theoharis C Composition for protection against superficial vasodilator flush syndrome
DE19839566C2 (de) * 1998-08-31 2002-01-17 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten in der Transplantationsmedizin
DE19848260C2 (de) 1998-10-20 2002-01-17 Fumapharm Ag Muri Fumarsäure-Mikrotabletten
DE19853487A1 (de) * 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
KR100297705B1 (ko) * 1999-03-29 2001-10-29 김덕중 낮은 온저항과 높은 항복전압을 갖는 전력용 반도체소자
US6537584B1 (en) 1999-11-12 2003-03-25 Macromed, Inc. Polymer blends that swell in an acidic environment and deswell in a basic environment
DE10000577A1 (de) * 2000-01-10 2001-07-26 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
US20020002306A1 (en) * 2000-02-15 2002-01-03 Yasushi Kadowaki Method for producing fumaric acid esters
JP4932116B2 (ja) * 2000-02-16 2012-05-16 ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド アスピリン誘発脂質メディエータ
IT1317042B1 (it) * 2000-06-14 2003-05-26 Biosalts Srl Fumarati doppi di una carnitina e creatina, e integratori alimentari,dietetici e farmaci che li contengono.
EP1172101A1 (en) * 2000-06-20 2002-01-16 Helsinn Healthcare S.A. The use of nimesulide for the treatment of psoriasis and psoriatic arthritis
WO2002002190A2 (en) * 2000-07-05 2002-01-10 Johns Hopkins School Of Medicine Prevention and treatment of neurodegenerative diseases by glutathione and phase ii detoxification enzymes
AU2002224417A1 (en) * 2000-10-18 2002-04-29 Immunex Corporation Methods for treating il-18 mediated disorders
DE10101307A1 (de) 2001-01-12 2002-08-01 Fumapharm Ag Muri Fumarsäurederivate als NF-kappaB-Inhibitor
CZ304198B6 (cs) * 2001-01-12 2013-12-27 Fumapharm Ag Amidy kyseliny fumarové
SE0100200D0 (sv) 2001-01-24 2001-01-24 Astrazeneca Ab New film coating
WO2003004001A1 (en) 2001-07-06 2003-01-16 Lifecycle Pharma A/S Controlled agglomeration
NO20014746D0 (no) 2001-09-28 2001-09-28 Clas M Kjoelberg Smertelindrende middel
TWI239520B (en) * 2001-10-12 2005-09-11 Konica Corp Objective lens, optical element, optical pick-up apparatus and optical information recording and/or reproducing apparatus equipped therewith
US20030152622A1 (en) * 2001-10-25 2003-08-14 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral diuretic
ATE383156T1 (de) 2001-11-13 2008-01-15 Pharmacia Corp Oral verabreichbare zusammensetzung enthaltend parecoxib
JP3796165B2 (ja) * 2001-11-20 2006-07-12 株式会社クラレ 癒着防止材
US6613800B1 (en) * 2001-12-03 2003-09-02 Steven A. Smith Method and compositions for treating psoriasis, eczema, seborrhea and arthritis
KR100540035B1 (ko) 2002-02-01 2005-12-29 주식회사 태평양 다단계 경구 약물 방출 제어 시스템
ES2399880T3 (es) 2002-03-15 2013-04-04 Cypress Bioscience, Inc. Milnaciprán para el tratamiento del síndrome del intestino irritable
DE10214031A1 (de) 2002-03-27 2004-02-19 Pharmatech Gmbh Verfahren zur Herstellung und Anwendung von Mikro- und Nanoteilchen durch aufbauende Mikronisation
US20030185915A1 (en) * 2002-03-28 2003-10-02 Jaime Carlo Synergetic composition for the treatment of psoriasis and other skin disorders and method therefor
DE10217314A1 (de) * 2002-04-18 2003-11-13 Fumapharm Ag Muri Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere
US20040038904A1 (en) * 2002-05-21 2004-02-26 Angela Ogden Method of treating multiple sclerosis
US20030219456A1 (en) * 2002-05-21 2003-11-27 Taing Ok Method of utilization of zygosaccharomyces rouxii
US6830759B2 (en) 2002-06-28 2004-12-14 Ajinomoto Co., Inc. Antidiabetic preparation for oral administration
WO2004018452A1 (en) 2002-08-19 2004-03-04 Glaxo Group Limited Pyrimidine derivatives as selective cox-2 inhibitors
CA2561082C (en) 2003-03-27 2014-07-15 Santosolve As Anti-inflammatory treatment based on strontium compounds
SI2266584T1 (sl) 2003-05-07 2012-12-31 Osteologix A/S, Symbion Sestavek s stroncijem in vitaminom D za profilakso in/ali zdravljenje patologij hrustanca in/ali kosti
CA2519189C (en) 2003-05-07 2012-07-17 Osteologix A/S Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions
US20060216358A1 (en) 2003-05-07 2006-09-28 Christian Hansen Controlled release composition containing a strontium salt
AR041089A1 (es) 2003-05-15 2005-05-04 Merck & Co Inc Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas
AU2003264002B2 (en) 2003-08-08 2010-09-02 Valeant International Bermuda Modified-release tablet of bupropion hydrochloride
EP1913942B1 (en) * 2003-09-09 2009-11-11 Biogen Idec International GmbH The use of fumaric acid derivatives for inhibition of PGF-induced thymidine uptake of bronchial smooth muscle cells and for inhibition of bronchial smooth cells proliferation
BRPI0508075A (pt) 2004-03-31 2007-07-17 Bpsi Holdings Inc revestimentos entéricos para substratos de ingestão oral
TW200603792A (en) 2004-04-23 2006-02-01 Pharmacia & Upjohn Co Llc Monotherapy for the treatment of psoriasis with cyclooxygenase-2 selective inhibitors
CN1245873C (zh) 2004-08-21 2006-03-22 王立峰 富马酸二甲酯微胶囊及其制备方法
CN101056624A (zh) 2004-10-08 2007-10-17 Adi技术制药股份公司 包含富马酸酯的控释药物组合物
PL2316430T3 (pl) * 2004-10-08 2012-11-30 Forward Pharma As Kompozycje farmaceutyczne o kontrolowanym uwalnianiu, zawierające ester kwasu fumarowego
WO2006050730A1 (en) 2004-11-10 2006-05-18 Aditech Pharma Ab Novel salts of fumaric acid monoalkylesters and their pharmaceutical use
US20080004344A1 (en) * 2004-11-10 2008-01-03 Aditech Pharma Ab Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use
DE102005022845A1 (de) * 2005-05-18 2006-11-23 Fumapharm Ag Thiobernsteinsäurederivate und deren Verwendung
US20070071819A1 (en) * 2005-05-30 2007-03-29 Kesarwani Amit K Multiple unit modified release compositions of carbamazepine and process for their preparation
WO2007005879A2 (en) 2005-07-01 2007-01-11 The Johns Hopkins University Compositions and methods for the treatment or prevention of disorders relating to oxidative stress
US20100144651A1 (en) * 2005-07-07 2010-06-10 Aditech Pharma Ab Novel glucopyranose esters and glucofuranose esters of alkyl- fumarates and their pharmaceutical use
EP1915334A2 (en) * 2005-07-07 2008-04-30 Aditech Pharma AB Novel salts of fumaric acid monoalkylesters and their pharmaceutical use
EP1940382A2 (en) 2005-10-07 2008-07-09 Aditech Pharma AB Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders
US20080299196A1 (en) * 2005-10-07 2008-12-04 Aditech Pharma Ab Controlled Release Pharmaceutical Compositions Comprising a Fumaric Acid Ester
US20090215145A1 (en) * 2006-02-15 2009-08-27 Md Bioalpha Co., Ltd. Method for controlling nad(p)/nad(p)h ratio by oxidoreductase
WO2007148744A1 (ja) 2006-06-21 2007-12-27 Santen Pharmaceutical Co., Ltd. フマル酸誘導体を有効成分として含む角結膜障害の予防または治療剤
AU2007289037A1 (en) 2006-09-01 2008-03-06 Gilead Sciences, Inc. Methods and compositions for increasing patient tolerability during myocardial imaging methods
LT2139467T (lt) * 2007-02-08 2016-10-10 Biogen Ma Inc. Neuroapsauga, sergant demielinizuojančia liga
EP2680006A1 (en) * 2007-02-08 2014-01-01 Biogen Idec MA Inc. Treatment for Amyotrophic Lateral Sclerosis
MX2009008760A (es) * 2007-02-21 2009-08-27 Mochida Pharm Co Ltd Composicion para el tratamiento de enfermedades del cartilago.
EP2136430A4 (en) 2007-04-12 2011-04-27 Panasonic Corp POWER SUPPLY SYSTEM AND METHOD FOR CHARGING A BATTERY PACK
WO2008134013A2 (en) 2007-04-25 2008-11-06 Teva Pharmaceutical Industries Ltd. Pharmaceutical excipient complex
US20080274182A1 (en) 2007-05-03 2008-11-06 Regina Helena Alida Boekema Tablet coatings made from modified carboxymethylcellulose materials
CA2690956C (en) 2007-07-01 2017-01-03 Joseph Peter Habboushe Combination tablet with chewable outer layer
KR20090028047A (ko) * 2007-09-13 2009-03-18 경북대학교 산학협력단 디메틸푸마레이트의 신규 용도
CN101318901A (zh) 2008-06-17 2008-12-10 健雄职业技术学院 一种富马酸二甲酯的合成新工艺
DK2334378T3 (da) * 2008-08-19 2014-07-07 Xenoport Inc Prodrugs af methylhydrogenfumarat, farmaceutiske sammensætninger deraf og fremgangsmåder til anvendelse
JP5420877B2 (ja) * 2008-10-07 2014-02-19 テイカ製薬株式会社 眼科用剤
EP2564839B1 (en) 2009-01-09 2016-05-11 Forward Pharma A/S Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
EP2379062A1 (en) * 2009-01-09 2011-10-26 Forward Pharma A/S Pharmaceutical composition comprising one or more fumaric acid esters
CN101475477A (zh) 2009-01-23 2009-07-08 上海化学试剂研究所 反丁烯二酸二甲酯的制备方法
DK2414542T3 (da) * 2009-03-30 2017-11-27 Tel Hashomer Medical Res Infrastructure & Services Ltd Fremgangsmåder til forudsigelse af klinisk forløb for og behandling af multipel sklerose
US20120165404A1 (en) 2009-04-29 2012-06-28 Biogen Idec Ma Inc. Treatment of neurodegeneration and neuroinflammation
CN101701943A (zh) 2009-11-05 2010-05-05 宁波中普检测技术服务有限公司 气相色谱-质谱联用测定产品中富马酸二甲酯的方法
DK2533634T3 (en) 2010-02-12 2016-01-25 Biogen Ma Inc NEURO PROTECTIVE demyelinating diseases
ES2531669T3 (es) * 2010-03-11 2015-03-18 Bender Analytical Holding B.V. Composición acuosa estéril basada en alginato para uso médico y procedimiento para la preparación de la misma
PE20141316A1 (es) 2011-05-26 2014-10-01 Biogen Idec Inc Metodos para tratar la esclerosis multiple y preservar y/o aumentar el contenido de mielina
PT2718257T (pt) 2011-06-08 2018-02-26 Biogen Ma Inc Processo para a preparação de fumarato de dimetilo de alta pureza e cristalino
RU2014125430A (ru) 2011-11-24 2015-12-27 Синтон Бв Контролируемое высвобождение частиц, содержащих диметилфумарат
CA2862885C (en) 2012-02-07 2020-06-02 Biogen Idec Ma Inc. Pharmaceutical compositions containing dimethyl fumarate
WO2014031844A1 (en) 2012-08-22 2014-02-27 Xenoport, Inc. Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
KR102092289B1 (ko) * 2013-06-03 2020-03-23 삼성전자주식회사 전자 기기 및 이의 문서 작성 방법
WO2015089420A1 (en) 2013-12-13 2015-06-18 Biogen Idec Ma Inc. Controlled release dosage form for once daily administration of dimethyl fumarate
US9636318B2 (en) 2015-08-31 2017-05-02 Banner Life Sciences Llc Fumarate ester dosage forms
US9326947B1 (en) 2014-02-28 2016-05-03 Banner Life Sciences Llc Controlled release fumarate esters
EP3501510B1 (en) 2014-02-28 2020-07-01 Banner Life Sciences LLC Controlled release enteric soft capsules of fumarate esters
US10098863B2 (en) 2014-02-28 2018-10-16 Banner Life Sciences Llc Fumarate esters
WO2016057133A1 (en) 2014-10-08 2016-04-14 Banner Life Sciences Llc Controlled release enteric soft capsules of fumarate esters
WO2017040272A1 (en) 2015-08-31 2017-03-09 Banner Life Sciences Llc Fumarate ester dosage forms
CA2997684A1 (en) * 2015-09-07 2017-03-16 Mochida Pharmaceutical Co., Ltd. Freeze-dried alginic acid preparation
WO2017151184A1 (en) 2016-02-29 2017-09-08 Banner Life Sciences Llc Fumarate ester dosage forms
WO2017159700A1 (ja) * 2016-03-14 2017-09-21 公益財団法人田附興風会 神経再生誘導材
US10523918B2 (en) 2017-03-24 2019-12-31 Samsung Electronics Co., Ltd. System and method for depth map

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of EP1799196A2 *

Cited By (164)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7803840B2 (en) 1998-11-19 2010-09-28 Biogen Idec International Gmbh Utilization of dialkylfumarates
US7915310B2 (en) 1998-11-19 2011-03-29 Biogen Idec International Gmbh Utilization of dialkylfumarates
US8524773B2 (en) 1998-11-19 2013-09-03 Biogen Idec International Gmbh Utilization of dialkylfumarates
US7320999B2 (en) 1998-11-19 2008-01-22 Fumapharm Ag Dimethyl fumarate for the treatment of multiple sclerosis
US8759393B2 (en) 1998-11-19 2014-06-24 Biogen Idec International Gmbh Utilization of dialkylfumarates
US7612110B2 (en) 1998-11-19 2009-11-03 Biogen Idec International Ag Utilization of dialkylfumarates
US7619001B2 (en) 1998-11-19 2009-11-17 Biogen Idec International Gmbh Utilization of dialkylfumarates
US10238615B2 (en) 2002-11-13 2019-03-26 Bracco S.P.A. 3,5,3′-triiodothyronine sulfate as thyromimetic agent and pharmaceutical formulations thereof
US8980832B2 (en) 2003-09-09 2015-03-17 Biogen Idec International Gmbh Use of fumaric acid derivatives for treating cardiac insufficiency, and asthma
US11052062B2 (en) 2004-10-08 2021-07-06 Biogen Swiss Manufacturing Gmbh Controlled release pharmaceutical compositions comprising a fumaric acid ester
US11229619B2 (en) 2004-10-08 2022-01-25 Biogen Swiss Manufacturing Gmbh Controlled release pharmaceutical compositions comprising a fumaric acid ester
EP2801354B1 (en) 2004-10-08 2017-02-08 Forward Pharma A/S Controlled release pharmaceutical compositions comprising a fumaric acid ester
EP2792349A2 (en) 2004-10-08 2014-10-22 Forward Pharma A/S Controlled release pharmaceutical compositions comprising a fumaric acid ester
EP1799196B1 (en) 2004-10-08 2016-06-22 Forward Pharma A/S Controlled release pharmaceutical compositions comprising a fumaric acid ester
EP1799196A2 (en) 2004-10-08 2007-06-27 Aditech Pharma AB Controlled release pharmaceutical compositions comprising a fumaric acid ester
US9278080B2 (en) 2005-05-11 2016-03-08 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US9132082B2 (en) 2005-05-11 2015-09-15 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US9370481B2 (en) 2005-05-11 2016-06-21 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
WO2007042035A3 (en) * 2005-10-07 2007-06-14 Aditech Pharma Ab Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders
WO2007042034A1 (en) * 2005-10-07 2007-04-19 Aditech Pharma Ab Controlled release pharmaceutical compositions comprising a fumaric acid ester
US9233092B2 (en) 2006-07-25 2016-01-12 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with PPI
EP3135282A1 (en) 2007-02-08 2017-03-01 Biogen MA Inc. Neuroprotection in demyelinating diseases
US8399514B2 (en) 2007-02-08 2013-03-19 Biogen Idec Ma Inc. Treatment for multiple sclerosis
WO2008097596A2 (en) 2007-02-08 2008-08-14 Biogen Idec Ma Inc. Nrf2 screening assays and related methods and compositions
EP2629097A1 (en) 2007-02-08 2013-08-21 Biogen Idec MA Inc. NRF2 screening assays and related methods and compositions
EP2137537B1 (en) * 2007-02-08 2013-05-29 Biogen Idec MA Inc. Compositions and Uses for Treating Multiple Sclerosis
EP2137537A2 (en) 2007-02-08 2009-12-30 Biogen Idec MA, Inc. Nrf2 screening assays and related methods and compositions
EP2653873A1 (en) 2007-02-08 2013-10-23 Biogen Idec MA Inc. Compositions and uses for treating Multiple Sclerosis
EP2680009A1 (en) 2007-02-08 2014-01-01 Biogen Idec MA Inc. Nrf2 screening assays and related methods and compositions
EP2680010A1 (en) 2007-02-08 2014-01-01 Biogen Idec MA Inc. Nrf2 screening assays and related methods and compositions
EP2680006A1 (en) 2007-02-08 2014-01-01 Biogen Idec MA Inc. Treatment for Amyotrophic Lateral Sclerosis
EP2680008A1 (en) 2007-02-08 2014-01-01 Biogen Idec MA Inc. Nrf2 screening assays and related methods and compositions
EP2680007A1 (en) 2007-02-08 2014-01-01 Biogen Idec MA Inc. Nrf2 screening assays and related methods and compositions
EP4137819A1 (en) 2007-02-08 2023-02-22 Biogen MA Inc. Compositions and uses for treating multiple sclerosis
EP2653873B1 (en) 2007-02-08 2022-07-20 Biogen MA Inc. Compositions and uses for treating Multiple Sclerosis
EP2518511A1 (en) 2007-02-08 2012-10-31 Biogen Idec MA Inc. Nrf2 screening assays and related methods and compositions
US8148414B2 (en) 2008-08-19 2012-04-03 Xenoport, Inc. Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use
US8785443B2 (en) 2008-08-19 2014-07-22 Xenoport, Inc. Methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof
EP2650279A2 (en) 2008-08-19 2013-10-16 XenoPort, Inc. Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use
US9452972B2 (en) 2008-08-19 2016-09-27 Xenoport, Inc. Methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof
US8778991B2 (en) 2008-08-19 2014-07-15 Xenoport, Inc. Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use
WO2010079221A1 (en) * 2009-01-09 2010-07-15 Forward Pharma A/S Pharmaceutical composition comprising one or more fumaric acid esters
EP2564839A3 (en) * 2009-01-09 2013-04-17 Forward Pharma A/S Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
US20190328675A1 (en) * 2009-01-09 2019-10-31 Biogen Swiss Manufacturing Gmbh Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
US8906420B2 (en) 2009-01-09 2014-12-09 Forward Pharma A/S Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
US11173123B2 (en) 2009-01-09 2021-11-16 Biogen Swiss Manufacturing Gmbh Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
RU2743637C2 (ru) * 2009-01-09 2021-02-20 Фвп Ип Апс Фармацевтический состав, содержащий один или более эфиров фумаровой кислоты в разлагаемой матрице
US20120034274A1 (en) * 2009-01-09 2012-02-09 Forward Pharma A/S Pharmaceutical composition comprising one or more fumaric acid esters
EP3295936A1 (en) 2009-01-09 2018-03-21 Forward Pharma A/S Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
WO2010079222A1 (en) * 2009-01-09 2010-07-15 Forward Pharma A/S Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
EP3090733A1 (en) 2009-01-09 2016-11-09 Forward Pharma A/S Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
EP2564839A2 (en) 2009-01-09 2013-03-06 Forward Pharma A/S Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
EP3318249A1 (en) 2009-04-29 2018-05-09 Biogen MA Inc. Dimethyl fumarate dosage regimens for the treatment of multiple sclerosis
EP2424357A1 (en) 2009-04-29 2012-03-07 Biogen Idec MA Inc. Treatment of neurodegeneration and neuroinflammation
EP3466420A1 (en) 2009-04-29 2019-04-10 Biogen MA Inc. Dimethyl fumarate for the treatment of friedreich ataxia
EP2424357A4 (en) * 2009-04-29 2012-10-10 Biogen Idec Inc TREATMENT OF NERVOUS GENERATION AND NERVE IGNITION
EP2982371A1 (en) 2010-02-12 2016-02-10 Biogen MA Inc. Dimethyl fumarate with glatiramer acetate or interferon-beta for treating multiple sclerosis
US10457635B2 (en) 2011-04-08 2019-10-29 Bracco Imaging S.P.A. Process for the preparation of a sulfated derivative of 3,5-diiodo-o-[3-iodophenyl]-l-tyrosine
US9422226B2 (en) 2011-06-08 2016-08-23 Biogen Ma Inc. Process for preparing high purity and crystalline dimethyl fumarate
US10426763B2 (en) 2011-12-19 2019-10-01 Bjoern Colin Kahrs Pharmaceutical compositions comprising glitazones and NRF2 activators
US9504679B2 (en) 2011-12-19 2016-11-29 Bjoern Colin Kahrs Pharmaceutical compositions comprising glitazones and Nrf2 activators
WO2013092269A1 (en) 2011-12-19 2013-06-27 Ares Trading S.A. Pharmaceutical compositions comprising glitazones and nrf2 activators
US11484530B2 (en) 2011-12-19 2022-11-01 Bjoern Colin Kahrs Pharmaceutical compositions comprising the PPAR agonist INT-131 and Nrf2 activators
US12083107B2 (en) 2011-12-19 2024-09-10 Bjoern Colin Kahrs Pharmaceutical compositions comprising glitazones and Nrf2 activators
EP2811994A4 (en) * 2012-02-07 2016-01-13 Biogen Ma Inc PHARMACEUTICAL COMPOSITIONS WITH DIMETHYLFUMARATE
US8952006B2 (en) 2012-02-07 2015-02-10 Xenoport, Inc. Morpholinoalkyl fumarate compounds, pharmaceutical compositions, and methods of use
WO2013119791A1 (en) 2012-02-07 2013-08-15 Xenoport, Inc. Morpholinoalkyl fumarate compounds, pharmaceutical compositions, and methods of use
EP2811994A1 (en) 2012-02-07 2014-12-17 Biogen Idec MA Inc. Pharmaceutical compositions containing dimethyl fumarate
KR102105217B1 (ko) * 2012-02-07 2020-06-01 바이오젠 엠에이 인코포레이티드 다이메틸 푸마레이트를 함유하는 약학 조성물
WO2013119677A1 (en) 2012-02-07 2013-08-15 Biogen Idec Ma Inc. Pharmaceutical compositions containing dimethyl fumarate
TWI676475B (zh) * 2012-02-07 2019-11-11 拜健麻州公司 含有反式丁烯二酸二甲酯之醫藥組成物
KR20150001726A (ko) * 2012-02-07 2015-01-06 바이오겐 아이덱 엠에이 인코포레이티드 다이메틸 푸마레이트를 함유하는 약학 조성물
US10940117B2 (en) 2012-08-22 2021-03-09 Arbor Pharmaceuticals, Llc Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
US10945984B2 (en) 2012-08-22 2021-03-16 Arbor Pharmaceuticals, Llc Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
US10716760B2 (en) 2012-08-22 2020-07-21 Arbor Pharmaceuticals, Llc Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
WO2014100728A1 (en) 2012-12-21 2014-06-26 Biogen Idec Ma Inc. Deuterium substituted fumarate derivatives
EP3566701A1 (en) 2012-12-21 2019-11-13 Biogen MA Inc. Deuterium substituted fumarate derivatives
US10399924B2 (en) 2012-12-21 2019-09-03 Biogen Ma Inc. Deuterium substituted fumarate derivatives
US10596140B2 (en) 2013-03-14 2020-03-24 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US9505776B2 (en) 2013-03-14 2016-11-29 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US11905298B2 (en) 2013-03-14 2024-02-20 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US10406133B2 (en) 2013-03-14 2019-09-10 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US12076306B2 (en) 2013-03-14 2024-09-03 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US11083703B2 (en) 2013-03-14 2021-08-10 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
EP4230264A2 (en) 2013-03-14 2023-08-23 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various deseases
US11679092B2 (en) 2013-03-14 2023-06-20 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US11230548B2 (en) 2013-03-14 2022-01-25 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
EP3366668A1 (en) 2013-03-14 2018-08-29 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various deseases
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
WO2014152494A1 (en) 2013-03-14 2014-09-25 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various deseases
US9090558B2 (en) 2013-03-14 2015-07-28 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US11938111B2 (en) 2013-03-24 2024-03-26 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of dimethyl fumarate
WO2014160633A1 (en) 2013-03-24 2014-10-02 Xenoport, Inc. Pharmaceutical compositions of dimethyl fumarate
US10179118B2 (en) 2013-03-24 2019-01-15 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of dimethyl fumarate
US9302977B2 (en) 2013-06-07 2016-04-05 Xenoport, Inc. Method of making monomethyl fumarate
WO2014197860A1 (en) 2013-06-07 2014-12-11 Xenoport, Inc. Method of making monomethyl fumarate
EP3492072A1 (en) 2013-08-26 2019-06-05 Fwp Ip Aps Pharmaceutical composition containing dimethyl fumarate for administration at a low daily dose
AU2019268052B2 (en) * 2013-08-26 2021-09-02 Fwp Ip Aps Pharmaceutical composition containing dimethyl fumarate for administration at a low daily dose
AU2019268049B2 (en) * 2013-08-26 2021-08-26 Fwp Ipa Aps Pharmaceutical composition containing dimethyl fumarate for administration at a low daily dose
EP3517102A1 (en) 2013-08-26 2019-07-31 Fwp Ip Aps Pharmaceutical composition containing dimethyl fumarate for administration at a low daily dose
EP3038606A1 (en) * 2013-08-26 2016-07-06 Forward Pharma A/S Pharmaceutical composition containing dimethyl fumarate for administration at a low daily dose
EP3038605A1 (en) * 2013-08-26 2016-07-06 Forward Pharma A/S Pharmaceutical composition containing dimethyl fumarate for administration at a low daily dose
US9682057B2 (en) 2013-09-06 2017-06-20 Xenoport, Inc. Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use
AU2019268075B2 (en) * 2013-12-12 2020-12-17 Almirall, S.A. Pharmaceutical compositions comprising dimethyl fumarate
EP3656379A1 (en) 2013-12-12 2020-05-27 Almirall S.A. Pharmaceutical compositions comprising dimethyl fumarate
WO2015086467A1 (en) * 2013-12-12 2015-06-18 Almirall, S.A. Pharmaceutical compositions comprising dimethyl fumarate
IL245685B (en) * 2013-12-12 2021-10-31 Almirall Sa Pharmaceutical preparations containing dimethyl fumarate
US20160310457A1 (en) * 2013-12-12 2016-10-27 Almirall, S.A. Pharmaceutical compositions comprising dimethyl fumarate
AU2014363792B2 (en) * 2013-12-12 2019-11-14 Almirall, S.A. Pharmaceutical compositions comprising dimethyl fumarate
US9604922B2 (en) 2014-02-24 2017-03-28 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
EP3766487A1 (en) 2014-02-28 2021-01-20 Banner Life Sciences LLC Controlled release enteric soft capsules of fumarate esters
US10918617B2 (en) 2014-02-28 2021-02-16 Banner Life Sciences Llc Fumarate ester pharmaceutical compositions
EP3501510A1 (en) 2014-02-28 2019-06-26 Banner Life Sciences LLC Controlled release enteric soft capsules of fumarate esters
US9517209B2 (en) 2014-02-28 2016-12-13 Banner Life Sciences Llc Fumarate ester pharmaceutical compositions
US9511043B2 (en) 2014-02-28 2016-12-06 Banner Life Sciences Llc Fumarate ester pharmaceutical compositions
US9814691B2 (en) 2014-02-28 2017-11-14 Banner Life Sciences Llc Fumarate ester pharmaceutical compositions
US10105337B2 (en) 2014-02-28 2018-10-23 Banner Life Sciences Llc Fumarate ester pharmaceutical compositions
US10918616B2 (en) 2014-02-28 2021-02-16 Banner Life Sciences Llc Fumarate ester pharmaceutical compositions
US9326965B2 (en) 2014-02-28 2016-05-03 Banner Life Sciences Llc Controlled release fumarate esters
US10105336B2 (en) 2014-02-28 2018-10-23 Banner Life Sciences Llc Fumarate ester pharmaceutical compositions
US10098863B2 (en) 2014-02-28 2018-10-16 Banner Life Sciences Llc Fumarate esters
US10918615B2 (en) 2014-02-28 2021-02-16 Banner Life Sciences Llc Fumarate esters
US9326947B1 (en) 2014-02-28 2016-05-03 Banner Life Sciences Llc Controlled release fumarate esters
US9820960B2 (en) 2014-02-28 2017-11-21 Banner Life Sciences Llc Fumarate ester pharmaceutical compositions
US10391160B2 (en) 2014-03-14 2019-08-27 Biogen Ma Inc. Dimethyl fumarate and vaccination regimens
EP3650042A1 (en) 2014-03-14 2020-05-13 Biogen MA Inc. Dimethyl fumarate and vaccination regimens
WO2015138917A1 (en) 2014-03-14 2015-09-17 Biogen Ma Inc. Dimethyl fumarate and vaccination regimens
US10555993B2 (en) 2014-03-14 2020-02-11 Biogen Ma Inc. Dimethyl fumarate and vaccination regimens
US10994003B2 (en) 2014-03-14 2021-05-04 Biogen Ma Inc. Dimethyl fumarate and vaccination regimens
US11135296B2 (en) 2014-03-24 2021-10-05 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of fumaric acid esters
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
WO2016061393A1 (en) 2014-10-15 2016-04-21 Xenoport, Inc. Fumarate compounds, pharmaceutical compositions, and methods of use
US10959972B2 (en) 2014-11-17 2021-03-30 Biogen Ma Inc. Methods of treating multiple sclerosis
US11246850B2 (en) 2014-11-17 2022-02-15 Biogen Ma Inc. Methods of treating multiple sclerosis
US11007167B2 (en) 2014-11-17 2021-05-18 Biogen Ma Inc. Methods of treating multiple sclerosis
US11007166B2 (en) 2014-11-17 2021-05-18 Biogen Ma Inc. Methods of treating multiple sclerosis
US11129806B2 (en) 2014-11-17 2021-09-28 Biogen Ma Inc. Methods of treating multiple sclerosis
KR20160076928A (ko) 2014-12-23 2016-07-01 한미약품 주식회사 푸마르산 에스테르를 함유하는 미니-정제 형태의 약제학적 제제
WO2016113754A3 (en) * 2015-01-14 2016-10-06 Leiutis Pharmaceuticals Pvt, Ltd. Novel oral dosage forms of dimethyl fumarate
IL252962B (en) * 2015-02-08 2022-07-01 Alkermes Pharma Ireland Ltd Monomethylfumarate prodrug compositions
AU2020205237B2 (en) * 2015-02-08 2022-04-14 Alkermes Pharma Ireland Limited Monomethylfumarate prodrug compositions
AU2019200868B2 (en) * 2015-02-08 2020-05-14 Alkermes Pharma Ireland Limited Monomethylfumarate prodrug compositions
WO2016124960A1 (en) 2015-02-08 2016-08-11 Alkermes Pharma Ireland Limited Monomethylfumarate prodrug compositions
EA037666B1 (ru) * 2015-02-08 2021-04-28 Алкермес Фарма Айрленд Лимитед Фармацевтическая композиция, содержащая 2-(2,5-диоксопирролидин-1-ил)этилметилфумарат, и ее применение в медицине
EP3253377B1 (en) 2015-02-08 2021-05-12 Alkermes Pharma Ireland Limited Monomethylfumarate prodrug compositions
WO2016153957A3 (en) * 2015-03-20 2016-11-10 Biogen Ma Inc. Methods and compositions for the intravenous administration of fumarates for the treatment of neurological diseases
WO2016194004A1 (en) * 2015-06-01 2016-12-08 Sun Pharmaceutical Industries Ltd. Pharmaceutical compositions of dimethyl fumarate
CN107920997A (zh) * 2015-06-17 2018-04-17 比奥根Ma公司 富马酸二甲酯颗粒和其药物组合物
WO2016205270A1 (en) * 2015-06-17 2016-12-22 Biogen Ma Inc. Dimethyl fumarate particles and pharmaceutical compositions thereof
US11291642B2 (en) 2015-06-17 2022-04-05 Biogen Ma Inc. Dimethyl fumarate particles and pharmaceutical compositions thereof
US9814692B2 (en) 2015-08-31 2017-11-14 Banner Life Sciences Llc Fumarate ester dosage forms
US9636318B2 (en) 2015-08-31 2017-05-02 Banner Life Sciences Llc Fumarate ester dosage forms
US9636319B1 (en) 2015-08-31 2017-05-02 Banner Life Sciences Llc Fumarate ester dosage forms
US10105335B2 (en) 2015-08-31 2018-10-23 Banner Life Sciences Llc Fumarate ester dosage forms
US9566259B1 (en) 2015-08-31 2017-02-14 Banner Life Sciences Llc Fumarate ester dosage forms
US10945985B2 (en) 2015-08-31 2021-03-16 Banner Life Sciences Llc Fumarate ester dosage forms
US11590095B2 (en) 2015-08-31 2023-02-28 Banner Life Sciences Llc Fumarate ester dosage forms
US9820961B2 (en) 2015-08-31 2017-11-21 Banner Life Sciences Llc Fumarate ester dosage forms
WO2017060420A1 (en) 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Protected fumaric acid-based metabolites for the treatment of autoimmune diseases
WO2017129370A1 (en) * 2016-01-28 2017-08-03 Zaklady Farmaceutyczne Polpharma S.A. Process for preparation of a granulate comprising dimethyl fumarate
US11602515B2 (en) 2017-06-23 2023-03-14 Almirall, S.A. Pharmaceutical compositions comprising dimethyl fumarate
WO2018234584A1 (en) 2017-06-23 2018-12-27 Almirall, S.A. PHARMACEUTICAL COMPOSITIONS CONTAINING DIMETHYL FUMARATE
EP3886835A4 (en) * 2018-11-30 2022-08-10 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi DELAYED RELEASE CAPSULE CONTAINING DIMETHYL FUMARATE
WO2021144478A2 (en) 2020-05-06 2021-07-22 Imcyse Sa Combination treatment for fumarate-related diseases

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